Experiment set8IT035 for Methanococcus maripaludis S2

Compare to:

Mc formate, casamino free, with 5mM L-Glutamate and 5mM L-Proline

200 most important genes:

  gene name fitness t score description  
MMP_RS06355 -4.2 -3.1 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS06350 -4.2 -7.8 HesA/MoeB/ThiF family protein compare
MMP_RS01500 -4.1 -3.4 CBS domain-containing protein compare
MMP_RS07005 -4.1 -0.8 4Fe-4S binding protein compare
MMP_RS01175 -4.1 -6.1 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS03015 -3.8 -16.2 GTP 3' 8-cyclase MoaA compare
MMP_RS08165 -3.7 -3.5 phosphoglycerate dehydrogenase compare
MMP_RS07345 -3.7 -10.7 glycine synthesis protein GlyXL (from data) compare
MMP_RS05515 -3.5 -7.9 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS05500 -3.5 -10.7 2-isopropylmalate synthase compare
MMP_RS06685 -3.5 -15.7 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS06680 -3.5 -17.3 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS06715 -3.2 -19.4 cache domain-containing protein compare
MMP_RS07635 -3.1 -9.8 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS06345 -3.1 -13.9 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS01700 -3.1 -0.8 dihydroxy-acid dehydratase compare
MMP_RS06700 -3.1 -16.9 hypothetical protein compare
MMP_RS07730 -3.0 -2.1 pyruvate synthase subunit beta compare
MMP_RS07365 -3.0 -15.0 2-phosphoglycerate kinase compare
MMP_RS06720 -3.0 -9.6 response regulator transcription factor compare
MMP_RS03450 -2.8 -3.1 glycine synthesis protein GlyXS (from data) compare
MMP_RS08720 -2.8 -2.4 4Fe-4S binding protein compare
MMP_RS05875 -2.8 -6.4 hydroxyethylthiazole kinase compare
MMP_RS07735 -2.8 -1.0 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha compare
MMP_RS08745 -2.8 -8.5 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS04900 -2.8 -19.7 hypothetical protein compare
MMP_RS07845 -2.7 -3.0 LL-diaminopimelate aminotransferase compare
MMP_RS06400 -2.7 -2.1 4Fe-4S binding protein compare
MMP_RS07630 -2.7 -2.0 ATP-binding cassette domain-containing protein compare
MMP_RS06705 -2.6 -7.3 formate/nitrite transporter family protein compare
MMP_RS05095 -2.6 -7.9 CO dehydrogenase/acetyl-CoA synthase complex subunit epsilon compare
MMP_RS07445 -2.6 -7.6 helix-turn-helix domain-containing protein compare
MMP_RS06625 -2.6 -2.7 DNA primase compare
MMP_RS06975 -2.6 -3.0 sulfide-dependent adenosine diphosphate thiazole synthase compare
MMP_RS04605 -2.6 -5.4 cobalt ECF transporter T component CbiQ compare
MMP_RS08715 -2.6 -2.3 formylmethanofuran dehydrogenase subunit B compare
MMP_RS07380 -2.5 -2.8 transcription elongation factor Spt5 compare
MMP_RS04615 -2.5 -3.3 PDGLE domain-containing protein compare
MMP_RS07185 -2.5 -15.5 pyridoxal phosphate-dependent aminotransferase compare
MMP_RS07575 -2.5 -5.7 RNA ligase partner protein compare
MMP_RS04620 -2.5 -13.7 cobalt transporter CbiM compare
MMP_RS05425 -2.5 -4.0 monovalent cation/H+ antiporter complex subunit F compare
MMP_RS02010 -2.4 -10.7 PHP domain-containing protein compare
MMP_RS02175 -2.4 -1.0 DUF1611 domain-containing protein compare
MMP_RS06105 -2.4 -9.5 hydrogenase maturation peptidase HycI compare
MMP_RS07525 -2.4 -10.6 4Fe-4S binding protein compare
MMP_RS03640 -2.4 -4.9 archaeal proteasome endopeptidase complex subunit beta compare
