Experiment set8IT034 for Pseudomonas fluorescens FW300-N2E2

Compare to:

4-Hydroxybenzoic Acid carbon source

200 most important genes:

  gene name fitness t score description  
Pf6N2E2_3248 -6.9 -4.8 Probable transmembrane protein compare
Pf6N2E2_4826 -6.1 -6.0 Indole-3-glycerol phosphate synthase (EC 4.1.1.48) compare
Pf6N2E2_64 -6.0 -4.1 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) compare
Pf6N2E2_4597 -5.7 -7.8 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf6N2E2_2835 -5.7 -3.9 Beta-ketoadipyl CoA thiolase (EC 2.3.1.-) compare
Pf6N2E2_4825 -5.6 -7.6 Anthranilate phosphoribosyltransferase (EC 2.4.2.18) compare
Pf6N2E2_3842 -5.4 -5.3 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) compare
Pf6N2E2_4279 -5.3 -11.4 Pyruvate carboxyl transferase subunit B (EC 6.4.1.1) compare
Pf6N2E2_302 -5.3 -5.2 Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) / Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) compare
Pf6N2E2_4047 -5.3 -3.6 Tryptophan synthase alpha chain (EC 4.2.1.20) compare
Pf6N2E2_4278 -5.1 -11.9 Pyruvate carboxyl transferase subunit A (EC 6.4.1.1) compare
Pf6N2E2_4048 -5.0 -7.7 Tryptophan synthase beta chain (EC 4.2.1.20) compare
Pf6N2E2_178 -5.0 -2.0 Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20) compare
Pf6N2E2_3932 -5.0 -8.4 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) compare
Pf6N2E2_3751 -5.0 -14.2 Glutamate synthase [NADPH] small chain (EC 1.4.1.13) compare
Pf6N2E2_3782 -4.9 -4.8 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) compare
Pf6N2E2_5175 -4.9 -13.7 Acetolactate synthase large subunit (EC 2.2.1.6) compare
Pf6N2E2_77 -4.9 -5.7 O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) / O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) compare
Pf6N2E2_2833 -4.8 -7.3 Protocatechuate 3,4-dioxygenase alpha chain (EC 1.13.11.3) conserved
Pf6N2E2_4761 -4.8 -11.2 8-amino-7-oxononanoate synthase (EC 2.3.1.47) compare
Pf6N2E2_3630 -4.7 -7.8 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf6N2E2_2839 -4.7 -12.8 Pca regulon regulatory protein PcaR conserved
Pf6N2E2_3839 -4.6 -4.5 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Pf6N2E2_71 -4.6 -8.2 Phosphoribosylanthranilate isomerase (EC 5.3.1.24) compare
Pf6N2E2_4596 -4.6 -11.1 Homoserine O-acetyltransferase (EC 2.3.1.31) compare
Pf6N2E2_4759 -4.6 -16.2 Biotin synthase (EC 2.8.1.6) compare
Pf6N2E2_2829 -4.6 -6.2 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) conserved
Pf6N2E2_5176 -4.6 -9.3 Acetolactate synthase small subunit (EC 2.2.1.6) compare
Pf6N2E2_3940 -4.5 -13.0 Phosphoserine phosphatase (EC 3.1.3.3) compare
Pf6N2E2_3610 -4.5 -6.1 ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17) compare
Pf6N2E2_4564 -4.4 -10.0 Dihydroxy-acid dehydratase (EC 4.2.1.9) compare
Pf6N2E2_66 -4.4 -11.7 3-isopropylmalate dehydrogenase (EC 1.1.1.85) compare
Pf6N2E2_3253 -4.3 -6.9 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Pf6N2E2_3783 -4.3 -5.8 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Pf6N2E2_2914 -4.3 -12.2 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) (from data) conserved
Pf6N2E2_3752 -4.2 -19.9 Glutamate synthase [NADPH] large chain (EC 1.4.1.13) compare
Pf6N2E2_2830 -4.2 -6.3 Beta-ketoadipate enol-lactone hydrolase (EC 3.1.1.24) conserved
