Experiment set7H15 for Pseudomonas stutzeri RCH2

Compare to:

RCH2 defined media with Lomefloxacin hydrochloride 0.00004 mM

200 most important genes:

  gene name fitness t score description  
Psest_0279 -5.7 -5.5 methionine biosynthesis protein MetW compare
Psest_1473 -5.6 -7.7 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent compare
Psest_0153 -5.2 -12.5 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit compare
Psest_3648 -5.1 -4.9 anthranilate phosphoribosyltransferase compare
Psest_3650 -5.0 -9.6 anthranilate synthase component I, non-proteobacterial lineages compare
Psest_3226 -4.9 -2.4 Predicted membrane protein compare
Psest_2584 -4.9 -5.8 Phosphoribosylanthranilate isomerase compare
Psest_1496 -4.9 -3.4 Holliday junction DNA helicase, RuvA subunit compare
Psest_3866 -4.9 -16.9 threonine ammonia-lyase, biosynthetic, long form compare
Psest_0326 -4.8 -14.9 Taurine catabolism dioxygenase TauD, TfdA family. compare
Psest_3299 -4.8 -10.3 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Psest_2579 -4.6 -6.3 amidophosphoribosyltransferase compare
Psest_0152 -4.6 -8.2 Imidazoleglycerol-phosphate dehydratase compare
Psest_1295 -4.5 -6.9 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_3647 -4.5 -7.5 Indole-3-glycerol phosphate synthase compare
Psest_3864 -4.5 -13.3 Histidinol-phosphatase (EC:3.1.3.15) (from data) compare
Psest_0155 -4.5 -6.2 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Psest_3298 -4.3 -11.2 histidinol dehydrogenase compare
Psest_3649 -4.3 -8.2 glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase compare
Psest_2578 -4.2 -14.3 O-succinylhomoserine sulfhydrylase compare
Psest_3159 -4.2 -8.5 phosphoribosylformylglycinamidine synthase, single chain form compare
Psest_0954 -4.2 -12.0 Fe-S oxidoreductase compare
Psest_0062 -4.1 -9.9 tryptophan synthase, alpha subunit compare
Psest_0952 -4.1 -4.8 Uncharacterized conserved protein compare
Psest_0718 -4.1 -4.8 nicotinate-nucleotide pyrophosphorylase compare
Psest_0508 -4.1 -9.0 gamma-glutamyl phosphate reductase compare
Psest_2589 -4.0 -13.3 3-isopropylmalate dehydrogenase compare
Psest_0063 -3.9 -6.5 tryptophan synthase, beta subunit compare
Psest_1154 -3.9 -11.1 RND family efflux transporter, MFP subunit conserved
Psest_1037 -3.8 -4.5 acetolactate synthase, small subunit compare
Psest_1474 -3.8 -2.6 phosphoribosylaminoimidazole synthetase compare
Psest_0687 -3.8 -9.5 ATP phosphoribosyltransferase, regulatory subunit compare
Psest_0953 -3.8 -11.1 iron-sulfur cluster-binding protein compare
Psest_3384 -3.7 -10.7 glutamate 5-kinase compare
Psest_1013 -3.7 -3.6 phosphoribosylamine--glycine ligase compare
Psest_0280 -3.7 -15.0 homoserine O-acetyltransferase compare
Psest_0325 -3.6 -16.6 Putative threonine efflux protein compare
Psest_4084 -3.6 -16.8 oxaloacetate decarboxylase alpha subunit compare
Psest_0411 -3.4 -11.7 biotin synthetase compare
Psest_1452 -3.4 -9.3 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase compare
Psest_0489 -3.4 -3.2 phosphoserine phosphatase SerB compare
Psest_3810 -3.3 -3.2 orotate phosphoribosyltransferase compare
Psest_1509 -3.3 -11.2 quinolinate synthetase complex, A subunit compare
Psest_2591 -3.1 -4.7 3-isopropylmalate dehydratase, large subunit compare
Psest_3297 -3.1 -12.0 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Psest_1153 -3.0 -20.6 Cation/multidrug efflux pump conserved
Psest_2088 -3.0 -2.5 Uncharacterized protein conserved in bacteria compare
