Gene info for BWI76_RS21010 in Klebsiella michiganensis M5al

Updated annotation (from data): Negative regulator of nickel and cobalt uptake (YfgG)
Rationale: Specifically important in stress Nickel (II) chloride hexahydrate, and also important for cobalt stress. Similar to E.coli yfgG, which has similar phenotypes. Both orthologs have strong negative cofitness with the Mg/Ni/Co transporter corA (BWI76_RS01225). BWI76_RS21010 is a putative small membrane protein and might inhibit corA or reduce its abundance (by analogy to the magnesium transporter MtgE and the small membrane protein MtgS that binds and stabilizes MtgS).
Original annotation: membrane protein
Type 1: Protein-coding gene
Located on scaffold NZ_CP020657, + strand, nucleotides 4,396,487 to 4,396,678
See nucleotide sequence around BWI76_RS21010 or for all of scaffold NZ_CP020657

Other databases: NCBI, uniprot: A0A285B7E2

Nearby Genes

500 ntBWI76_RS20985 and BWI76_RS20990 are separated by 3 nucleotidesBWI76_RS20990 and BWI76_RS20995 are separated by 177 nucleotidesBWI76_RS20995 and BWI76_RS21000 are separated by 3 nucleotidesBWI76_RS21000 and BWI76_RS21005 are separated by 37 nucleotidesBWI76_RS21005 and BWI76_RS21010 are separated by 370 nucleotidesBWI76_RS21010 and BWI76_RS21015 are separated by 16 nucleotidesBWI76_RS21015 and BWI76_RS21020 are separated by 97 nucleotidesBWI76_RS21020 and BWI76_RS21025 are separated by 155 nucleotidesBWI76_RS21025 and BWI76_RS21030 are separated by 68 nucleotidesBWI76_RS21030 and BWI76_RS21035 are separated by 158 nucleotides BWI76_RS20985: BWI76_RS20985 - glycosyl hydrolase family protein, at 4,387,299 to 4,388,396 _RS20985 BWI76_RS20990: BWI76_RS20990 - hypothetical protein, at 4,388,400 to 4,390,073 _RS20990 BWI76_RS20995: BWI76_RS20995 - RNA degradosome polyphosphate kinase, at 4,390,251 to 4,392,311 _RS20995 BWI76_RS21000: BWI76_RS21000 - exopolyphosphatase, at 4,392,315 to 4,393,856 _RS21000 BWI76_RS21005: BWI76_RS21005 - sensor domain-containing phosphodiesterase, at 4,393,894 to 4,396,116 _RS21005 BWI76_RS21010: BWI76_RS21010 - Negative regulator of nickel and cobalt uptake (YfgG) (from data), at 4,396,487 to 4,396,678 _RS21010 BWI76_RS21015: BWI76_RS21015 - LysR family transcriptional regulator, at 4,396,695 to 4,397,582 _RS21015 BWI76_RS21020: BWI76_RS21020 - MFS transporter, at 4,397,680 to 4,398,876 _RS21020 BWI76_RS21025: BWI76_RS21025 - GMP synthase (glutamine-hydrolyzing), at 4,399,032 to 4,400,609 _RS21025 BWI76_RS21030: BWI76_RS21030 - IMP dehydrogenase, at 4,400,678 to 4,402,144 _RS21030 BWI76_RS21035: BWI76_RS21035 - exodeoxyribonuclease VII large subunit, at 4,402,303 to 4,403,676 _RS21035
Locus Name Description Strand Phenotype
BWI76_RS20985 BWI76_RS20985 glycosyl hydrolase family protein + insig.
BWI76_RS20990 BWI76_RS20990 hypothetical protein - insig.
BWI76_RS20995 BWI76_RS20995 RNA degradosome polyphosphate kinase + strong
BWI76_RS21000 BWI76_RS21000 exopolyphosphatase + strong
BWI76_RS21005 BWI76_RS21005 sensor domain-containing phosphodiesterase - sig.
BWI76_RS21010 BWI76_RS21010 Negative regulator of nickel and cobalt uptake (YfgG) (from data) + strong
BWI76_RS21015 BWI76_RS21015 LysR family transcriptional regulator - insig.
BWI76_RS21020 BWI76_RS21020 MFS transporter + insig.
BWI76_RS21025 BWI76_RS21025 GMP synthase (glutamine-hydrolyzing) - no data
BWI76_RS21030 BWI76_RS21030 IMP dehydrogenase - no data
BWI76_RS21035 BWI76_RS21035 exodeoxyribonuclease VII large subunit + insig.

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