Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0144 and Rv0145 are separated by 88 nucleotidesRv0145 and Rv0146 are separated by 42 nucleotidesRv0146 and Rv0147 are separated by 94 nucleotidesRv0147 and Rv0148 are separated by 74 nucleotides Rv0144: Rv0144 - Probable transcriptional regulatory protein (possibly TetR-family), at 170,284 to 171,126 Rv0144 Rv0145: Rv0145 - Possible S-adenosylmethionine-dependent methyltransferase, at 171,215 to 172,168 Rv0145 Rv0146: Rv0146 - Possible S-adenosylmethionine-dependent methyltransferase, at 172,211 to 173,143 Rv0146 Rv0147: Rv0147 - Probable aldehyde dehydrogenase (NAD+) dependent, at 173,238 to 174,758 Rv0147 Rv0148: Rv0148 - Probable short-chain type dehydrogenase/reductase, at 174,833 to 175,693 Rv0148
Group Condition Rv0144 Rv0145 Rv0146 Rv0147 Rv0148
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.0 -0.9 -1.8 -0.0 +0.0
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.2 -0.4 -2.4 +0.1 +0.2
stress 7H9 with Isoniazid 0.025 ug/mL +0.0 -0.0 -0.5 -0.2 -0.4
stress 7H9 with Pretomanid 0.213 ug/mL -0.1 -0.8 -0.1 -0.0 -0.0
stress 7H9 with copper (II) chloride 0.08 mM -0.1 -0.4 -0.1 -0.1 -0.3
nitrogen source L-Asparagine 10 mM (N) -0.2 -0.3 -0.3 +0.2 -0.4
no stress control no stress control -0.1 -0.6 -0.1 -0.1 -0.1
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.2 -0.4 -0.2 -0.1 -0.1
stress 7H9 with Linezolid 0.3 ug/mL -0.0 -0.3 -0.1 -0.1 -0.4
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.0 -1.0 -0.3 +0.2 +0.3
stress 7H9 with Hydrogen peroxide 3.97 mM -0.0 -0.6 +0.2 +0.1 -0.5
stress 7H9 with Linezolid 0.3 ug/mL +0.0 -0.6 -0.0 -0.1 -0.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.0 -0.8 -0.2 +0.1 -0.0
stress 7H9 with Amikacin di2 ug/mL +0.1 -0.2 -0.2 -0.1 -0.3
stress 7H9 with Hydrogen peroxide 3.97 mM +0.2 -0.4 -0.1 -0.1 -0.3
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM +0.3 -0.9 +0.2 +0.2 -0.2
stress 7H9 with Dodecyl Sulfate 0.02 vol% +0.2 -0.1 +0.2 -0.2 -0.4
stress 7H9 with Formaldehyde 0.23 mM -0.0 -0.7 +0.0 -0.1 +0.4
nitrogen source Urea 10mM (N) +0.3 -0.4 -0.2 +0.3 -0.3
no stress control no stress control +0.0 -0.7 -0.0 +0.0 +0.6
stress 7H9 with hypochlorite 0.4 vol% +0.1 -0.3 +0.3 +0.0 -0.2
carbon source Palmitic 100 uM (C) -0.4 +0.3 -0.1 +0.1 +0.0
stress 7H9 with Linezolid 0.44 ug/mL +0.1 +0.3 +0.2 -0.2 -0.2
no stress control no stress control +0.1 -0.5 +0.2 +0.1 +0.4
stress 7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM -0.0 -0.2 +0.4 +0.2 -0.1
stress 7H9 with Irgasan 0.065 mM -0.0 +0.3 +0.3 +0.0 -0.3
carbon source oleate 200uM (C) +0.0 +0.6 -0.0 -0.2 +0.2
stress 7H9 with Ethionamide 0.1 ug/mL +0.2 +0.5 -0.3 +0.3 +0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.1 -0.0 +0.2 +0.3 +0.4
stress 7H9 with Clofazimine 0.45 ug/mL +0.2 +0.4 +0.2 +0.0 +0.4
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