Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0444c and Rv0445c are separated by 43 nucleotidesRv0445c and Rv0446c are separated by 48 nucleotidesRv0446c and Rv0447c are separated by 8 nucleotidesRv0447c and Rv0448c overlap by 4 nucleotides Rv0444c: Rv0444c - Anti-sigma factor RskA (regulator of sigma K), at 533,091 to 533,789 Rv0444c Rv0445c: Rv0445c - Alternative RNA polymerase sigma factor SigK, at 533,833 to 534,396 Rv0445c Rv0446c: Rv0446c - Possible conserved transmembrane protein, at 534,445 to 535,215 Rv0446c Rv0447c: Rv0447c - Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase), at 535,224 to 536,507 Rv0447c Rv0448c: Rv0448c - Conserved hypothetical protein, at 536,504 to 537,169 Rv0448c
Group Condition Rv0444c Rv0445c Rv0446c Rv0447c Rv0448c
stress 7H9 with Linezolid 0.44 ug/mL -1.0 -0.1 -0.2 -0.3 +0.0
stress 7H9 with Linezolid 0.3 ug/mL -1.1 -0.0 -0.2 -0.1 +0.1
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM -0.9 -0.3 -0.2 +0.1 +0.0
stress 7H9 with Rifampicin 0.014 ug/mL -1.1 +0.0 -0.1 -0.0 +0.1
carbon source Stearic 100 uM (C) -1.1 -0.1 +0.0 -0.1 +0.2
stress 7H9 with Novobiocin 0.004 mM -0.7 -0.3 -0.2 -0.0 +0.1
stress 7H9 with Linezolid 0.3 ug/mL -0.9 -0.1 -0.1 -0.0 +0.1
carbon source L-Asparagine (C) -1.3 +0.0 +0.1 +0.1 +0.1
carbon source L-Asparagine (C) -1.2 +0.2 +0.1 +0.0 -0.0
carbon source Stearic 100 uM (C) -0.8 +0.0 +0.2 -0.0 -0.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.8 -0.2 +0.2 -0.1 +0.1
stress 7H9 with Rifampicin 0.014 ug/mL -1.3 +0.2 -0.1 +0.1 +0.2
carbon source L-Glutamic (C) -0.9 +0.1 -0.1 +0.0 +0.1
stress 7H9 with Hygromycin B 0.0095 mM -0.9 +0.1 +0.1 +0.1 -0.1
stress 7H9 with Rifampicin 0.00045 ug/mL -0.8 +0.2 +0.0 -0.1 +0.1
stress 7H9 with copper (II) chloride 0.08 mM -0.9 -0.2 +0.0 +0.2 +0.3
carbon source L-Aspartic Acid (C) -0.9 +0.2 +0.0 -0.1 +0.2
stress 7H9 with Amikacin di2 ug/mL -0.5 -0.2 +0.1 +0.2 -0.3
stress 7H9 with Sulfamethizole 0.026 mM -0.6 -0.3 +0.0 +0.0 +0.2
carbon source L-Aspartic Acid (C) -0.8 +0.2 +0.1 -0.0 +0.0
stress 7H9 with Doxycycline hyclate 0.0035 mM -0.8 +0.1 +0.2 -0.1 +0.0
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.4 +0.2 -0.3 +0.2 -0.2
stress 7H9 with Sutezolid 0.12 ug/mL -0.7 +0.1 -0.2 +0.0 +0.3
stress 7H9 with Sisomicin 0.07 mM -0.3 -0.2 +0.2 +0.2 -0.3
no stress control no stress control +0.5 -0.2 -0.0 -0.1 -0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.4 -0.3 +0.2 +0.1 -0.2
nitrogen source Ammonium chloride 10mM (N) -0.6 +0.1 +0.1 +0.1 +0.4
stress 7H9 with Ethionamide 0.1 ug/mL +0.7 +0.2 +0.0 -0.3 -0.5
stress 7H9 with hypochlorite 0.4 vol% -0.3 -0.1 -0.1 +0.2 +0.6
stress 7H9 with Ethionamide 0.1 ug/mL +0.6 -0.3 +0.3 +0.2 -0.4
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