Experiment set6S760 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0247c		-4.1	-1.2	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv2801c		-3.5	-1.4	Toxin MazF9
Rv0955		-2.7	-2.0	Probable conserved integral membrane protein
Rv3419c		-2.7	-2.5	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv3220c		-2.2	-3.9	Probable two component sensor kinase
Rv3481c		-2.2	-1.6	Probable integral membrane protein
Rv0437c		-2.1	-1.4	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3046c		-2.1	-1.0	Conserved protein
Rv2281		-2.0	-3.8	Putative phosphate-transport permease PitB
Rv1010		-1.9	-1.4	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv1620c		-1.8	-3.5	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv2581c		-1.8	-1.4	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv1693		-1.8	-1.8	Conserved hypothetical protein
Rv3650		-1.7	-0.8	PE family protein PE33
Rv2879c		-1.7	-0.7	Conserved hypothetical protein
Rv1640c		-1.7	-7.8	Lysyl-tRNA synthetase 2 LysX
Rv3559c		-1.6	-1.1	Probable oxidoreductase
Rv2709		-1.5	-5.1	Probable conserved transmembrane protein
Rv2551c		-1.5	-1.5	Conserved hypothetical protein
Rv3287c		-1.5	-0.6	Anti-sigma factor RsbW (sigma negative effector)
Rv2989		-1.4	-0.8	Probable transcriptional regulatory protein
Rv0928		-1.4	-3.8	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv1116A		-1.3	-1.3	Conserved hypothetical protein (fragment)
Rv0857		-1.3	-1.6	Conserved hypothetical protein
Rv0549c		-1.3	-1.1	Possible toxin VapC3
Rv1159		-1.3	-2.0	Mannosyltransferase PimE
Rv1072		-1.2	-0.8	Probable conserved transmembrane protein
Rv2099c		-1.2	-2.1	PE family protein PE21
Rv2335		-1.2	-1.7	Probable serine acetyltransferase CysE (sat)
Rv2500c		-1.2	-1.3	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv1284		-1.2	-0.6	Beta-carbonic anhydrase
Rv2046		-1.2	-2.0	Probable lipoprotein LppI
Rv2680		-1.2	-1.1	Conserved protein
Rv2055c		-1.1	-1.3	30S ribosomal protein S18 RpsR2
Rv1791		-1.1	-0.9	PE family protein PE19
Rv1003		-1.1	-0.7	Conserved protein
Rv3922c		-1.1	-2.0	Possible hemolysin
Rv2154c		-1.1	-1.6	FtsW-like protein FtsW
Rv1798		-1.0	-0.7	ESX conserved component EccA5. ESX-5 type VII secretion system protein.
Rv3364c		-1.0	-2.1	Conserved protein
Rv2975c		-1.0	-0.8	Conserved hypothetical protein
Rv1209		-1.0	-3.7	Conserved protein
Rv0520		-1.0	-2.9	Possible methyltransferase/methylase (fragment)
Rv3249c		-1.0	-1.4	Possible transcriptional regulatory protein (probably TetR-family)
Rv1025		-1.0	-0.5	Conserved protein
Rv1825		-1.0	-3.5	Conserved protein
Rv0494		-1.0	-1.9	Probable transcriptional regulatory protein (probably GntR-family)
Rv0820		-1.0	-3.4	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv0497		-1.0	-1.1	Probable conserved transmembrane protein
Rv1303		-1.0	-0.6	Conserved hypothetical transmembrane protein
Rv1621c		-1.0	-2.0	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv1459c		-1.0	-0.8	Possible conserved integral membrane protein
Rv0959		-0.9	-0.7	Conserved hypothetical protein
Rv3484		-0.9	-4.7	Possible conserved protein CpsA
Rv3687c		-0.9	-0.7	Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B)
Rv3311		-0.9	-2.9	Conserved protein
Rv3538		-0.9	-0.9	Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase.
