Experiment set6S694 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv3364c		-4.3	-3.1	Conserved protein
Rv0675		-3.9	-1.1	Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3202c		-3.0	-8.6	Possible ATP-dependent DNA helicase
Rv2096c		-2.8	-4.1	Proteasome accessory factor B PafB
Rv3201c		-2.7	-7.5	Probable ATP-dependent DNA helicase
Rv2095c		-2.7	-11.2	Proteasome accessory factor C PafC
Rv2737c		-2.4	-5.2	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Rv1062		-2.3	-1.3	Conserved hypothetical protein
Rv1278		-2.2	-3.7	Hypothetical protein
Rv0930		-2.2	-7.5	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0819		-2.2	-4.1	GCN5-related N-acetyltransferase, MshD
Rv0928		-1.8	-3.0	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv1108c		-1.7	-5.0	Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit)
Rv0929		-1.6	-2.0	Phosphate-transport integral membrane ABC transporter PstC2
Rv0820		-1.6	-3.9	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1010		-1.6	-1.4	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv2691		-1.4	-6.5	TRK system potassium uptake protein CeoB
Rv0247c		-1.4	-1.0	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv3004		-1.4	-2.5	Low molecular weight protein antigen 6 (CFP-6)
Rv0563		-1.4	-1.6	Probable protease transmembrane protein heat shock protein HtpX
Rv3249c		-1.4	-1.5	Possible transcriptional regulatory protein (probably TetR-family)
Rv3273		-1.4	-8.5	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Rv0275c		-1.4	-2.7	Possible transcriptional regulatory protein (possibly TetR-family)
Rv0003		-1.4	-3.6	DNA replication and repair protein RecF (single-strand DNA binding protein)
Rv0007		-1.3	-0.9	Possible conserved membrane protein
Rv1277		-1.3	-3.5	Conserved hypothetical protein
Rv3306c		-1.3	-1.7	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv3046c		-1.3	-0.7	Conserved protein
Rv2171		-1.3	-2.0	Probable conserved lipoprotein LppM
Rv0871		-1.3	-2.5	Probable cold shock-like protein B CspB
Rv2374c		-1.3	-1.6	Probable heat shock protein transcriptional repressor HrcA
Rv2945c		-1.3	-7.3	Probable conserved lipoprotein LppX
Rv0452		-1.3	-3.7	Possible transcriptional regulatory protein
Rv1159		-1.3	-1.8	Mannosyltransferase PimE
Rv2694c		-1.3	-2.6	Conserved protein
Rv1158c		-1.2	-2.0	Conserved hypothetical ala-, pro-rich protein
Rv3715c		-1.2	-1.7	Probable recombination protein RecR
Rv0472c		-1.2	-3.5	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3360		-1.2	-3.8	Conserved hypothetical protein
Rv1836c		-1.2	-1.7	Conserved protein
Rv2170		-1.2	-1.4	GCN5-related N-acetyltransferase
Rv0241c		-1.1	-2.8	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv1291c		-1.1	-1.4	Conserved hypothetical secreted protein
Rv3188		-1.1	-1.7	Conserved hypothetical protein
Rv3272		-1.1	-5.5	Conserved hypothetical protein
Rv2232		-1.1	-1.8	Protein tyrosine kinase transcriptional regulatory protein PtkA
Rv1974		-1.1	-2.0	Probable conserved membrane protein
Rv1502		-1.1	-1.5	Hypothetical protein
Rv3338		-1.1	-1.3	Conserved hypothetical protein
Rv1946c		-1.1	-2.2	Possible lipoprotein
Rv1821		-1.1	-4.1	Possible preprotein translocase ATPase SecA2
Rv2272		-1.0	-0.8	Probable conserved transmembrane protein
Rv2427A		-1.0	-2.1	'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11
Rv2474c		-1.0	-1.1	Conserved hypothetical protein
Rv3358		-1.0	-1.4	Toxin RelK
Rv0016c		-1.0	-3.1	Probable penicillin-binding protein PbpA
Rv0989c		-1.0	-5.3	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv2116		-1.0	-2.0	Conserved lipoprotein LppK
Rv0088		-1.0	-1.0	Possible polyketide cyclase/dehydrase
Rv2014		-1.0	-1.6	Transposase
Rv1020		-1.0	-5.8	Probable transcription-repair coupling factor Mfd (TRCF)
Rv0468		-1.0	-1.3	3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv0580c		-1.0	-1.3	Conserved protein
Rv1634		-1.0	-5.0	Possible drug efflux membrane protein
