Experiment set8H33 for Pseudomonas stutzeri RCH2

Compare to:

RCH2 defined media with Polymyxin B sulfate 0.00008 mg/ml

200 most important genes:

  gene name fitness t score description  
Psest_0152 -6.6 -8.0 Imidazoleglycerol-phosphate dehydratase compare
Psest_0153 -5.9 -18.3 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit compare
Psest_0952 -5.8 -5.2 Uncharacterized conserved protein compare
Psest_0155 -5.8 -10.0 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Psest_3226 -5.8 -1.5 Predicted membrane protein compare
Psest_0170 -5.7 -10.9 5,10-methenyltetrahydrofolate synthetase compare
Psest_2584 -5.6 -10.7 Phosphoribosylanthranilate isomerase compare
Psest_1473 -5.5 -10.2 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent compare
Psest_3866 -5.4 -25.0 threonine ammonia-lyase, biosynthetic, long form compare
Psest_0062 -5.4 -14.4 tryptophan synthase, alpha subunit compare
Psest_0687 -5.3 -13.3 ATP phosphoribosyltransferase, regulatory subunit compare
Psest_3944 -5.2 -2.9 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Psest_3650 -5.1 -19.2 anthranilate synthase component I, non-proteobacterial lineages compare
Psest_3648 -5.1 -11.7 anthranilate phosphoribosyltransferase compare
Psest_0279 -5.0 -8.9 methionine biosynthesis protein MetW compare
Psest_0954 -5.0 -10.2 Fe-S oxidoreductase compare
Psest_0953 -5.0 -13.0 iron-sulfur cluster-binding protein compare
Psest_0063 -4.9 -11.0 tryptophan synthase, beta subunit compare
Psest_3818 -4.9 -11.4 endoribonuclease L-PSP, putative compare
Psest_1772 -4.9 -5.8 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_3298 -4.8 -14.7 histidinol dehydrogenase compare
Psest_3303 -4.8 -9.1 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) compare
Psest_3299 -4.7 -14.9 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Psest_3647 -4.7 -10.0 Indole-3-glycerol phosphate synthase compare
Psest_1295 -4.6 -8.3 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_3864 -4.6 -18.6 Histidinol-phosphatase (EC:3.1.3.15) (from data) compare
Psest_3307 -4.6 -11.8 ABC-type transport system involved in resistance to organic solvents, ATPase component compare
Psest_3384 -4.6 -14.6 glutamate 5-kinase compare
Psest_0280 -4.5 -17.2 homoserine O-acetyltransferase compare
Psest_0508 -4.5 -11.6 gamma-glutamyl phosphate reductase compare
Psest_2578 -4.5 -17.1 O-succinylhomoserine sulfhydrylase compare
Psest_0411 -4.4 -14.2 biotin synthetase compare
Psest_2579 -4.3 -4.2 amidophosphoribosyltransferase compare
Psest_2591 -4.3 -4.7 3-isopropylmalate dehydratase, large subunit compare
Psest_2590 -4.2 -1.6 3-isopropylmalate dehydratase, small subunit compare
Psest_0325 -4.1 -19.5 Putative threonine efflux protein compare
Psest_3304 -4.1 -7.7 ABC-type transport system involved in resistance to organic solvents, auxiliary component compare
Psest_1814 -4.1 -24.3 pseudaminic acid biosynthesis N-acetyl transferase compare
Psest_2712 -4.1 -8.3 Surface lipoprotein compare
Psest_3721 -4.0 -10.9 Malic enzyme compare
Psest_0306 -3.9 -21.0 adenosylmethionine-8-amino-7-oxononanoate transaminase compare
Psest_2088 -3.9 -3.5 Uncharacterized protein conserved in bacteria compare
Psest_3305 -3.8 -11.2 ABC-type transport system involved in resistance to organic solvents, periplasmic component compare
Psest_1452 -3.8 -14.3 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase compare
Psest_3306 -3.8 -5.9 conserved hypothetical integral membrane protein compare
Psest_0412 -3.8 -14.2 8-amino-7-oxononanoate synthase compare
