Experiment set6S704 for Mycobacterium tuberculosis H37Rv

Compare to:

no stress control

200 most important genes:

  gene name fitness t score description  
Rv2374c -2.9 -3.6 Probable heat shock protein transcriptional repressor HrcA compare
Rv3204 -2.8 -1.2 Possible DNA-methyltransferase (modification methylase) compare
Rv2774c -2.6 -1.1 Hypothetical protein compare
Rv0757 -2.5 -2.0 Possible two component system response transcriptional positive regulator PhoP compare
Rv2989 -2.5 -1.0 Probable transcriptional regulatory protein compare
Rv0497 -2.3 -1.5 Probable conserved transmembrane protein compare
Rv1072 -2.0 -1.5 Probable conserved transmembrane protein compare
Rv1284 -1.9 -1.0 Beta-carbonic anhydrase compare
Rv0098 -1.9 -1.9 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv0949 -1.9 -0.8 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv1010 -1.8 -1.7 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3046c -1.8 -0.9 Conserved protein compare
Rv1420 -1.8 -1.8 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2140c -1.7 -2.5 Conserved protein TB18.6 compare
Rv1679 -1.7 -1.2 Possible acyl-CoA dehydrogenase FadE16 compare
Rv3850 -1.7 -1.9 Conserved protein compare
Rv3143 -1.6 -0.6 Probable response regulator compare
Rv1620c -1.6 -2.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3920c -1.6 -1.3 Conserved protein similar to jag protein compare
Rv1621c -1.6 -3.7 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2384 -1.6 -2.1 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv0929 -1.5 -2.8 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3114 -1.5 -1.3 Conserved hypothetical protein compare
Rv2365c -1.4 -0.7 Conserved hypothetical protein compare
Rv0241c -1.4 -3.4 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0825c -1.4 -2.0 Conserved protein compare
Rv3610c -1.3 -1.3 Membrane-bound protease FtsH (cell division protein) compare
Rv3249c -1.3 -0.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0674 -1.3 -0.8 Conserved hypothetical protein compare
Rv3658c -1.3 -0.7 Probable conserved transmembrane protein compare
Rv2647 -1.3 -1.7 Hypothetical protein compare
Rv0177 -1.3 -1.8 Probable conserved Mce associated protein compare
Rv2372c -1.3 -1.4 Conserved hypothetical protein compare
Rv2348c -1.3 -0.8 Hypothetical protein compare
Rv0959 -1.2 -1.0 Conserved hypothetical protein compare
Rv0930 -1.2 -4.1 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0245 -1.2 -1.6 Possible oxidoreductase compare
Rv0680c -1.2 -1.5 Probable conserved transmembrane protein compare
Rv2553c -1.2 -0.8 Probable conserved membrane protein compare
Rv0989c -1.2 -6.1 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv3208A -1.2 -1.0 Conserved protein TB9.4 compare
Rv2782c -1.2 -2.0 Probable zinc protease PepR compare
Rv0437c -1.2 -1.1 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv1128c -1.2 -1.2 Conserved hypothetical protein compare
Rv0472c -1.1 -2.9 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv2733c -1.1 -1.5 Conserved hypothetical alanine, arginine-rich protein compare
Rv0928 -1.1 -2.1 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2976c -1.1 -0.8 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv0609 -1.1 -0.9 Possible toxin VapC28. Contains PIN domain. compare
Rv2277c -1.1 -2.0 Possible glycerolphosphodiesterase compare
Rv0939 -1.1 -1.1 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2173 -1.1 -3.6 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv1116A -1.1 -1.0 Conserved hypothetical protein (fragment) compare
Rv2369c -1.1 -1.0 Hypothetical protein compare
Rv1180 -1.1 -2.1 Probable polyketide beta-ketoacyl synthase Pks3 compare
Rv1951c -1.1 -2.5 Conserved hypothetical protein compare
Rv3445c -1.0 -1.1 ESAT-6 like protein EsxU compare
Rv1137c -1.0 -2.2 Hypothetical protein compare
Rv2993c -1.0 -1.6 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) compare
Rv0309 -1.0 -2.9 Possible conserved exported protein compare
Rv3198c -1.0 -0.8 Probable ATP-dependent DNA helicase II UvrD2 compare
Rv1957 -1.0 -1.3 Hypothetical protein compare
Rv1025 -1.0 -0.6 Conserved protein compare
Rv3010c -1.0 -3.0 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv0766c -1.0 -1.0 Probable cytochrome P450 123 Cyp123 compare
