Gene info for AO353_25685 in Pseudomonas fluorescens FW300-N2E3

Updated annotation (from data): acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16)
Rationale: Specifically important for: Sodium butyrate; L-Isoleucine. Degradation of acetoacetyl-CoA (EC 2.3.1.9) is consistent with a role in butyrate degradation. The role in Ile degradation suggests that 2-methylacetoacetyl-CoA is also a substrate (conversion to propionyl-CoA + acetyl-CoA). Hence the broader EC # 2.3.1.16.
Original annotation: acetyl-CoA acetyltransferase
Type 1: Protein-coding gene
Located on scaffold CP012830, - strand, nucleotides 5,663,998 to 5,665,191
See nucleotide sequence around AO353_25685 or for all of scaffold CP012830

Other databases: NCBI, uniprot: A0A0N9X119

Nearby Genes

500 ntAO353_25660 and AO353_25665 are separated by 458 nucleotidesAO353_25665 and AO353_25670 are separated by 3 nucleotidesAO353_25670 and AO353_25675 are separated by 96 nucleotidesAO353_25675 and AO353_25680 are separated by 13 nucleotidesAO353_25680 and AO353_25685 are separated by 9 nucleotidesAO353_25685 and AO353_25690 are separated by 12 nucleotidesAO353_25690 and AO353_25695 are separated by 16 nucleotidesAO353_25695 and AO353_25700 are separated by 83 nucleotidesAO353_25700 and AO353_25705 overlap by 20 nucleotidesAO353_25705 and AO353_25710 are separated by 249 nucleotides AO353_25660: AO353_25660 - ABC transporter substrate-binding protein, at 5,658,478 to 5,659,257 _25660 AO353_25665: AO353_25665 - 3-hydroxy-isobutyryl-CoA hydrolase (EC 3.1.2.4) (from data), at 5,659,716 to 5,660,822 _25665 AO353_25670: AO353_25670 - isobutyryl-CoA dehydrogenase (EC 1.3.8.5) (from data), at 5,660,826 to 5,661,977 _25670 AO353_25675: AO353_25675 - enoyl-CoA hydratase, at 5,662,074 to 5,662,847 _25675 AO353_25680: AO353_25680 - 2-methylbutanoyl-CoA dehydrogenase / butanoyl-CoA dehydrogenase / isobutyryl-CoA dehydrogenase (EC 1.3.8.1; EC 1.3.8.5) (from data), at 5,662,861 to 5,663,988 _25680 AO353_25685: AO353_25685 - acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) (from data), at 5,663,998 to 5,665,191 _25685 AO353_25690: AO353_25690 - 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, at 5,665,204 to 5,665,965 _25690 AO353_25695: AO353_25695 - AMP-binding protein, at 5,665,982 to 5,667,646 _25695 AO353_25700: AO353_25700 - hypothetical protein, at 5,667,730 to 5,667,948 _25700 AO353_25705: AO353_25705 - AraC family transcriptional regulator, at 5,667,929 to 5,668,948 _25705 AO353_25710: AO353_25710 - iron transporter, at 5,669,198 to 5,670,049 _25710
Locus Name Description Strand Phenotype
AO353_25660 AO353_25660 ABC transporter substrate-binding protein - strong
AO353_25665 AO353_25665 3-hydroxy-isobutyryl-CoA hydrolase (EC 3.1.2.4) (from data) + strong
AO353_25670 AO353_25670 isobutyryl-CoA dehydrogenase (EC 1.3.8.5) (from data) + strong
AO353_25675 AO353_25675 enoyl-CoA hydratase - no data
AO353_25680 AO353_25680 2-methylbutanoyl-CoA dehydrogenase / butanoyl-CoA dehydrogenase / isobutyryl-CoA dehydrogenase (EC 1.3.8.1; EC 1.3.8.5) (from data) - strong
AO353_25685 AO353_25685 acetyl-CoA:acetyl-CoA C-acetyltransferase / acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase (EC 2.3.1.9; EC 2.3.1.16) (from data) - strong
AO353_25690 AO353_25690 3-hydroxy-2-methylbutyryl-CoA dehydrogenase - no data
AO353_25695 AO353_25695 AMP-binding protein - strong
AO353_25700 AO353_25700 hypothetical protein + insig.
AO353_25705 AO353_25705 AraC family transcriptional regulator - strong
AO353_25710 AO353_25710 iron transporter + insig.

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