MMP_RS06175 -2.3 -10.0 winged helix-turn-helix transcriptional regulator compare
MMP_RS03960 -2.3 -1.4 hypothetical protein compare
MMP_RS06925 -2.3 -3.5 ribonuclease VapC4 compare
MMP_RS01005 -2.3 -1.7 riboflavin synthase compare
MMP_RS07555 -2.3 -1.0 monovalent cation/H+ antiporter subunit E compare
MMP_RS00040 -2.3 -4.9 TIGR03576 family pyridoxal phosphate-dependent enzyme compare
MMP_RS01195 -2.2 -1.6 metalloregulator ArsR/SmtB family transcription factor compare
MMP_RS00295 -2.2 -2.5 gamma carbonic anhydrase family protein compare
MMP_RS03435 -2.2 -1.9 ketol-acid reductoisomerase compare
MMP_RS01380 -2.2 -4.8 PHP domain-containing protein compare
MMP_RS05085 -2.2 -11.1 AAA family ATPase compare
MMP_RS05080 -2.2 -11.4 acetyl-CoA decarbonylase/synthase complex subunit delta compare
MMP_RS05090 -2.2 -8.7 CO dehydrogenase/CO-methylating acetyl-CoA synthase complex subunit beta compare
MMP_RS05060 -2.1 -10.1 AAA family ATPase compare
MMP_RS03035 -2.1 -4.0 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS05765 -2.1 -7.3 M42 family metallopeptidase compare
MMP_RS00300 -2.1 -0.9 6 7-dimethyl-8-ribityllumazine synthase compare
MMP_RS09055 -2.1 -1.3 CAP domain-containing protein compare
MMP_RS05075 -2.1 -14.0 acetyl-CoA decarbonylase/synthase complex subunit gamma compare
MMP_RS01325 -2.1 -2.2 dihydroneopterin aldolase family protein compare
MMP_RS05100 -2.1 -14.2 CO dehydrogenase/acetyl-CoA synthase complex subunit alpha compare
MMP_RS06840 -2.0 -1.1 DNA-directed RNA polymerase subunit N compare
MMP_RS05055 -2.0 -13.1 DUF166 domain-containing protein compare
MMP_RS02195 -2.0 -3.5 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase compare
MMP_RS01985 -2.0 -6.4 F420-dependent methylenetetrahydromethanopterin dehydrogenase compare
MMP_RS05070 -2.0 -8.3 4Fe-4S dicluster domain-containing protein compare
MMP_RS01085 -1.9 -2.1 hypothetical protein compare
MMP_RS03475 -1.9 -0.9 hypothetical protein compare
MMP_RS08330 -1.9 -5.4 NADH-quinone oxidoreductase subunit H compare
MMP_RS02280 -1.9 -1.0 DUF211 domain-containing protein compare
MMP_RS03025 -1.9 -5.9 molybdenum cofactor guanylyltransferase compare
MMP_RS06295 -1.8 -5.4 methanogenesis marker 14 protein compare
MMP_RS08460 -1.8 -3.1 proteasome-activating nucleotidase compare
MMP_RS04870 -1.8 -4.7 TIGR02253 family HAD-type hydrolase compare
MMP_RS04780 -1.8 -2.9 ribonuclease P compare
MMP_RS00685 -1.8 -4.3 2-phospho-L-lactate guanylyltransferase compare
MMP_RS08300 -1.8 -1.3 metal-sulfur cluster assembly factor compare
MMP_RS01265 -1.8 -2.4 hypothetical protein compare
MMP_RS02800 -1.8 -4.4 nucleotidyltransferase domain-containing protein compare
MMP_RS08635 -1.8 -2.1 UbiA family prenyltransferase compare
MMP_RS07605 -1.7 -2.8 diadenylate cyclase compare
MMP_RS01545 -1.7 -1.2 CBS domain-containing protein compare
MMP_RS00305 -1.7 -2.2 phosphoribosyl-ATP diphosphatase compare
MMP_RS05265 -1.7 -2.2 2-isopropylmalate synthase compare
MMP_RS05930 -1.7 -2.6 3-isopropylmalate dehydratase large subunit compare
MMP_RS02355 -1.7 -2.4 30S ribosomal protein S27ae compare
MMP_RS05065 -1.7 -4.4 CooT family nickel-binding protein compare
MMP_RS01020 -1.7 -1.2 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS05555 -1.7 -1.5 DUF4040 domain-containing protein compare
