Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0188 and Rv0189c are separated by 78 nucleotidesRv0189c and Rv0190 are separated by 147 nucleotidesRv0190 and Rv0191 are separated by 127 nucleotidesRv0191 and Rv0192 are separated by 33 nucleotides Rv0188: Rv0188 - Probable conserved transmembrane protein, at 219,486 to 219,917 Rv0188 Rv0189c: Rv0189c - Probable dihydroxy-acid dehydratase IlvD (dad), at 219,996 to 221,723 Rv0189c Rv0190: Rv0190 - Conserved protein, at 221,871 to 222,161 Rv0190 Rv0191: Rv0191 - Probable conserved integral membrane protein, at 222,289 to 223,530 Rv0191 Rv0192: Rv0192 - Conserved hypothetical protein, at 223,564 to 224,664 Rv0192
Group Condition Rv0188 Rv0189c Rv0190 Rv0191 Rv0192
stress 7H9 with Isoniazid 0.025 ug/mL -0.1 N.D. -2.1 -0.1 N.D.
stress 7H9 with Sisomicin 0.07 mM -1.3 N.D. -1.0 +0.2 N.D.
carbon source D-Lactate 10 mM (C) -0.5 N.D. -1.6 +0.1 N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.3 N.D. -1.9 +0.3 N.D.
carbon source propionate (C) -0.2 N.D. -1.6 +0.0 N.D.
stress 7H9 with Sisomicin 0.07 mM -0.8 N.D. -0.7 -0.1 N.D.
carbon source propionate (C) +0.2 N.D. -1.7 -0.0 N.D.
stress 7H9 with nitrite 5 mM -0.7 N.D. -0.8 +0.0 N.D.
stress 7H9 with Hygromycin B 0.0095 mM -0.5 N.D. -1.0 +0.1 N.D.
carbon source Stearic 100 uM (C) -0.5 N.D. -0.7 -0.2 N.D.
carbon source L-Lactate 10 mM (C) -0.4 N.D. -0.9 -0.1 N.D.
carbon source Glycerol (C) +0.3 N.D. -1.4 -0.2 N.D.
stress 7H9 with nitrite 3 mM; pH 5.5 -0.3 N.D. -0.9 -0.1 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 N.D. -1.3 +0.2 N.D.
carbon source D-Lactate 10 mM (C) -0.2 N.D. -1.0 -0.0 N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.4 N.D. -1.0 +0.1 N.D.
carbon source Stearic 100 uM (C) -0.3 N.D. -0.7 -0.2 N.D.
stress 7H9 with Irgasan 0.065 mM -0.2 N.D. -1.0 +0.1 N.D.
pH 7H9 pH 5.5 -0.2 N.D. -0.9 +0.2 N.D.
pH pH 4.5 +0.4 N.D. -0.9 -0.3 N.D.
carbon source Glycerol (C) +0.5 N.D. -1.2 -0.2 N.D.
nitrogen source L-Alanine 10 mM (N) +0.3 N.D. -1.0 -0.0 N.D.
pH pH 4.5 +1.0 N.D. -0.8 -0.4 N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.7 N.D. -0.8 +0.0 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.5 N.D. -0.7 +0.2 N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.3 N.D. +0.8 -0.3 N.D.
stress 7H9 with copper (II) chloride 0.08 mM -1.0 N.D. +1.6 -0.0 N.D.
stress 7H9 with copper (II) chloride 0.08 mM -0.4 N.D. +1.8 -0.1 N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.7 N.D. +1.7 -0.2 N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.0 N.D. +2.8 -0.1 N.D.
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