Gene info for SO1275 in Shewanella oneidensis MR-1

Name: gabD
Updated annotation (from data): succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16]
Rationale: Specifically important for: L-Isoleucine. Also very important with putrescine as the N source. The more specific KEGG annotation is consistent its role on N putrescine (which is converted to 4-aminobutyrate and then to succinate semialdehyde). Its role on isoleucine is unclear but a close homolog, Shewana3_3092, also has this phenotype (albeit milder). Also note that isoleucine is catabolized to propionyl-CoA and Shewana3_3092 is very important for propionate utilization. The annotation of son:SO_1275 in KEGG has been updated to list glutarate-semialdehyde as an additional substrate. (KEGG_correct)
Original annotation: succinate-semialdehyde dehydrogenase (NCBI ptt file)
Type 1: Protein-coding gene
Located on scaffold 139, + strand, nucleotides 1,324,098 to 1,325,546
See nucleotide sequence around SO1275 or for all of scaffold 139

Other databases: MicrobesOnline, NCBI, uniprot: Q8EHE8

Nearby Genes

500 ntSO1270 and SO1271 are separated by 159 nucleotidesSO1271 and SO1272 overlap by 4 nucleotidesSO1272 and SO1273 overlap by 4 nucleotidesSO1273 and SO1274 are separated by 236 nucleotidesSO1274 and gabD are separated by 56 nucleotidesgabD and gabT are separated by 63 nucleotidesgabT and SO1277 are separated by 85 nucleotidesSO1277 and SO1278 are separated by 469 nucleotidesSO1278 and SO1279 are separated by 64 nucleotidesSO1279 and SO_1280 are separated by 571 nucleotides SO1270: SO1270 - polyamine ABC transporter, periplasmic polyamine-binding protein (NCBI ptt file), at 1,318,405 to 1,319,508 SO1270 SO1271: SO1271 - polyamine ABC transporter, ATP-binding protein (NCBI ptt file), at 1,319,668 to 1,320,804 SO1271 SO1272: SO1272 - polyamine ABC transporter, permease protein (NCBI ptt file), at 1,320,801 to 1,321,706 SO1272 SO1273: SO1273 - polyamine ABC transporter, permease protein (NCBI ptt file), at 1,321,703 to 1,322,518 SO1273 SO1274: SO1274 - conserved hypothetical protein (NCBI ptt file), at 1,322,755 to 1,324,041 SO1274 SO1275: gabD - succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (from data), at 1,324,098 to 1,325,546 gabD SO1276: gabT - 4-aminobutyrate aminotransferase (NCBI ptt file), at 1,325,610 to 1,326,887 gabT SO1277: SO1277 - proton-dependent oligopeptide transporter (POT) family protein (NCBI ptt file), at 1,326,973 to 1,328,523 SO1277 SO1278: SO1278 - methyl-accepting chemotaxis protein (NCBI ptt file), at 1,328,993 to 1,331,113 SO1278 SO1279: SO1279 - hypothetical protein (NCBI ptt file), at 1,331,178 to 1,331,354 SO1279 SO_1280: SO_1280 - no description, at 1,331,926 to 1,332,642 _1280
Locus Name Description Strand Phenotype
SO1270 SO1270 polyamine ABC transporter, periplasmic polyamine-binding protein (NCBI ptt file) + strong
SO1271 SO1271 polyamine ABC transporter, ATP-binding protein (NCBI ptt file) + strong
SO1272 SO1272 polyamine ABC transporter, permease protein (NCBI ptt file) + strong
SO1273 SO1273 polyamine ABC transporter, permease protein (NCBI ptt file) + strong
SO1274 SO1274 conserved hypothetical protein (NCBI ptt file) + strong
SO1275 gabD succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (from data) + strong
SO1276 gabT 4-aminobutyrate aminotransferase (NCBI ptt file) + sig.
SO1277 SO1277 proton-dependent oligopeptide transporter (POT) family protein (NCBI ptt file) - strong
SO1278 SO1278 methyl-accepting chemotaxis protein (NCBI ptt file) + insig.
SO1279 SO1279 hypothetical protein (NCBI ptt file) + insig.
SO_1280 SO_1280 no description - no data

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