Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0405 and Rv0406c overlap by 53 nucleotidesRv0406c and Rv0407 are separated by 77 nucleotidesRv0407 and Rv0408 overlap by 8 nucleotidesRv0408 and Rv0409 overlap by 8 nucleotides Rv0405: Rv0405 - Probable membrane bound polyketide synthase Pks6, at 485,731 to 489,939 Rv0405 Rv0406c: Rv0406c - Beta lactamase like protein, at 489,887 to 490,705 Rv0406c Rv0407: Rv0407 - F420-dependent glucose-6-phosphate dehydrogenase Fgd1, at 490,783 to 491,793 Rv0407 Rv0408: Rv0408 - Probable phosphate acetyltransferase Pta (phosphotransacetylase), at 491,786 to 493,858 Rv0408 Rv0409: Rv0409 - Probable acetate kinase AckA (acetokinase), at 493,851 to 495,008 Rv0409
Group Condition Rv0405 Rv0406c Rv0407 Rv0408 Rv0409
carbon source acetate (C) -0.1 +0.8 -1.3 -3.1 -1.7
carbon source acetate (C) -0.0 +0.9 -0.4 -3.2 -2.1
carbon source propionate (C) +0.0 -0.4 -1.2 -1.8 -1.4
carbon source propionate (C) +0.0 -0.4 -1.0 -2.0 -1.4
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.1 +0.1 -4.3 +0.2 +0.5
stress 7H9 with Menadione 0.005 mM -0.0 +0.1 -2.2 +0.3 -0.0
carbon source Palmitic 100 uM (C) -0.1 +0.1 -0.8 -0.5 -0.3
stress 7H9 with Menadione 0.005 mM +0.0 -0.2 -1.8 +0.4 +0.2
stress 7H9 with Plumbagin 0.01 mM +0.0 +0.2 -2.0 +0.6 +0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.2 +0.1 -1.2 +0.2 -0.3
stress 7H9 with Hydrogen peroxide 3.97 mM -0.1 -0.2 -0.8 +0.5 -0.1
stress 7H9 with Sisomicin 0.07 mM +0.2 -0.2 +0.5 -0.6 -0.6
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +0.1 +0.2 -1.5 -0.0 +0.6
stress 7H9 with Hydrogen peroxide 3.97 mM -0.0 -0.2 -1.0 +0.4 +0.2
no stress control no stress control +0.0 -0.6 -0.5 +0.3 +0.3
nitrogen source L-Asparagine 10 mM (N) +0.3 -0.6 -0.5 +0.1 +0.6
nitrogen source L-Asparagine 10 mM (N) +0.2 -0.4 -0.4 -0.0 +0.6
nitrogen source L-Glutamine 10 mM (N) +0.2 -0.1 -0.1 -0.3 +1.0
nitrogen source L-Glutamine 10 mM (N) +0.2 +0.2 -0.3 -0.1 +0.9
nitrogen source L-Glutamic 10 mM (N) +0.2 +0.2 -0.3 +0.1 +0.9
stress 7H9 with Antimycin A 0.0186 mM +0.1 +0.3 -0.2 +0.2 +0.7
stress 7H9 with Lomefloxacin 0.0035 mM +0.1 +0.2 -0.1 +0.7 +0.6
nitrogen source L-Glutamic 10 mM (N) +0.2 +0.1 -0.5 +0.8 +1.0
stress 7H9 with Delamanid 0.236 ug/mL +0.0 +0.2 +2.1 -0.2 +0.2
stress 7H9 with Delamanid 0.236 ug/mL +0.1 -0.1 +2.1 -0.1 +0.4
stress 7H9 with Geneticin G418 0.35 mM +0.3 +0.2 +0.9 +0.5 +0.6
pH pH 4.5 -0.1 -0.1 +0.9 +1.9 +1.0
stress 7H9 with Pretomanid 0.213 ug/mL +0.1 -0.4 +3.8 +0.2 +0.0
pH pH 4.5 -0.1 -0.1 +1.3 +1.9 +0.9
stress 7H9 with Pretomanid 0.213 ug/mL +0.3 -0.7 +4.3 +0.3 -0.0
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