Psest_0445 -3.7 -21.6 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_0313 -3.6 -6.1 5,10-methylenetetrahydrofolate reductase, prokaryotic form compare
Psest_0326 -3.6 -15.2 Taurine catabolism dioxygenase TauD, TfdA family. compare
Psest_3998 -3.5 -7.1 glutamate--cysteine ligase compare
Psest_1724 -3.5 -4.9 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) compare
Psest_1509 -3.5 -11.2 quinolinate synthetase complex, A subunit compare
Psest_3297 -3.4 -14.3 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Psest_2589 -3.4 -9.9 3-isopropylmalate dehydrogenase compare
Psest_4298 -3.4 -1.3 Response regulator containing a CheY-like receiver domain and a GGDEF domain compare
Psest_1813 -3.4 -13.6 pseudaminic acid biosynthesis-associated protein PseG compare
Psest_2333 -3.2 -1.5 Protein of unknown function (DUF3359). compare
Psest_0718 -3.2 -6.2 nicotinate-nucleotide pyrophosphorylase compare
Psest_0413 -3.1 -7.3 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) compare
Psest_4085 -3.1 -18.2 Biotin carboxylase compare
Psest_0951 -3.1 -11.5 FAD/FMN-containing dehydrogenases compare
Psest_1037 -3.1 -3.7 acetolactate synthase, small subunit compare
Psest_2329 -3.0 -18.9 Transcriptional regulator compare
Psest_1474 -3.0 -2.1 phosphoribosylaminoimidazole synthetase compare
Psest_3943 -3.0 -5.1 Phosphoribosyl-AMP cyclohydrolase compare
Psest_0266 -2.9 -9.7 thiamine biosynthesis protein ThiS compare
Psest_0489 -2.9 -2.8 phosphoserine phosphatase SerB compare
Psest_4084 -2.9 -18.2 oxaloacetate decarboxylase alpha subunit compare
Psest_0414 -2.9 -6.6 biotin biosynthesis protein BioC compare
Psest_4086 -2.8 -14.1 Transcriptional regulator compare
Psest_0415 -2.8 -5.5 dethiobiotin synthase compare
Psest_3649 -2.8 -13.8 glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase compare
Psest_0955 -2.8 -7.3 D,L-lactate:H+ symporter (from data) compare
Psest_3810 -2.8 -2.7 orotate phosphoribosyltransferase compare
Psest_3322 -2.7 -19.4 TIGR02099 family protein compare
Psest_2232 -2.6 -15.1 UTP-glucose-1-phosphate uridylyltransferase compare
Psest_0267 -2.6 -14.7 Uncharacterized enzyme of thiazole biosynthesis compare
Psest_0515 -2.5 -4.2 rare lipoprotein A compare
Psest_3123 -2.5 -3.4 dihydroorotase, homodimeric type compare
Psest_3159 -2.5 -7.3 phosphoribosylformylglycinamidine synthase, single chain form compare
Psest_2104 -2.5 -3.7 IscR-regulated protein YhgI compare
Psest_2862 -2.5 -10.7 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 compare
Psest_1013 -2.4 -4.8 phosphoribosylamine--glycine ligase compare
Psest_2863 -2.4 -6.2 Transcriptional regulator compare
Psest_1115 -2.3 -3.6 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 compare
Psest_1496 -2.3 -1.5 Holliday junction DNA helicase, RuvA subunit compare
Psest_1163 -2.3 -4.2 diguanylate cyclase (GGDEF) domain compare
Psest_1824 -2.3 -3.8 Sugar transferases involved in lipopolysaccharide synthesis compare
Psest_0466 -2.2 -4.6 Lipopolysaccharide kinase (Kdo/WaaP) family. compare
Psest_0285 -2.2 -11.7 pilus retraction protein PilT compare
Psest_1812 -2.2 -12.9 pseudaminic acid CMP-transferase compare
Psest_2324 -2.0 -14.4 hypothetical protein compare
Psest_1704 -2.0 -1.9 Dehydrogenases (flavoproteins) compare
Psest_0477 -2.0 -13.3 thiamine biosynthesis protein ThiC compare
Psest_1809 -2.0 -12.2 Membrane protein involved in the export of O-antigen and teichoic acid compare
Psest_2325 -2.0 -11.5 alpha-L-glutamate ligase-related protein compare
Psest_0393 -2.0 -7.3 Methylase of chemotaxis methyl-accepting proteins compare
Psest_0281 -2.0 -7.8 Dynamin family. compare
Psest_1292 -1.9 -9.3 monothiol glutaredoxin, Grx4 family compare