MMP_RS01220 -1.7 -7.2 hypothetical protein compare
MMP_RS01365 -1.6 -3.4 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS04125 -1.6 -3.5 TetR/AcrR family transcriptional regulator compare
MMP_RS01440 -1.6 -5.0 NAAT family transporter compare
MMP_RS08645 -1.5 -7.0 UPF0179 family protein compare
MMP_RS06200 -1.5 -6.3 M24 family metallopeptidase compare
MMP_RS00290 -1.5 -6.2 hypothetical protein compare
MMP_RS08820 -1.5 -4.9 hypothetical protein compare
MMP_RS04890 -1.5 -0.8 adenylyltransferase/cytidyltransferase family protein compare
MMP_RS01445 -1.4 -5.8 hypothetical protein compare
MMP_RS01240 -1.4 -1.5 7-cyano-7-deazaguanine synthase QueC compare
MMP_RS01610 -1.4 -2.7 hypothetical protein compare
MMP_RS07710 -1.4 -5.8 cell division protein FtsZ compare
MMP_RS02170 -1.4 -3.5 CBS domain-containing protein compare
MMP_RS01800 -1.4 -4.2 TIGR00303 family protein compare
MMP_RS06630 -1.4 -0.9 UPF0058 family protein compare
MMP_RS00620 -1.4 -7.0 4Fe-4S binding protein compare
MMP_RS09020 -1.4 -1.6 hypothetical protein compare
MMP_RS03145 -1.4 -5.9 fibrillarin-like rRNA/tRNA 2'-O-methyltransferase compare
MMP_RS05850 -1.4 -2.9 Ldh family oxidoreductase compare
MMP_RS00515 -1.4 -0.8 DUF655 domain-containing protein compare
MMP_RS05540 -1.3 -2.5 hypothetical protein compare
MMP_RS04585 -1.3 -7.6 AIR synthase related protein compare
MMP_RS07960 -1.3 -5.5 sugar phosphate isomerase/epimerase compare
MMP_RS08790 -1.3 -2.2 translation initiation factor IF-2 subunit alpha compare
MMP_RS06340 -1.3 -5.4 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS06730 -1.3 -1.5 phosphopantothenate/pantothenate synthetase compare
MMP_RS07720 -1.3 -7.2 4Fe-4S binding protein compare
MMP_RS02805 -1.2 -1.3 HEPN domain-containing protein compare
MMP_RS00695 -1.2 -0.8 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS01830 -1.2 -1.5 tRNA-Val compare
MMP_RS07580 -1.2 -3.0 DUF356 domain-containing protein compare
MMP_RS07535 -1.2 -6.0 4Fe-4S binding protein compare
MMP_RS08210 -1.2 -1.2 phosphatidylglycerophosphatase A compare
MMP_RS01755 -1.2 -1.3 DUF2097 domain-containing protein compare
MMP_RS02900 -1.2 -0.5 imidazoleglycerol-phosphate dehydratase HisB compare
MMP_RS05550 -1.2 -0.5 cation:proton antiporter compare
MMP_RS05440 -1.1 -5.1 winged helix-turn-helix transcriptional regulator compare
MMP_RS06020 -1.1 -2.7 archaeoflavoprotein AfpA compare
MMP_RS02340 -1.1 -1.5 DNA-directed RNA polymerase subunit E'' compare
MMP_RS04255 -1.1 -3.5 coenzyme F420 hydrogenase subunit beta compare
MMP_RS06865 -1.1 -1.3 HypC/HybG/HupF family hydrogenase formation chaperone compare
MMP_RS00555 -1.1 -3.5 MFS transporter compare
MMP_RS07545 -1.1 -1.1 HTH domain-containing protein compare
MMP_RS02235 -1.1 -3.6 CBS domain-containing protein compare
MMP_RS01250 -1.1 -3.1 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS08615 -1.1 -1.3 flagellar protein G compare
MMP_RS04875 -1.1 -4.4 energy-converting hydrogenase B subunit P compare
MMP_RS06270 -1.0 -3.6 TIGR00300 family protein compare
MMP_RS04775 -1.0 -2.5 adenosylhomocysteinase compare
MMP_RS06475 -1.0 -2.8 FAD-dependent oxidoreductase compare
MMP_RS03140 -1.0 -6.3 hypothetical protein compare
MMP_RS07350 -1.0 -1.7 preprotein translocase subunit Sec61beta compare
