Experiment set6S705 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Ciprofloxacin Hydrochloride 0.001 mM

200 most important genes:

  gene name fitness t score description  
Rv0361 -4.0 -2.4 Probable conserved membrane protein compare
Rv3364c -3.6 -2.5 Conserved protein compare
Rv2737c -2.5 -7.1 RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. compare
Rv0929 -2.5 -3.1 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0955 -2.4 -1.7 Probable conserved integral membrane protein compare
Rv0930 -2.4 -6.9 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2095c -2.4 -9.6 Proteasome accessory factor C PafC compare
Rv2096c -2.4 -5.0 Proteasome accessory factor B PafB compare
Rv3202c -2.3 -8.2 Possible ATP-dependent DNA helicase compare
Rv0003 -2.2 -4.4 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv3201c -2.1 -5.9 Probable ATP-dependent DNA helicase compare
Rv3306c -2.0 -1.6 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv0928 -2.0 -4.2 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0820 -2.0 -3.9 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv1046c -1.9 -1.9 Hypothetical protein compare
Rv2647 -1.8 -1.9 Hypothetical protein compare
Rv3204 -1.7 -0.9 Possible DNA-methyltransferase (modification methylase) compare
Rv1634 -1.7 -7.7 Possible drug efflux membrane protein compare
Rv2869c -1.7 -1.9 Membrane bound metalloprotease compare
Rv3273 -1.6 -9.1 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) compare
Rv0819 -1.6 -3.4 GCN5-related N-acetyltransferase, MshD compare
Rv0007 -1.5 -0.8 Possible conserved membrane protein compare
Rv3277 -1.5 -0.7 Probable conserved transmembrane protein compare
Rv1107c -1.5 -1.1 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv1930c -1.5 -0.8 Conserved hypothetical protein compare
Rv1633 -1.4 -8.3 Probable excinuclease ABC (subunit B-helicase) UvrB compare
Rv1495 -1.4 -1.2 Possible toxin MazF4 compare
Rv3715c -1.3 -1.2 Probable recombination protein RecR compare
Rv2372c -1.3 -1.4 Conserved hypothetical protein compare
Rv2694c -1.3 -3.4 Conserved protein compare
Rv1277 -1.3 -4.9 Conserved hypothetical protein compare
Rv0867c -1.3 -0.8 Possible resuscitation-promoting factor RpfA compare
Rv3687c -1.3 -0.9 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv1566c -1.3 -3.4 Possible Inv protein compare
Rv2236c -1.3 -2.2 Probable cobalamin biosynthesis transmembrane protein CobD compare
Rv0437c -1.3 -1.0 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv3267 -1.2 -3.4 Conserved protein (CPSA-related protein) compare
Rv0241c -1.2 -2.6 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv3272 -1.2 -6.3 Conserved hypothetical protein compare
Rv1055 -1.2 -0.9 Possible integrase (fragment) compare
Rv0531 -1.2 -0.8 Possible conserved membrane protein compare
Rv1836c -1.1 -2.2 Conserved protein compare
Rv2183c -1.1 -1.3 Conserved protein compare
Rv1577c -1.1 -0.8 Probable PhiRv1 phage protein compare
Rv2975c -1.1 -0.9 Conserved hypothetical protein compare
Rv3261 -1.1 -1.6 Probable F420 biosynthesis protein FbiA compare
Rv1701 -1.1 -2.4 Probable integrase/recombinase compare
Rv2408 -1.1 -1.4 Possible PE family-related protein PE24 compare
Rv1324 -1.1 -0.9 Possible thioredoxin compare
Rv3046c -1.1 -0.6 Conserved protein compare
Rv0563 -1.1 -2.0 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0610c -1.1 -0.6 Hypothetical protein compare
Rv0557 -1.1 -1.6 Mannosyltransferase MgtA compare
Rv2887 -1.1 -1.2 Probable transcriptional regulatory protein compare
Rv2374c -1.0 -2.1 Probable heat shock protein transcriptional repressor HrcA compare
Rv3208A -1.0 -1.3 Conserved protein TB9.4 compare
Rv1361c -1.0 -2.1 PPE family protein PPE19 compare
Rv1502 -1.0 -1.4 Hypothetical protein compare
Rv3165c -1.0 -1.1 Unknown protein compare
Rv1824 -1.0 -1.2 Conserved hypothetical membrane protein compare
Rv1450c -1.0 -1.0 PE-PGRS family protein PE_PGRS27 compare
Rv1278 -1.0 -1.8 Hypothetical protein compare
Rv3072c -1.0 -2.0 Conserved hypothetical protein compare
Rv0184 -1.0 -3.0 Conserved hypothetical protein compare
Rv3249c -1.0 -1.0 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv1108c -1.0 -3.1 Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) compare
