Experiment set6S749 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Sodium hypochlorite 0.4 vol%

200 most important genes:

  gene name fitness t score description  
Rv2976c -2.6 -1.1 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv0929 -2.5 -2.6 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0955 -2.3 -1.8 Probable conserved integral membrane protein compare
Rv1621c -2.3 -3.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv3687c -2.2 -1.3 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv0928 -2.0 -4.6 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3650 -1.9 -1.2 PE family protein PE33 compare
Rv2774c -1.8 -1.0 Hypothetical protein compare
Rv1072 -1.8 -1.5 Probable conserved transmembrane protein compare
Rv2680 -1.8 -2.3 Conserved protein compare
Rv2272 -1.8 -0.5 Probable conserved transmembrane protein compare
Rv1930c -1.7 -1.0 Conserved hypothetical protein compare
Rv1590 -1.7 -3.4 Conserved hypothetical protein compare
Rv3716c -1.6 -1.1 Conserved protein compare
Rv1013 -1.6 -8.3 Putative polyketide synthase Pks16 compare
Rv3222c -1.6 -1.6 Conserved hypothetical protein compare
Rv1421 -1.6 -3.2 Conserved protein compare
Rv1459c -1.6 -1.4 Possible conserved integral membrane protein compare
Rv3046c -1.6 -1.0 Conserved protein compare
Rv1010 -1.5 -1.4 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0819 -1.5 -3.8 GCN5-related N-acetyltransferase, MshD compare
Rv0820 -1.5 -4.1 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0930 -1.5 -4.6 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv1411c -1.4 -2.4 Conserved lipoprotein LprG compare
Rv3610c -1.4 -3.5 Membrane-bound protease FtsH (cell division protein) compare
Rv1897c -1.4 -1.9 Conserved hypothetical protein compare
Rv1890c -1.4 -1.1 Hypothetical protein compare
Rv3193c -1.4 -1.8 Probable conserved transmembrane protein compare
Rv1620c -1.4 -3.1 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0949 -1.4 -0.7 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3200c -1.4 -3.2 Possible transmembrane cation transporter compare
Rv3338 -1.4 -1.1 Conserved hypothetical protein compare
Rv0018c -1.3 -3.9 Phosphoserine/threonine phosphatase PstP compare
Rv1159 -1.3 -2.4 Mannosyltransferase PimE compare
Rv1589 -1.2 -6.5 Probable biotin synthetase BioB compare
Rv1570 -1.2 -2.0 Dethiobiotin synthetase BioD compare
Rv2762c -1.2 -1.2 Conserved hypothetical protein compare
Rv2003c -1.2 -1.1 Conserved hypothetical protein compare
Rv2694c -1.2 -4.3 Conserved protein compare
Rv2709 -1.2 -4.6 Probable conserved transmembrane protein compare
Rv3614c -1.2 -2.6 ESX-1 secretion-associated protein EspD compare
Rv1568 -1.1 -4.9 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA compare
Rv0933 -1.1 -0.8 Phosphate-transport ATP-binding protein ABC transporter PstB compare
Rv2222c -1.1 -2.3 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv0242c -1.1 -3.6 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2335 -1.1 -1.4 Probable serine acetyltransferase CysE (sat) compare
Rv3311 -1.1 -3.8 Conserved protein compare
Rv1506c -1.1 -1.3 Hypothetical protein compare
Rv2231c -1.1 -1.4 Possible aminotransferase CobC compare
Rv0093c -1.1 -0.8 Probable conserved membrane protein compare
Rv1259 -1.1 -0.7 Probable uracil DNA glycosylase, UdgB compare
Rv1531 -1.1 -1.7 Conserved protein compare
Rv0247c -1.1 -0.5 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv2674 -1.1 -4.2 Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase) compare
Rv2270 -1.1 -1.4 Probable lipoprotein LppN compare
Rv3816c -1.0 -0.6 Possible acyltransferase compare
Rv0504c -1.0 -1.3 Conserved protein compare
Rv0017c -1.0 -3.0 Probable cell division protein RodA compare
Rv1284 -1.0 -0.6 Beta-carbonic anhydrase compare
Rv0141c -1.0 -2.6 Unknown protein compare
Rv3855 -1.0 -3.0 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv1569 -1.0 -3.5 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv2365c -1.0 -0.6 Conserved hypothetical protein compare
Rv0016c -1.0 -2.9 Probable penicillin-binding protein PbpA compare
Rv2571c -1.0 -2.3 Probable transmembrane alanine and valine and leucine rich protein compare
