Gene info for SM_b21121 in Sinorhizobium meliloti 1021

Updated annotation (from data): Isovaleryl-CoA dehydrogenase (EC 1.3.8.4)
Rationale: Specifically important for utilizing L-Leucine. Automated validation from mutant phenotype: the predicted function (RXN0-2301) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Original annotation: isovaleryl-CoA dehydrogenase
Type 1: Protein-coding gene
Located on scaffold NC_003078, + strand, nucleotides 759,569 to 760,732
See nucleotide sequence around SM_b21121 or for all of scaffold NC_003078

Other databases: NCBI, uniprot: Q92VK1

Nearby Genes

500 ntSM_b21115 and SM_b21116 are separated by 213 nucleotidesSM_b21116 and SM_b21117 are separated by 83 nucleotidesSM_b21117 and SM_b21119 are separated by 250 nucleotidesSM_b21119 and SM_b21120 overlap by 23 nucleotidesSM_b21120 and SM_b21121 overlap by 8 nucleotidesSM_b21121 and SM_b21122 are separated by 27 nucleotidesSM_b21122 and SM_b21123 are separated by 14 nucleotidesSM_b21123 and SM_b21124 are separated by 16 nucleotidesSM_b21124 and SM_b21125 overlap by 4 nucleotidesSM_b21125 and SM_b21126 overlap by 4 nucleotides SM_b21115: SM_b21115 - response regulator protein, at 756,618 to 757,106 _b21115 SM_b21116: SM_b21116 - trifolitoxin biosynthesis protein, at 757,320 to 758,051 _b21116 SM_b21117: SM_b21117 - transcriptional regulator, at 758,135 to 758,593 _b21117 SM_b21119: SM_b21119 - gluconokinase, at 758,844 to 759,380 _b21119 SM_b21120: SM_b21120 - hypothetical protein, at 759,358 to 759,576 _b21120 SM_b21121: SM_b21121 - Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) (from data), at 759,569 to 760,732 _b21121 SM_b21122: SM_b21122 - 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) (from data), at 760,760 to 762,367 _b21122 SM_b21123: SM_b21123 - translation initiation inhibitor, at 762,382 to 762,765 _b21123 SM_b21124: SM_b21124 - 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) (from data), at 762,782 to 764,770 _b21124 SM_b21125: SM_b21125 - Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (from data), at 764,767 to 765,636 _b21125 SM_b21126: SM_b21126 - 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18) (from data), at 765,633 to 766,418 _b21126
Locus Name Description Strand Phenotype
SM_b21115 SM_b21115 response regulator protein - insig.
SM_b21116 SM_b21116 trifolitoxin biosynthesis protein - insig.
SM_b21117 SM_b21117 transcriptional regulator - insig.
SM_b21119 SM_b21119 gluconokinase + insig.
SM_b21120 SM_b21120 hypothetical protein + strong
SM_b21121 SM_b21121 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) (from data) + strong
SM_b21122 SM_b21122 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) (from data) + strong
SM_b21123 SM_b21123 translation initiation inhibitor + insig.
SM_b21124 SM_b21124 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) (from data) + strong
SM_b21125 SM_b21125 Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4) (from data) + strong
SM_b21126 SM_b21126 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18) (from data) + cofit

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