Experiment set6S766 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv1798		-2.8	-1.1	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv0955		-2.8	-1.9	Probable conserved integral membrane protein
Rv2474c		-2.8	-1.4	Conserved hypothetical protein
Rv3204		-2.6	-1.1	Possible DNA-methyltransferase (modification methylase)
Rv2506		-2.4	-4.3	Probable transcriptional regulatory protein (probably TetR-family)
Rv2086		-2.3	-3.5	Conserved hypothetical protein
Rv0825c		-2.2	-2.7	Conserved protein
Rv0819		-2.0	-3.9	GCN5-related N-acetyltransferase, MshD
Rv0674		-2.0	-1.0	Conserved hypothetical protein
Rv0991c		-2.0	-1.2	Conserved serine rich protein
Rv2912c		-1.9	-4.3	Probable transcriptional regulatory protein (probably TetR-family)
Rv2733c		-1.8	-2.9	Conserved hypothetical alanine, arginine-rich protein
Rv1207		-1.8	-5.6	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)
Rv2691		-1.8	-6.3	TRK system potassium uptake protein CeoB
Rv0070c		-1.7	-1.7	Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2)
Rv3309c		-1.7	-1.7	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Rv2728c		-1.7	-3.6	Conserved alanine rich protein
Rv3193c		-1.6	-1.4	Probable conserved transmembrane protein
Rv0204c		-1.6	-5.2	Probable conserved transmembrane protein
Rv1620c		-1.6	-3.4	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv1459c		-1.6	-1.1	Possible conserved integral membrane protein
Rv1791		-1.6	-1.9	PE family protein PE19
Rv2694c		-1.5	-5.0	Conserved protein
Rv3819		-1.5	-0.7	Unknown protein
Rv2671		-1.5	-3.1	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv3920c		-1.5	-1.3	Conserved protein similar to jag protein
Rv2709		-1.5	-5.6	Probable conserved transmembrane protein
Rv0012		-1.5	-4.9	Probable conserved membrane protein
Rv0609		-1.5	-1.0	Possible toxin VapC28. Contains PIN domain.
Rv1102c		-1.5	-1.3	Toxin MazF3
Rv0353		-1.4	-4.6	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv0018c		-1.4	-5.3	Phosphoserine/threonine phosphatase PstP
Rv3433c		-1.4	-2.9	Conserved protein
Rv0989c		-1.4	-7.3	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1957		-1.3	-1.1	Hypothetical protein
Rv2240c		-1.3	-1.7	Unknown protein
Rv1640c		-1.3	-5.5	Lysyl-tRNA synthetase 2 LysX
Rv0084		-1.3	-1.4	Possible formate hydrogenlyase HycD (FHL)
Rv3569c		-1.3	-1.2	4,9-DHSA hydrolase
Rv2140c		-1.3	-1.4	Conserved protein TB18.6
Rv0617		-1.3	-2.2	Possible toxin VapC29. Contains PIN domain.
Rv3405c		-1.3	-1.2	Possible transcriptional regulatory protein
Rv2630		-1.3	-1.5	Hypothetical protein
Rv1192		-1.2	-2.2	Unknown protein
Rv2277c		-1.2	-1.9	Possible glycerolphosphodiesterase
Rv1127c		-1.2	-1.3	Probable pyruvate, phosphate dikinase PpdK
Rv0019c		-1.2	-3.7	Conserved protein with FHA domain, FhaB
Rv3200c		-1.2	-3.2	Possible transmembrane cation transporter
Rv2173		-1.2	-2.8	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv1010		-1.2	-1.1	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv3249c		-1.2	-1.6	Possible transcriptional regulatory protein (probably TetR-family)
Rv3513c		-1.2	-1.0	Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv3816c		-1.2	-0.8	Possible acyltransferase
Rv0927c		-1.1	-1.1	Probable short-chain type dehydrogenase/reductase
Rv1062		-1.1	-0.5	Conserved hypothetical protein
Rv2348c		-1.1	-0.9	Hypothetical protein
Rv1963c		-1.1	-1.3	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv1324		-1.1	-1.2	Possible thioredoxin
Rv0049		-1.1	-2.7	Conserved hypothetical protein
Rv3848		-1.1	-1.6	Probable conserved transmembrane protein
Rv1487		-1.1	-2.5	Conserved membrane protein
Rv1178		-1.1	-2.6	Probable aminotransferase
Rv2046		-1.1	-2.1	Probable lipoprotein LppI
Rv0680c		-1.1	-1.7	Probable conserved transmembrane protein
Rv2668		-1.1	-4.1	Possible exported alanine and valine rich protein
Rv2798c		-1.1	-2.0	Conserved hypothetical protein
Rv1148c		-1.1	-1.2	Conserved hypothetical protein
Rv3139		-1.1	-4.1	Probable acyl-CoA dehydrogenase FadE24
Rv2047c		-1.0	-4.2	Conserved hypothetical protein
Rv3850		-1.0	-1.1	Conserved protein
Rv0202c		-1.0	-5.5	Probable conserved transmembrane transport protein MmpL11
Rv3085		-1.0	-0.9	Probable short-chain type dehydrogenase/reductase
Rv3874		-1.0	-0.9	10 kDa culture filtrate antigen EsxB (LHP) (CFP10)
Rv1072		-1.0	-1.3	Probable conserved transmembrane protein