MMP_RS05245 -1.0 -4.2 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS00115 -1.0 -5.2 radical SAM protein compare
MMP_RS03305 -1.0 -3.4 winged helix-turn-helix domain-containing protein compare
MMP_RS03445 -1.0 -0.8 methanogenesis marker 17 protein compare
MMP_RS01570 -1.0 -1.2 hypothetical protein compare
MMP_RS08940 -1.0 -0.8 MetS family NSS transporter small subunit compare
MMP_RS03600 -1.0 -1.5 triose-phosphate isomerase compare
MMP_RS01790 -1.0 -2.5 restriction endonuclease compare
MMP_RS02885 -1.0 -6.1 molybdopterin biosynthesis protein compare
MMP_RS02345 -1.0 -2.4 GTP-dependent dephospho-CoA kinase family protein compare
MMP_RS08350 -1.0 -0.7 hypothetical protein compare
MMP_RS02240 -1.0 -2.2 methanogenesis marker 7 protein compare
MMP_RS06285 -1.0 -1.4 precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT compare
MMP_RS05505 -0.9 -4.9 class IV adenylate cyclase compare
MMP_RS00060 -0.9 -1.4 3-dehydroquinate synthase II compare
MMP_RS02930 -0.9 -1.6 class I SAM-dependent methyltransferase compare
MMP_RS08415 -0.9 -2.2 radical SAM protein compare
MMP_RS03205 -0.9 -1.0 peptidyl-tRNA hydrolase Pth2 compare
MMP_RS06870 -0.9 -2.3 DedA family protein compare
MMP_RS08240 -0.9 -3.4 methanogenesis marker 16 metalloprotein compare
MMP_RS02610 -0.9 -2.3 DUF2162 domain-containing protein compare
MMP_RS03485 -0.9 -2.9 TIGR00267 family protein compare
MMP_RS07705 -0.9 -3.3 transcriptional regulator compare
MMP_RS02165 -0.9 -3.2 tRNA-dihydrouridine synthase compare
MMP_RS05910 -0.9 -2.0 cell division ATPase MinD compare
MMP_RS03080 -0.9 -1.9 universal stress protein compare
MMP_RS02875 -0.8 -4.1 chorismate pyruvate-lyase family protein compare
MMP_RS04090 -0.8 -1.8 hypothetical protein compare
MMP_RS01795 -0.8 -1.1 methanogenesis marker 6 protein compare
MMP_RS07600 -0.8 -1.6 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS04055 -0.8 -1.1 hypothetical protein compare
MMP_RS07685 -0.8 -3.3 TIGR01212 family radical SAM protein compare
MMP_RS05865 -0.8 -0.9 hypothetical protein compare
MMP_RS06325 -0.8 -0.9 hypothetical protein compare
MMP_RS08320 -0.8 -2.4 molybdopterin molybdotransferase MoeA compare
MMP_RS00965 -0.8 -1.0 hypothetical protein compare
MMP_RS05285 -0.8 -3.5 MMPL family transporter compare
MMP_RS00535 -0.8 -1.5 TIGR00375 family protein compare
MMP_RS02045 -0.8 -1.0 tRNA-Met compare
MMP_RS07200 -0.7 -2.7 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS05985 -0.7 -0.9 hypothetical protein compare
MMP_RS07725 -0.7 -1.5 4Fe-4S dicluster domain-containing protein compare
MMP_RS06315 -0.7 -0.6 cobalt-precorrin-7 (C(5))-methyltransferase compare
MMP_RS05445 -0.7 -2.5 CoB--CoM heterodisulfide reductase subunit B compare
MMP_RS03550 -0.7 -1.2 DUF2124 domain-containing protein compare
MMP_RS00720 -0.7 -2.8 metal-dependent hydrolase compare
MMP_RS01110 -0.7 -2.1 FmdE family protein compare
MMP_RS02145 -0.7 -4.0 winged helix-turn-helix transcriptional regulator compare
MMP_RS05510 -0.7 -1.5 Rrf2 family transcriptional regulator compare
MMP_RS04790 -0.7 -4.7 4-hydroxy-tetrahydrodipicolinate reductase compare
MMP_RS05280 -0.7 -4.0 COG1361 S-layer family protein compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in nutrient t1 experiments

For nutrient t1 L-Glutamic acid monopotassium salt monohydrate across organisms