Psest_0296 -1.9 -9.6 glutathione synthetase, prokaryotic compare
Psest_2090 -1.9 -3.9 Protein of unknown function (DUF2970). compare
Psest_0461 -1.9 -10.1 Glycosyltransferase involved in LPS biosynthesis compare
Psest_0536 -1.8 -4.1 thiamine-phosphate pyrophosphorylase compare
Psest_3720 -1.8 -14.1 penicillin-binding protein, 1A family compare
Psest_1679 -1.8 -1.8 ribonuclease, Rne/Rng family compare
Psest_3338 -1.8 -1.8 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain compare
Psest_2323 -1.7 -11.2 Uncharacterized protein conserved in archaea compare
Psest_3884 -1.7 -1.0 Signal transduction histidine kinase compare
Psest_1765 -1.7 -7.0 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_1947 -1.7 -1.1 dihydroorotate dehydrogenase, subfamily 2 compare
Psest_0993 -1.7 -8.9 Glucose-6-phosphate isomerase compare
Psest_1510 -1.6 -4.0 Putative Zn-dependent protease, contains TPR repeats compare
Psest_2946 -1.6 -4.2 septum site-determining protein MinD compare
Psest_2651 -1.6 -4.2 DNA topoisomerase I, bacterial compare
Psest_3988 -1.6 -7.8 phosphoenolpyruvate carboxykinase (ATP) compare
Psest_4345 -1.6 -9.3 Bacteriophytochrome (light-regulated signal transduction histidine kinase) compare
Psest_4363 -1.6 -7.9 ATPases involved in chromosome partitioning compare
Psest_0537 -1.6 -1.5 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase compare
Psest_3288 -1.6 -11.1 type IV-A pilus assembly ATPase PilB compare
Psest_0462 -1.6 -14.7 Lipid A core - O-antigen ligase and related enzymes compare
Psest_4297 -1.6 -8.8 PAS domain S-box compare
Psest_0297 -1.5 -3.8 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain compare
Psest_4097 -1.5 -10.2 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_2809 -1.5 -3.0 protein-L-isoaspartate(D-aspartate) O-methyltransferase compare
Psest_1031 -1.5 -7.4 Uncharacterized protein conserved in bacteria compare
Psest_2580 -1.5 -5.6 Uncharacterized membrane protein, required for colicin V production compare
Psest_1012 -1.5 -4.8 Signal transduction histidine kinase compare
Psest_0138 -1.5 -10.3 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain compare
Psest_2810 -1.5 -4.7 5'/3'-nucleotidase SurE compare
Psest_3419 -1.5 -6.5 Predicted transcriptional regulators compare
Psest_3883 -1.4 -5.9 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain compare
Psest_2327 -1.4 -7.4 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein compare
Psest_0442 -1.4 -5.2 ATPases of the AAA+ class compare
Psest_3301 -1.4 -2.6 Predicted transcriptional regulator, BolA superfamily compare
Psest_2719 -1.4 -2.1 acetylornithine and succinylornithine aminotransferases/succinylornithine transaminase family compare
Psest_2945 -1.4 -1.4 septum site-determining protein MinC compare
Psest_1277 -1.4 -9.5 2-isopropylmalate synthase, yeast type compare
Psest_0136 -1.4 -10.6 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family compare
Psest_0491 -1.4 -8.4 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_4191 -1.4 -2.4 Transcriptional regulator compare
Psest_3931 -1.4 -3.7 Signal transduction histidine kinase, nitrogen specific compare
Psest_2293 -1.4 -1.6 hypothetical protein compare
Psest_1511 -1.3 -3.3 Predicted redox protein, regulator of disulfide bond formation compare
Psest_4003 -1.3 -5.4 TIGR00153 family protein compare
Psest_1132 -1.3 -5.0 mutator mutT protein compare
Psest_1695 -1.3 -2.8 Tfp pilus assembly protein PilZ compare
Psest_0263 -1.3 -7.8 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_1819 -1.3 -11.2 Nucleoside-diphosphate-sugar epimerases compare