Pf6N2E2_50 -4.2 -9.1 Biosynthetic Aromatic amino acid aminotransferase alpha (EC 2.6.1.57) @ Aromatic-amino-acid aminotransferase (EC 2.6.1.57) compare
Pf6N2E2_2073 -4.1 -8.2 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) compare
Pf6N2E2_3762 -3.9 -7.9 NADP-dependent malic enzyme (EC 1.1.1.40) compare
Pf6N2E2_4764 -3.9 -7.8 Dethiobiotin synthetase (EC 6.3.3.3) compare
Pf6N2E2_4762 -3.8 -4.2 Biotin synthesis protein BioH compare
Pf6N2E2_5177 -3.8 -10.3 Ketol-acid reductoisomerase (EC 1.1.1.86) compare
Pf6N2E2_2834 -3.8 -5.1 Protocatechuate 3,4-dioxygenase beta chain (EC 1.13.11.3) conserved
Pf6N2E2_2837 -3.8 -9.2 3-oxoadipate CoA-transferase subunit A (EC 2.8.3.6); Glutaconate CoA-transferase subunit A (EC 2.8.3.12) compare
Pf6N2E2_4277 -3.6 -9.2 LysR family transcriptional regulator PA5437 compare
Pf6N2E2_3252 -3.5 -9.0 Histidinol dehydrogenase (EC 1.1.1.23) compare
Pf6N2E2_4763 -3.5 -11.7 Biotin synthesis protein BioC compare
Pf6N2E2_2913 -3.4 -7.3 Transcriptional regulator PobR, AraC family conserved
Pf6N2E2_5156 -3.4 -3.2 Two-component sensor CbrB: intrcellular carbon:nitrogen balance compare
Pf6N2E2_2836 -3.2 -4.2 3-oxoadipate CoA-transferase subunit B (EC 2.8.3.6); Glutaconate CoA-transferase subunit B (EC 2.8.3.12) compare
Pf6N2E2_4631 -3.2 -8.5 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) compare
Pf6N2E2_5527 -3.2 -3.0 Cold shock protein CspC compare
Pf6N2E2_2831 -3.1 -2.9 3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2) compare
Pf6N2E2_1400 -3.0 -11.2 Sensory box histidine kinase/response regulator compare
Pf6N2E2_2277 -3.0 -3.4 NADPH-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13) compare
Pf6N2E2_5728 -3.0 -4.7 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) compare
Pf6N2E2_3264 -3.0 -2.8 Uncharacterized protein YrbK clustered with lipopolysaccharide transporters compare
Pf6N2E2_3095 -2.9 -1.6 hypothetical protein compare
Pf6N2E2_3460 -2.9 -2.0 Exodeoxyribonuclease V beta chain (EC 3.1.11.5) compare
Pf6N2E2_4071 -2.9 -4.7 Phosphate transport system regulatory protein PhoU compare
Pf6N2E2_2574 -2.7 -3.1 Flagellar synthesis regulator FleN compare
Pf6N2E2_4638 -2.7 -4.5 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) compare
Pf6N2E2_3841 -2.7 -4.9 Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-) compare
Pf6N2E2_5006 -2.7 -6.8 Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13) compare
Pf6N2E2_5178 -2.6 -3.0 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) compare
Pf6N2E2_5579 -2.6 -7.2 Ornithine carbamoyltransferase (EC 2.1.3.3) compare
Pf6N2E2_1932 -2.6 -7.5 Transcriptional regulator, IclR family compare
Pf6N2E2_3251 -2.6 -10.4 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Pf6N2E2_5014 -2.6 -1.7 Apolipoprotein N-acyltransferase (EC 2.3.1.-) / Copper homeostasis protein CutE compare
Pf6N2E2_5316 -2.5 -2.9 Periplasmic thiol:disulfide oxidoreductase DsbB, required for DsbA reoxidation compare
Pf6N2E2_4372 -2.5 -6.4 FIG00460773: hypothetical protein compare
Pf6N2E2_63 -2.5 -3.8 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) compare
Pf6N2E2_4797 -2.5 -2.6 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) compare
Pf6N2E2_2217 -2.5 -6.0 ATP-dependent Clp protease ATP-binding subunit ClpX compare
Pf6N2E2_1402 -2.4 -6.3 hypothetical protein compare