Rv1824		-1.0	-1.5	Conserved hypothetical membrane protein
Rv0050		-1.0	-2.0	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv2731		-1.0	-2.7	Conserved alanine and arginine rich protein
Rv2887		-1.0	-1.4	Probable transcriptional regulatory protein
Rv1173		-1.0	-1.9	Probable F420 biosynthesis protein FbiC
Rv0082		-1.0	-2.8	Probable oxidoreductase
Rv3162c		-1.0	-1.0	Possible integral membrane protein
Rv2500c		-1.0	-1.2	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv3335c		-1.0	-1.6	Probable conserved integral membrane protein
Rv1693		-1.0	-0.9	Conserved hypothetical protein
Rv2967c		-1.0	-4.9	Probable pyruvate carboxylase Pca (pyruvic carboxylase)
Rv3817		-1.0	-1.7	Possible phosphotransferase
Rv3033		-0.9	-0.4	Unknown protein
Rv1840c		-0.9	-1.6	PE-PGRS family protein PE_PGRS34
Rv1710		-0.9	-1.0	Possible segregation and condensation protein ScpB
Rv3262		-0.9	-1.3	Probable F420 biosynthesis protein FbiB
Rv3140		-0.9	-3.3	Probable acyl-CoA dehydrogenase FadE23
Rv1745c		-0.9	-1.4	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv1825		-0.9	-2.1	Conserved protein
Rv0470c		-0.9	-1.9	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv1259		-0.9	-0.6	Probable uracil DNA glycosylase, UdgB
Rv1829		-0.9	-4.3	Conserved protein
Rv2657c		-0.9	-0.8	Probable PhiRv2 prophage protein
Rv0383c		-0.9	-0.7	Possible conserved secreted protein
Rv3650		-0.9	-0.5	PE family protein PE33
Rv1851		-0.9	-0.9	Urease accessory protein UreF
Rv0523c		-0.9	-1.3	Conserved protein
Rv1209		-0.9	-1.8	Conserved protein
Rv1468c		-0.9	-1.1	PE-PGRS family protein PE_PGRS29
Rv0766c		-0.9	-1.4	Probable cytochrome P450 123 Cyp123
Rv1836c		-0.8	-1.8	Conserved protein
Rv2569c		-0.8	-2.6	Conserved hypothetical protein
Rv1260		-0.8	-2.4	Probable oxidoreductase
Rv0219		-0.8	-1.6	Probable conserved transmembrane protein
Rv2553c		-0.8	-0.5	Probable conserved membrane protein
Rv2502c		-0.8	-5.0	Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1
Rv1100		-0.8	-2.8	Conserved protein
Rv3600c		-0.8	-2.4	Conserved protein
Rv3368c		-0.8	-3.0	Possible oxidoreductase
Rv1528c		-0.8	-2.5	Probable conserved polyketide synthase associated protein PapA4
Rv2476c		-0.8	-2.4	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv2237A		-0.8	-0.8	Conserved protein
Rv3905c		-0.8	-2.0	Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13)
Rv1004c		-0.8	-1.5	Probable membrane protein
Rv3631		-0.8	-0.8	Possible transferase (possibly glycosyltransferase)
Rv3922c		-0.8	-1.9	Possible hemolysin
Rv0121c		-0.8	-1.9	Conserved protein
Rv0942		-0.8	-1.3	Hypothetical protein
Rv3036c		-0.8	-3.9	Probable conserved secreted protein TB22.2
Rv0757		-0.8	-0.7	Possible two component system response transcriptional positive regulator PhoP
Rv3321c		-0.8	-1.5	Possible antitoxin VapB44
Rv0392c		-0.8	-0.7	Probable membrane NADH dehydrogenase NdhA
Rv0016c		-0.8	-3.2	Probable penicillin-binding protein PbpA
Rv1531		-0.8	-1.0	Conserved protein
Rv1955		-0.8	-2.3	Possible toxin HigB
Rv3050c		-0.8	-2.7	Probable transcriptional regulatory protein (probably AsnC-family)
Rv3412		-0.8	-2.7	Conserved hypothetical protein
Rv2867c		-0.8	-3.0	GCN5-related N-acetyltransferase
Rv1821		-0.8	-2.1	Possible preprotein translocase ATPase SecA2
Rv2707		-0.8	-5.7	Probable conserved transmembrane alanine and leucine rich protein
Rv0135c		-0.8	-2.7	Possible transcriptional regulatory protein
Rv1701		-0.8	-2.4	Probable integrase/recombinase
Rv3498c		-0.8	-4.8	Mce-family protein Mce4B
Rv0328		-0.8	-0.9	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv0622		-0.8	-0.9	Possible membrane protein
Rv0190		-0.8	-3.0	Conserved protein
Rv1908c		-0.7	-1.5	Catalase-peroxidase-peroxynitritase T KatG
Rv0092		-0.7	-3.0	Cation transporter P-type ATPase a CtpA
Rv3182		-0.7	-0.5	Conserved hypothetical protein
Rv0764c		-0.7	-1.7	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)
Rv1792		-0.7	-0.9	ESAT-6 like protein EsxM
Rv1621c		-0.7	-1.5	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv1074c		-0.7	-3.9	Probable beta-ketoacyl CoA thiolase FadA3
Rv2230c		-0.7	-0.8	Conserved protein
Rv0437c		-0.7	-0.6	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv2581c		-0.7	-0.9	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv2369c		-0.7	-0.6	Hypothetical protein
Rv0598c		-0.7	-1.6	Possible toxin VapC27. Contains PIN domain.
