Gene info for SO1683 in Shewanella oneidensis MR-1

Updated annotation (from data): 3-hydroxy-2-methylbutyryl-CoA dehydrogenase IvdG (EC:1.1.1.178)
Rationale: Important for utilization of L-isoleucine as a carbon or nitrogen source. SO1683 is expected to be the 3-hydroxy-2-methylbutyryl-CoA dehydrogenase for isoleucine degradation (PMC2612455), and this is confirmed by its mutants' phenotype. (Also see data from an independent set of transposon mutants in PMC3219624.) Mutants in SO1683 have many other phenotypes which are not explained.
Original annotation: 3-oxoacyl-(acyl-carrier-protein) reductase, putative (NCBI ptt file)
Type 1: Protein-coding gene
Located on scaffold 139, + strand, nucleotides 1,770,317 to 1,771,075
See nucleotide sequence around SO1683 or for all of scaffold 139

Other databases: MicrobesOnline, NCBI, uniprot: Q8EGC1

Nearby Genes

500 ntmmsA and SO1679 are separated by 162 nucleotidesSO1679 and SO1680 are separated by 52 nucleotidesSO1680 and SO1681 overlap by 1 nucleotidesSO1681 and mmsB are separated by 83 nucleotidesmmsB and SO1683 are separated by 24 nucleotidesSO1683 and SO1685 are separated by 207 nucleotidesSO1685 and SO1686 are separated by 70 nucleotidesSO1686 and SO1687 are separated by 61 nucleotidesSO1687 and SO1689 are separated by 426 nucleotidesSO1689 and SO1690 are separated by 368 nucleotides SO1678: mmsA - methylmalonate-semialdehyde dehydrogenase (NCBI ptt file), at 1,764,510 to 1,766,009 mmsA SO1679: SO1679 - 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) (from data), at 1,766,172 to 1,767,329 SO1679 SO1680: SO1680 - enoyl-CoA hydratase/isomerase family protein (NCBI ptt file), at 1,767,382 to 1,768,155 SO1680 SO1681: SO1681 - enoyl-CoA hydratase/isomerase family protein (NCBI ptt file), at 1,768,155 to 1,769,306 SO1681 SO1682: mmsB - 3-hydroxyisobutyrate dehydrogenase (NCBI ptt file), at 1,769,390 to 1,770,292 mmsB SO1683: SO1683 - 3-hydroxy-2-methylbutyryl-CoA dehydrogenase IvdG (EC:1.1.1.178) (from data), at 1,770,317 to 1,771,075 SO1683 SO1685: SO1685 - hypothetical protein (NCBI ptt file), at 1,771,283 to 1,771,534 SO1685 SO1686: SO1686 - prolyl oligopeptidase family protein (NCBI ptt file), at 1,771,605 to 1,773,641 SO1686 SO1687: SO1687 - transcriptional regulator, MerR family (NCBI ptt file), at 1,773,703 to 1,774,092 SO1687 SO1689: SO1689 - cation transport ATPase, E1-E2 family (NCBI ptt file), at 1,774,519 to 1,776,780 SO1689 SO1690: SO1690 - ABC transporter, ATP-binding protein (NCBI ptt file), at 1,777,149 to 1,778,741 SO1690
Locus Name Description Strand Phenotype
SO1678 mmsA methylmalonate-semialdehyde dehydrogenase (NCBI ptt file) + strong
SO1679 SO1679 2-methylbutanoyl-CoA dehydrogenase (EC 1.3.8.5) (from data) + strong
SO1680 SO1680 enoyl-CoA hydratase/isomerase family protein (NCBI ptt file) + strong
SO1681 SO1681 enoyl-CoA hydratase/isomerase family protein (NCBI ptt file) + strong
SO1682 mmsB 3-hydroxyisobutyrate dehydrogenase (NCBI ptt file) + strong
SO1683 SO1683 3-hydroxy-2-methylbutyryl-CoA dehydrogenase IvdG (EC:1.1.1.178) (from data) + strong
SO1685 SO1685 hypothetical protein (NCBI ptt file) + no data
SO1686 SO1686 prolyl oligopeptidase family protein (NCBI ptt file) + strong
SO1687 SO1687 transcriptional regulator, MerR family (NCBI ptt file) - sig.
SO1689 SO1689 cation transport ATPase, E1-E2 family (NCBI ptt file) + sig.
SO1690 SO1690 ABC transporter, ATP-binding protein (NCBI ptt file) + sig.

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