Gene info for BPHYT_RS11290 in Burkholderia phytofirmans PsJN

Updated annotation (from data): 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43)
Rationale: Specifically important for: D-Gluconic Acid sodium salt. Gluconate is probably primarily catabolized via gluconate kinase (BPHYT_RS16720) and the Entner-Doudoroff pathway (starting with phosphogluconate dehydratase, BPHYT_RS16735). However it appears that there is a side pathway involving gluconate 2-dehydrogenase (BPHYT_RS14520, which has no phenotype because this side path is not beneficial), 2-ketogluconate kinase (BPHYT_RS11300, no fitness data), and 2-ketogluconate-6-P reductase (this gene). A similar side path is known in P. putida (PMCID:PMC4646247) and this gene is similar to the P. putida 2-ketoglutarate-6-phosphate reductase (PP3376). (SEED_correct)
Original annotation: bifunctional glyoxylate/hydroxypyruvate reductase B
Type 1: Protein-coding gene
Located on scaffold NC_010681, - strand, nucleotides 2,563,830 to 2,564,795
See nucleotide sequence around BPHYT_RS11290 or for all of scaffold NC_010681

Other databases: NCBI, uniprot: B2T518

Nearby Genes

500 ntBPHYT_RS11265 and BPHYT_RS11270 are separated by 298 nucleotidesBPHYT_RS11270 and BPHYT_RS11275 are separated by 45 nucleotidesBPHYT_RS11275 and BPHYT_RS11280 are separated by 154 nucleotidesBPHYT_RS11280 and BPHYT_RS11285 are separated by 71 nucleotidesBPHYT_RS11285 and BPHYT_RS11290 are separated by 19 nucleotidesBPHYT_RS11290 and BPHYT_RS11295 overlap by 1 nucleotidesBPHYT_RS11295 and BPHYT_RS11300 are separated by 164 nucleotidesBPHYT_RS11300 and BPHYT_RS11305 are separated by 309 nucleotidesBPHYT_RS11305 and BPHYT_RS11310 are separated by 361 nucleotidesBPHYT_RS11310 and BPHYT_RS11315 are separated by 121 nucleotides BPHYT_RS11265: BPHYT_RS11265 - hypothetical protein, at 2,560,012 to 2,560,527 _RS11265 BPHYT_RS11270: BPHYT_RS11270 - hypothetical protein, at 2,560,826 to 2,561,263 _RS11270 BPHYT_RS11275: BPHYT_RS11275 - hypothetical protein, at 2,561,309 to 2,561,677 _RS11275 BPHYT_RS11280: BPHYT_RS11280 - membrane protein, at 2,561,832 to 2,562,650 _RS11280 BPHYT_RS11285: BPHYT_RS11285 - LacI family transcription regulator, at 2,562,722 to 2,563,810 _RS11285 BPHYT_RS11290: BPHYT_RS11290 - 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) (from data), at 2,563,830 to 2,564,795 _RS11290 BPHYT_RS11295: BPHYT_RS11295 - MFS transporter, at 2,564,795 to 2,566,090 _RS11295 BPHYT_RS11300: BPHYT_RS11300 - 2-dehydro-3-deoxygluconokinase, at 2,566,255 to 2,567,238 _RS11300 BPHYT_RS11305: BPHYT_RS11305 - xylose isomerase, at 2,567,548 to 2,568,321 _RS11305 BPHYT_RS11310: BPHYT_RS11310 - LysR family transcriptional regulator, at 2,568,683 to 2,569,600 _RS11310 BPHYT_RS11315: BPHYT_RS11315 - membrane protein, at 2,569,722 to 2,570,819 _RS11315
Locus Name Description Strand Phenotype
BPHYT_RS11265 BPHYT_RS11265 hypothetical protein + strong
BPHYT_RS11270 BPHYT_RS11270 hypothetical protein + sig.
BPHYT_RS11275 BPHYT_RS11275 hypothetical protein - insig.
BPHYT_RS11280 BPHYT_RS11280 membrane protein - insig.
BPHYT_RS11285 BPHYT_RS11285 LacI family transcription regulator - insig.
BPHYT_RS11290 BPHYT_RS11290 2-ketogluconate 6-phosphate reductase (EC 1.1.1.43) (from data) - strong
BPHYT_RS11295 BPHYT_RS11295 MFS transporter - insig.
BPHYT_RS11300 BPHYT_RS11300 2-dehydro-3-deoxygluconokinase - no data
BPHYT_RS11305 BPHYT_RS11305 xylose isomerase - insig.
BPHYT_RS11310 BPHYT_RS11310 LysR family transcriptional regulator - insig.
BPHYT_RS11315 BPHYT_RS11315 membrane protein + no data

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