Gene info for BWI76_RS03070 in Klebsiella michiganensis M5al

Updated annotation (from data): Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27)
Rationale: Specifically important for utilizing m-Inositol. Automated validation from mutant phenotype: the predicted function (RXN-2902) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Original annotation: methylmalonate-semialdehyde dehydrogenase (CoA acylating)
Type 1: Protein-coding gene
Located on scaffold NZ_CP020657, + strand, nucleotides 629,200 to 630,705
See nucleotide sequence around BWI76_RS03070 or for all of scaffold NZ_CP020657

Other databases: NCBI, uniprot: A0A285AWX9

Nearby Genes

500 ntBWI76_RS03045 and BWI76_RS03050 overlap by 11 nucleotidesBWI76_RS03050 and BWI76_RS03055 overlap by 1 nucleotidesBWI76_RS03055 and BWI76_RS03060 are separated by 42 nucleotidesBWI76_RS03060 and BWI76_RS03065 are separated by 86 nucleotidesBWI76_RS03065 and BWI76_RS03070 are separated by 361 nucleotidesBWI76_RS03070 and BWI76_RS03075 are separated by 18 nucleotidesBWI76_RS03075 and BWI76_RS03080 are separated by 196 nucleotidesBWI76_RS03080 and BWI76_RS03085 are separated by 151 nucleotidesBWI76_RS03085 and BWI76_RS03090 are separated by 526 nucleotidesBWI76_RS03090 and BWI76_RS03095 are separated by 48 nucleotides BWI76_RS03045: BWI76_RS03045 - hypothetical protein, at 624,097 to 624,216 _RS03045 BWI76_RS03050: BWI76_RS03050 - LPS export ABC transporter permease LptF, at 624,206 to 625,303 _RS03050 BWI76_RS03055: BWI76_RS03055 - LPS export ABC transporter permease LptG, at 625,303 to 626,385 _RS03055 BWI76_RS03060: BWI76_RS03060 - ATP-binding protein, at 626,428 to 627,930 _RS03060 BWI76_RS03065: BWI76_RS03065 - hypothetical protein, at 628,017 to 628,838 _RS03065 BWI76_RS03070: BWI76_RS03070 - Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27) (from data), at 629,200 to 630,705 _RS03070 BWI76_RS03075: BWI76_RS03075 - 5-deoxy-D-glucuronate isomerase (EC 5.3.1.30) (from data), at 630,724 to 631,533 _RS03075 BWI76_RS03080: BWI76_RS03080 - (Fe-S)-cluster assembly protein, at 631,730 to 632,587 _RS03080 BWI76_RS03085: BWI76_RS03085 - 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) (from data), at 632,739 to 634,652 _RS03085 BWI76_RS03090: BWI76_RS03090 - 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase IolD (EC 3.7.1.22) (from data), at 635,179 to 637,119 _RS03090 BWI76_RS03095: BWI76_RS03095 - Inositol 2-dehydrogenase (EC 1.1.1.18) (from data), at 637,168 to 638,181 _RS03095
Locus Name Description Strand Phenotype
BWI76_RS03045 BWI76_RS03045 hypothetical protein - strong
BWI76_RS03050 BWI76_RS03050 LPS export ABC transporter permease LptF + no data
BWI76_RS03055 BWI76_RS03055 LPS export ABC transporter permease LptG + no data
BWI76_RS03060 BWI76_RS03060 ATP-binding protein - insig.
BWI76_RS03065 BWI76_RS03065 hypothetical protein - insig.
BWI76_RS03070 BWI76_RS03070 Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27) (from data) + sig.
BWI76_RS03075 BWI76_RS03075 5-deoxy-D-glucuronate isomerase (EC 5.3.1.30) (from data) + strong
BWI76_RS03080 BWI76_RS03080 (Fe-S)-cluster assembly protein - strong
BWI76_RS03085 BWI76_RS03085 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92); possible 5-dehydro-2-deoxyphosphogluconate aldolase DUF2090 (EC 4.1.2.29) (from data) - strong
BWI76_RS03090 BWI76_RS03090 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase IolD (EC 3.7.1.22) (from data) + strong
BWI76_RS03095 BWI76_RS03095 Inositol 2-dehydrogenase (EC 1.1.1.18) (from data) + strong

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