Rv1982c -1.0 -2.8 Possible toxin VapC36. Contains PIN domain. compare
Rv3182 -1.0 -0.5 Conserved hypothetical protein compare
Rv0361 -1.0 -1.0 Probable conserved membrane protein compare
Rv3193c -0.9 -0.9 Probable conserved transmembrane protein compare
Rv1173 -0.9 -1.3 Probable F420 biosynthesis protein FbiC compare
Rv3311 -0.9 -2.7 Conserved protein compare
Rv3477 -0.9 -1.2 PE family protein PE31 compare
Rv1798 -0.9 -0.9 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv0504c -0.9 -1.2 Conserved protein compare
Rv1100 -0.9 -3.1 Conserved protein compare
Rv2979c -0.9 -2.2 Probable resolvase compare
Rv1170 -0.9 -2.1 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv1836c -0.9 -1.7 Conserved protein compare
Rv0765c -0.9 -1.2 Probable oxidoreductase compare
Rv1421 -0.9 -1.0 Conserved protein compare
Rv0009 -0.8 -0.7 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv0583c -0.8 -3.9 Probable conserved lipoprotein LpqN compare
Rv2624c -0.8 -0.9 Universal stress protein family protein compare
Rv0918 -0.8 -1.7 Conserved protein compare
Rv3287c -0.8 -0.6 Anti-sigma factor RsbW (sigma negative effector) compare
Rv2732c -0.8 -2.0 Probable conserved transmembrane protein compare
Rv2691 -0.8 -4.8 TRK system potassium uptake protein CeoB compare
Rv3569c -0.8 -0.9 4,9-DHSA hydrolase compare
Rv3863 -0.8 -2.7 Unknown alanine rich protein compare
Rv0201c -0.8 -0.9 Conserved protein compare
Rv0566c -0.8 -1.3 Conserved protein compare
Rv2717c -0.8 -2.3 Conserved protein compare
Rv3560c -0.8 -2.2 Probable acyl-CoA dehydrogenase FadE30 compare
Rv1495 -0.8 -0.9 Possible toxin MazF4 compare
Rv3726 -0.8 -1.1 Possible dehydrogenase compare
Rv0590A -0.8 -1.2 Mce-family related protein compare
Rv1890c -0.8 -0.7 Hypothetical protein compare
Rv0324 -0.8 -1.5 Possible transcriptional regulatory protein (possibly ArsR-family) compare
Rv0135c -0.8 -2.5 Possible transcriptional regulatory protein compare
Rv2088 -0.8 -0.9 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) compare
Rv0999 -0.8 -1.5 Unknown protein compare
Rv1791 -0.8 -1.0 PE family protein PE19 compare
Rv3715c -0.8 -1.1 Probable recombination protein RecR compare
Rv2275 -0.7 -1.1 Conserved hypothetical protein compare
Rv1441c -0.7 -2.5 PE-PGRS family protein PE_PGRS26 compare
Rv1745c -0.7 -1.9 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv1821 -0.7 -2.0 Possible preprotein translocase ATPase SecA2 compare
Rv1332 -0.7 -0.7 Probable transcriptional regulatory protein compare
Rv0984 -0.7 -1.7 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) compare
Rv1839c -0.7 -1.4 Possible antitoxin VapB13 compare
Rv0353 -0.7 -2.5 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv2694c -0.7 -1.2 Conserved protein compare
Rv1840c -0.7 -1.3 PE-PGRS family protein PE_PGRS34 compare
Rv1159A -0.7 -1.6 Unknown protein compare
Rv2427A -0.7 -1.8 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv3332 -0.7 -1.6 Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase) compare
Rv2709 -0.7 -4.0 Probable conserved transmembrane protein compare
Rv2044c -0.7 -0.5 Conserved hypothetical protein compare
Rv0675 -0.7 -0.7 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0655 -0.7 -3.1 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv2702 -0.7 -0.3 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv3416 -0.7 -1.1 Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster. compare
Rv0642c -0.7 -0.8 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv0819 -0.7 -1.1 GCN5-related N-acetyltransferase, MshD compare
Rv0653c -0.7 -2.8 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2912c -0.7 -1.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1013 -0.7 -4.0 Putative polyketide synthase Pks16 compare
Rv2567 -0.7 -3.5 Conserved hypothetical alanine and leucine rich protein compare
Rv1986 -0.7 -1.0 Probable conserved integral membrane protein compare
Rv0065 -0.7 -1.4 Possible toxin VapC1 compare
Rv1884c -0.7 -1.1 Probable resuscitation-promoting factor RpfC compare
Rv0820 -0.7 -2.6 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2216 -0.7 -1.9 Conserved protein compare
Rv1324 -0.7 -0.8 Possible thioredoxin compare
