Gene info for AO356_01580 in Pseudomonas fluorescens FW300-N2C3

Updated annotation (from data): Isovaleryl-CoA dehydrogenase (EC 1.3.8.4)
Rationale: Specifically important for utilizing L-Leucine. Automated validation from mutant phenotype: the predicted function (RXN0-2301) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
Original annotation: isovaleryl-CoA dehydrogenase
Type 1: Protein-coding gene
Located on scaffold CP012831, + strand, nucleotides 356,570 to 357,733
See nucleotide sequence around AO356_01580 or for all of scaffold CP012831

Other databases: NCBI, uniprot: A0A0N7H1C1

Nearby Genes

500 ntAO356_01555 and AO356_01560 are separated by 189 nucleotidesAO356_01560 and AO356_01565 are separated by 186 nucleotidesAO356_01565 and AO356_01570 are separated by 151 nucleotidesAO356_01570 and AO356_01575 are separated by 654 nucleotidesAO356_01575 and AO356_01580 are separated by 196 nucleotidesAO356_01580 and AO356_01585 are separated by 11 nucleotidesAO356_01585 and AO356_01590 are separated by 13 nucleotidesAO356_01590 and AO356_01595 overlap by 4 nucleotidesAO356_01595 and AO356_01600 are separated by 29 nucleotidesAO356_01600 and AO356_01605 are separated by 130 nucleotides AO356_01555: AO356_01555 - acyl-CoA dehydrogenase, at 350,034 to 351,263 _01555 AO356_01560: AO356_01560 - LysR family transcriptional regulator, at 351,453 to 352,382 _01560 AO356_01565: AO356_01565 - MerR family transcriptional regulator, at 352,569 to 352,970 _01565 AO356_01570: AO356_01570 - hydroxymethylglutaryl-CoA lyase, at 353,122 to 354,021 _01570 AO356_01575: AO356_01575 - AMP-binding protein, at 354,676 to 356,373 _01575 AO356_01580: AO356_01580 - Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) (from data), at 356,570 to 357,733 _01580 AO356_01585: AO356_01585 - 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) (from data), at 357,745 to 359,352 _01585 AO356_01590: AO356_01590 - Methylglutaconyl-CoA hydratase (EC 4.2.1.18) (from data), at 359,366 to 360,187 _01590 AO356_01595: AO356_01595 - 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) (from data), at 360,184 to 362,133 _01595 AO356_01600: AO356_01600 - Cro/Cl family transcriptional regulator, at 362,163 to 362,810 _01600 AO356_01605: AO356_01605 - hypothetical protein, at 362,941 to 363,282 _01605
Locus Name Description Strand Phenotype
AO356_01555 AO356_01555 acyl-CoA dehydrogenase - strong
AO356_01560 AO356_01560 LysR family transcriptional regulator + insig.
AO356_01565 AO356_01565 MerR family transcriptional regulator + strong
AO356_01570 AO356_01570 hydroxymethylglutaryl-CoA lyase + strong
AO356_01575 AO356_01575 AMP-binding protein - insig.
AO356_01580 AO356_01580 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) (from data) + strong
AO356_01585 AO356_01585 3-methylcrotonyl-CoA carboxylase, beta subunit (EC 6.4.1.4) (from data) + strong
AO356_01590 AO356_01590 Methylglutaconyl-CoA hydratase (EC 4.2.1.18) (from data) + strong
AO356_01595 AO356_01595 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) (from data) + strong
AO356_01600 AO356_01600 Cro/Cl family transcriptional regulator - strong
AO356_01605 AO356_01605 hypothetical protein + insig.

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