Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0557 and Rv0558 are separated by 16 nucleotidesRv0558 and Rv0559c are separated by 13 nucleotidesRv0559c and Rv0560c are separated by 33 nucleotidesRv0560c and Rv0561c are separated by 24 nucleotides Rv0557: Rv0557 - Mannosyltransferase MgtA, at 648,536 to 649,672 Rv0557 Rv0558: Rv0558 - Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase), at 649,689 to 650,393 Rv0558 Rv0559c: Rv0559c - Possible conserved secreted protein, at 650,407 to 650,745 Rv0559c Rv0560c: Rv0560c - Possible benzoquinone methyltransferase (methylase), at 650,779 to 651,504 Rv0560c Rv0561c: Rv0561c - Possible oxidoreductase, at 651,529 to 652,755 Rv0561c
Group Condition Rv0557 Rv0558 Rv0559c Rv0560c Rv0561c
stress 7H9 with Phenazine ethosulfate 0.0137 mM -0.2 N.D. +0.0 -0.5 -1.8
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.4 N.D. -0.5 -0.3 -1.2
no stress control no stress control -0.6 N.D. +0.6 +0.0 -2.5
stress 7H9 with Amikacin di2 ug/mL -0.4 N.D. -0.1 -0.1 -1.6
stress 7H9 with Sutezolid 0.12 ug/mL +0.0 N.D. +0.1 +0.0 -2.0
stress 7H9 with Benzethonium chloride 0.068 mM -0.5 N.D. -0.1 +0.5 -1.5
stress 7H9 with Norfloxacin 0.125 mM -0.2 N.D. +0.3 -0.3 -1.3
stress 7H9 with Bedaquiline 0.15 ug/mL +0.2 N.D. -0.3 +0.2 -1.5
nitrogen source Urea 10mM (N) -0.2 N.D. +0.4 +0.3 -1.9
stress 7H9 with Spectinomycin 0.029 mM +0.2 N.D. -0.3 +0.3 -1.5
stress 7H9 with copper (II) chloride 0.08 mM +0.1 N.D. +0.7 -0.6 -1.3
nitrogen source L-Valine 10 mM (N) +0.5 N.D. -0.1 -0.4 -1.0
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.4 N.D. +0.2 +0.3 -1.4
stress 7H9 with Phenazine ethosulfate 0.0137 mM -0.3 N.D. +0.1 +0.8 -1.0
carbon source oleate 200uM (C) +0.6 N.D. +0.4 +0.4 -1.8
nitrogen source L-Glutamic 10 mM (N) -0.6 N.D. -0.0 -0.5 +0.8
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -1.1 N.D. -0.1 +0.2 +0.8
stress 7H9 with Levofloxacin 0.3 ug/mL -0.6 N.D. +0.1 -0.2 +0.9
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 N.D. -0.7 -0.4 +1.2
stress 7H9 with Nickel (II) chloride 0.6 mM -0.2 N.D. -0.2 -0.3 +1.3
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.4 N.D. -0.2 -0.6 +1.1
stress 7H9 with hypochlorite 0.4 vol% -0.3 N.D. -0.2 +0.2 +1.1
stress 7H9 with Nickel (II) chloride 0.6 mM -0.3 N.D. -0.1 -0.3 +1.6
no stress control no stress control +0.5 N.D. -0.2 -0.5 +1.2
stress 7H9 with Geneticin G418 0.35 mM +0.4 N.D. +0.2 -0.4 +1.0
stress 7H9 with Geneticin G418 0.35 mM +0.7 N.D. -0.2 +0.2 +1.3
nitrogen source L-Alanine 10 mM (N) -0.1 N.D. +0.1 +0.5 +1.5
stress 7H9 with EDTA (disodium salt) 0.2 mM +0.0 N.D. +0.2 +0.2 +1.6
no stress control no stress control +1.1 N.D. -0.1 +0.6 +0.6
stress 7H9 with hypochlorite 0.4 vol% +1.3 N.D. +0.1 -0.3 +1.5
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