Rv1178 -0.7 -1.5 Probable aminotransferase compare
Rv1675c -0.7 -1.2 Probable transcriptional regulatory protein Cmr compare
Rv0867c -0.7 -0.5 Possible resuscitation-promoting factor RpfA compare
Rv2707 -0.7 -4.1 Probable conserved transmembrane alanine and leucine rich protein compare
Rv0247c -0.7 -0.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv2522c -0.6 -2.4 Conserved hypothetical protein compare
Rv0821c -0.6 -1.7 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv2675c -0.6 -2.8 Conserved hypothetical protein compare
Rv0818 -0.6 -2.4 Transcriptional regulatory protein compare
Rv1580c -0.6 -1.4 Probable PhiRv1 phage protein compare
Rv1473A -0.6 -0.6 Possible transcriptional regulatory protein compare
Rv2322c -0.6 -0.8 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv3755c -0.6 -2.2 Conserved protein compare
Rv0608 -0.6 -0.9 Possible antitoxin VapB28 compare
Rv2544 -0.6 -1.7 Probable conserved lipoprotein LppB compare
Rv3841 -0.6 -1.9 Bacterioferritin BfrB compare
Rv2772c -0.6 -0.9 Probable conserved transmembrane protein compare
Rv3819 -0.6 -0.4 Unknown protein compare
Rv3527 -0.6 -0.8 Hypothetical protein compare
Rv0650 -0.6 -2.6 Possible sugar kinase compare
Rv0933 -0.6 -0.8 Phosphate-transport ATP-binding protein ABC transporter PstB compare
Rv0563 -0.6 -1.6 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0782 -0.6 -1.2 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv0427c -0.6 -0.9 Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) compare
Rv0086 -0.6 -1.9 Possible hydrogenase HycQ compare
Rv0121c -0.6 -1.5 Conserved protein compare
Rv0868c -0.6 -0.9 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv1303 -0.6 -0.4 Conserved hypothetical transmembrane protein compare
Rv0557 -0.6 -1.1 Mannosyltransferase MgtA compare
Rv1067c -0.6 -2.3 PE-PGRS family protein PE_PGRS19 compare
Rv2344c -0.6 -3.0 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv1943c -0.6 -1.7 Possible antitoxin MazE5 compare
Rv2506 -0.6 -1.6 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1140 -0.6 -0.9 Probable integral membrane protein compare
Rv1538c -0.6 -1.9 Probable L-aparaginase AnsA compare
Rv3107c -0.6 -2.5 Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase) compare
Rv0038 -0.6 -2.3 Conserved protein compare
Rv0171 -0.6 -3.5 Mce-family protein Mce1C compare
Rv3874 -0.6 -0.6 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv0130 -0.6 -0.7 Probable 3-hydroxyl-thioester dehydratase compare
Rv2335 -0.6 -0.7 Probable serine acetyltransferase CysE (sat) compare
Rv2729c -0.6 -1.8 Probable conserved integral membrane alanine valine and leucine rich protein compare
Rv0921 -0.6 -1.3 Possible resolvase compare
Rv2887 -0.6 -0.7 Probable transcriptional regulatory protein compare
Rv1008 -0.6 -2.3 Probable deoxyribonuclease TatD (YJJV protein) compare
Rv0861c -0.6 -2.0 DNA helicase Ercc3 compare
Rv2250c -0.6 -1.5 Possible transcriptional regulatory protein compare
Rv2432c -0.6 -0.9 Hypothetical protein compare
Rv1108c -0.6 -1.7 Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) compare
Rv3408 -0.6 -2.2 Possible toxin VapC47. Contains PIN domain. compare
Rv0204c -0.6 -1.3 Probable conserved transmembrane protein compare
Rv1231c -0.6 -1.8 Probable membrane protein compare
Rv1022 -0.6 -2.0 Probable conserved lipoprotein LpqU compare
Rv3123 -0.6 -1.4 Hypothetical protein compare
Rv2190c -0.6 -2.6 Conserved hypothetical protein compare
Rv0876c -0.6 -1.2 Possible conserved transmembrane protein compare
Rv0223c -0.5 -1.7 Probable aldehyde dehydrogenase compare
Rv0394c -0.5 -1.9 Possible secreted protein compare
Rv2813 -0.5 -1.0 Conserved hypothetical protein compare
Rv1193 -0.5 -1.7 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3045 -0.5 -1.0 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv3771c -0.5 -1.1 Conserved hypothetical protein compare
Rv0172 -0.5 -2.4 Mce-family protein Mce1D compare
Rv0154c -0.5 -1.6 Probable acyl-CoA dehydrogenase FadE2 compare
Rv0202c -0.5 -2.5 Probable conserved transmembrane transport protein MmpL11 compare
Rv0870c -0.5 -0.8 Possible conserved integral membrane protein compare


Specific Phenotypes

For 1 genes in this experiment