Pf6N2E2_3170 -2.4 -6.5 2-isopropylmalate synthase (EC 2.3.3.13) compare
Pf6N2E2_4057 -2.3 -1.3 lipoprotein, putative compare
Pf6N2E2_5723 -2.3 -9.2 GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I / Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) compare
Pf6N2E2_3984 -2.3 -11.0 T1SS associated transglutaminase-like cysteine proteinase LapP compare
Pf6N2E2_4453 -2.3 -13.5 Polyphosphate kinase (EC 2.7.4.1) compare
Pf6N2E2_1401 -2.3 -6.7 FIG00955631: hypothetical protein compare
Pf6N2E2_4601 -2.2 -3.1 Hypothetical protein YggS, proline synthase co-transcribed bacterial homolog PROSC compare
Pf6N2E2_5331 -2.2 -8.0 ATPase, AFG1 family compare
Pf6N2E2_5667 -2.2 -6.5 Arginine N-succinyltransferase (EC 2.3.1.109) compare
Pf6N2E2_51 -2.2 -7.9 hypothetical protein compare
Pf6N2E2_5666 -2.1 -8.2 Arginine N-succinyltransferase, alpha subunit (EC 2.3.1.109) compare
Pf6N2E2_3349 -2.1 -4.0 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) compare
Pf6N2E2_1381 -2.1 -5.8 Aldehyde dehydrogenase (EC 1.2.1.3) compare
Pf6N2E2_5111 -2.1 -2.4 FKBP-type peptidyl-prolyl cis-trans isomerase SlpA (EC 5.2.1.8) compare
Pf6N2E2_3941 -2.1 -3.6 Adenosine (5')-pentaphospho-(5'')-adenosine pyrophosphohydrolase (EC 3.6.1.-) compare
Pf6N2E2_4766 -2.1 -10.4 Acyl-CoA dehydrogenase (EC 1.3.8.7) compare
Pf6N2E2_2832 -2.1 -8.7 dicarboxylic acid transporter PcaT compare
Pf6N2E2_5258 -2.0 -7.0 Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) / Adenylylsulfate kinase (EC 2.7.1.25) compare
Pf6N2E2_2465 -2.0 -6.0 Cys regulon transcriptional activator CysB compare
Pf6N2E2_2753 -2.0 -3.2 HtrA protease/chaperone protein compare
Pf6N2E2_2852 -1.9 -9.8 GGDEF domain/EAL domain protein compare
Pf6N2E2_5242 -1.9 -2.5 Malate:quinone oxidoreductase (EC 1.1.5.4) compare
Pf6N2E2_4009 -1.9 -8.3 GGDEF domain protein compare
Pf6N2E2_2003 -1.9 -3.0 hypothetical protein compare
Pf6N2E2_2588 -1.9 -2.8 Anti-sigma F factor antagonist (spoIIAA-2); Anti-sigma B factor antagonist RsbV compare
Pf6N2E2_1034 -1.8 -1.4 Ferric siderophore transport system, periplasmic binding protein TonB compare
Pf6N2E2_2536 -1.8 -1.3 Fumarate hydratase class II (EC 4.2.1.2) compare
Pf6N2E2_5843 -1.8 -2.0 hypothetical protein compare
Pf6N2E2_2274 -1.8 -5.8 Soluble pyridine nucleotide transhydrogenase (EC 1.6.1.1) compare
Pf6N2E2_5103 -1.8 -0.9 Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA compare
Pf6N2E2_2218 -1.8 -4.8 ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) compare
Pf6N2E2_2518 -1.8 -2.7 Cyclohexadienyl dehydrogenase (EC 1.3.1.12)(EC 1.3.1.43) / 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) compare
Pf6N2E2_3908 -1.7 -6.0 Glutamate--cysteine ligase (EC 6.3.2.2) compare
Pf6N2E2_2074 -1.7 -1.2 required for sulfate utilization, putative electron transport protein for sulfite reductase (from data) compare
Pf6N2E2_5425 -1.7 -1.7 hypothetical protein compare
Pf6N2E2_4077 -1.7 -1.4 cytosolic long-chain acyl-CoA thioester hydrolase family protein compare
Pf6N2E2_2264 -1.6 -4.4 NADPH dependent preQ0 reductase (EC 1.7.1.13) compare
Pf6N2E2_4599 -1.6 -3.9 Integral membrane protein YggT, involved in response to extracytoplasmic stress (osmotic shock) compare
Pf6N2E2_3763 -1.6 -2.5 hypothetical protein compare
Pf6N2E2_2879 -1.6 -4.8 membrane protein, putative conserved