Psest_3721 -3.0 -9.0 Malic enzyme compare
Psest_3123 -2.9 -5.5 dihydroorotase, homodimeric type compare
Psest_4086 -2.9 -13.2 Transcriptional regulator compare
Psest_4085 -2.9 -13.8 Biotin carboxylase compare
Psest_0415 -2.9 -5.5 dethiobiotin synthase compare
Psest_2872 -2.9 -2.8 protein RecA compare
Psest_0414 -2.8 -5.9 biotin biosynthesis protein BioC compare
Psest_2590 -2.8 -2.3 3-isopropylmalate dehydratase, small subunit compare
Psest_0313 -2.8 -3.3 5,10-methylenetetrahydrofolate reductase, prokaryotic form compare
Psest_0476 -2.8 -9.5 type I secretion outer membrane protein, TolC family compare
Psest_2104 -2.7 -3.1 IscR-regulated protein YhgI compare
Psest_1947 -2.6 -1.8 dihydroorotate dehydrogenase, subfamily 2 compare
Psest_3818 -2.6 -7.2 endoribonuclease L-PSP, putative compare
Psest_0306 -2.5 -15.3 adenosylmethionine-8-amino-7-oxononanoate transaminase compare
Psest_2945 -2.5 -2.2 septum site-determining protein MinC compare
Psest_0442 -2.4 -7.7 ATPases of the AAA+ class compare
Psest_0212 -2.4 -1.6 exodeoxyribonuclease V, gamma subunit compare
Psest_0412 -2.3 -11.3 8-amino-7-oxononanoate synthase compare
Psest_2719 -2.3 -5.0 acetylornithine and succinylornithine aminotransferases/succinylornithine transaminase family compare
Psest_3767 -2.3 -4.7 tyrosine recombinase XerC compare
Psest_2329 -2.3 -14.5 Transcriptional regulator compare
Psest_0413 -2.2 -7.2 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) compare
Psest_1012 -2.1 -6.0 Signal transduction histidine kinase compare
Psest_3944 -2.1 -2.3 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Psest_3943 -2.0 -3.6 Phosphoribosyl-AMP cyclohydrolase compare
Psest_2646 -2.0 -2.6 SOS regulatory protein LexA compare
Psest_1686 -2.0 -6.1 fatty acid/phospholipid synthesis protein PlsX compare
Psest_1772 -2.0 -4.8 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_0520 -2.0 -1.3 hypothetical protein compare
Psest_1115 -1.9 -4.3 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 compare
Psest_0536 -1.9 -3.9 thiamine-phosphate pyrophosphorylase compare
Psest_3766 -1.8 -2.9 Uncharacterized protein conserved in bacteria compare
Psest_2988 -1.8 -7.0 aspartate kinase, monofunctional class compare
Psest_0266 -1.8 -7.3 thiamine biosynthesis protein ThiS compare
Psest_1031 -1.8 -7.7 Uncharacterized protein conserved in bacteria compare
Psest_0951 -1.7 -9.5 FAD/FMN-containing dehydrogenases compare
Psest_2855 -1.7 -2.2 Outer membrane protein and related peptidoglycan-associated (lipo)proteins compare
Psest_0267 -1.7 -8.7 Uncharacterized enzyme of thiazole biosynthesis compare
Psest_0170 -1.7 -5.4 5,10-methenyltetrahydrofolate synthetase compare
Psest_0498 -1.6 -2.1 ribosome small subunit-dependent GTPase A compare
Psest_2316 -1.6 -11.0 phosphoenolpyruvate synthase compare
Psest_1640 -1.6 -8.1 (p)ppGpp synthetase, RelA/SpoT family compare
Psest_4310 -1.6 -1.8 ABC-type Mn2+/Zn2+ transport systems, permease components compare
Psest_0955 -1.5 -4.1 D,L-lactate:H+ symporter (from data) compare
Psest_3039 -1.5 -2.2 periplasmic nitrate reductase, NapE protein compare
Psest_3998 -1.5 -5.1 glutamate--cysteine ligase compare
Psest_1804 -1.5 -2.7 Superfamily II DNA and RNA helicases compare
Psest_2864 -1.4 -4.7 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain compare
Psest_1642 -1.4 -3.8 Uncharacterized protein conserved in bacteria compare
Psest_3092 -1.4 -2.5 ribonuclease III, bacterial compare
Psest_2407 -1.4 -2.8 nitrite reductase [NAD(P)H], small subunit compare
