Experiment set6S726 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with copper (II) chloride dihydrate 0.08 mM

200 most important genes:

  gene name fitness t score description  
Rv0009 -4.9 -1.1 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv0929 -3.7 -2.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1159 -3.5 -2.8 Mannosyltransferase PimE compare
Rv2292c -3.2 -1.0 Hypothetical protein compare
Rv3033 -2.7 -0.6 Unknown protein compare
Rv0472c -2.6 -4.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3102c -2.5 -3.0 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3819 -2.4 -0.5 Unknown protein compare
Rv0819 -2.3 -2.8 GCN5-related N-acetyltransferase, MshD compare
Rv3843c -2.1 -1.8 Probable conserved transmembrane protein compare
Rv2869c -2.0 -1.9 Membrane bound metalloprotease compare
Rv0200 -1.9 -2.2 Possible conserved transmembrane protein compare
Rv1291c -1.8 -1.4 Conserved hypothetical secreted protein compare
Rv0007 -1.8 -0.7 Possible conserved membrane protein compare
Rv0955 -1.8 -1.1 Probable conserved integral membrane protein compare
Rv1411c -1.8 -3.2 Conserved lipoprotein LprG compare
Rv1414 -1.7 -0.9 Conserved hypothetical protein compare
Rv0928 -1.7 -3.7 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv3835 -1.7 -2.4 Conserved membrane protein compare
Rv3316 -1.7 -1.7 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv1173 -1.6 -2.3 Probable F420 biosynthesis protein FbiC compare
Rv3081 -1.6 -0.9 Conserved hypothetical protein compare
Rv2744c -1.5 -2.5 Conserved 35 kDa alanine rich protein compare
Rv3631 -1.5 -0.6 Possible transferase (possibly glycosyltransferase) compare
Rv3267 -1.5 -4.6 Conserved protein (CPSA-related protein) compare
Rv1400c -1.5 -0.7 Probable lipase LipH compare
Rv1898 -1.5 -1.8 Conserved hypothetical protein compare
Rv3501c -1.5 -2.8 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv3076 -1.5 -1.8 Conserved hypothetical protein compare
Rv1013 -1.4 -6.4 Putative polyketide synthase Pks16 compare
Rv3810 -1.4 -2.0 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv3005c -1.4 -9.2 Conserved hypothetical protein compare
Rv2366c -1.4 -2.1 Probable conserved transmembrane protein compare
Rv0113 -1.4 -0.9 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv0825c -1.4 -1.7 Conserved protein compare
Rv0367c -1.3 -0.5 Hypothetical protein compare
Rv0043c -1.3 -1.2 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv3085 -1.3 -0.7 Probable short-chain type dehydrogenase/reductase compare
Rv2417c -1.3 -3.3 Conserved protein compare
Rv2942 -1.3 -7.8 Conserved transmembrane transport protein MmpL7 compare
Rv2367c -1.3 -1.8 Conserved hypothetical protein compare
Rv0361 -1.3 -0.8 Probable conserved membrane protein compare
Rv2928 -1.3 -2.7 Probable thioesterase TesA compare
Rv2945c -1.3 -6.3 Probable conserved lipoprotein LppX compare
Rv2014 -1.3 -1.2 Transposase compare
Rv2581c -1.3 -1.0 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0413 -1.3 -3.2 Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) compare
Rv2788 -1.2 -1.8 Probable transcriptional repressor SirR compare
Rv0984 -1.2 -1.7 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) compare
Rv0504c -1.2 -1.2 Conserved protein compare
Rv0610c -1.2 -0.7 Hypothetical protein compare
Rv1366A -1.2 -0.8 Conserved protein compare
Rv0954 -1.2 -4.2 Probable conserved transmembrane protein compare
Rv2029c -1.2 -1.2 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) compare
Rv2938 -1.2 -7.2 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv3394c -1.2 -1.9 Conserved hypothetical protein compare
Rv3306c -1.2 -1.1 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv1410c -1.2 -5.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3140 -1.2 -2.3 Probable acyl-CoA dehydrogenase FadE23 compare
Rv1821 -1.2 -3.4 Possible preprotein translocase ATPase SecA2 compare
Rv2936 -1.2 -6.6 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv2302 -1.1 -0.8 Conserved protein compare
Rv2862A -1.1 -1.7 Possible antitoxin VapB23 compare
Rv1836c -1.1 -1.8 Conserved protein compare
Rv1096 -1.1 -0.7 Possible glycosyl hydrolase compare
Rv0309 -1.1 -2.6 Possible conserved exported protein compare
