Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0530A and Rv0531 are separated by 46 nucleotidesRv0531 and Rv0532 are separated by 146 nucleotidesRv0532 and Rv0533c overlap by 105 nucleotidesRv0533c and Rv0534c are separated by 81 nucleotides Rv0530A: Rv0530A - Conserved protein, at 622,121 to 622,282 Rv0530A Rv0531: Rv0531 - Possible conserved membrane protein, at 622,329 to 622,646 Rv0531 Rv0532: Rv0532 - PE-PGRS family protein PE_PGRS6, at 622,793 to 624,577 Rv0532 Rv0533c: Rv0533c - 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III), at 624,473 to 625,480 Rv0533c Rv0534c: Rv0534c - 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase), at 625,562 to 626,440 Rv0534c
Group Condition Rv0530A Rv0531 Rv0532 Rv0533c Rv0534c
stress 7H9 with Pretomanid 0.213 ug/mL -0.5 -1.2 -0.0 -0.7 N.D.
stress 7H9 with Pretomanid 0.213 ug/mL -0.1 -1.6 +0.0 -0.6 N.D.
stress 7H9 with Ethambutol 0.75 ug/mL +0.0 -1.9 -0.2 +0.1 N.D.
nitrogen source L-Glutamic 10 mM (N) -0.3 -1.4 -0.1 -0.2 N.D.
stress 7H9 with Hygromycin B 0.0095 mM -0.9 -1.0 +0.0 -0.0 N.D.
stress 7H9 with Hygromycin B 0.0095 mM -0.5 -1.1 -0.0 -0.0 N.D.
stress 7H9 with Rifampicin 0.00045 ug/mL -0.3 -1.0 -0.2 -0.1 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.2 -2.1 +0.1 +0.2 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.0 -1.6 +0.1 +0.1 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 -1.1 -0.3 +0.0 N.D.
stress 7H9 with Meropenem 9.6 ug/mL -0.5 -0.8 +0.1 -0.1 N.D.
stress 7H9 with Ethambutol 0.75 ug/mL -0.1 -1.2 -0.0 +0.0 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 -1.1 -0.4 +0.1 N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL -0.2 -1.0 +0.1 -0.2 N.D.
carbon source D-Trehalose 10 mM (C) -0.6 -0.5 +0.3 -0.1 N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL +0.6 -1.7 +0.1 +0.1 N.D.
carbon source D-Lactate 10 mM (C) +0.4 -1.0 +0.0 -0.0 N.D.
carbon source D-Glucose (C) +0.3 -0.9 +0.1 +0.1 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.5 -1.0 +0.2 +0.1 N.D.
nitrogen source L-Serine 10 mM (N) -0.8 +0.5 +0.2 +0.0 N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.2 -0.7 +0.3 +0.2 N.D.
stress 7H9 with Streptomycin 0.178 ug/mL +0.4 -0.7 +0.3 +0.1 N.D.
carbon source D,L-Malic Acid 10 mM (C) +1.0 -0.3 -0.2 -0.1 N.D.
carbon source casaminos 1 mg/mL (C) +0.6 -0.5 +0.2 +0.1 N.D.
nitrogen source L-Glutamic 10 mM (N) -0.2 +1.2 -0.3 -0.2 N.D.
carbon source casaminos 1 mg/mL (C) +1.1 -0.2 +0.1 +0.0 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.3 +0.5 +0.5 +0.2 N.D.
carbon source L-Asparagine (C) +1.4 +0.6 -0.2 -0.2 N.D.
carbon source D,L-Malic Acid 10 mM (C) +1.1 +0.3 +0.1 +0.1 N.D.
carbon source L-Asparagine (C) +1.5 +0.9 +0.1 -0.1 N.D.
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