Rv0360c -1.0 -2.3 Conserved protein compare
Rv0857 -0.9 -1.3 Conserved hypothetical protein compare
Rv2237A -0.9 -0.6 Conserved protein compare
Rv1173 -0.9 -1.4 Probable F420 biosynthesis protein FbiC compare
Rv1740 -0.9 -1.1 Possible antitoxin VapB34 compare
Rv3073c -0.9 -1.0 Conserved hypothetical protein compare
Rv2691 -0.9 -3.8 TRK system potassium uptake protein CeoB compare
Rv2170 -0.9 -1.1 GCN5-related N-acetyltransferase compare
Rv2942 -0.9 -6.5 Conserved transmembrane transport protein MmpL7 compare
Rv3143 -0.9 -0.5 Probable response regulator compare
Rv3200c -0.9 -3.0 Possible transmembrane cation transporter compare
Rv2938 -0.9 -6.1 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv0275c -0.9 -1.6 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv1137c -0.9 -1.4 Hypothetical protein compare
Rv0680c -0.9 -1.1 Probable conserved transmembrane protein compare
Rv0085 -0.9 -1.2 Possible hydrogenase HycP compare
Rv2224c -0.9 -5.7 Probable carboxylesterase CaeA compare
Rv1170 -0.9 -1.7 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv2922c -0.9 -2.7 Probable chromosome partition protein Smc compare
Rv0012 -0.8 -3.8 Probable conserved membrane protein compare
Rv2945c -0.8 -4.4 Probable conserved lipoprotein LppX compare
Rv1022 -0.8 -4.0 Probable conserved lipoprotein LpqU compare
Rv3054c -0.8 -2.2 Conserved hypothetical protein compare
Rv1051c -0.8 -1.4 Conserved hypothetical protein compare
Rv3174 -0.8 -1.1 Probable short-chain dehydrogenase/reductase compare
Rv0994 -0.8 -4.5 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv3354 -0.8 -1.9 Conserved hypothetical protein compare
Rv3651 -0.8 -2.5 Conserved hypothetical protein compare
Rv3720 -0.8 -4.2 Possible fatty acid synthase compare
Rv2949c -0.8 -0.8 Chorismate pyruvate lyase compare
Rv1823 -0.8 -2.6 Conserved protein compare
Rv1049 -0.8 -1.1 Probable transcriptional repressor protein compare
Rv3358 -0.8 -1.1 Toxin RelK compare
Rv1291c -0.8 -0.9 Conserved hypothetical secreted protein compare
Rv2819c -0.8 -2.0 Hypothetical protein compare
Rv3810 -0.8 -1.1 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv0986 -0.8 -1.5 Probable adhesion component transport ATP-binding protein ABC transporter compare
Rv2252 -0.8 -0.6 Diacylglycerol kinase compare
Rv3162c -0.8 -0.8 Possible integral membrane protein compare
Rv0609 -0.8 -0.7 Possible toxin VapC28. Contains PIN domain. compare
Rv2154c -0.8 -1.5 FtsW-like protein FtsW compare
Rv1332 -0.8 -0.7 Probable transcriptional regulatory protein compare
Rv0375c -0.8 -1.1 Probable carbon monoxyde dehydrogenase (medium chain) compare
Rv1262c -0.7 -1.2 Hypothetical hit-like protein compare
Rv3101c -0.7 -1.0 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0825c -0.7 -0.9 Conserved protein compare
Rv0017c -0.7 -2.2 Probable cell division protein RodA compare
Rv1019 -0.7 -3.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1004c -0.7 -1.5 Probable membrane protein compare
Rv0504c -0.7 -1.1 Conserved protein compare
Rv3843c -0.7 -1.0 Probable conserved transmembrane protein compare
Rv3748 -0.7 -0.9 Conserved hypothetical protein compare
Rv2581c -0.7 -0.6 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0964c -0.7 -1.1 Hypothetical protein compare
Rv2588c -0.7 -1.2 Probable conserved membrane protein secretion factor YajC compare
Rv3131 -0.7 -0.8 Conserved protein compare
Rv0540 -0.7 -1.6 Conserved hypothetical protein compare
Rv1421 -0.7 -1.6 Conserved protein compare
Rv2936 -0.7 -4.9 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv2023A -0.7 -2.0 Hypothetical protein, pseudogene compare
Rv1272c -0.7 -2.8 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1542c -0.7 -2.6 Hemoglobin GlbN compare
Rv3346c -0.7 -1.1 Conserved transmembrane protein compare
Rv0474 -0.7 -2.5 Probable transcriptional regulatory protein compare
Rv0345 -0.7 -1.9 Conserved hypothetical protein compare
Rv2714 -0.7 -3.2 Conserved alanine and leucine rich protein compare
Rv3819 -0.7 -0.4 Unknown protein compare
Rv0675 -0.7 -0.6 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1006 -0.6 -2.3 Unknown protein compare