Rv2942		-1.0	-7.3	Conserved transmembrane transport protein MmpL7
Rv1013		-1.0	-4.5	Putative polyketide synthase Pks16
Rv3585		-1.0	-5.4	DNA repair protein RadA (DNA repair protein SMS)	conserved
Rv1531		-1.0	-1.3	Conserved protein
Rv0818		-0.9	-3.4	Transcriptional regulatory protein
Rv2887		-0.9	-0.9	Probable transcriptional regulatory protein
Rv2937		-0.9	-6.6	Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
Rv0157A		-0.9	-1.5	Conserved protein
Rv2408		-0.9	-1.3	Possible PE family-related protein PE24
Rv1331		-0.9	-2.5	Conserved hypothetical protein
Rv3140		-0.9	-2.5	Probable acyl-CoA dehydrogenase FadE23
Rv3850		-0.9	-0.9	Conserved protein
Rv2938		-0.9	-5.8	Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC
Rv0504c		-0.9	-1.1	Conserved protein
Rv3810		-0.9	-1.5	Exported repetitive protein precursor PirG (cell surface protein) (EXP53)
Rv2792c		-0.9	-2.3	Possible resolvase
Rv3655c		-0.9	-1.1	Conserved hypothetical protein
Rv1930c		-0.9	-0.7	Conserved hypothetical protein
Rv2936		-0.9	-6.4	Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
Rv3033		-0.9	-0.7	Unknown protein
Rv1710		-0.9	-1.3	Possible segregation and condensation protein ScpB
Rv3200c		-0.8	-2.8	Possible transmembrane cation transporter
Rv3922c		-0.8	-2.2	Possible hemolysin
Rv2975c		-0.8	-0.5	Conserved hypothetical protein
Rv3642c		-0.8	-1.1	Hypothetical protein
Rv2185c		-0.8	-2.0	Conserved protein TB16.3
Rv2736c		-0.8	-1.1	Regulatory protein RecX
Rv0177		-0.8	-1.6	Probable conserved Mce associated protein
Rv1222		-0.8	-2.9	Anti-sigma factor RseA
Rv3065		-0.8	-1.2	Multidrugs-transport integral membrane protein Mmr
Rv1495		-0.8	-1.0	Possible toxin MazF4
Rv3267		-0.8	-3.4	Conserved protein (CPSA-related protein)
Rv3365c		-0.8	-3.1	Conserved protein
Rv2551c		-0.8	-1.3	Conserved hypothetical protein
Rv1775		-0.8	-2.2	Conserved hypothetical protein
Rv1851		-0.8	-1.2	Urease accessory protein UreF
Rv0009		-0.8	-0.6	Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A)
Rv3726		-0.8	-1.0	Possible dehydrogenase
Rv2624c		-0.8	-1.0	Universal stress protein family protein
Rv3196A		-0.8	-2.1	Unknown protein
Rv0376c		-0.8	-1.9	Conserved hypothetical protein
Rv0617		-0.8	-1.7	Possible toxin VapC29. Contains PIN domain.
Rv2046		-0.8	-1.5	Probable lipoprotein LppI
Rv3755c		-0.7	-2.4	Conserved protein
Rv2384		-0.7	-1.0	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase
Rv2382c		-0.7	-0.5	Polyketide synthetase MbtC (polyketide synthase)
Rv0050		-0.7	-1.9	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
Rv3005c		-0.7	-4.7	Conserved hypothetical protein
Rv1272c		-0.7	-3.2	Probable drugs-transport transmembrane ATP-binding protein ABC transporter
Rv1140		-0.7	-1.1	Probable integral membrane protein
Rv2277c		-0.7	-0.7	Possible glycerolphosphodiesterase
Rv0766c		-0.7	-1.2	Probable cytochrome P450 123 Cyp123
Rv3114		-0.7	-0.7	Conserved hypothetical protein
Rv3855		-0.7	-3.6	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv1284		-0.7	-0.4	Beta-carbonic anhydrase
Rv2065		-0.7	-1.2	Precorrin-8X methylmutase CobH (aka precorrin isomerase)
Rv2154c		-0.7	-0.7	FtsW-like protein FtsW
Rv2553c		-0.7	-0.7	Probable conserved membrane protein
Rv2707		-0.7	-5.2	Probable conserved transmembrane alanine and leucine rich protein
Rv3174		-0.7	-1.2	Probable short-chain dehydrogenase/reductase
Rv2687c		-0.7	-1.5	Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter
Rv3237c		-0.7	-1.4	Conserved protein
Rv0012		-0.7	-3.5	Probable conserved membrane protein
Rv0070c		-0.7	-1.2	Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2)
Rv1633		-0.7	-4.8	Probable excinuclease ABC (subunit B-helicase) UvrB
Rv3657c		-0.7	-1.8	Possible conserved alanine rich membrane protein
Rv0765c		-0.7	-1.1	Probable oxidoreductase
Rv3675		-0.7	-2.7	Possible membrane protein
Rv1359		-0.7	-1.8	Probable transcriptional regulatory protein