Rv1008 -1.1 -3.4 Probable deoxyribonuclease TatD (YJJV protein) compare
Rv0876c -1.1 -1.6 Possible conserved transmembrane protein compare
Rv2183c -1.1 -1.2 Conserved protein compare
Rv1745c -1.1 -3.2 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv2919c -1.1 -1.2 Probable nitrogen regulatory protein P-II GlnB compare
Rv0924c -1.1 -2.0 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv1940 -1.1 -1.8 Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) compare
Rv0047c -1.1 -1.6 Conserved protein compare
Rv2452c -1.1 -1.4 Hypothetical protein compare
Rv2937 -1.1 -5.8 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv3919c -1.1 -1.7 Probable glucose-inhibited division protein B Gid compare
Rv0207c -1.1 -1.8 Conserved hypothetical protein compare
Rv2553c -1.1 -0.4 Probable conserved membrane protein compare
Rv1009 -1.0 -2.8 Probable resuscitation-promoting factor RpfB compare
Rv2224c -1.0 -6.5 Probable carboxylesterase CaeA compare
Rv0820 -1.0 -2.2 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0385 -1.0 -6.3 Probable monooxygenase compare
Rv0994 -1.0 -4.4 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv0050 -1.0 -1.8 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv0564c -1.0 -1.4 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) compare
Rv0765c -1.0 -1.2 Probable oxidoreductase compare
Rv0653c -1.0 -3.4 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2705c -1.0 -2.1 Conserved hypothetical protein compare
Rv0942 -1.0 -1.9 Hypothetical protein compare
Rv2312 -1.0 -2.8 Hypothetical protein compare
Rv1276c -1.0 -1.4 Conserved hypothetical protein compare
Rv2065 -1.0 -1.5 Precorrin-8X methylmutase CobH (aka precorrin isomerase) compare
Rv0125 -1.0 -3.0 Probable serine protease PepA (serine proteinase) (MTB32A) compare
Rv3358 -1.0 -2.4 Toxin RelK compare
Rv3420c -0.9 -1.5 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) compare
Rv1220c -0.9 -3.7 Probable methyltransferase compare
Rv3214 -0.9 -0.7 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) compare
Rv3717 -0.9 -2.5 Conserved hypothetical protein compare
Rv3768 -0.9 -1.4 Unknown protein compare
Rv0400c -0.9 -1.5 Acyl-CoA dehydrogenase FadE7 compare
Rv1116A -0.9 -0.7 Conserved hypothetical protein (fragment) compare
Rv3119 -0.9 -1.4 Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) compare
Rv2696c -0.9 -0.8 Conserved alanine and glycine and valine rich protein compare
Rv3664c -0.9 -1.8 Probable dipeptide-transport integral membrane protein ABC transporter DppC compare
Rv0530A -0.9 -2.0 Conserved protein compare
Rv1053c -0.9 -0.4 Hypothetical protein compare
Rv1354c -0.9 -1.9 Conserved hypothetical protein compare
Rv0321 -0.9 -1.6 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) compare
Rv0622 -0.9 -2.1 Possible membrane protein compare
Rv3249c -0.9 -0.7 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2707 -0.9 -5.3 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3353c -0.9 -1.4 Conserved hypothetical protein compare
Rv2064 -0.9 -1.6 Precorrin-3B synthase CobG compare
Rv0444c -0.9 -3.6 Anti-sigma factor RskA (regulator of sigma K) compare
Rv0550c -0.9 -1.2 Possible antitoxin VapB3 compare
Rv3610c -0.9 -1.4 Membrane-bound protease FtsH (cell division protein) compare
Rv2702 -0.9 -0.5 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv0492A -0.8 -1.9 Hypothetical protein compare
Rv0989c -0.8 -3.9 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0870c -0.8 -0.9 Possible conserved integral membrane protein compare
Rv2976c -0.8 -0.6 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv0999 -0.8 -1.7 Unknown protein compare
Rv3663c -0.8 -1.1 Probable dipeptide-transport ATP-binding protein ABC transporter DppD compare
Rv0744c -0.8 -1.7 Possible transcriptional regulatory protein compare
Rv2525c -0.8 -3.9 Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. compare
Rv3704c -0.8 -2.9 Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) compare
Rv1112 -0.8 -0.7 Probable GTP binding protein compare
Rv1506c -0.8 -1.5 Hypothetical protein compare
Rv3045 -0.8 -1.5 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv1448c -0.8 -2.0 Probable transaldolase Tal compare
Rv1111c -0.8 -1.8 Conserved hypothetical protein compare
Rv2008c -0.8 -1.9 Conserved hypothetical protein compare