Rv0734		-0.9	-1.3	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv2374c		-0.9	-1.5	Probable heat shock protein transcriptional repressor HrcA
Rv3200c		-0.9	-2.4	Possible transmembrane cation transporter
Rv0629c		-0.9	-1.8	Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide)
Rv0757		-0.9	-0.8	Possible two component system response transcriptional positive regulator PhoP
Rv0170		-0.9	-2.0	Mce-family protein Mce1B
Rv2372c		-0.9	-1.2	Conserved hypothetical protein
Rv3433c		-0.9	-1.5	Conserved protein
Rv1323		-0.9	-2.5	Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase)
Rv0019c		-0.9	-3.1	Conserved protein with FHA domain, FhaB
Rv2208		-0.9	-1.4	Probable cobalamin 5'-phosphate synthase CobS
Rv2275		-0.9	-1.1	Conserved hypothetical protein
Rv1331		-0.9	-1.7	Conserved hypothetical protein
Rv0208c		-0.8	-3.6	Hypothetical methlytransferase (methylase)
Rv1792		-0.8	-0.9	ESAT-6 like protein EsxM
Rv2793c		-0.8	-0.7	Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase)
Rv1422		-0.8	-0.8	Conserved hypothetical protein
Rv1335		-0.8	-3.7	Sulfur carrier protein CysO
Rv0353		-0.8	-2.5	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv0321		-0.8	-2.9	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv0050		-0.8	-1.7	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3389c		-0.8	-1.6	Probable 3-hydroxyacyl-thioester dehydratase HtdY
Rv2274c		-0.8	-1.4	Possible toxin MazF8
Rv1420		-0.8	-1.6	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv3546		-0.8	-1.7	Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase)
Rv2271		-0.8	-1.9	Conserved hypothetical protein
Rv0332		-0.8	-2.3	Conserved protein
Rv0242c		-0.8	-2.1	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv0088		-0.8	-0.7	Possible polyketide cyclase/dehydrase
Rv1055		-0.8	-0.6	Possible integrase (fragment)
Rv2384		-0.8	-1.3	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Rv1626		-0.8	-2.6	Probable two-component system transcriptional regulator
Rv1127c		-0.8	-1.0	Probable pyruvate, phosphate dikinase PpdK
Rv2821c		-0.8	-1.3	Conserved hypothetical protein
Rv2696c		-0.7	-1.0	Conserved alanine and glycine and valine rich protein
Rv2774c		-0.7	-0.7	Hypothetical protein
Rv0989c		-0.7	-3.6	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv2569c		-0.7	-2.9	Conserved hypothetical protein
Rv0621		-0.7	-1.3	Possible membrane protein
Rv3007c		-0.7	-2.2	Possible oxidoreductase
Rv3208A		-0.7	-1.1	Conserved protein TB9.4
Rv2444c		-0.7	-1.8	Possible ribonuclease E Rne
Rv0900		-0.7	-1.2	Possible membrane protein
Rv2237A		-0.7	-0.7	Conserved protein
Rv3726		-0.7	-0.8	Possible dehydrogenase
Rv3855		-0.7	-2.9	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv2171		-0.7	-1.3	Probable conserved lipoprotein LppM
Rv0219		-0.7	-2.0	Probable conserved transmembrane protein
Rv0802c		-0.7	-2.3	Possible succinyltransferase in the GCN5-related N-acetyltransferase family
Rv0003		-0.7	-1.4	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv3813c		-0.7	-1.6	Conserved protein
Rv3314c		-0.7	-0.8	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv2038c		-0.7	-2.5	Probable sugar-transport ATP-binding protein ABC transporter
Rv0452		-0.7	-1.2	Possible transcriptional regulatory protein
Rv2694c		-0.7	-2.2	Conserved protein
Rv3073c		-0.7	-0.9	Conserved hypothetical protein
Rv2088		-0.7	-0.8	Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
Rv2985		-0.7	-1.2	Possible hydrolase MutT1
Rv2026c		-0.7	-0.6	Universal stress protein family protein
Rv0642c		-0.7	-0.9	Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase)
Rv1180		-0.7	-1.5	Probable polyketide beta-ketoacyl synthase Pks3
Rv1496		-0.7	-1.5	Possible transport system kinase
Rv0690c		-0.7	-1.3	Conserved hypothetical protein
Rv2691		-0.7	-2.7	TRK system potassium uptake protein CeoB
Rv1013		-0.7	-3.2	Putative polyketide synthase Pks16
Rv0018c		-0.7	-1.2	Phosphoserine/threonine phosphatase PstP
Rv1528c		-0.6	-2.4	Probable conserved polyketide synthase associated protein PapA4
Rv1972		-0.6	-2.5	Probable conserved Mce associated membrane protein
Rv3050c		-0.6	-2.2	Probable transcriptional regulatory protein (probably AsnC-family)
Rv3196A		-0.6	-1.8	Unknown protein
Rv1944c		-0.6	-2.3	Conserved protein
Rv0766c		-0.6	-1.1	Probable cytochrome P450 123 Cyp123
Rv1948c		-0.6	-1.8	Hypothetical protein
Rv3416		-0.6	-1.4	Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.