Pf6N2E2_3477 -1.5 -2.0 2-Oxobutyrate oxidase, putative compare
Pf6N2E2_4160 -1.5 -1.5 Cytochrome c5 compare
Pf6N2E2_2480 -1.5 -1.7 FIG00957636: hypothetical protein compare
Pf6N2E2_204 -1.5 -1.8 hypothetical protein compare
Pf6N2E2_5766 -1.4 -1.7 Quaternary ammonium compound-resistance protein SugE compare
Pf6N2E2_5153 -1.4 -3.9 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) compare
Pf6N2E2_4206 -1.4 -1.5 Chromosome (plasmid) partitioning protein ParB compare
Pf6N2E2_924 -1.4 -2.5 Transcriptional regulator XdhR, TetR family compare
Pf6N2E2_2586 -1.4 -1.5 Hpt domain protein compare
Pf6N2E2_3938 -1.4 -7.8 Threonine dehydratase biosynthetic (EC 4.3.1.19) compare
Pf6N2E2_2473 -1.4 -1.3 Major outer membrane lipoprotein I compare
Pf6N2E2_58 -1.4 -1.6 tRNA-dihydrouridine synthase C (EC 1.-.-.-) compare
Pf6N2E2_3062 -1.4 -3.5 Membrane-associated zinc metalloprotease compare
Pf6N2E2_3667 -1.4 -1.1 Heptose kinase WapQ, eukaryotic type compare
Pf6N2E2_2794 -1.3 -1.7 putative membrane protein compare
Pf6N2E2_1116 -1.3 -2.0 Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) compare
Pf6N2E2_3373 -1.3 -3.9 Outer membrane lipoprotein SmpA, a component of the essential YaeT outer-membrane protein assembly complex compare
Pf6N2E2_2071 -1.3 -3.1 hypothetical protein compare
Pf6N2E2_4187 -1.3 -3.8 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) compare
Pf6N2E2_1987 -1.3 -1.7 hypothetical protein compare
Pf6N2E2_3282 -1.3 -2.0 FIG005080: Possible exported protein compare
Pf6N2E2_5573 -1.3 -4.1 Glycerol-3-phosphate regulon repressor, DeoR family compare
Pf6N2E2_5665 -1.2 -5.0 Succinylornithine transaminase (EC 2.6.1.81) compare
Pf6N2E2_5257 -1.2 -6.5 Sulfate adenylyltransferase subunit 2 (EC 2.7.7.4) compare
Pf6N2E2_3770 -1.2 -1.4 ATP-dependent hsl protease ATP-binding subunit HslU compare
Pf6N2E2_2756 -1.2 -3.9 RNA polymerase sigma-H factor AlgT compare
Pf6N2E2_1182 -1.2 -2.0 Transcriptional regulator, LysR family compare
Pf6N2E2_5676 -1.2 -2.0 Aspartokinase (EC 2.7.2.4) compare
Pf6N2E2_425 -1.2 -3.6 FIG00957304: hypothetical protein compare
Pf6N2E2_5252 -1.2 -2.0 FIG00956396: hypothetical protein compare
Pf6N2E2_2065 -1.2 -3.1 Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) compare
Pf6N2E2_4636 -1.1 -3.6 periplasmic binding protein, putative compare
Pf6N2E2_3514 -1.1 -2.7 Ribosomal protein L11 methyltransferase (EC 2.1.1.-) compare
Pf6N2E2_2088 -1.1 -2.0 SOS-response repressor and protease LexA (EC 3.4.21.88) compare
Pf6N2E2_1173 -1.1 -1.3 hypothetical protein compare
Pf6N2E2_4205 -1.1 -2.6 Chromosome (plasmid) partitioning protein ParA compare
Pf6N2E2_2186 -1.1 -4.5 Isovaleryl-CoA dehydrogenase (EC 1.3.8.4) compare
Pf6N2E2_2877 -1.1 -4.3 Membrane fusion component of tripartite multidrug resistance system conserved
Pf6N2E2_623 -1.1 -1.4 FIG00954674: hypothetical protein compare
Pf6N2E2_2878 -1.1 -2.0 required for 4-hydroxybenzoate and octanoate transport, together with MFP and FUSC proteins (Pf6N2E2_2877, Pf6N2E2_2879) (from data) compare
Pf6N2E2_4049 -1.0 -5.2 Glycine cleavage system transcriptional activator compare
Pf6N2E2_4612 -1.0 -2.2 Glutathione synthetase (EC 6.3.2.3) compare
Pf6N2E2_288 -1.0 -1.6 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42); Monomeric isocitrate dehydrogenase [NADP] (EC 1.1.1.42) compare