Psest_3809 -1.3 -4.4 hypothetical protein compare
Psest_0831 -1.3 -1.1 hypothetical protein compare
Psest_0120 -1.3 -4.7 hypothetical protein compare
Psest_1008 -1.3 -1.3 hypothetical protein compare
Psest_1663 -1.3 -2.2 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes compare
Psest_4396 -1.2 -6.7 Site-specific recombinases, DNA invertase Pin homologs compare
Psest_2648 -1.2 -1.5 hypothetical protein compare
Psest_3716 -1.2 -8.8 Tfp pilus assembly protein PilP compare
Psest_2872 -1.2 -1.7 protein RecA compare
Psest_2370 -1.2 -2.9 Protein of unknown function (DUF1652). compare
Psest_2680 -1.2 -6.2 transcriptional regulator, BolA protein family compare
Psest_3637 -1.2 -2.2 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases compare
Psest_3323 -1.2 -3.8 ribonuclease, Rne/Rng family compare
Psest_1260 -1.2 -5.9 type IV pilus biogenesis/stability protein PilW compare
Psest_2067 -1.1 -1.4 ABC-type oligopeptide transport system, periplasmic component compare
Psest_3717 -1.1 -6.3 Tfp pilus assembly protein PilO compare
Psest_3146 -1.1 -1.4 hypothetical protein compare
Psest_0182 -1.1 -3.7 glycine cleavage system H protein compare
Psest_3645 -1.1 -7.5 Predicted redox protein, regulator of disulfide bond formation compare
Psest_0225 -1.1 -1.5 Predicted permease, DMT superfamily compare
Psest_1818 -1.1 -7.3 GDP-mannose 4,6-dehydratase compare
Psest_1822 -1.1 -4.7 Glycosyltransferases involved in cell wall biogenesis compare
Psest_1810 -1.1 -8.5 UDP-N-acetylglucosamine 4,6-dehydratase compare
Psest_3719 -1.1 -7.6 type IV pilus assembly protein PilM compare
Psest_0440 -1.0 -2.9 hypothetical protein compare
Psest_0284 -1.0 -7.3 pyridoxal phosphate enzyme, YggS family compare
Psest_0248 -1.0 -6.4 Transcriptional regulator compare
Psest_0457 -1.0 -3.0 Lipopolysaccharide kinase (Kdo/WaaP) family. compare
Psest_0257 -1.0 -2.4 Predicted Zn-dependent peptidases compare
Psest_3375 -1.0 -5.7 prepilin-type N-terminal cleavage/methylation domain compare
Psest_2981 -1.0 -2.1 sodium pump decarboxylases, gamma subunit compare
Psest_1640 -1.0 -7.6 (p)ppGpp synthetase, RelA/SpoT family compare
Psest_1825 -1.0 -7.0 Predicted nucleoside-diphosphate sugar epimerases compare
Psest_3715 -1.0 -7.7 type IV pilus secretin (or competence protein) PilQ compare
Psest_2001 -1.0 -1.3 2-phosphoglycolate phosphatase, prokaryotic compare
Psest_3287 -1.0 -3.2 Type II secretory pathway, component PulF compare
Psest_3532 -1.0 -4.6 Peptidase propeptide and YPEB domain. compare
Psest_3535 -1.0 -2.5 hypothetical protein compare
Psest_0137 -0.9 -5.6 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family compare
Psest_1870 -0.9 -1.0 Transcriptional regulators compare
Psest_1486 -0.9 -2.7 hypothetical protein compare
Psest_2641 -0.9 -7.4 Conserved secreted protein compare
Psest_4070 -0.9 -5.2 PAS domain S-box compare
Psest_3718 -0.9 -4.3 Tfp pilus assembly protein PilN compare
Psest_3918 -0.9 -6.0 hypothetical protein compare
Psest_2458 -0.9 -1.7 MoxR-like ATPases compare
Psest_3092 -0.9 -1.0 ribonuclease III, bacterial compare
Psest_1054 -0.9 -4.4 Diaminopimelate decarboxylase compare
Psest_1815 -0.9 -6.7 pseudaminic acid synthase compare
Psest_4043 -0.9 -2.4 Site-specific recombinases, DNA invertase Pin homologs compare
Psest_0139 -0.9 -3.3 ABC-type histidine transport system, ATPase component compare
Psest_3474 -0.9 -2.3 Short-chain dehydrogenases of various substrate specificities compare


Specific Phenotypes

For 8 genes in this experiment

For stress Polymyxin B sulfate in Pseudomonas stutzeri RCH2

For stress Polymyxin B sulfate across organisms