Rv1255c -1.0 -2.4 Probable transcriptional regulatory protein compare
Rv0361 -1.0 -0.7 Probable conserved membrane protein compare
Rv3493c -1.0 -2.3 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv2687c -1.0 -2.4 Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter compare
Rv3270 -1.0 -1.4 Probable metal cation-transporting P-type ATPase C CtpC compare
Rv1851 -1.0 -1.2 Urease accessory protein UreF compare
Rv1710 -1.0 -1.2 Possible segregation and condensation protein ScpB compare
Rv2173 -1.0 -2.7 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv0563 -1.0 -2.1 Probable protease transmembrane protein heat shock protein HtpX compare
Rv3131 -0.9 -1.0 Conserved protein compare
Rv2500c -0.9 -0.9 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv3893c -0.9 -1.0 PE family protein PE36 compare
Rv0665 -0.9 -1.2 Possible toxin VapC8 compare
Rv3702c -0.9 -1.8 Conserved hypothetical protein compare
Rv2657c -0.9 -0.7 Probable PhiRv2 prophage protein compare
Rv1745c -0.9 -3.2 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2850c -0.9 -0.9 Possible magnesium chelatase compare
Rv3386 -0.9 -0.9 Possible transposase compare
Rv0019c -0.9 -3.9 Conserved protein with FHA domain, FhaB compare
Rv1798 -0.9 -0.9 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv1148c -0.9 -1.0 Conserved hypothetical protein compare
Rv0078 -0.9 -1.3 Probable transcriptional regulatory protein compare
Rv2985 -0.9 -1.5 Possible hydrolase MutT1 compare
Rv2686c -0.8 -1.2 Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter compare
Rv0204c -0.8 -3.1 Probable conserved transmembrane protein compare
Rv0497 -0.8 -1.3 Probable conserved transmembrane protein compare
Rv0452 -0.8 -2.8 Possible transcriptional regulatory protein compare
Rv3438 -0.8 -1.7 Conserved protein compare
Rv0954 -0.8 -2.5 Probable conserved transmembrane protein compare
Rv3310 -0.8 -2.5 Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) compare
Rv1410c -0.8 -3.9 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3358 -0.8 -1.1 Toxin RelK compare
Rv2691 -0.8 -4.2 TRK system potassium uptake protein CeoB compare
Rv1674c -0.8 -3.5 Probable transcriptional regulatory protein compare
Rv2661c -0.8 -1.4 Hypothetical protein compare
Rv2004c -0.8 -1.8 Conserved protein compare
Rv0354c -0.8 -1.3 PPE family protein PPE7 compare
Rv1112 -0.8 -0.9 Probable GTP binding protein compare
Rv2869c -0.8 -1.2 Membrane bound metalloprotease compare
Rv3419c -0.8 -1.0 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv0177 -0.8 -1.2 Probable conserved Mce associated protein compare
Rv1420 -0.8 -1.3 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv1260 -0.8 -1.9 Probable oxidoreductase compare
Rv0966c -0.8 -2.5 Conserved protein compare
Rv0208c -0.8 -1.0 Hypothetical methlytransferase (methylase) compare
Rv0472c -0.8 -2.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3400 -0.8 -3.1 Probable hydrolase compare
Rv3843c -0.7 -0.9 Probable conserved transmembrane protein compare
Rv2001 -0.7 -0.6 Conserved hypothetical protein compare
Rv0691c -0.7 -1.4 Probable transcriptional regulatory protein compare
Rv3433c -0.7 -1.2 Conserved protein compare
Rv1889c -0.7 -1.6 Conserved hypothetical protein compare
Rv2206 -0.7 -2.0 Probable conserved transmembrane protein compare
Rv0201c -0.7 -1.4 Conserved protein compare
Rv0751c -0.7 -1.6 Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh) compare
Rv1273c -0.7 -3.1 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0690c -0.7 -1.9 Conserved hypothetical protein compare
Rv3649 -0.7 -2.6 Probable helicase compare
Rv0241c -0.7 -1.8 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv2609c -0.7 -1.8 Probable conserved membrane protein compare
Rv2429 -0.7 -1.2 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) compare
Rv1647 -0.7 -3.2 Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) compare
Rv0675 -0.7 -0.4 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3643 -0.7 -1.2 Hypothetical protein compare
Rv2789c -0.7 -2.7 Probable acyl-CoA dehydrogenase FadE21 compare
Rv3139 -0.7 -2.5 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3747 -0.7 -1.9 Conserved protein compare
