Experiment set6S728 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv2728c		-3.8	-5.8	Conserved alanine rich protein
Rv2671		-3.4	-4.9	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase)
Rv1025		-2.9	-1.2	Conserved protein
Rv3897c		-2.8	-1.2	Conserved hypothetical protein
Rv1400c		-2.6	-1.1	Probable lipase LipH
Rv3920c		-2.6	-2.1	Conserved protein similar to jag protein
Rv1207		-2.5	-5.3	Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2)
Rv2476c		-2.5	-5.3	Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase)
Rv1259		-2.4	-1.6	Probable uracil DNA glycosylase, UdgB
Rv2553c		-2.2	-0.9	Probable conserved membrane protein
Rv2474c		-2.0	-1.5	Conserved hypothetical protein
Rv2140c		-1.9	-2.0	Conserved protein TB18.6
Rv1745c		-1.8	-4.9	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv0674		-1.8	-1.0	Conserved hypothetical protein
Rv0361		-1.7	-1.3	Probable conserved membrane protein
Rv1112		-1.7	-1.4	Probable GTP binding protein
Rv2581c		-1.7	-1.5	Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Rv0379		-1.6	-1.1	Possible protein transport protein SecE2
Rv0241c		-1.6	-2.4	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv0200		-1.6	-2.2	Possible conserved transmembrane protein
Rv2500c		-1.6	-1.6	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv2588c		-1.6	-2.3	Probable conserved membrane protein secretion factor YajC
Rv2429		-1.5	-1.5	Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D)
Rv2335		-1.5	-1.9	Probable serine acetyltransferase CysE (sat)
Rv1531		-1.5	-1.4	Conserved protein
Rv0819		-1.5	-3.6	GCN5-related N-acetyltransferase, MshD
Rv1290A		-1.5	-1.0	Hypothetical protein
Rv1930c		-1.5	-0.9	Conserved hypothetical protein
Rv3135		-1.5	-3.1	PPE family protein PPE50
Rv1420		-1.4	-2.1	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv3136		-1.4	-3.2	PPE family protein PPE51
Rv2302		-1.4	-1.2	Conserved protein
Rv3306c		-1.3	-1.7	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv2348c		-1.3	-0.8	Hypothetical protein
Rv0242c		-1.3	-3.5	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv1003		-1.3	-0.6	Conserved protein
Rv2762c		-1.3	-1.2	Conserved hypothetical protein
Rv1908c		-1.3	-1.8	Catalase-peroxidase-peroxynitritase T KatG
Rv1068c		-1.3	-2.8	PE-PGRS family protein PE_PGRS20
Rv0825c		-1.3	-1.2	Conserved protein
Rv0940c		-1.2	-1.4	Possible oxidoreductase
Rv0007		-1.2	-0.7	Possible conserved membrane protein
Rv3314c		-1.2	-1.1	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv2014		-1.2	-1.4	Transposase
Rv0367c		-1.1	-0.6	Hypothetical protein
Rv3843c		-1.1	-1.4	Probable conserved transmembrane protein
Rv1791		-1.1	-1.4	PE family protein PE19
Rv2891		-1.1	-3.2	Conserved hypothetical protein
Rv0436c		-1.1	-1.2	Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase)
Rv3559c		-1.1	-0.7	Probable oxidoreductase
Rv1411c		-1.0	-2.2	Conserved lipoprotein LprG
Rv3614c		-1.0	-2.9	ESX-1 secretion-associated protein EspD
Rv3910		-1.0	-1.3	Probable conserved transmembrane protein
Rv1422		-1.0	-1.4	Conserved hypothetical protein
Rv0201c		-1.0	-1.6	Conserved protein
Rv2029c		-1.0	-2.1	6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase)
Rv0310c		-1.0	-2.0	Conserved protein
Rv2274c		-1.0	-2.1	Possible toxin MazF8
Rv1821		-1.0	-2.9	Possible preprotein translocase ATPase SecA2
Rv3512		-1.0	-2.5	PE-PGRS family protein PE_PGRS56
Rv3768		-1.0	-1.8	Unknown protein
