Gene info for BWI76_RS08740 in Klebsiella michiganensis M5al

Updated annotation (from data): Histidine ammonia-lyase (EC 4.3.1.3)
Rationale: Specifically important for utilizing L-Histidine. Automated validation from mutant phenotype: the predicted function (HISTIDINE-AMMONIA-LYASE-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Original annotation: histidine ammonia-lyase
Type 1: Protein-coding gene
Located on scaffold NZ_CP020657, + strand, nucleotides 1,841,384 to 1,842,907
See nucleotide sequence around BWI76_RS08740 or for all of scaffold NZ_CP020657

Other databases: NCBI, uniprot: A0A285B1C1

Nearby Genes

500 ntBWI76_RS08715 and BWI76_RS08720 are separated by 230 nucleotidesBWI76_RS08720 and BWI76_RS08725 overlap by 4 nucleotidesBWI76_RS08725 and BWI76_RS08730 are separated by 53 nucleotidesBWI76_RS08730 and BWI76_RS08735 are separated by 143 nucleotidesBWI76_RS08735 and BWI76_RS08740 overlap by 4 nucleotidesBWI76_RS08740 and BWI76_RS08745 are separated by 100 nucleotidesBWI76_RS08745 and BWI76_RS08750 are separated by 104 nucleotidesBWI76_RS08750 and BWI76_RS08755 are separated by 69 nucleotidesBWI76_RS08755 and BWI76_RS08760 are separated by 85 nucleotidesBWI76_RS08760 and BWI76_RS08765 overlap by 4 nucleotides BWI76_RS08715: BWI76_RS08715 - acyl-CoA thioesterase, at 1,835,092 to 1,836,375 _RS08715 BWI76_RS08720: BWI76_RS08720 - imidazolonepropionase, at 1,836,606 to 1,837,823 _RS08720 BWI76_RS08725: BWI76_RS08725 - Formiminoglutamase (EC 3.5.3.8) (from data), at 1,837,820 to 1,838,776 _RS08725 BWI76_RS08730: BWI76_RS08730 - histidine utilization repressor, at 1,838,830 to 1,839,555 _RS08730 BWI76_RS08735: BWI76_RS08735 - Urocanate hydratase (EC 4.2.1.49) (from data), at 1,839,699 to 1,841,387 _RS08735 BWI76_RS08740: BWI76_RS08740 - Histidine ammonia-lyase (EC 4.3.1.3) (from data), at 1,841,384 to 1,842,907 _RS08740 BWI76_RS08745: BWI76_RS08745 - proline-specific permease, at 1,843,008 to 1,844,387 _RS08745 BWI76_RS08750: BWI76_RS08750 - kinase inhibitor, at 1,844,492 to 1,844,968 _RS08750 BWI76_RS08755: BWI76_RS08755 - adenosylmethionine--8-amino-7-oxononanoate transaminase, at 1,845,038 to 1,846,327 _RS08755 BWI76_RS08760: BWI76_RS08760 - biotin synthase, at 1,846,413 to 1,847,453 _RS08760 BWI76_RS08765: BWI76_RS08765 - 8-amino-7-oxononanoate synthase, at 1,847,450 to 1,848,607 _RS08765
Locus Name Description Strand Phenotype
BWI76_RS08715 BWI76_RS08715 acyl-CoA thioesterase - sig.
BWI76_RS08720 BWI76_RS08720 imidazolonepropionase + insig.
BWI76_RS08725 BWI76_RS08725 Formiminoglutamase (EC 3.5.3.8) (from data) + strong
BWI76_RS08730 BWI76_RS08730 histidine utilization repressor + strong
BWI76_RS08735 BWI76_RS08735 Urocanate hydratase (EC 4.2.1.49) (from data) + strong
BWI76_RS08740 BWI76_RS08740 Histidine ammonia-lyase (EC 4.3.1.3) (from data) + strong
BWI76_RS08745 BWI76_RS08745 proline-specific permease + insig.
BWI76_RS08750 BWI76_RS08750 kinase inhibitor - insig.
BWI76_RS08755 BWI76_RS08755 adenosylmethionine--8-amino-7-oxononanoate transaminase - strong
BWI76_RS08760 BWI76_RS08760 biotin synthase + strong
BWI76_RS08765 BWI76_RS08765 8-amino-7-oxononanoate synthase + sig.

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