Rv3704c -0.7 -4.0 Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) compare
Rv1400c -0.7 -0.6 Probable lipase LipH compare
Rv3703c -0.7 -4.4 Conserved hypothetical protein compare
Rv3498c -0.7 -2.7 Mce-family protein Mce4B compare
Rv3249c -0.7 -0.6 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0131c -0.7 -2.4 Probable acyl-CoA dehydrogenase FadE1 compare
Rv3368c -0.7 -1.2 Possible oxidoreductase compare
Rv0550c -0.7 -0.9 Possible antitoxin VapB3 compare
Rv0154c -0.7 -1.9 Probable acyl-CoA dehydrogenase FadE2 compare
Rv3694c -0.7 -2.1 Possible conserved transmembrane protein compare
Rv3301c -0.7 -1.6 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv0375c -0.7 -1.1 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv3922c -0.7 -1.4 Possible hemolysin compare
Rv0960 -0.7 -1.8 Possible toxin VapC9 compare
Rv0576 -0.7 -1.8 Probable transcriptional regulatory protein (possibly ArsR-family) compare
Rv2772c -0.7 -1.0 Probable conserved transmembrane protein compare
Rv3885c -0.6 -1.2 ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein. compare
Rv1829 -0.6 -2.7 Conserved protein compare
Rv1061 -0.6 -2.6 Conserved protein compare
Rv2260 -0.6 -0.9 Conserved hypothetical protein compare
Rv1003 -0.6 -0.5 Conserved protein compare
Rv3022A -0.6 -1.3 PE family protein PE29 compare
Rv0049 -0.6 -1.9 Conserved hypothetical protein compare
Rv0968 -0.6 -1.5 Conserved protein compare
Rv1581c -0.6 -1.6 Probable PhiRv1 phage protein compare
Rv1514c -0.6 -1.5 Conserved hypothetical protein compare
Rv2553c -0.6 -0.5 Probable conserved membrane protein compare
Rv3817 -0.6 -1.2 Possible phosphotransferase compare
Rv1986 -0.6 -1.0 Probable conserved integral membrane protein compare
Rv3481c -0.6 -0.8 Probable integral membrane protein compare
Rv1173 -0.6 -1.5 Probable F420 biosynthesis protein FbiC compare
Rv2707 -0.6 -4.9 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3322c -0.6 -1.4 Possible methyltransferase compare
Rv0309 -0.6 -2.2 Possible conserved exported protein compare
Rv2170 -0.6 -0.9 GCN5-related N-acetyltransferase compare
Rv1669 -0.6 -1.5 Hypothetical protein compare
Rv2548 -0.6 -0.8 Possible toxin VapC19 compare
Rv2606c -0.6 -2.4 Possible pyridoxine biosynthesis protein SnzP compare
Rv1262c -0.6 -0.6 Hypothetical hit-like protein compare
Rv2733c -0.6 -0.9 Conserved hypothetical alanine, arginine-rich protein compare
Rv1335 -0.6 -3.3 Sulfur carrier protein CysO compare
Rv2734 -0.6 -2.5 Conserved hypothetical protein compare
Rv1344 -0.6 -2.1 Acyl carrier protein (ACP) MbtL compare
Rv0566c -0.6 -2.0 Conserved protein compare
Rv1116A -0.6 -0.7 Conserved hypothetical protein (fragment) compare
Rv2369c -0.6 -0.6 Hypothetical protein compare
Rv0174 -0.6 -2.4 Mce-family protein Mce1F compare
Rv0374c -0.6 -1.2 Probable carbon monoxyde dehydrogenase (small chain) compare
Rv1679 -0.6 -0.6 Possible acyl-CoA dehydrogenase FadE16 compare
Rv3010c -0.6 -2.7 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv0976c -0.6 -2.0 Conserved hypothetical protein compare
Rv3657c -0.6 -1.6 Possible conserved alanine rich membrane protein compare
Rv3288c -0.6 -2.2 Putative protein UsfY compare
Rv3161c -0.6 -2.6 Possible dioxygenase compare
Rv0088 -0.6 -0.5 Possible polyketide cyclase/dehydrase compare
Rv3770B -0.6 -1.1 Probable remnant of a transposase compare
Rv0106 -0.6 -1.8 Conserved hypothetical protein compare
Rv2432c -0.6 -1.1 Hypothetical protein compare
Rv3695 -0.6 -2.2 Possible conserved membrane protein compare
Rv3813c -0.6 -1.3 Conserved protein compare
Rv0924c -0.6 -1.6 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv1332 -0.6 -0.5 Probable transcriptional regulatory protein compare
Rv0248c -0.6 -2.8 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0068 -0.6 -2.1 Probable oxidoreductase compare
Rv2567 -0.6 -2.9 Conserved hypothetical alanine and leucine rich protein compare
Rv1919c -0.6 -1.3 Conserved protein compare
Rv0999 -0.6 -1.3 Unknown protein compare
Rv1004c -0.6 -0.7 Probable membrane protein compare


Specific Phenotypes

For 5 genes in this experiment

For stress Sodium hypochlorite in Mycobacterium tuberculosis H37Rv

For stress Sodium hypochlorite across organisms