Rv0989c		-1.0	-5.0	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1851		-1.0	-1.1	Urease accessory protein UreF
Rv2609c		-1.0	-2.2	Probable conserved membrane protein
Rv0929		-1.0	-1.5	Phosphate-transport integral membrane ABC transporter PstC2
Rv1062		-1.0	-0.8	Conserved hypothetical protein
Rv2292c		-0.9	-0.7	Hypothetical protein
Rv3835		-0.9	-1.9	Conserved membrane protein
Rv0744c		-0.9	-2.3	Possible transcriptional regulatory protein
Rv3856c		-0.9	-1.3	Conserved hypothetical protein
Rv0765c		-0.9	-1.5	Probable oxidoreductase
Rv0742		-0.9	-1.1	PE-PGRS family protein PE_PGRS8
Rv1940		-0.9	-1.3	Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)
Rv2072c		-0.9	-0.7	Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL
Rv2475c		-0.9	-2.2	Conserved protein
Rv3358		-0.9	-3.1	Toxin RelK
Rv2381c		-0.9	-1.2	Polyketide synthetase MbtD (polyketide synthase)
Rv2506		-0.9	-1.8	Probable transcriptional regulatory protein (probably TetR-family)
Rv3220c		-0.9	-1.8	Probable two component sensor kinase
Rv2661c		-0.8	-1.2	Hypothetical protein
Rv3855		-0.8	-3.1	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv2007c		-0.8	-1.4	Ferredoxin FdxA
Rv0782		-0.8	-1.8	Probable protease II PtrBb [second part] (oligopeptidase B)
Rv1957		-0.8	-0.8	Hypothetical protein
Rv1004c		-0.8	-1.0	Probable membrane protein
Rv2705c		-0.8	-2.0	Conserved hypothetical protein
Rv3723		-0.8	-1.7	Probable conserved transmembrane protein
Rv0036c		-0.8	-2.9	Conserved protein
Rv0275c		-0.8	-1.4	Possible transcriptional regulatory protein (possibly TetR-family)
Rv1351		-0.8	-1.1	Hypothetical protein
Rv3419c		-0.8	-0.8	Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease)
Rv2691		-0.8	-3.8	TRK system potassium uptake protein CeoB
Rv1577c		-0.8	-0.8	Probable PhiRv1 phage protein
Rv3311		-0.8	-2.5	Conserved protein
Rv1421		-0.8	-1.7	Conserved protein
Rv0924c		-0.8	-2.7	Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP)
Rv3157		-0.8	-3.6	Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Rv2384		-0.8	-1.9	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Rv1097c		-0.8	-1.2	Probable membrane glycine and proline rich protein
Rv2694c		-0.7	-1.2	Conserved protein
Rv3010c		-0.7	-2.4	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Rv1836c		-0.7	-1.0	Conserved protein
Rv0184		-0.7	-2.2	Conserved hypothetical protein
Rv3249c		-0.7	-0.7	Possible transcriptional regulatory protein (probably TetR-family)
Rv1103c		-0.7	-1.3	Possible antitoxin MazE3
Rv3557c		-0.7	-1.9	Transcriptional regulatory protein (probably TetR-family)
Rv3076		-0.7	-1.4	Conserved hypothetical protein
Rv0918		-0.7	-1.2	Conserved protein
Rv2042c		-0.7	-0.7	Conserved protein
Rv2722		-0.7	-1.9	Conserved hypothetical protein
Rv0653c		-0.7	-2.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv0017c		-0.7	-2.3	Probable cell division protein RodA
Rv1679		-0.7	-0.4	Possible acyl-CoA dehydrogenase FadE16
Rv1090		-0.7	-3.4	Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase)
Rv1897c		-0.7	-1.1	Conserved hypothetical protein
Rv3214		-0.7	-0.7	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Rv3438		-0.7	-1.3	Conserved protein
Rv3486		-0.7	-1.2	Conserved protein
Rv0028		-0.7	-2.5	Conserved hypothetical protein
Rv0749		-0.7	-1.8	Possible toxin VapC31. Contains PIN domain.
Rv3286c		-0.7	-1.2	Alternative RNA polymerase sigma factor SigF
Rv2011c		-0.7	-1.0	Conserved hypothetical protein, probable transcription repressor.
