Experiment set6S768 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Hydrogen peroxide 2.5 mM; pH 6.5

200 most important genes:

  gene name fitness t score description  
Rv0949 -4.0 -1.1 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv1112 -3.1 -1.6 Probable GTP binding protein compare
Rv0929 -2.7 -3.5 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0674 -2.7 -1.1 Conserved hypothetical protein compare
Rv1908c -2.7 -2.7 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3810 -2.5 -3.1 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv0757 -2.5 -1.5 Possible two component system response transcriptional positive regulator PhoP compare
Rv1127c -2.4 -1.0 Probable pyruvate, phosphate dikinase PpdK compare
Rv0928 -2.3 -4.1 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0819 -2.2 -5.1 GCN5-related N-acetyltransferase, MshD compare
Rv3386 -2.1 -1.3 Possible transposase compare
Rv1836c -2.1 -3.3 Conserved protein compare
Rv3177 -2.0 -1.4 Possible peroxidase (non-haem peroxidase) compare
Rv2581c -1.9 -1.4 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0930 -1.9 -5.9 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0955 -1.8 -1.4 Probable conserved integral membrane protein compare
Rv2774c -1.8 -1.2 Hypothetical protein compare
Rv0820 -1.7 -4.0 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2691 -1.7 -9.9 TRK system potassium uptake protein CeoB compare
Rv3874 -1.7 -1.1 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv3085 -1.6 -1.0 Probable short-chain type dehydrogenase/reductase compare
Rv3658c -1.6 -1.1 Probable conserved transmembrane protein compare
Rv2694c -1.6 -5.0 Conserved protein compare
Rv2335 -1.6 -2.0 Probable serine acetyltransferase CysE (sat) compare
Rv2372c -1.6 -1.8 Conserved hypothetical protein compare
Rv1170 -1.6 -2.3 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv1332 -1.5 -1.4 Probable transcriptional regulatory protein compare
Rv3920c -1.5 -1.5 Conserved protein similar to jag protein compare
Rv2671 -1.4 -3.0 Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase) compare
Rv0135c -1.4 -2.6 Possible transcriptional regulatory protein compare
Rv3261 -1.4 -2.5 Probable F420 biosynthesis protein FbiA compare
Rv1925 -1.4 -6.7 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) compare
Rv1372 -1.4 -1.7 Conserved hypothetical protein compare
Rv0989c -1.3 -6.3 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv2989 -1.3 -0.7 Probable transcriptional regulatory protein compare
Rv1290A -1.3 -0.9 Hypothetical protein compare
Rv2001 -1.3 -0.8 Conserved hypothetical protein compare
Rv0615 -1.2 -0.8 Probable integral membrane protein compare
Rv0818 -1.2 -3.4 Transcriptional regulatory protein compare
Rv3131 -1.2 -1.2 Conserved protein compare
Rv3477 -1.2 -1.4 PE family protein PE31 compare
Rv0452 -1.2 -2.6 Possible transcriptional regulatory protein compare
Rv0078 -1.2 -1.9 Probable transcriptional regulatory protein compare
Rv1824 -1.2 -1.5 Conserved hypothetical membrane protein compare
Rv2706c -1.2 -1.0 Hypothetical protein compare
Rv2728c -1.2 -2.4 Conserved alanine rich protein compare
Rv2632c -1.2 -1.1 Conserved protein compare
Rv3139 -1.2 -3.3 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3102c -1.2 -2.7 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0201c -1.2 -1.4 Conserved protein compare
Rv0451c -1.1 -1.1 Probable conserved membrane protein MmpS4 compare
Rv2365c -1.1 -0.5 Conserved hypothetical protein compare
Rv1255c -1.1 -2.2 Probable transcriptional regulatory protein compare
Rv0758 -1.1 -2.3 Possible two component system response sensor kinase membrane associated PhoR compare
Rv2408 -1.1 -1.2 Possible PE family-related protein PE24 compare
Rv1207 -1.1 -4.0 Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2) compare
Rv1107c -1.1 -1.2 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv2374c -1.1 -1.9 Probable heat shock protein transcriptional repressor HrcA compare
Rv1420 -1.1 -1.6 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv3716c -1.0 -0.6 Conserved protein compare
Rv3389c -1.0 -1.1 Probable 3-hydroxyacyl-thioester dehydratase HtdY compare
Rv2680 -1.0 -1.3 Conserved protein compare
Rv0070c -1.0 -1.1 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) compare
Rv1359 -1.0 -2.8 Probable transcriptional regulatory protein compare
