Gene info for SMc04385 in Sinorhizobium meliloti 1021

Updated annotation (from data): L-2-aminoadipate semialdehyde dehydrogenase (EC 1.2.1.31)
Rationale: Specifically important for L-lysine utilization. This reaction is part of lysine catabolism via lysine 6-dehydrogenase (SMc02503), which forms (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which spontaenously interconverts with L-2-aminoadipate semialdehyde (also known as (S)-2-amino-6-oxohexanoate) in water.
Original annotation: aldehyde dehydrogenase transmembrane protein
Type 1: Protein-coding gene
Located on scaffold NC_003047, + strand, nucleotides 3,586,114 to 3,587,646
See nucleotide sequence around SMc04385 or for all of scaffold NC_003047

Other databases: NCBI, IMG: 637184124, uniprot: Q92L07

Nearby Genes

500 ntSMc04381 and SMc04382 are separated by 176 nucleotidesSMc04382 and SMc04882 are separated by 440 nucleotidesSMc04882 and SMc04383 are separated by 113 nucleotidesSMc04383 and SMc04384 are separated by 10 nucleotidesSMc04384 and SMc04385 are separated by 34 nucleotidesSMc04385 and SMc04386 are separated by 16 nucleotidesSMc04386 and SMc04387 are separated by 188 nucleotidesSMc04387 and SMc04388 are separated by 145 nucleotidesSMc04388 and SMc04389 are separated by 78 nucleotidesSMc04389 and SMc04390 are separated by 15 nucleotides SMc04381: SMc04381 - hypothetical protein, at 3,571,967 to 3,573,124 SMc04381 SMc04382: SMc04382 - beta-(1,2)-glucan production associated transmembrane protein, at 3,573,301 to 3,581,799 SMc04382 SMc04882: SMc04882 - transcriptional regulator, at 3,582,240 to 3,583,133 SMc04882 SMc04383: SMc04383 - putative hydrolase, required for lysine catabolism (from data), at 3,583,247 to 3,584,647 SMc04383 SMc04384: SMc04384 - (R)-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) (from data), at 3,584,658 to 3,586,079 SMc04384 SMc04385: SMc04385 - L-2-aminoadipate semialdehyde dehydrogenase (EC 1.2.1.31) (from data), at 3,586,114 to 3,587,646 SMc04385 SMc04386: SMc04386 - 2-aminoadipate:2-oxoglutarate aminotransferase (EC 2.6.1.39) (from data), at 3,587,663 to 3,588,895 SMc04386 SMc04387: SMc04387 - aldehyde dehydrogenase, at 3,589,084 to 3,589,632 SMc04387 SMc04388: SMc04388 - beta alanine--pyruvate transaminase, at 3,589,778 to 3,591,115 SMc04388 SMc04389: SMc04389 - hydroxypyruvate reductase, at 3,591,194 to 3,592,561 SMc04389 SMc04390: SMc04390 - L-sorbose dehydrogenase, FAD dependent protein, at 3,592,577 to 3,594,232 SMc04390
Locus Name Description Strand Phenotype
SMc04381 SMc04381 hypothetical protein - cofit
SMc04382 SMc04382 beta-(1,2)-glucan production associated transmembrane protein - strong
SMc04882 SMc04882 transcriptional regulator - strong
SMc04383 SMc04383 putative hydrolase, required for lysine catabolism (from data) + strong
SMc04384 SMc04384 (R)-2-hydroxyglutarate dehydrogenase (EC 1.1.99.39) (from data) + strong
SMc04385 SMc04385 L-2-aminoadipate semialdehyde dehydrogenase (EC 1.2.1.31) (from data) + strong
SMc04386 SMc04386 2-aminoadipate:2-oxoglutarate aminotransferase (EC 2.6.1.39) (from data) + strong
SMc04387 SMc04387 aldehyde dehydrogenase - insig.
SMc04388 SMc04388 beta alanine--pyruvate transaminase + insig.
SMc04389 SMc04389 hydroxypyruvate reductase - insig.
SMc04390 SMc04390 L-sorbose dehydrogenase, FAD dependent protein - insig.

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