Rv1335		-0.7	-2.0	Sulfur carrier protein CysO
Rv1173		-0.7	-1.5	Probable F420 biosynthesis protein FbiC
Rv1372		-0.7	-1.1	Conserved hypothetical protein
Rv3417c		-0.7	-1.4	60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1)
Rv1055		-0.7	-0.6	Possible integrase (fragment)
Rv0655		-0.7	-2.3	Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl
Rv0426c		-0.7	-1.9	Possible transmembrane protein
Rv2342		-0.7	-2.3	Conserved hypothetical protein
Rv0019c		-0.7	-2.6	Conserved protein with FHA domain, FhaB
Rv1366A		-0.6	-0.7	Conserved protein
Rv0118c		-0.6	-1.9	Probable oxalyl-CoA decarboxylase OxcA
Rv3650		-0.6	-0.4	PE family protein PE33
Rv2275		-0.6	-1.0	Conserved hypothetical protein
Rv1329c		-0.6	-3.2	Probable ATP-dependent helicase DinG
Rv1502		-0.6	-1.0	Hypothetical protein
Rv1621c		-0.6	-1.7	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv0020c		-0.6	-3.4	Conserved protein with FHA domain, FhaA
Rv0131c		-0.6	-2.2	Probable acyl-CoA dehydrogenase FadE1
Rv3893c		-0.6	-1.5	PE family protein PE36
Rv2055c		-0.6	-0.7	30S ribosomal protein S18 RpsR2
Rv2271		-0.6	-1.6	Conserved hypothetical protein
Rv0680c		-0.6	-0.7	Probable conserved transmembrane protein
Rv3261		-0.6	-1.4	Probable F420 biosynthesis protein FbiA
Rv1530		-0.6	-2.1	Probable alcohol dehydrogenase Adh
Rv1534		-0.6	-2.3	Probable transcriptional regulator
Rv0741		-0.6	-1.4	Probable transposase (fragment)
Rv1286		-0.6	-1.3	Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase
Rv2655c		-0.6	-2.0	Possible PhiRv2 prophage protein
Rv3066		-0.6	-2.2	Probable transcriptional regulatory protein (probably DeoR-family)
Rv0243		-0.6	-2.8	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv3050c		-0.6	-1.4	Probable transcriptional regulatory protein (probably AsnC-family)
Rv2064		-0.6	-1.2	Precorrin-3B synthase CobG
Rv0671		-0.6	-1.5	Possible conserved lipoprotein LpqP
Rv2252		-0.6	-0.4	Diacylglycerol kinase
Rv1986		-0.6	-0.9	Probable conserved integral membrane protein
Rv3262		-0.6	-1.0	Probable F420 biosynthesis protein FbiB
Rv3114		-0.6	-0.6	Conserved hypothetical protein
Rv1270c		-0.6	-2.0	Possible lipoprotein LprA
Rv0016c		-0.6	-1.9	Probable penicillin-binding protein PbpA
Rv2183c		-0.6	-0.9	Conserved protein
Rv3394c		-0.6	-1.0	Conserved hypothetical protein
Rv1920		-0.6	-2.9	Probable membrane protein
Rv2749		-0.6	-0.6	Conserved protein
Rv0098		-0.6	-0.7	Probable fatty acyl CoA thioesterase type III FcoT
Rv2446c		-0.6	-3.5	Probable conserved integral membrane protein
Rv2297		-0.6	-1.6	Unknown protein
Rv0472c		-0.6	-1.6	Probable transcriptional regulatory protein (possibly TetR-family)
Rv2498c		-0.6	-2.0	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)
Rv0751c		-0.6	-2.2	Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh)
Rv1900c		-0.6	-2.4	Probable lignin peroxidase LipJ
Rv2707		-0.6	-4.0	Probable conserved transmembrane alanine and leucine rich protein
Rv2044c		-0.6	-0.3	Conserved hypothetical protein
Rv2025c		-0.6	-1.1	Conserved membrane protein
Rv0610c		-0.6	-0.4	Hypothetical protein
Rv2696c		-0.6	-0.9	Conserved alanine and glycine and valine rich protein
Rv1077		-0.6	-3.3	Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)
Rv1013		-0.6	-2.7	Putative polyketide synthase Pks16
Rv2569c		-0.6	-1.9	Conserved hypothetical protein
Rv0590		-0.6	-0.7	Mce-family protein Mce2B
Rv3472		-0.6	-1.4	Conserved protein
Rv0281		-0.5	-1.9	Possible S-adenosylmethionine-dependent methyltransferase
Rv0360c		-0.5	-1.2	Conserved protein
Rv0861c		-0.5	-1.9	DNA helicase Ercc3
Rv0278c		-0.5	-2.6	PE-PGRS family protein PE_PGRS3
Rv0383c		-0.5	-0.6	Possible conserved secreted protein
Rv1668c		-0.5	-1.9	Probable first part of macrolide-transport ATP-binding protein ABC transporter
Rv2144c		-0.5	-1.4	Probable transmembrane protein
Rv0609		-0.5	-0.6	Possible toxin VapC28. Contains PIN domain.
Rv2466c		-0.5	-2.2	Conserved protein
Rv0617		-0.5	-0.8	Possible toxin VapC29. Contains PIN domain.
Rv2503c		-0.5	-1.1	Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
Rv3213c		-0.5	-1.1	Possible SOJ/para-related protein
Rv2993c		-0.5	-0.7	Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase)
Rv0608		-0.5	-0.8	Possible antitoxin VapB28
Rv3747		-0.5	-1.3	Conserved protein
Rv0451c		-0.5	-0.4	Probable conserved membrane protein MmpS4
Rv1079		-0.5	-2.1	Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase)
Rv2175c		-0.5	-0.7	Conserved regulatory protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Sodium nitrite across organisms