Rv1117 -1.0 -3.8 Conserved protein compare
Rv3413c -1.0 -0.7 Unknown alanine and proline rich protein compare
Rv3262 -1.0 -1.3 Probable F420 biosynthesis protein FbiB compare
Rv3249c -1.0 -1.4 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1851 -1.0 -0.7 Urease accessory protein UreF compare
Rv0049 -1.0 -1.8 Conserved hypothetical protein compare
Rv3494c -1.0 -5.6 Mce-family protein Mce4F compare
Rv0580c -1.0 -0.9 Conserved protein compare
Rv2476c -1.0 -2.9 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv2240c -1.0 -0.8 Unknown protein compare
Rv1516c -0.9 -1.7 Probable sugar transferase compare
Rv1693 -0.9 -0.9 Conserved hypothetical protein compare
Rv0959 -0.9 -0.7 Conserved hypothetical protein compare
Rv3496c -0.9 -5.6 Mce-family protein Mce4D compare
Rv2799 -0.9 -4.7 Probable membrane protein compare
Rv1324 -0.9 -1.0 Possible thioredoxin compare
Rv0353 -0.9 -2.5 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv3495c -0.9 -5.0 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv2793c -0.9 -0.8 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv0867c -0.9 -0.6 Possible resuscitation-promoting factor RpfA compare
Rv1131 -0.9 -2.0 Probable methylcitrate synthase PrpC compare
Rv0655 -0.9 -3.4 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv2047c -0.9 -3.4 Conserved hypothetical protein compare
Rv3499c -0.9 -4.9 Mce-family protein Mce4A compare
Rv3498c -0.9 -4.3 Mce-family protein Mce4B compare
Rv1821 -0.9 -2.6 Possible preprotein translocase ATPase SecA2 compare
Rv1260 -0.9 -1.4 Probable oxidoreductase compare
Rv0675 -0.8 -0.4 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2869c -0.8 -1.1 Membrane bound metalloprotease compare
Rv1173 -0.8 -1.7 Probable F420 biosynthesis protein FbiC compare
Rv3848 -0.8 -1.1 Probable conserved transmembrane protein compare
Rv3046c -0.8 -0.5 Conserved protein compare
Rv1234 -0.8 -1.4 Probable transmembrane protein compare
Rv2668 -0.8 -3.0 Possible exported alanine and valine rich protein compare
Rv3433c -0.8 -1.6 Conserved protein compare
Rv0157A -0.8 -1.3 Conserved protein compare
Rv3478 -0.8 -2.8 PE family protein PPE60 compare
Rv1148c -0.8 -0.9 Conserved hypothetical protein compare
Rv0243 -0.8 -3.9 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv2086 -0.8 -1.5 Conserved hypothetical protein compare
Rv2234 -0.8 -2.0 Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) compare
Rv1745c -0.8 -1.5 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv0539 -0.8 -1.7 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) compare
Rv2048c -0.8 -2.9 Polyketide synthase Pks12 compare
Rv3500c -0.8 -4.6 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv3650 -0.8 -0.4 PE family protein PE33 compare
Rv2348c -0.8 -0.6 Hypothetical protein compare
Rv0219 -0.7 -2.2 Probable conserved transmembrane protein compare
Rv0155 -0.7 -2.2 Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part; catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha) compare
Rv2222c -0.7 -1.8 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv1780 -0.7 -1.6 Conserved protein compare
Rv2018 -0.7 -2.3 Conserved protein compare
Rv1123c -0.7 -1.2 Possible peroxidase BpoB (non-haem peroxidase) compare
Rv0463 -0.7 -2.0 Probable conserved membrane protein compare
Rv0361 -0.7 -0.6 Probable conserved membrane protein compare
Rv0765c -0.7 -1.3 Probable oxidoreductase compare
Rv0499 -0.7 -1.2 Conserved hypothetical protein compare
Rv3200c -0.7 -1.8 Possible transmembrane cation transporter compare
Rv3893c -0.7 -1.2 PE family protein PE36 compare
Rv0991c -0.7 -0.6 Conserved serine rich protein compare
Rv2696c -0.7 -1.1 Conserved alanine and glycine and valine rich protein compare
Rv3492c -0.7 -1.5 Conserved hypothetical Mce associated protein compare
Rv2275 -0.7 -0.9 Conserved hypothetical protein compare
Rv3481c -0.7 -0.5 Probable integral membrane protein compare
Rv3659c -0.7 -1.7 Conserved hypothetical protein compare
Rv1946c -0.7 -1.1 Possible lipoprotein compare
Rv3922c -0.7 -1.6 Possible hemolysin compare
Rv3202c -0.7 -2.9 Possible ATP-dependent DNA helicase compare
Rv1566c -0.7 -1.2 Possible Inv protein compare
Rv0187 -0.7 -2.2 Probable O-methyltransferase compare
Rv2624c -0.7 -0.8 Universal stress protein family protein compare
Rv2206 -0.7 -1.4 Probable conserved transmembrane protein compare
