Experiment set6S734 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Sisomicin sulfate salt 0.07 mM

200 most important genes:

  gene name fitness t score description  
Rv2989 -4.0 -1.1 Probable transcriptional regulatory protein compare
Rv0949 -2.4 -0.9 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2237A -2.3 -1.2 Conserved protein compare
Rv2500c -2.3 -1.8 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv0928 -2.2 -4.8 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0929 -2.2 -2.2 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0262c -2.1 -2.8 Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC) compare
Rv3314c -2.0 -1.4 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv0930 -2.0 -4.3 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2774c -2.0 -1.3 Hypothetical protein compare
Rv2581c -1.9 -1.6 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv1281c -1.9 -4.0 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv1414 -1.9 -1.1 Conserved hypothetical protein compare
Rv3273 -1.8 -8.6 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv3193c -1.8 -1.8 Probable conserved transmembrane protein compare
Rv0313 -1.8 -1.9 Conserved protein compare
Rv0734 -1.8 -3.4 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv1107c -1.8 -1.5 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv2976c -1.7 -1.0 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv3610c -1.7 -2.5 Membrane-bound protease FtsH (cell division protein) compare
Rv2376c -1.7 -0.6 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv0451c -1.7 -1.9 Probable conserved membrane protein MmpS4 compare
Rv2044c -1.7 -0.7 Conserved hypothetical protein compare
Rv1072 -1.6 -1.8 Probable conserved transmembrane protein compare
Rv0609 -1.6 -1.2 Possible toxin VapC28. Contains PIN domain. compare
Rv1640c -1.6 -7.4 Lysyl-tRNA synthetase 2 LysX compare
Rv0820 -1.5 -3.9 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1398c -1.5 -1.8 Possible antitoxin VapB10 compare
Rv3664c -1.5 -2.9 Probable dipeptide-transport integral membrane protein ABC transporter DppC compare
Rv1930c -1.4 -0.9 Conserved hypothetical protein compare
Rv1809 -1.4 -5.7 PPE family protein PPE33 compare
Rv3081 -1.4 -1.0 Conserved hypothetical protein compare
Rv1055 -1.4 -1.0 Possible integrase (fragment) compare
Rv1258c -1.4 -8.2 Probable conserved integral membrane transport protein compare
Rv0088 -1.3 -0.9 Possible polyketide cyclase/dehydrase compare
Rv0242c -1.3 -2.7 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1897c -1.2 -1.5 Conserved hypothetical protein compare
Rv0881 -1.2 -2.7 Possible rRNA methyltransferase (rRNA methylase) compare
Rv1234 -1.2 -2.1 Probable transmembrane protein compare
Rv2693c -1.2 -3.5 Probable conserved integral membrane alanine and leucine rich protein compare
Rv0825c -1.1 -1.3 Conserved protein compare
Rv0867c -1.1 -0.5 Possible resuscitation-promoting factor RpfA compare
Rv1459c -1.1 -0.9 Possible conserved integral membrane protein compare
Rv0201c -1.1 -1.7 Conserved protein compare
Rv1729c -1.1 -2.8 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv2630 -1.1 -1.1 Hypothetical protein compare
Rv0653c -1.1 -4.3 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2383c -1.1 -3.5 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) compare
Rv0437c -1.1 -1.0 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv3810 -1.1 -2.1 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv0740 -1.0 -3.1 Conserved hypothetical protein compare
Rv0098 -1.0 -0.9 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv3065 -1.0 -1.7 Multidrugs-transport integral membrane protein Mmr compare
Rv1280c -1.0 -4.9 Probable periplasmic oligopeptide-binding lipoprotein OppA compare
Rv1808 -1.0 -6.6 PPE family protein PPE32 compare
Rv3272 -1.0 -4.8 Conserved hypothetical protein compare
Rv1130 -1.0 -3.0 Possible methylcitrate dehydratase PrpD compare
Rv3855 -1.0 -3.5 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv0991c -1.0 -0.8 Conserved serine rich protein compare
Rv1745c -1.0 -4.0 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv0550c -1.0 -1.4 Possible antitoxin VapB3 compare
Rv0052 -1.0 -2.2 Conserved protein compare
