Gene info for BT3338 in Bacteroides thetaiotaomicron VPI-5482

Updated annotation (from data): RND efflux system, inner membrane component BipB
Rationale: Specifically important in stress Fusidic acid sodium salt; stress Chlorpromazine hydrochloride; stress Thioridazine hydrochloride; stress Cefoxitin sodium salt. This protein belongs to the RND family of inner membrane transporters. It is unclear if this system is an efflux pump for hydrophobic compounds, as suggested by many of its phenotypes, or an efflux pump for magnesium (PMC11078008), which apparently reduces biofilm formation and might alter susceptibility to those compounds.
Original annotation: AcrB/AcrD family multidrug resistance protein (NCBI ptt file)
Type 1: Protein-coding gene
Located on scaffold 241, - strand, nucleotides 4,296,721 to 4,299,936
See nucleotide sequence around BT3338 or for all of scaffold 241

Other databases: MicrobesOnline, NCBI, refseq: BT_RS16900, uniprot: Q8A2G7

Nearby Genes

500 ntBT3333 and BT3334 are separated by 299 nucleotidesBT3334 and BT3335 are separated by 111 nucleotidesBT3335 and BT3336 are separated by 60 nucleotidesBT3336 and BT3337 are separated by 18 nucleotidesBT3337 and BT3338 are separated by 11 nucleotidesBT3338 and BT3339 are separated by 16 nucleotidesBT3339 and BT3340 are separated by 179 nucleotidesBT3340 and BT3341 are separated by 150 nucleotidesBT3341 and BT3342 are separated by 40 nucleotidesBT3342 and BT3343 are separated by 5 nucleotides BT3333: BT3333 - arylsulfatase A precursor (ASA) (NCBI ptt file), at 4,287,822 to 4,289,357 BT3333 BT3334: BT3334 - two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file), at 4,289,657 to 4,293,721 BT3334 BT3335: BT3335 - hypothetical protein (NCBI ptt file), at 4,293,833 to 4,294,474 BT3335 BT3336: BT3336 - UDP-N-acetylglucosamine acetyltransferase (NCBI ptt file), at 4,294,535 to 4,295,305 BT3336 BT3337: BT3337 - RND efflux system, outer membrane component BipA (from data), at 4,295,324 to 4,296,709 BT3337 BT3338: BT3338 - RND efflux system, inner membrane component BipB (from data), at 4,296,721 to 4,299,936 BT3338 BT3339: BT3339 - RND efflux system, membrane fusion component BipC (from data), at 4,299,953 to 4,301,128 BT3339 BT3340: BT3340 - Beta-galactosidase (EC 3.2.1.23) (from data), at 4,301,308 to 4,304,418 BT3340 BT3341: BT3341 - conserved hypothetical protein (NCBI ptt file), at 4,304,569 to 4,306,497 BT3341 BT3342: BT3342 - hypothetical protein (NCBI ptt file), at 4,306,538 to 4,307,317 BT3342 BT3343: BT3343 - putative phenylacetic acid degradation protein (NCBI ptt file), at 4,307,323 to 4,307,727 BT3343
Locus Name Description Strand Phenotype
BT3333 BT3333 arylsulfatase A precursor (ASA) (NCBI ptt file) - sig.
BT3334 BT3334 two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) - strong
BT3335 BT3335 hypothetical protein (NCBI ptt file) + sig.
BT3336 BT3336 UDP-N-acetylglucosamine acetyltransferase (NCBI ptt file) - strong
BT3337 BT3337 RND efflux system, outer membrane component BipA (from data) - strong
BT3338 BT3338 RND efflux system, inner membrane component BipB (from data) - strong
BT3339 BT3339 RND efflux system, membrane fusion component BipC (from data) - strong
BT3340 BT3340 Beta-galactosidase (EC 3.2.1.23) (from data) - strong
BT3341 BT3341 conserved hypothetical protein (NCBI ptt file) + no data
BT3342 BT3342 hypothetical protein (NCBI ptt file) + sig.
BT3343 BT3343 putative phenylacetic acid degradation protein (NCBI ptt file) - insig.

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