Rv1421		-0.7	-1.8	Conserved protein
Rv0184		-0.7	-2.5	Conserved hypothetical protein
Rv3586		-0.7	-1.9	Conserved hypothetical protein
Rv3305c		-0.7	-1.1	Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase)
Rv3833		-0.6	-1.4	Transcriptional regulatory protein (probably AraC-family)
Rv1109c		-0.6	-1.9	Conserved protein
Rv2809		-0.6	-1.6	Hypothetical protein
Rv2734		-0.6	-2.0	Conserved hypothetical protein
Rv2252		-0.6	-0.5	Diacylglycerol kinase
Rv0557		-0.6	-1.2	Mannosyltransferase MgtA
Rv0550c		-0.6	-1.0	Possible antitoxin VapB3
Rv2696c		-0.6	-1.1	Conserved alanine and glycine and valine rich protein
Rv0499		-0.6	-1.4	Conserved hypothetical protein
Rv1833c		-0.6	-1.3	Possible haloalkane dehalogenase
Rv1657		-0.6	-1.1	Probable arginine repressor ArgR (AHRC)
Rv1103c		-0.6	-1.1	Possible antitoxin MazE3
Rv2501c		-0.6	-2.5	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Rv1130		-0.6	-2.5	Possible methylcitrate dehydratase PrpD
Rv0876c		-0.6	-1.1	Possible conserved transmembrane protein
Rv0020c		-0.6	-2.3	Conserved protein with FHA domain, FhaA
Rv3751		-0.6	-1.1	Probable integrase (fragment)
Rv2798c		-0.6	-0.7	Conserved hypothetical protein
Rv2821c		-0.6	-1.2	Conserved hypothetical protein
Rv1398c		-0.6	-0.9	Possible antitoxin VapB10
Rv1410c		-0.6	-2.0	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0653c		-0.6	-2.6	Possible transcriptional regulatory protein (probably TetR-family)
Rv1900c		-0.6	-2.7	Probable lignin peroxidase LipJ
Rv3102c		-0.6	-1.5	Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter)
Rv1420		-0.6	-0.9	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv0263c		-0.6	-2.1	Conserved hypothetical protein
Rv3316		-0.6	-0.9	Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Rv1322		-0.6	-1.0	Conserved hypothetical protein
Rv2231c		-0.6	-0.9	Possible aminotransferase CobC
Rv2077A		-0.6	-1.9	Conserved hypothetical protein
Rv1100		-0.6	-2.6	Conserved protein
Rv1534		-0.6	-2.1	Probable transcriptional regulator
Rv3047c		-0.6	-2.7	Hypothetical protein
Rv0749		-0.6	-0.9	Possible toxin VapC31. Contains PIN domain.
Rv0937c		-0.6	-1.1	DNA end-binding protein, Mku
Rv0677c		-0.6	-0.7	Possible conserved membrane protein MmpS5
Rv0634A		-0.6	-2.3	Unknown protein
Rv3494c		-0.6	-3.3	Mce-family protein Mce4F
Rv1324		-0.6	-0.6	Possible thioredoxin
Rv1745c		-0.6	-1.7	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv1357c		-0.6	-2.3	Conserved hypothetical protein
Rv1377c		-0.6	-2.2	Putative transferase
Rv2230c		-0.6	-0.8	Conserved protein
Rv2224c		-0.6	-3.9	Probable carboxylesterase CaeA
Rv3723		-0.6	-1.2	Probable conserved transmembrane protein
Rv3717		-0.6	-1.5	Conserved hypothetical protein
Rv0321		-0.6	-1.1	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)
Rv1740		-0.6	-1.0	Possible antitoxin VapB34
Rv2661c		-0.6	-0.6	Hypothetical protein
Rv2973c		-0.6	-1.9	Probable ATP-dependent DNA helicase RecG
Rv3501c		-0.6	-1.9	Conserved integral membrane protein YrbE4A. Possible ABC transporter.
Rv1131		-0.6	-1.2	Probable methylcitrate synthase PrpC
Rv0249c		-0.6	-2.1	Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase)
Rv3633		-0.6	-1.4	Conserved protein
Rv0356c		-0.5	-0.8	Conserved protein
Rv3445c		-0.5	-1.2	ESAT-6 like protein EsxU
Rv1581c		-0.5	-0.9	Probable PhiRv1 phage protein
Rv0229c		-0.5	-2.3	Possible conserved membrane protein with PIN domain
Rv0690c		-0.5	-1.2	Conserved hypothetical protein
Rv1473A		-0.5	-0.6	Possible transcriptional regulatory protein
Rv3543c		-0.5	-1.6	Probable acyl-CoA dehydrogenase FadE29
Rv2567		-0.5	-2.3	Conserved hypothetical alanine and leucine rich protein
Rv3493c		-0.5	-1.9	Conserved hypothetical Mce associated alanine and valine rich protein

Specific Phenotypes

For 1 genes in this experiment

For stress Levofloxacin in Mycobacterium tuberculosis H37Rv

For stress Levofloxacin across organisms