Rv0241c -1.0 -2.0 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0070c -1.0 -1.2 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) compare
Rv1053c -1.0 -0.5 Hypothetical protein compare
Rv2365c -1.0 -0.6 Conserved hypothetical protein compare
Rv3897c -1.0 -0.6 Conserved hypothetical protein compare
Rv3803c -0.9 -4.5 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv2224c -0.9 -6.2 Probable carboxylesterase CaeA compare
Rv0819 -0.9 -2.3 GCN5-related N-acetyltransferase, MshD compare
Rv0540 -0.9 -1.6 Conserved hypothetical protein compare
Rv1986 -0.9 -1.3 Probable conserved integral membrane protein compare
Rv1283c -0.9 -1.4 Probable oligopeptide-transport integral membrane protein ABC transporter OppB compare
Rv3567c -0.9 -2.4 Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. compare
Rv3477 -0.9 -1.1 PE family protein PE31 compare
Rv2879c -0.9 -0.6 Conserved hypothetical protein compare
Rv0561c -0.9 -0.9 Possible oxidoreductase compare
Rv2011c -0.9 -1.9 Conserved hypothetical protein, probable transcription repressor. compare
Rv2140c -0.9 -0.9 Conserved protein TB18.6 compare
Rv3309c -0.9 -0.9 Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) compare
Rv0679c -0.9 -1.3 Conserved threonine rich protein compare
Rv1851 -0.9 -1.0 Urease accessory protein UreF compare
Rv3569c -0.9 -1.1 4,9-DHSA hydrolase compare
Rv2813 -0.9 -2.0 Conserved hypothetical protein compare
Rv2680 -0.9 -1.0 Conserved protein compare
Rv2055c -0.9 -1.0 30S ribosomal protein S18 RpsR2 compare
Rv2782c -0.9 -2.2 Probable zinc protease PepR compare
Rv2798c -0.8 -1.1 Conserved hypothetical protein compare
Rv3885c -0.8 -1.9 ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein. compare
Rv0056 -0.8 -1.8 50S ribosomal protein L9 RplI compare
Rv2491 -0.8 -2.9 Conserved hypothetical protein compare
Rv0188 -0.8 -1.1 Probable conserved transmembrane protein compare
Rv1824 -0.8 -0.7 Conserved hypothetical membrane protein compare
Rv2026c -0.8 -0.6 Universal stress protein family protein compare
Rv2173 -0.8 -2.0 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv3204 -0.8 -0.6 Possible DNA-methyltransferase (modification methylase) compare
Rv0531 -0.8 -0.8 Possible conserved membrane protein compare
Rv2004c -0.8 -2.0 Conserved protein compare
Rv0989c -0.8 -3.3 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0610c -0.8 -0.6 Hypothetical protein compare
Rv3304 -0.8 -1.6 Conserved protein compare
Rv1810 -0.8 -3.2 Conserved protein compare
Rv3140 -0.8 -1.7 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2858c -0.8 -1.3 Probable aldehyde dehydrogenase AldC compare
Rv3386 -0.8 -1.0 Possible transposase compare
Rv2657c -0.8 -0.9 Probable PhiRv2 prophage protein compare
Rv2645 -0.8 -2.5 Hypothetical protein compare
Rv2369c -0.8 -0.9 Hypothetical protein compare
Rv2707 -0.8 -5.2 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1531 -0.8 -0.7 Conserved protein compare
Rv1401 -0.8 -1.0 Possible membrane protein compare
Rv1244 -0.8 -3.5 Probable lipoprotein LpqZ compare
Rv3249c -0.8 -0.7 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3766 -0.7 -1.2 Hypothetical protein compare
Rv0082 -0.7 -2.0 Probable oxidoreductase compare
Rv1908c -0.7 -0.8 Catalase-peroxidase-peroxynitritase T KatG compare
Rv3557c -0.7 -2.0 Transcriptional regulatory protein (probably TetR-family) compare
Rv2270 -0.7 -1.0 Probable lipoprotein LppN compare
Rv3512 -0.7 -2.3 PE-PGRS family protein PE_PGRS56 compare
Rv1070c -0.7 -2.5 Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1366A -0.7 -0.7 Conserved protein compare
Rv0905 -0.7 -1.8 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3122 -0.7 -2.6 Hypothetical protein compare
Rv0783c -0.7 -2.6 Possible multidrug resistance integral membrane efflux protein EmrB compare
Rv3488 -0.7 -2.0 Conserved hypothetical protein compare
Rv0190 -0.7 -1.7 Conserved protein compare
Rv1446c -0.7 -1.8 Putative OXPP cycle protein OpcA compare
Rv3704c -0.7 -2.6 Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) compare
Rv1766 -0.7 -0.9 Conserved protein compare
Rv0487 -0.7 -3.4 Conserved hypothetical protein compare
Rv3045 -0.7 -1.5 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv3576 -0.7 -2.5 Possible conserved lipoprotein LppH compare
Rv0243 -0.7 -3.1 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv0724 -0.7 -3.2 Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase) compare