Rv0040c -0.8 -3.6 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv3363c -0.8 -1.9 Conserved hypothetical protein compare
Rv1217c -0.8 -1.8 Probable tetronasin-transport integral membrane protein ABC transporter compare
Rv0613c -0.8 -2.9 Unknown protein compare
Rv0452 -0.8 -1.5 Possible transcriptional regulatory protein compare
Rv0671 -0.8 -2.0 Possible conserved lipoprotein LpqP compare
Rv1244 -0.8 -2.3 Probable lipoprotein LpqZ compare
Rv2571c -0.8 -2.0 Probable transmembrane alanine and valine and leucine rich protein compare
Rv0930 -0.8 -2.3 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv1948c -0.8 -1.6 Hypothetical protein compare
Rv3855 -0.8 -2.0 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv2004c -0.8 -1.0 Conserved protein compare
Rv2230c -0.8 -0.7 Conserved protein compare
Rv3365c -0.8 -4.1 Conserved protein compare
Rv1531 -0.8 -0.7 Conserved protein compare
Rv1271c -0.8 -1.2 Conserved hypothetical secreted protein compare
Rv0016c -0.7 -2.8 Probable penicillin-binding protein PbpA compare
Rv2891 -0.7 -2.4 Conserved hypothetical protein compare
Rv2446c -0.7 -1.8 Probable conserved integral membrane protein compare
Rv3564 -0.7 -1.8 Probable acyl-CoA dehydrogenase FadE33 compare
Rv3101c -0.7 -0.8 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv3747 -0.7 -1.2 Conserved protein compare
Rv2855 -0.7 -1.1 NADPH-dependent mycothiol reductase Mtr compare
Rv1546 -0.7 -1.5 Conserved protein compare
Rv1290A -0.7 -0.5 Hypothetical protein compare
Rv0131c -0.7 -1.5 Probable acyl-CoA dehydrogenase FadE1 compare
Rv0737 -0.7 -1.0 Possible transcriptional regulatory protein compare
Rv2635 -0.7 -0.6 Hypothetical protein compare
Rv0566c -0.7 -1.7 Conserved protein compare
Rv1908c -0.7 -1.0 Catalase-peroxidase-peroxynitritase T KatG compare
Rv1350 -0.7 -0.3 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) compare
Rv3493c -0.7 -1.8 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv2382c -0.7 -0.5 Polyketide synthetase MbtC (polyketide synthase) compare
Rv3818 -0.7 -2.7 Unknown protein compare
Rv1761c -0.7 -1.5 Possible exported protein compare
Rv3633 -0.7 -3.0 Conserved protein compare
Rv2087 -0.7 -1.2 Conserved hypothetical protein compare
Rv1286 -0.7 -1.9 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase compare
Rv2630 -0.7 -0.6 Hypothetical protein compare
Rv3120 -0.7 -1.7 Conserved hypothetical protein compare
Rv3862c -0.7 -1.8 Possible transcriptional regulatory protein WhiB-like WhiB6 compare
Rv3327 -0.7 -2.1 Probable transposase fusion protein compare
Rv3413c -0.7 -0.5 Unknown alanine and proline rich protein compare
Rv2280 -0.7 -1.4 Probable dehydrogenase compare
Rv0655 -0.7 -1.9 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1364c -0.7 -2.0 Possible sigma factor regulatory protein compare
Rv1441c -0.7 -1.6 PE-PGRS family protein PE_PGRS26 compare
Rv1287 -0.7 -1.1 Conserved hypothetical protein compare
Rv1679 -0.7 -0.4 Possible acyl-CoA dehydrogenase FadE16 compare
Rv1188 -0.7 -1.3 Probable proline dehydrogenase compare
Rv0813c -0.7 -2.4 Conserved protein compare
Rv0036c -0.7 -1.2 Conserved protein compare
Rv0590 -0.7 -1.4 Mce-family protein Mce2B compare
Rv0256c -0.7 -3.8 PPE family protein PPE2 compare
Rv0172 -0.7 -2.4 Mce-family protein Mce1D compare
Rv0995 -0.6 -0.7 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv3693 -0.6 -0.8 Possible conserved membrane protein compare
Rv2762c -0.6 -0.6 Conserved hypothetical protein compare
Rv3301c -0.6 -1.2 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 compare
Rv0939 -0.6 -0.6 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2042c -0.6 -0.8 Conserved protein compare
Rv2322c -0.6 -0.6 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv3089 -0.6 -2.0 Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) compare
Rv2466c -0.6 -1.7 Conserved protein compare
Rv3174 -0.6 -0.6 Probable short-chain dehydrogenase/reductase compare
Rv3282 -0.6 -0.7 Conserved hypothetical protein compare
Rv0650 -0.6 -2.3 Possible sugar kinase compare


Specific Phenotypes

For 3 genes in this experiment

For stress copper (II) chloride dihydrate in Mycobacterium tuberculosis H37Rv

For stress copper (II) chloride dihydrate across organisms