Rv0204c -0.7 -1.3 Probable conserved transmembrane protein compare
Rv3497c -0.7 -3.6 Mce-family protein Mce4C compare
Rv0954 -0.6 -2.2 Probable conserved transmembrane protein compare
Rv3755c -0.6 -2.8 Conserved protein compare
Rv0968 -0.6 -2.1 Conserved protein compare
Rv0520 -0.6 -1.3 Possible methyltransferase/methylase (fragment) compare
Rv1272c -0.6 -3.7 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1620c -0.6 -1.7 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0680c -0.6 -1.1 Probable conserved transmembrane protein compare
Rv2046 -0.6 -0.9 Probable lipoprotein LppI compare
Rv2231c -0.6 -0.8 Possible aminotransferase CobC compare
Rv0934 -0.6 -2.1 Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1) compare
Rv1270c -0.6 -1.3 Possible lipoprotein LprA compare
Rv2039c -0.6 -1.1 Probable sugar-transport integral membrane protein ABC transporter compare
Rv3101c -0.6 -1.0 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv2850c -0.6 -0.5 Possible magnesium chelatase compare
Rv3045 -0.6 -1.2 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv1003 -0.6 -0.4 Conserved protein compare
Rv1766 -0.6 -1.2 Conserved protein compare
Rv2277c -0.6 -1.2 Possible glycerolphosphodiesterase compare
Rv2250c -0.6 -0.8 Possible transcriptional regulatory protein compare
Rv1072 -0.6 -0.9 Probable conserved transmembrane protein compare
Rv1013 -0.6 -2.9 Putative polyketide synthase Pks16 compare
Rv1683 -0.6 -2.1 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv1178 -0.6 -1.7 Probable aminotransferase compare
Rv3338 -0.6 -0.5 Conserved hypothetical protein compare
Rv1203c -0.6 -1.5 Hypothetical protein compare
Rv0019c -0.6 -2.5 Conserved protein with FHA domain, FhaB compare
Rv1678 -0.6 -1.7 Probable integral membrane protein compare
Rv0275c -0.6 -0.9 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv0649 -0.6 -1.0 Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT) compare
Rv1584c -0.6 -1.3 Possible PhiRv1 phage protein compare
Rv0241c -0.6 -1.5 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0018c -0.6 -0.9 Phosphoserine/threonine phosphatase PstP compare
Rv3649 -0.6 -2.0 Probable helicase compare
Rv2949c -0.6 -0.8 Chorismate pyruvate lyase compare
Rv0202c -0.6 -3.3 Probable conserved transmembrane transport protein MmpL11 compare
Rv1364c -0.6 -2.1 Possible sigma factor regulatory protein compare
Rv0642c -0.6 -0.6 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv0564c -0.6 -1.0 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) compare
Rv2259 -0.6 -1.6 S-nitrosomycothiol reductase MscR compare
Rv0319 -0.6 -1.7 Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase) compare
Rv1128c -0.6 -0.8 Conserved hypothetical protein compare
Rv2049c -0.6 -0.6 Conserved hypothetical protein compare
Rv2102 -0.6 -1.6 Conserved hypothetical protein compare
Rv0691c -0.6 -1.2 Probable transcriptional regulatory protein compare
Rv3891c -0.6 -1.7 Possible ESAT-6 like protein EsxD compare
Rv3237c -0.6 -2.2 Conserved protein compare
Rv1273c -0.6 -1.9 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3501c -0.6 -2.2 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv2812 -0.6 -1.5 Probable transposase compare
Rv1884c -0.6 -1.0 Probable resuscitation-promoting factor RpfC compare
Rv1513 -0.6 -0.8 Conserved protein compare
Rv3135 -0.6 -1.4 PPE family protein PPE50 compare
Rv2031c -0.6 -2.0 Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) compare
Rv0016c -0.6 -1.7 Probable penicillin-binding protein PbpA compare
Rv2344c -0.6 -2.2 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv1218c -0.6 -2.6 Probable tetronasin-transport ATP-binding protein ABC transporter compare
Rv1328 -0.5 -1.9 Probable glycogen phosphorylase GlgP compare
Rv0563 -0.5 -1.5 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0470c -0.5 -1.4 Mycolic acid synthase PcaA (cyclopropane synthase) compare
Rv3538 -0.5 -0.6 Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. compare
Rv0081 -0.5 -1.0 Probable transcriptional regulatory protein compare
Rv3493c -0.5 -1.3 Conserved hypothetical Mce associated alanine and valine rich protein compare


Specific Phenotypes

For 1 genes in this experiment

For stress Hydrogen peroxide in Mycobacterium tuberculosis H37Rv

For stress Hydrogen peroxide across organisms