Gene info for PGA1_c06040 in Phaeobacter inhibens DSM 17395

Updated annotation (from data): DNA damage response helicase, ligase-associated
Rationale: Conserved and specific phenotype: important for resisting cisplatin. Related to Lhr, which is either a DNA:DNA or DNA:RNA helicase, but lacks the long C-terminal extension that might have a regulatory role (see putative winged helix domain in E. coli lhr). This is also related to the archael protein saci_1500, which has also been linked to DNA damage response, as a mutant is sensitive to UV (PMID: 26148716)
Original annotation: putative DEAD/DEAH box helicase
Type 1: Protein-coding gene
Located on scaffold PGA1_c, - strand, nucleotides 616,845 to 619,280
See nucleotide sequence around PGA1_c06040 or for all of scaffold PGA1_c

Other databases: NCBI, IMG: 2510179168, uniprot: I7DY23

Nearby Genes

500 ntPGA1_c05990 and PGA1_c06000 are separated by 58 nucleotidesPGA1_c06000 and PGA1_c06010 are separated by 40 nucleotidesPGA1_c06010 and PGA1_c06020 are separated by 99 nucleotidesPGA1_c06020 and PGA1_c06030 are separated by 85 nucleotidesPGA1_c06030 and PGA1_c06040 are separated by 52 nucleotidesPGA1_c06040 and PGA1_c06050 are separated by 74 nucleotidesPGA1_c06050 and PGA1_c06060 are separated by 183 nucleotidesPGA1_c06060 and PGA1_c06070 are separated by 19 nucleotidesPGA1_c06070 and PGA1_c06080 are separated by 40 nucleotidesPGA1_c06080 and PGA1_c06090 are separated by 3 nucleotides PGA1_c05990: PGA1_c05990 - formate--tetrahydrofolate ligase Fhs, at 612,539 to 614,215 _c05990 PGA1_c06000: PGA1_c06000 - chorismate mutase-like protein, at 614,274 to 614,579 _c06000 PGA1_c06010: PGA1_c06010 - bifunctional protein FolD, at 614,620 to 615,522 _c06010 PGA1_c06020: PGA1_c06020 - thioesterase domain-containing protein, at 615,622 to 616,032 _c06020 PGA1_c06030: PGA1_c06030 - DNA repair nuclease, ligase-associated (TIGR04123) (from data), at 616,118 to 616,792 _c06030 PGA1_c06040: PGA1_c06040 - DNA damage response helicase, ligase-associated (from data), at 616,845 to 619,280 _c06040 PGA1_c06050: PGA1_c06050 - hypothetical protein, at 619,355 to 620,662 _c06050 PGA1_c06060: PGA1_c06060 - Flp pilus assembly protein, protease CpaA, at 620,846 to 621,352 _c06060 PGA1_c06070: PGA1_c06070 - hypothetical protein, at 621,372 to 622,220 _c06070 PGA1_c06080: PGA1_c06080 - hypothetical protein, at 622,261 to 622,863 _c06080 PGA1_c06090: PGA1_c06090 - type II secretion system protein F-like protein, at 622,867 to 623,847 _c06090
Locus Name Description Strand Phenotype
PGA1_c05990 PGA1_c05990 formate--tetrahydrofolate ligase Fhs + strong
PGA1_c06000 PGA1_c06000 chorismate mutase-like protein + sig.
PGA1_c06010 PGA1_c06010 bifunctional protein FolD + no data
PGA1_c06020 PGA1_c06020 thioesterase domain-containing protein - insig.
PGA1_c06030 PGA1_c06030 DNA repair nuclease, ligase-associated (TIGR04123) (from data) - sig.
PGA1_c06040 PGA1_c06040 DNA damage response helicase, ligase-associated (from data) - sig.
PGA1_c06050 PGA1_c06050 hypothetical protein - insig.
PGA1_c06060 PGA1_c06060 Flp pilus assembly protein, protease CpaA - insig.
PGA1_c06070 PGA1_c06070 hypothetical protein - sig.
PGA1_c06080 PGA1_c06080 hypothetical protein - insig.
PGA1_c06090 PGA1_c06090 type II secretion system protein F-like protein - sig.

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