Gene info for SMc02776 in Sinorhizobium meliloti 1021

Updated annotation (from data): D-arabinoate dehydratase (EC 4.2.1.5); also involved in L-fucose catabolism
Rationale: Specifically important in carbon source D-Arabinose; carbon source L-Fucose. SMc02776 is 36% identical to D-galactarate dehydratase (garD) from E. coli, which is a similar reaction. The product (2-dehydro-3-deoxy-D-arabinonate) is consumed by SMa0247. The role of SMc02776 role in L-fucose catabolism is unclear because two other dehydratases (SM_b21107 and SM_b21110) are also required but the pathway requires only one dehydratase reaction (PMID:17144652). Probably two of these dehydratases act together (with one of them in reverse) to switch the stereochemistry of a chiral center.
Original annotation: altronate hydrolase
Type 1: Protein-coding gene
Located on scaffold NC_003047, + strand, nucleotides 16,752 to 18,257
See nucleotide sequence around SMc02776 or for all of scaffold NC_003047

Other databases: NCBI, IMG: 637180791, uniprot: Q92TD9

Nearby Genes

500 ntSMc02781 and SMc02780 are separated by 167 nucleotidesSMc02780 and SMc02779 are separated by 195 nucleotidesSMc02779 and SMc02778 are separated by 281 nucleotidesSMc02778 and SMc02777 are separated by 12 nucleotidesSMc02777 and SMc02776 are separated by 167 nucleotidesSMc02776 and SMc02775 are separated by 56 nucleotidesSMc02775 and SMc02774 are separated by 108 nucleotidesSMc02774 and SMc02773 are separated by 111 nucleotidesSMc02773 and SMc02772 are separated by 33 nucleotidesSMc02772 and SMc02771 are separated by 46 nucleotides SMc02781: SMc02781 - oxidoreductase, at 11,232 to 11,828 SMc02781 SMc02780: SMc02780 - succinate-semialdehyde dehydrogenase [NADP+] protein, at 11,996 to 13,450 SMc02780 SMc02779: SMc02779 - transposase, at 13,646 to 14,611 SMc02779 SMc02778: SMc02778 - hydroxyacid aldolase, at 14,893 to 15,693 SMc02778 SMc02777: SMc02777 - transcriptional regulator, at 15,706 to 16,584 SMc02777 SMc02776: SMc02776 - D-arabinoate dehydratase (EC 4.2.1.5); also involved in L-fucose catabolism (from data), at 16,752 to 18,257 SMc02776 SMc02775: SMc02775 - D-arabinose 1-dehydrogenase (from data), at 18,314 to 19,333 SMc02775 SMc02774: SMc02774 - ABC transporter substrate-binding protein, at 19,442 to 20,431 SMc02774 SMc02773: SMc02773 - ABC transporter ATP-binding protein, at 20,543 to 22,096 SMc02773 SMc02772: SMc02772 - sugar ABC transporter permease, at 22,130 to 23,104 SMc02772 SMc02771: SMc02771 - zinc-type alcohol dehydrogenase, at 23,151 to 24,167 SMc02771
Locus Name Description Strand Phenotype
SMc02781 SMc02781 oxidoreductase - insig.
SMc02780 SMc02780 succinate-semialdehyde dehydrogenase [NADP+] protein + insig.
SMc02779 SMc02779 transposase - no data
SMc02778 SMc02778 hydroxyacid aldolase + insig.
SMc02777 SMc02777 transcriptional regulator - strong
SMc02776 SMc02776 D-arabinoate dehydratase (EC 4.2.1.5); also involved in L-fucose catabolism (from data) + strong
SMc02775 SMc02775 D-arabinose 1-dehydrogenase (from data) + strong
SMc02774 SMc02774 ABC transporter substrate-binding protein + insig.
SMc02773 SMc02773 ABC transporter ATP-binding protein + insig.
SMc02772 SMc02772 sugar ABC transporter permease + insig.
SMc02771 SMc02771 zinc-type alcohol dehydrogenase + insig.

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