Rv3672c -0.6 -0.7 Conserved hypothetical protein compare
Rv0135c -0.6 -1.1 Possible transcriptional regulatory protein compare
Rv2467 -0.6 -3.2 Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase) compare
Rv3102c -0.6 -1.4 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3335c -0.6 -1.3 Probable conserved integral membrane protein compare
Rv3491 -0.6 -2.4 Unknown protein compare
Rv1020 -0.6 -3.8 Probable transcription-repair coupling factor Mfd (TRCF) compare
Rv1148c -0.6 -0.8 Conserved hypothetical protein compare
Rv2573 -0.6 -1.4 Conserved hypothetical protein compare
Rv0653c -0.6 -2.4 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0441c -0.6 -1.3 Hypothetical protein compare
Rv0971c -0.6 -1.1 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2831 -0.6 -1.0 Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2679 -0.6 -1.3 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0130 -0.6 -0.7 Probable 3-hydroxyl-thioester dehydratase compare
Rv1214c -0.6 -1.7 PE family protein PE14 compare
Rv3045 -0.6 -1.5 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv0999 -0.6 -1.5 Unknown protein compare
Rv3585 -0.6 -3.7 DNA repair protein RadA (DNA repair protein SMS) compare
Rv2650c -0.6 -0.6 Possible PhiRv2 prophage protein compare
Rv1159A -0.6 -1.0 Unknown protein compare
Rv1129c -0.6 -1.4 Probable transcriptional regulator protein compare
Rv2937 -0.6 -3.7 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv3237c -0.6 -1.7 Conserved protein compare
Rv3365c -0.6 -2.7 Conserved protein compare
Rv0921 -0.6 -1.3 Possible resolvase compare
Rv1524 -0.6 -1.7 Probable glycosyltransferase compare
Rv0818 -0.6 -1.9 Transcriptional regulatory protein compare
Rv0649 -0.6 -1.3 Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT) compare
Rv0220 -0.6 -1.5 Probable esterase LipC compare
Rv1801 -0.6 -2.6 PPE family protein PPE29 compare
Rv2798c -0.6 -1.2 Conserved hypothetical protein compare
Rv1169c -0.6 -1.0 PE family protein. Possible lipase LipX. compare
Rv1807 -0.6 -2.1 PPE family protein PPE31 compare
Rv0821c -0.5 -1.8 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv1109c -0.5 -1.8 Conserved protein compare
Rv1839c -0.5 -1.7 Possible antitoxin VapB13 compare
Rv1675c -0.5 -1.1 Probable transcriptional regulatory protein Cmr compare
Rv3471c -0.5 -1.8 Conserved hypothetical protein compare
Rv0463 -0.5 -2.0 Probable conserved membrane protein compare
Rv0472c -0.5 -1.7 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv2216 -0.5 -1.5 Conserved protein compare
Rv1111c -0.5 -2.0 Conserved hypothetical protein compare
Rv0196 -0.5 -1.6 Possible transcriptional regulatory protein compare
Rv2529 -0.5 -1.9 Hypothetical protein compare
Rv2644c -0.5 -1.0 Hypothetical protein compare
Rv2425c -0.5 -2.6 Conserved hypothetical protein compare
Rv0621 -0.5 -1.0 Possible membrane protein compare
Rv1273c -0.5 -1.4 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3005c -0.5 -3.2 Conserved hypothetical protein compare
Rv3694c -0.5 -1.2 Possible conserved transmembrane protein compare
Rv2623 -0.5 -1.2 Universal stress protein family protein TB31.7 compare
Rv0265c -0.5 -2.4 Probable periplasmic iron-transport lipoprotein compare
Rv0632c -0.5 -0.6 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2567 -0.5 -2.5 Conserved hypothetical alanine and leucine rich protein compare
Rv0379 -0.5 -0.5 Possible protein transport protein SecE2 compare
Rv2973c -0.5 -1.5 Probable ATP-dependent DNA helicase RecG compare
Rv3231c -0.5 -1.8 Conserved protein compare
Rv2551c -0.5 -0.8 Conserved hypothetical protein compare
Rv1940 -0.5 -1.5 Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) compare
Rv2635 -0.5 -0.4 Hypothetical protein compare
Rv3414c -0.5 -1.8 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv1191 -0.5 -2.9 Conserved protein compare
Rv3262 -0.5 -0.7 Probable F420 biosynthesis protein FbiB compare
Rv3488 -0.5 -0.9 Conserved hypothetical protein compare


Specific Phenotypes

For 1 genes in this experiment

For stress Ciprofloxacin Hydrochloride in Mycobacterium tuberculosis H37Rv

For stress Ciprofloxacin Hydrochloride across organisms