Psest_0277 -1.4 -1.8 non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family compare
Psest_3803 -1.4 -1.5 DNA repair protein radc compare
Psest_1657 -1.3 -2.2 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit compare
Psest_1056 -1.3 -2.1 2-isopropylmalate synthase, bacterial type compare
Psest_1167 -1.3 -1.4 hypothetical protein compare
Psest_4243 -1.3 -1.9 type VI secretion lipoprotein, VC_A0113 family compare
Psest_1292 -1.3 -5.9 monothiol glutaredoxin, Grx4 family compare
Psest_2333 -1.3 -1.7 Protein of unknown function (DUF3359). compare
Psest_2324 -1.3 -10.3 hypothetical protein compare
Psest_2025 -1.3 -1.5 cold shock domain protein CspD compare
Psest_4098 -1.3 -2.3 Superfamily I DNA and RNA helicases compare
Psest_0327 -1.2 -4.5 Transcriptional regulator compare
Psest_2809 -1.2 -3.6 protein-L-isoaspartate(D-aspartate) O-methyltransferase compare
Psest_0259 -1.2 -2.0 cell division ATP-binding protein FtsE compare
Psest_1704 -1.2 -2.2 Dehydrogenases (flavoproteins) compare
Psest_3168 -1.2 -2.4 Molybdopterin converting factor, large subunit compare
Psest_2946 -1.2 -4.3 septum site-determining protein MinD compare
Psest_3178 -1.2 -3.2 formyltetrahydrofolate deformylase compare
Psest_3718 -1.2 -5.1 Tfp pilus assembly protein PilN compare
Psest_0334 -1.2 -2.9 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_3231 -1.1 -2.2 hypothetical protein compare
Psest_2632 -1.1 -4.2 ribosomal protein S12 methylthiotransferase RimO compare
Psest_2323 -1.1 -8.3 Uncharacterized protein conserved in archaea compare
Psest_0477 -1.1 -7.5 thiamine biosynthesis protein ThiC compare
Psest_0300 -1.1 -6.1 Methyl-accepting chemotaxis protein compare
Psest_1511 -1.1 -5.3 Predicted redox protein, regulator of disulfide bond formation compare
Psest_3301 -1.1 -3.2 Predicted transcriptional regulator, BolA superfamily compare
Psest_0120 -1.1 -3.5 hypothetical protein compare
Psest_3908 -1.1 -1.1 Cytochrome c553 compare
Psest_0999 -1.1 -2.6 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains compare
Psest_2637 -1.1 -1.6 putative methyltransferase, YaeB/AF_0241 family compare
Psest_1999 -1.0 -1.2 pseudouridine synthase compare
Psest_0191 -1.0 -1.1 PAS domain S-box compare
Psest_2325 -1.0 -6.1 alpha-L-glutamate ligase-related protein compare
Psest_1029 -1.0 -2.5 Regulator of competence-specific genes compare
Psest_1204 -1.0 -1.5 Transcriptional regulators compare
Psest_3177 -1.0 -1.8 hypothetical protein compare
Psest_1306 -1.0 -1.0 hypothetical protein compare
Psest_4103 -1.0 -1.2 AraC-type DNA-binding domain-containing proteins compare
Psest_2532 -0.9 -3.0 Uncharacterized protein conserved in bacteria compare
Psest_0208 -0.9 -4.3 Uncharacterized protein conserved in bacteria compare
Psest_2531 -0.9 -7.2 cytochrome c oxidase accessory protein FixG compare
Psest_0998 -0.9 -2.7 poly(A) polymerase compare
Psest_1814 -0.9 -7.0 pseudaminic acid biosynthesis N-acetyl transferase compare
Psest_0845 -0.9 -0.8 hypothetical protein compare
Psest_3890 -0.9 -1.0 Multisubunit Na+/H+ antiporter, MnhB subunit compare
Psest_3518 -0.9 -1.2 Transcriptional regulators compare
Psest_4363 -0.9 -4.8 ATPases involved in chromosome partitioning compare
Psest_2667 -0.9 -1.9 Uncharacterized protein involved in propionate catabolism compare
Psest_1388 -0.9 -0.9 Uncharacterized protein conserved in bacteria compare
Psest_2146 -0.9 -3.0 Transcriptional regulator compare
Psest_3832 -0.9 -1.5 hypothetical protein compare