Pf6N2E2_1676 -1.0 -1.6 conserved protein associated with acetyl-CoA C-acyltransferase compare
Pf6N2E2_4987 -1.0 -1.1 MaoC-like domain protein compare
Pf6N2E2_5219 -1.0 -4.6 FIG140336: TPR domain protein compare
Pf6N2E2_84 -1.0 -1.8 hypothetical protein compare
Pf6N2E2_193 -1.0 -2.7 hypothetical protein compare
Pf6N2E2_2999 -1.0 -1.5 probable tail fiber assembly protein compare
Pf6N2E2_6140 -1.0 -0.6 Large Subunit Ribosomal RNA; lsuRNA; LSU rRNA compare
Pf6N2E2_5520 -1.0 -3.8 Sensory box histidine kinase compare
Pf6N2E2_634 -1.0 -5.2 NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form compare
Pf6N2E2_2510 -1.0 -2.3 Lipid carrier : UDP-N-acetylgalactosaminyltransferase (EC 2.4.1.-) / Alpha-1,3-N-acetylgalactosamine transferase PglA (EC 2.4.1.-); Putative glycosyltransferase compare
Pf6N2E2_3847 -1.0 -2.4 FIG001341: Probable Fe(2+)-trafficking protein YggX compare
Pf6N2E2_2986 -1.0 -2.9 Transcriptional regulator, LuxR family compare
Pf6N2E2_1673 -1.0 -2.2 Transcriptional regulator, TetR family compare
Pf6N2E2_3088 -1.0 -1.1 hypothetical protein compare
Pf6N2E2_1445 -1.0 -2.3 Glutathione S-transferase compare
Pf6N2E2_2313 -1.0 -2.3 Cytochrome c oxidase subunit CcoP (EC 1.9.3.1) compare
Pf6N2E2_4092 -1.0 -2.1 FIG00954395: hypothetical protein compare
Pf6N2E2_5086 -1.0 -1.0 hypothetical protein compare
Pf6N2E2_3786 -1.0 -2.1 Twin-arginine translocation protein TatC compare
Pf6N2E2_2886 -1.0 -7.3 Phosphogluconate repressor HexR, RpiR family compare
Pf6N2E2_1081 -0.9 -1.4 probable membrane protein YPO3302 compare
Pf6N2E2_4062 -0.9 -3.1 hypothetical protein compare
Pf6N2E2_3810 -0.9 -2.6 Phosphonate ABC transporter phosphate-binding periplasmic component (TC 3.A.1.9.1) compare
Pf6N2E2_3677 -0.9 -6.3 Sensory box/GGDEF family protein compare
Pf6N2E2_2007 -0.9 -3.3 Error-prone, lesion bypass DNA polymerase V (UmuC) compare
Pf6N2E2_3199 -0.9 -3.5 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 5.-.-.-) compare
Pf6N2E2_3271 -0.9 -1.7 Phosphocarrier protein, nitrogen regulation associated compare
Pf6N2E2_642 -0.9 -2.1 Sigma factor regulator VreR (cytoplasmic membrane-localized) of trans-envelope signaling system compare
Pf6N2E2_3300 -0.9 -2.3 Predicted D-glucarate or D-galactorate regulator, GntR family compare
Pf6N2E2_6045 -0.9 -1.2 hypothetical protein compare
Pf6N2E2_5406 -0.9 -1.5 FIG00958224: hypothetical protein compare
Pf6N2E2_1870 -0.9 -1.4 hypothetical protein compare
Pf6N2E2_2390 -0.9 -2.9 FIG00959101: hypothetical protein compare
Pf6N2E2_919 -0.9 -1.7 FIG00954373: hypothetical protein compare
Pf6N2E2_3198 -0.9 -1.2 tRNA-guanine transglycosylase (EC 2.4.2.29) compare
Pf6N2E2_1287 -0.9 -3.1 Mobile element protein compare
Pf6N2E2_5679 -0.9 -2.6 hypothetical protein compare
Pf6N2E2_579 -0.9 -1.4 FIG00962753: hypothetical protein compare
Pf6N2E2_3696 -0.9 -0.8 hypothetical protein compare
Pf6N2E2_4416 -0.9 -2.0 Tyrosine recombinase XerC compare
Pf6N2E2_5739 -0.9 -0.9 Cobalamin biosynthesis protein BluB @ 5,6-dimethylbenzimidazole synthase, flavin destructase family compare


Specific Phenotypes

For 10 genes in this experiment

For carbon source 4-Hydroxybenzoic Acid in Pseudomonas fluorescens FW300-N2E2

For carbon source 4-Hydroxybenzoic Acid across organisms