Gene info for BT2402 in Bacteroides thetaiotaomicron VPI-5482

Updated annotation (from data): homoserine phosphotransferase HomK
Rationale: Important for fitness in minimal medium unless threonine is added. Furthermore, this gene complements a strain of E. coli that lacks homoserine kinase (Valentine Trotter & Adam Deutschbauer). HomK (TIGR02535) are related to phosphoglycerate mutases, and the catalytic serine and metal-binding residues are conserved, so HomK must transfer a phosphate group from an unidentified donor to L-homoserine to form O-phospho-L-homoserine. The phosphate donor is not known, but we suspect phosphoserine or phosphoenopyruvate. Many genomes with this family lack glycerate kinase, so we do not expect that phosphoglycerate is the phosphate donor.
Original annotation: phosphoglycerate mutase (NCBI ptt file)
Type 1: Protein-coding gene
Located on scaffold 241, - strand, nucleotides 2,997,809 to 2,999,032
See nucleotide sequence around BT2402 or for all of scaffold 241

Other databases: MicrobesOnline, NCBI, refseq: BT_RS12140, uniprot: Q8A542

Nearby Genes

500 ntBT2397 and BT2398 are separated by 105 nucleotidesBT2398 and BT2399 are separated by 32 nucleotidesBT2399 and BT2400 are separated by 1108 nucleotidesBT2400 and BT2401 are separated by 34 nucleotidesBT2401 and BT2402 overlap by 4 nucleotidesBT2402 and BT2403 are separated by 15 nucleotidesBT2403 and BT2404 are separated by 454 nucleotidesBT2404 and BT2405 are separated by 101 nucleotidesBT2405 and BT2406 are separated by 12 nucleotidesBT2406 and BT2407 are separated by 20 nucleotides BT2397: BT2397 - conserved hypothetical protein (NCBI ptt file), at 2,992,778 to 2,993,401 BT2397 BT2398: BT2398 - hypothetical protein (NCBI ptt file), at 2,993,507 to 2,993,869 BT2398 BT2399: BT2399 - transposase (NCBI ptt file), at 2,993,902 to 2,994,795 BT2399 BT2400: BT2400 - DNA-3-methyladenine glycosylase I (NCBI ptt file), at 2,995,904 to 2,996,476 BT2400 BT2401: BT2401 - threonine synthase (NCBI ptt file), at 2,996,511 to 2,997,812 BT2401 BT2402: BT2402 - homoserine phosphotransferase HomK (from data), at 2,997,809 to 2,999,032 BT2402 BT2403: BT2403 - aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) (from data), at 2,999,048 to 3,001,483 BT2403 BT2404: BT2404 - L-asparaginase I (NCBI ptt file), at 3,001,938 to 3,002,921 BT2404 BT2405: BT2405 - conserved hypothetical protein (NCBI ptt file), at 3,003,023 to 3,004,222 BT2405 BT2406: BT2406 - putative DNA repair protein (NCBI ptt file), at 3,004,235 to 3,005,602 BT2406 BT2407: BT2407 - NAD-utilizing dehydrogenases (NCBI ptt file), at 3,005,623 to 3,007,272 BT2407
Locus Name Description Strand Phenotype
BT2397 BT2397 conserved hypothetical protein (NCBI ptt file) + strong
BT2398 BT2398 hypothetical protein (NCBI ptt file) + no data
BT2399 BT2399 transposase (NCBI ptt file) + no data
BT2400 BT2400 DNA-3-methyladenine glycosylase I (NCBI ptt file) - strong
BT2401 BT2401 threonine synthase (NCBI ptt file) - strong
BT2402 BT2402 homoserine phosphotransferase HomK (from data) - strong
BT2403 BT2403 aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) (from data) - strong
BT2404 BT2404 L-asparaginase I (NCBI ptt file) + insig.
BT2405 BT2405 conserved hypothetical protein (NCBI ptt file) + sig.
BT2406 BT2406 putative DNA repair protein (NCBI ptt file) + strong
BT2407 BT2407 NAD-utilizing dehydrogenases (NCBI ptt file) + sig.

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