Rv3291c -0.7 -2.5 Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) compare
Rv1124 -0.7 -1.5 Probable epoxide hydrolase EphC (epoxide hydratase) compare
Rv1569 -0.7 -1.8 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) compare
Rv0007 -0.7 -0.4 Possible conserved membrane protein compare
Rv1003 -0.7 -0.4 Conserved protein compare
Rv3472 -0.7 -1.0 Conserved protein compare
Rv2887 -0.7 -0.8 Probable transcriptional regulatory protein compare
Rv0078 -0.7 -1.2 Probable transcriptional regulatory protein compare
Rv0818 -0.7 -2.9 Transcriptional regulatory protein compare
Rv0009 -0.6 -0.5 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv0311 -0.6 -1.2 Unknown protein compare
Rv1720c -0.6 -1.6 Possible toxin VapC12 compare
Rv3445c -0.6 -0.7 ESAT-6 like protein EsxU compare
Rv3614c -0.6 -1.5 ESX-1 secretion-associated protein EspD compare
Rv2739c -0.6 -1.7 Possible alanine rich transferase compare
Rv2214c -0.6 -3.9 Possible short-chain dehydrogenase EphD compare
Rv1823 -0.6 -3.1 Conserved protein compare
Rv1973 -0.6 -1.2 Possible conserved Mce associated membrane protein compare
Rv1221 -0.6 -1.7 Alternative RNA polymerase sigma factor SigE compare
Rv1131 -0.6 -1.2 Probable methylcitrate synthase PrpC compare
Rv1061 -0.6 -2.9 Conserved protein compare
Rv3503c -0.6 -1.3 Probable ferredoxin FdxD compare
Rv3358 -0.6 -1.6 Toxin RelK compare
Rv2706c -0.6 -0.5 Hypothetical protein compare
Rv3419c -0.6 -0.6 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv1213 -0.6 -3.9 Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase) compare
Rv0426c -0.6 -1.4 Possible transmembrane protein compare
Rv3334 -0.6 -1.6 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv0093c -0.6 -0.8 Probable conserved membrane protein compare
Rv2618 -0.6 -1.8 Conserved hypothetical protein compare
Rv0580c -0.6 -0.6 Conserved protein compare
Rv0984 -0.6 -1.2 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) compare
Rv3322c -0.6 -2.1 Possible methyltransferase compare
Rv0782 -0.6 -1.3 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv3640c -0.6 -2.4 Probable transposase compare
Rv1220c -0.6 -2.3 Probable methyltransferase compare
Rv0450c -0.6 -3.5 Probable conserved transmembrane transport protein MmpL4 compare
Rv3663c -0.6 -1.0 Probable dipeptide-transport ATP-binding protein ABC transporter DppD compare
Rv2103c -0.6 -1.9 Possible toxin VapC37. Contains PIN domain. compare
Rv1422 -0.6 -0.8 Conserved hypothetical protein compare
Rv2007c -0.6 -0.6 Ferredoxin FdxA compare
Rv0269c -0.6 -2.2 Conserved hypothetical protein compare
Rv0472c -0.6 -1.7 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0418 -0.6 -1.9 Probable lipoprotein aminopeptidase LpqL compare
Rv2268c -0.6 -1.3 Probable cytochrome P450 128 Cyp128 compare
Rv2809 -0.6 -1.2 Hypothetical protein compare
Rv0125 -0.6 -2.7 Probable serine protease PepA (serine proteinase) (MTB32A) compare
Rv3590c -0.6 -2.1 PE-PGRS family protein PE_PGRS58 compare
Rv2063A -0.6 -1.7 Possible toxin MazF7 compare
Rv3306c -0.6 -0.6 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv2475c -0.6 -1.5 Conserved protein compare
Rv3282 -0.6 -0.6 Conserved hypothetical protein compare
Rv2938 -0.6 -3.9 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv1400c -0.6 -0.4 Probable lipase LipH compare
Rv3630 -0.6 -2.3 Probable conserved integral membrane protein compare
Rv3383c -0.6 -2.2 Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) compare
Rv0995 -0.5 -0.7 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv2014 -0.5 -0.9 Transposase compare
Rv2042c -0.5 -1.3 Conserved protein compare
Rv1259 -0.5 -0.6 Probable uracil DNA glycosylase, UdgB compare
Rv0012 -0.5 -2.1 Probable conserved membrane protein compare
Rv1866 -0.5 -2.6 Conserved protein compare
Rv1129c -0.5 -2.9 Probable transcriptional regulator protein compare
Rv1710 -0.5 -0.5 Possible segregation and condensation protein ScpB compare
Rv3744 -0.5 -2.0 Metal sensor transcriptional regulator (ArsR-SmtB family) compare
Rv2206 -0.5 -2.2 Probable conserved transmembrane protein compare


Specific Phenotypes

For 7 genes in this experiment

For stress Sisomicin sulfate salt in Mycobacterium tuberculosis H37Rv

For stress Sisomicin sulfate salt across organisms