Rv2501c		-0.7	-2.1	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Rv0178		-0.7	-2.4	Probable conserved Mce associated membrane protein
Rv3157		-0.7	-2.2	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Rv1474c		-0.7	-2.2	Probable transcriptional regulatory protein
Rv3586		-0.7	-2.5	Conserved hypothetical protein
Rv3311		-0.7	-2.0	Conserved protein
Rv0760c		-0.7	-1.4	Conserved protein
Rv1678		-0.7	-2.1	Probable integral membrane protein
Rv2007c		-0.7	-1.1	Ferredoxin FdxA
Rv1019		-0.7	-2.6	Probable transcriptional regulatory protein (probably TetR-family)
Rv1013		-0.7	-3.4	Putative polyketide synthase Pks16
Rv2686c		-0.7	-1.0	Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter
Rv3007c		-0.7	-1.7	Possible oxidoreductase
Rv0378		-0.7	-1.1	Conserved hypothetical glycine rich protein
Rv0436c		-0.7	-0.9	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv2796c		-0.7	-1.9	Probable conserved lipoprotein LppV
Rv3220c		-0.7	-1.6	Probable two component sensor kinase
Rv1909c		-0.7	-1.8	Ferric uptake regulation protein FurA (fur)
Rv3561		-0.7	-2.8	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Rv3395c		-0.7	-1.6	Conserved hypothetical protein
Rv2475c		-0.7	-2.2	Conserved protein
Rv3855		-0.7	-2.3	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv2589		-0.7	-4.1	4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at)
Rv0678		-0.7	-3.6	Conserved protein
Rv0020c		-0.7	-3.0	Conserved protein with FHA domain, FhaA
Rv3301c		-0.7	-2.3	Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1
Rv0390		-0.7	-1.5	Conserved protein
Rv2049c		-0.7	-0.7	Conserved hypothetical protein
Rv0653c		-0.7	-2.0	Possible transcriptional regulatory protein (probably TetR-family)
Rv3150		-0.7	-3.1	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)
Rv2044c		-0.7	-0.5	Conserved hypothetical protein
Rv1565c		-0.6	-2.7	Conserved hypothetical membrane protein
Rv2732c		-0.6	-1.4	Probable conserved transmembrane protein
Rv0464c		-0.6	-2.7	Conserved protein
Rv3208A		-0.6	-1.0	Conserved protein TB9.4
Rv0508		-0.6	-1.5	Conserved hypothetical protein
Rv0734		-0.6	-1.8	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv2206		-0.6	-1.4	Probable conserved transmembrane protein
Rv2316		-0.6	-2.1	Probable sugar-transport integral membrane protein ABC transporter UspA
Rv2048c		-0.6	-2.6	Polyketide synthase Pks12
Rv1773c		-0.6	-1.2	Probable transcriptional regulatory protein
Rv3702c		-0.6	-1.9	Conserved hypothetical protein
Rv2344c		-0.6	-3.3	Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Rv2836c		-0.6	-1.0	Possible DNA-damage-inducible protein F DinF
Rv0560c		-0.6	-1.8	Possible benzoquinone methyltransferase (methylase)
Rv1973		-0.6	-1.0	Possible conserved Mce associated membrane protein
Rv0208c		-0.6	-2.6	Hypothetical methlytransferase (methylase)
Rv0918		-0.6	-1.2	Conserved protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Sodium nitrite across organisms