Gene info for BT3761 in Bacteroides thetaiotaomicron VPI-5482

Updated annotation (from data): N-succinylglutamate synthase
Rationale: This gene is in an operon with and conserved cofit with other arginine synthesis genes. The traditional synthase (argA) was not found in the genome. This protein is 59% identical to Cabys_1732 which is reported to form N-acetylglutamate (PMID:28265262). However, Bacteroides are believed to use succinylated intermediates for arginine synthesis, as they have N-succinylornithine carbamoyltransferase (PMID:16704984) and N-succinylglutamate kinase (PhD thesis of Juan Manuel Cabrera Luque, 2010). The prior studies were of Bacteroides fragilis, but Bacteroides thetaiotaomicron has close homologs (the carbamoyltransferase is BT3717; the kinase is BT3395; mutants of all of these genes from B. thetaiotaomicron appear to be arginine auxotrophs)
Original annotation: hypothetical protein (NCBI ptt file)
Type 1: Protein-coding gene
Located on scaffold 241, - strand, nucleotides 4,881,796 to 4,882,374
See nucleotide sequence around BT3761 or for all of scaffold 241

Other databases: MicrobesOnline, NCBI, refseq: BT_RS18965, uniprot: Q8A1A5

Nearby Genes

500 ntBT3756 and BT3757 are separated by 39 nucleotidesBT3757 and BT3758 are separated by 135 nucleotidesBT3758 and BT3759 are separated by 13 nucleotidesBT3759 and BT3760 overlap by 4 nucleotidesBT3760 and BT3761 are separated by 13 nucleotidesBT3761 and BT3762 are separated by 25 nucleotidesBT3762 and BT3763 are separated by 233 nucleotidesBT3763 and BT3764 are separated by 59 nucleotidesBT3764 and BT3765 are separated by 3 nucleotidesBT3765 and BT3766 are separated by 12 nucleotides BT3756: BT3756 - transcriptional regulator (NCBI ptt file), at 4,876,971 to 4,877,525 BT3756 BT3757: BT3757 - pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data), at 4,877,565 to 4,878,338 BT3757 BT3758: BT3758 - N-succinylornithine aminotransferase (EC 2.6.1.81) (from data), at 4,878,474 to 4,879,595 BT3758 BT3759: BT3759 - N-succinylglutamylphosphate reductase (EC 1.2.1.-) (from data), at 4,879,609 to 4,880,577 BT3759 BT3760: BT3760 - arginosuccinate synthetase (EC 6.3.4.5) (from data), at 4,880,574 to 4,881,782 BT3760 BT3761: BT3761 - N-succinylglutamate synthase (from data), at 4,881,796 to 4,882,374 BT3761 BT3762: BT3762 - arginine repressor, transcriptional regulator of arginine metabolism (NCBI ptt file), at 4,882,400 to 4,882,873 BT3762 BT3763: BT3763 - rhamnulose kinase/L-fuculose kinase (NCBI ptt file), at 4,883,107 to 4,884,564 BT3763 BT3764: BT3764 - L-rhamnose isomerase (NCBI ptt file), at 4,884,624 to 4,885,880 BT3764 BT3765: BT3765 - L-rhamnose:H+ symporter (from data), at 4,885,884 to 4,886,903 BT3765 BT3766: BT3766 - rhamnulose 1-phosphate aldolase RhaD (EC 4.1.2.19) (from data), at 4,886,916 to 4,887,725 BT3766
Locus Name Description Strand Phenotype
BT3756 BT3756 transcriptional regulator (NCBI ptt file) - sig.
BT3757 BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) (from data) - strong
BT3758 BT3758 N-succinylornithine aminotransferase (EC 2.6.1.81) (from data) - strong
BT3759 BT3759 N-succinylglutamylphosphate reductase (EC 1.2.1.-) (from data) - strong
BT3760 BT3760 arginosuccinate synthetase (EC 6.3.4.5) (from data) - strong
BT3761 BT3761 N-succinylglutamate synthase (from data) - strong
BT3762 BT3762 arginine repressor, transcriptional regulator of arginine metabolism (NCBI ptt file) - strong
BT3763 BT3763 rhamnulose kinase/L-fuculose kinase (NCBI ptt file) + strong
BT3764 BT3764 L-rhamnose isomerase (NCBI ptt file) + strong
BT3765 BT3765 L-rhamnose:H+ symporter (from data) + strong
BT3766 BT3766 rhamnulose 1-phosphate aldolase RhaD (EC 4.1.2.19) (from data) + strong

Or browse nearby genes

Or see the comparative fitness browser