Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0354c and Rv0355c are separated by 82 nucleotidesRv0355c and Rv0356c are separated by 150 nucleotidesRv0356c and Rv0357c overlap by 4 nucleotidesRv0357c and Rv0358 are separated by 90 nucleotides Rv0354c: Rv0354c - PPE family protein PPE7, at 424,269 to 424,694 Rv0354c Rv0355c: Rv0355c - PPE family protein PPE8, at 424,777 to 434,679 Rv0355c Rv0356c: Rv0356c - Conserved protein, at 434,830 to 435,474 Rv0356c Rv0357c: Rv0357c - Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase), at 435,471 to 436,769 Rv0357c Rv0358: Rv0358 - Conserved protein, at 436,860 to 437,507 Rv0358
Group Condition Rv0354c Rv0355c Rv0356c Rv0357c Rv0358
stress 7H9 with Clofazimine 0.072 ug/mL -0.9 +0.0 +0.3 N.D. N.D.
carbon source L-Asparagine (C) -0.7 -0.0 +0.3 N.D. N.D.
stress 7H9 with Rifampicin 0.00045 ug/mL -0.5 +0.0 +0.6 N.D. N.D.
no stress control no stress control -0.4 +0.0 +0.6 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.3 +0.0 +0.6 N.D. N.D.
nitrogen source Glycine 10 mM (N) -0.3 +0.2 +0.6 N.D. N.D.
stress 7H9 with Rifampicin 0.00045 ug/mL -0.2 +0.1 +0.6 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 +0.0 +0.8 N.D. N.D.
nitrogen source Glycine 10 mM (N) -0.2 +0.1 +0.8 N.D. N.D.
stress 7H9 with Hygromycin B 0.0095 mM +0.5 -0.1 +0.3 N.D. N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.7 -0.0 +0.2 N.D. N.D.
carbon source butyrate 10 mM (C) +0.6 -0.0 +0.3 N.D. N.D.
no stress control no stress control +0.5 -0.1 +0.5 N.D. N.D.
carbon source L-Lactate 10 mM (C) +0.6 +0.0 +0.3 N.D. N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.5 -0.0 +0.5 N.D. N.D.
stress 7H9 with Clofazimine 0.45 ug/mL +0.4 +0.1 +0.4 N.D. N.D.
carbon source Palmitic 100 uM (C) +0.5 +0.1 +0.3 N.D. N.D.
nitrogen source L-Asparagine 10 mM (N) +0.2 +0.0 +0.7 N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.4 -0.0 +0.7 N.D. N.D.
nitrogen source L-Asparagine 10 mM (N) -0.4 +0.1 +1.3 N.D. N.D.
nitrogen source L-Aspartic Acid 10 mM (N) +0.2 +0.1 +0.8 N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL +0.5 -0.0 +0.6 N.D. N.D.
nitrogen source L-Glutamine 10 mM (N) +0.1 +0.1 +1.0 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.2 -0.0 +1.5 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) +0.2 +0.1 +1.0 N.D. N.D.
carbon source Stearic 100 uM (C) +0.3 +0.1 +0.9 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +0.7 +0.1 +0.6 N.D. N.D.
nitrogen source L-Aspartic Acid 10 mM (N) +0.4 +0.2 +0.9 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) +0.6 +0.2 +0.9 N.D. N.D.
nitrogen source L-Glutamine 10 mM (N) +0.6 +0.1 +1.1 N.D. N.D.
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