Psest_2645 -0.9 -3.6 Transcriptional regulator compare
Psest_0218 -0.9 -2.0 Acyl-CoA hydrolase compare
Psest_0853 -0.9 -1.9 6-phosphogluconolactonase compare
Psest_1284 -0.8 -2.7 exodeoxyribonuclease VII, large subunit conserved
Psest_3288 -0.8 -6.4 type IV-A pilus assembly ATPase PilB compare
Psest_3828 -0.8 -0.5 zinc-binding alcohol dehydrogenase family protein compare
Psest_3185 -0.8 -0.9 MoxR-like ATPases compare
Psest_3711 -0.8 -6.3 Glutamate synthase domain 2 compare
Psest_3710 -0.8 -6.1 glutamate synthase small subunit family protein, proteobacterial compare
Psest_3101 -0.8 -6.5 L-aspartate oxidase compare
Psest_3464 -0.8 -4.4 Signal transduction histidine kinase compare
Psest_0779 -0.8 -1.9 tyrosine aminotransferase (EC 2.6.1.57) (from data) compare
Psest_3716 -0.8 -4.7 Tfp pilus assembly protein PilP compare
Psest_1434 -0.8 -2.5 NADPH:quinone reductase and related Zn-dependent oxidoreductases compare
Psest_0346 -0.8 -1.5 small component of pyruvate/D-alanine transporter (TIGR03647) (from data) compare
Psest_1527 -0.8 -5.7 Na+/proline symporter compare
Psest_4191 -0.8 -1.4 Transcriptional regulator compare
Psest_4044 -0.8 -3.3 type I site-specific deoxyribonuclease, HsdR family compare
Psest_1132 -0.8 -3.7 mutator mutT protein compare
Psest_0118 -0.8 -2.7 Predicted membrane protein compare
Psest_0357 -0.8 -1.9 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) compare
Psest_3809 -0.8 -3.0 hypothetical protein compare
Psest_1419 -0.8 -2.7 Transcriptional regulator compare
Psest_3910 -0.8 -1.1 Uncharacterized protein conserved in bacteria compare
Psest_2810 -0.8 -3.1 5'/3'-nucleotidase SurE compare
Psest_0193 -0.8 -0.7 conserved hypothetical protein compare
Psest_0186 -0.8 -2.4 Protein-disulfide isomerase compare
Psest_0393 -0.8 -3.4 Methylase of chemotaxis methyl-accepting proteins compare
Psest_1065 -0.8 -1.4 hypothetical protein compare
Psest_2668 -0.8 -2.0 Lactoylglutathione lyase and related lyases compare
Psest_3458 -0.8 -1.0 hypothetical protein compare
Psest_1260 -0.8 -4.4 type IV pilus biogenesis/stability protein PilW compare
Psest_3878 -0.8 -1.7 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain compare
Psest_3715 -0.8 -6.1 type IV pilus secretin (or competence protein) PilQ compare
Psest_3670 -0.8 -5.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) compare
Psest_4151 -0.8 -2.0 Flagellar hook capping protein compare
Psest_2018 -0.8 -2.2 Uncharacterized conserved protein compare
Psest_0537 -0.8 -1.0 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase compare
Psest_1884 -0.8 -1.5 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain compare
Psest_0445 -0.8 -5.9 PAS domain S-box/diguanylate cyclase (GGDEF) domain compare
Psest_3128 -0.8 -3.2 Protein-disulfide isomerase compare
Psest_0722 -0.8 -4.1 Predicted ATPase compare
Psest_2349 -0.8 -2.5 urea carboxylase-associated protein 1 compare
Psest_0154 -0.8 -2.5 Uncharacterized conserved protein compare
Psest_0164 -0.8 -0.8 Glutaredoxin, GrxC family compare
Psest_3932 -0.7 -2.8 nitrogen regulation protein NR(I) compare
Psest_3719 -0.7 -5.3 type IV pilus assembly protein PilM compare
Psest_0785 -0.7 -2.4 Thioredoxin reductase compare
Psest_1691 -0.7 -2.5 aminodeoxychorismate lyase compare
Psest_2450 -0.7 -3.1 hypothetical protein compare


Specific Phenotypes

For 3 genes in this experiment

For stress Lomefloxacin hydrochloride in Pseudomonas stutzeri RCH2

For stress Lomefloxacin hydrochloride across organisms