Rv1019		-0.6	-3.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv0204c		-0.6	-1.6	Probable conserved transmembrane protein
Rv3338		-0.6	-0.7	Conserved hypothetical protein
Rv1507c		-0.6	-1.7	Conserved protein
Rv2613c		-0.6	-1.5	Conserved protein
Rv0764c		-0.6	-1.7	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)
Rv0929		-0.6	-0.8	Phosphate-transport integral membrane ABC transporter PstC2
Rv2912c		-0.6	-1.5	Probable transcriptional regulatory protein (probably TetR-family)
Rv2706c		-0.6	-0.6	Hypothetical protein
Rv2736c		-0.6	-0.8	Regulatory protein RecX
Rv0328		-0.6	-1.0	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2061c		-0.6	-1.6	Conserved protein
Rv3905c		-0.6	-1.9	Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13)
Rv1100		-0.6	-1.6	Conserved protein
Rv0752c		-0.6	-1.7	Probable acyl-CoA dehydrogenase FadE9
Rv1108c		-0.6	-1.3	Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit)
Rv2798c		-0.6	-1.0	Conserved hypothetical protein
Rv1102c		-0.6	-0.8	Toxin MazF3
Rv2668		-0.6	-2.2	Possible exported alanine and valine rich protein
Rv0049		-0.6	-1.5	Conserved hypothetical protein
Rv0655		-0.6	-2.0	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv3760		-0.6	-0.7	Possible conserved membrane protein
Rv2644c		-0.6	-1.6	Hypothetical protein
Rv0199		-0.6	-1.5	Probable conserved membrane protein
Rv0679c		-0.6	-1.4	Conserved threonine rich protein
Rv3036c		-0.6	-3.6	Probable conserved secreted protein TB22.2
Rv0550c		-0.6	-0.8	Possible antitoxin VapB3
Rv3284		-0.6	-1.3	Conserved hypothetical protein
Rv0913c		-0.6	-2.1	Possible dioxygenase
Rv1107c		-0.6	-0.8	Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit)
Rv2624c		-0.6	-0.7	Universal stress protein family protein
Rv3069		-0.6	-1.1	Probable conserved transmembrane protein
Rv2970A		-0.6	-1.6	Conserved hypothetical protein
Rv3655c		-0.6	-1.0	Conserved hypothetical protein
Rv3828c		-0.5	-1.3	Possible resolvase
Rv2799		-0.5	-2.8	Probable membrane protein
Rv2047c		-0.5	-2.6	Conserved hypothetical protein
Rv3291c		-0.5	-1.9	Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family)
Rv2626c		-0.5	-2.2	Hypoxic response protein 1 Hrp1
Rv1908c		-0.5	-1.3	Catalase-peroxidase-peroxynitritase T KatG
Rv0539		-0.5	-1.4	Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase)
Rv2065		-0.5	-0.9	Precorrin-8X methylmutase CobH (aka precorrin isomerase)
Rv2031c		-0.5	-1.6	Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3)
Rv3143		-0.5	-0.4	Probable response regulator
Rv3631		-0.5	-0.6	Possible transferase (possibly glycosyltransferase)
Rv1421		-0.5	-1.2	Conserved protein
Rv1355c		-0.5	-1.9	Possible molybdopterin biosynthesis protein MoeY
Rv0992c		-0.5	-3.4	Conserved hypothetical protein
Rv2893		-0.5	-1.8	Possible oxidoreductase
Rv0173		-0.5	-2.1	Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E)
Rv0926c		-0.5	-1.7	Conserved hypothetical protein
Rv2234		-0.5	-1.9	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Rv3747		-0.5	-1.5	Conserved protein
Rv1564c		-0.5	-2.2	Probable maltooligosyltrehalose synthase TreX
Rv3836		-0.5	-1.6	Conserved hypothetical protein
Rv2718c		-0.5	-2.8	Probable transcriptional regulatory protein NrdR
Rv1665		-0.5	-1.4	Chalcone synthase Pks11
Rv2831		-0.5	-1.2	Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv1234		-0.5	-1.1	Probable transmembrane protein
Rv3556c		-0.5	-1.3	Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase)
Rv0470c		-0.5	-0.9	Mycolic acid synthase PcaA (cyclopropane synthase)
Rv2297		-0.5	-1.2	Unknown protein
Rv0531		-0.5	-0.5	Possible conserved membrane protein
Rv0968		-0.5	-2.2	Conserved protein
Rv2265		-0.5	-1.6	Possible conserved integral membrane protein
Rv1124		-0.5	-1.1	Probable epoxide hydrolase EphC (epoxide hydratase)
Rv0202c		-0.5	-3.0	Probable conserved transmembrane transport protein MmpL11
Rv3850		-0.5	-0.7	Conserved protein
Rv3569c		-0.5	-0.8	4,9-DHSA hydrolase

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in pH experiments