Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0358 and Rv0359 are separated by 10 nucleotidesRv0359 and Rv0360c are separated by 4 nucleotidesRv0360c and Rv0361 are separated by 82 nucleotidesRv0361 and Rv0362 are separated by 221 nucleotides Rv0358: Rv0358 - Conserved protein, at 436,860 to 437,507 Rv0358 Rv0359: Rv0359 - Probable conserved integral membrane protein, at 437,518 to 438,297 Rv0359 Rv0360c: Rv0360c - Conserved protein, at 438,302 to 438,739 Rv0360c Rv0361: Rv0361 - Probable conserved membrane protein, at 438,822 to 439,649 Rv0361 Rv0362: Rv0362 - Possible Mg2+ transport transmembrane protein MgtE, at 439,871 to 441,253 Rv0362
Group Condition Rv0358 Rv0359 Rv0360c Rv0361 Rv0362
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. -0.1 +0.0 -4.6 +0.3
stress 7H9 with Clofazimine 0.45 ug/mL N.D. -0.1 +0.2 -4.7 +0.3
carbon source D-Trehalose 10 mM (C) N.D. +0.1 +0.1 -3.1 +0.2
carbon source acetate (C) N.D. +0.0 +0.3 -2.7 +0.0
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.1 +0.5 -2.4 -0.3
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.0 +0.1 -2.1 -0.1
stress 7H9 with Hygromycin B 0.0095 mM N.D. -0.0 -0.4 -1.0 -0.7
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. +0.0 +0.3 -2.6 +0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.1 +0.9 -3.0 +0.0
nitrogen source L-Serine 10 mM (N) N.D. +0.2 +0.2 -2.0 -0.2
carbon source Stearic 100 uM (C) N.D. +0.2 +0.1 -2.1 +0.1
carbon source Glycerol (C) N.D. +0.2 +0.1 -1.9 -0.1
stress 7H9 with Meropenem 9.6 ug/mL N.D. +0.2 -0.2 -1.6 -0.1
carbon source D-Glucose (C) N.D. +0.1 +0.4 -1.9 -0.2
nitrogen source L-Asparagine 10 mM (N) N.D. +0.1 -0.1 -2.0 +0.5
no stress control no stress control N.D. -0.0 +0.1 -1.6 +0.2
carbon source L-Asparagine (C) N.D. -0.1 +0.4 -1.7 +0.2
stress 7H9 with Delamanid 0.236 ug/mL N.D. -0.2 +0.2 -1.3 +0.1
stress 7H9 with Pretomanid 0.213 ug/mL N.D. +0.0 +0.3 -1.5 -0.1
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. +0.3 -0.4 -1.1 +0.1
carbon source Glycerol (C) N.D. +0.2 +0.2 -1.4 +0.0
nitrogen source L-Glutamine 10 mM (N) N.D. +0.1 +0.0 -1.4 +0.2
stress 7H9 with Sulfamethizole 0.026 mM N.D. +0.0 -0.2 -1.3 +0.5
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. +0.1 +0.3 -1.3 +0.1
carbon source casaminos 1 mg/mL (C) N.D. -0.1 +0.1 -1.1 +0.4
carbon source L-Lactate 10 mM (C) N.D. +0.1 +0.2 -1.3 +0.4
carbon source pyruvate (C) N.D. +0.1 +0.3 -1.1 +0.3
no stress control no stress control N.D. +0.2 +0.9 -1.4 -0.2
carbon source L-Aspartic Acid (C) N.D. +0.2 +0.5 -1.1 +0.2
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.2 +1.4 +0.1 +0.1
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