Gene info for BT3348 in Bacteroides thetaiotaomicron VPI-5482

Updated annotation (from data): unsaturated glucuronide lyase acting on chondroitin/heparin disaccharides (EC 3.2.1.180)
Rationale: Specifically important in carbon source Hyaluronic acid sodium salt from Streptococcus equi; carbon source Chondroitin sulfate A sodium salt from bovine trachea; carbon source Heparin sodium salt from porcine intestinal mucosa. It is 51% identical to C6Y0D8 which preferentially cleaves 1,4-type unsaturated glucuronides that arise during heparin degradation (PMC3931040). B. thetaiotaomicron is believed to degrade chondroitin sulfate via unsaturated 1,3-glucoronides (PMID:25041429). This in combination with the mutant phenotypes suggest that BT3348 has a broader specificity.
Original annotation: putative unsaturated glucuronyl hydrolase (NCBI ptt file)
Type 1: Protein-coding gene
Located on scaffold 241, + strand, nucleotides 4,316,255 to 4,317,457
See nucleotide sequence around BT3348 or for all of scaffold 241

Other databases: MicrobesOnline, NCBI, refseq: BT_RS16950, uniprot: Q8A2F7

Nearby Genes

500 ntBT3343 and BT3344 are separated by 305 nucleotidesBT3344 and BT3345 are separated by 28 nucleotidesBT3345 and BT3346 are separated by 22 nucleotidesBT3346 and BT3347 are separated by 23 nucleotidesBT3347 and BT3348 are separated by 604 nucleotidesBT3348 and BT3349 are separated by 106 nucleotidesBT3349 and BT3350 are separated by 138 nucleotidesBT3350 and BT3351 are separated by 123 nucleotidesBT3351 and BT3352 are separated by 103 nucleotidesBT3352 and BT3353 are separated by 115 nucleotides BT3343: BT3343 - putative phenylacetic acid degradation protein (NCBI ptt file), at 4,307,323 to 4,307,727 BT3343 BT3344: BT3344 - hypothetical protein (NCBI ptt file), at 4,308,033 to 4,309,043 BT3344 BT3345: BT3345 - conserved hypothetical protein, putative outer membrane protein (NCBI ptt file), at 4,309,072 to 4,311,111 BT3345 BT3346: BT3346 - putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file), at 4,311,134 to 4,314,217 BT3346 BT3347: BT3347 - hypothetical protein (NCBI ptt file), at 4,314,241 to 4,315,650 BT3347 BT3348: BT3348 - unsaturated glucuronide lyase acting on chondroitin/heparin disaccharides (EC 3.2.1.180) (from data), at 4,316,255 to 4,317,457 BT3348 BT3349: BT3349 - chondroitin disaccharide sulfatase (from data), at 4,317,564 to 4,319,090 BT3349 BT3350: BT3350 - putative chondroitinase (chondroitin lyase) (NCBI ptt file), at 4,319,229 to 4,322,090 BT3350 BT3351: BT3351 - cysteinyl-tRNA synthetase (NCBI ptt file), at 4,322,214 to 4,323,695 BT3351 BT3352: BT3352 - haloacid dehalogenase-like hydrolase (NCBI ptt file), at 4,323,799 to 4,324,611 BT3352 BT3353: BT3353 - Snf2 family helicase (NCBI ptt file), at 4,324,727 to 4,327,810 BT3353
Locus Name Description Strand Phenotype
BT3343 BT3343 putative phenylacetic acid degradation protein (NCBI ptt file) - insig.
BT3344 BT3344 hypothetical protein (NCBI ptt file) - insig.
BT3345 BT3345 conserved hypothetical protein, putative outer membrane protein (NCBI ptt file) - insig.
BT3346 BT3346 putative outer membrane protein, probably involved in nutrient binding (NCBI ptt file) - insig.
BT3347 BT3347 hypothetical protein (NCBI ptt file) - sig.
BT3348 BT3348 unsaturated glucuronide lyase acting on chondroitin/heparin disaccharides (EC 3.2.1.180) (from data) + strong
BT3349 BT3349 chondroitin disaccharide sulfatase (from data) + strong
BT3350 BT3350 putative chondroitinase (chondroitin lyase) (NCBI ptt file) + sig.
BT3351 BT3351 cysteinyl-tRNA synthetase (NCBI ptt file) - no data
BT3352 BT3352 haloacid dehalogenase-like hydrolase (NCBI ptt file) - sig.
BT3353 BT3353 Snf2 family helicase (NCBI ptt file) - sig.

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