Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv1054 and Rv1055 overlap by 4 nucleotidesRv1055 and GFF1101 are separated by 22 nucleotidesGFF1101 and Rv1056 are separated by 158 nucleotidesRv1056 and Rv1057 are separated by 1003 nucleotides Rv1054: Rv1054 - Probable integrase (fragment), at 1,176,928 to 1,177,242 Rv1054 Rv1055: Rv1055 - Possible integrase (fragment), at 1,177,239 to 1,177,373 Rv1055 GFF1101 - tRNA-Leu, at 1,177,396 to 1,177,469 GFF1101 Rv1056: Rv1056 - Conserved protein, at 1,177,628 to 1,178,392 Rv1056 Rv1057: Rv1057 - Conserved hypothetical protein, at 1,179,396 to 1,180,577 Rv1057
Group Condition Rv1054 Rv1055 GFF1101 Rv1056 Rv1057
stress 7H9 with Sisomicin 0.07 mM -0.1 -2.3 N.D. -0.1 -0.2
no stress control no stress control -0.2 -1.9 N.D. +0.1 +0.2
stress 7H9 with Plumbagin 0.01 mM -0.2 -1.3 N.D. -0.1 -0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 -0.1 -1.5 N.D. -0.2 +0.2
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM -0.4 -1.2 N.D. +0.1 -0.1
stress 7H9 with Norfloxacin 0.125 mM -0.1 -1.1 N.D. -0.2 -0.2
pH pH 4.5 -1.0 +0.5 N.D. -0.4 -0.6
stress 7H9 with Linezolid 0.3 ug/mL +0.1 -1.4 N.D. +0.1 +0.0
stress 7H9 with Sisomicin 0.07 mM +0.3 -1.4 N.D. -0.1 +0.0
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM +0.2 -1.2 N.D. +0.1 -0.2
pH 7H9 pH 5.5 -0.4 -1.0 N.D. +0.1 +0.2
no stress control no stress control -0.1 -1.1 N.D. +0.3 +0.3
stress 7H9 with Menadione 0.005 mM +0.3 -0.9 N.D. +0.3 -0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.4 +0.9 N.D. -0.1 -0.2
no stress control no stress control -0.2 +1.0 N.D. -0.1 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 +0.9 N.D. +0.3 +0.1
stress 7H9 with Hydrogen peroxide 3.97 mM -0.1 +1.3 N.D. -0.1 +0.0
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.1 +0.9 N.D. +0.2 +0.3
stress 7H9 with Ofloxacin 0.8 ug/mL -0.0 +1.1 N.D. +0.1 +0.3
nitrogen source Urea 10mM (N) +0.1 +1.2 N.D. +0.1 +0.2
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.6 +0.6 N.D. +0.2 +0.2
stress 7H9 with Ofloxacin 0.8 ug/mL +0.0 +1.4 N.D. +0.1 +0.2
stress 7H9 with Cumene hydroperoxide 0.05 mM +0.6 +0.8 N.D. +0.4 -0.0
no stress control no stress control +0.5 +1.0 N.D. +0.1 +0.2
stress 7H9 with Ethionamide 0.1 ug/mL +0.6 +0.7 N.D. +0.1 +0.3
carbon source acetate (C) +0.0 +1.4 N.D. +0.2 +0.1
no stress control no stress control +0.1 +1.5 N.D. +0.1 +0.2
no stress control no stress control +0.3 +1.0 N.D. +0.2 +0.2
stress 7H9 with Irgasan 0.065 mM +0.3 +1.4 N.D. +0.1 +0.1
no stress control no stress control +0.3 +1.1 N.D. +0.4 +0.2
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