Experiment set6S688 for Mycobacterium tuberculosis H37Rv

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7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM

200 most important genes:

  gene name fitness t score description  
Rv3065 -4.8 -2.8 Multidrugs-transport integral membrane protein Mmr compare
Rv0929 -4.1 -3.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1421 -3.8 -4.5 Conserved protein compare
Rv0949 -3.7 -1.1 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0049 -3.4 -2.9 Conserved hypothetical protein compare
Rv0930 -2.8 -5.7 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0820 -2.7 -5.0 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2581c -2.5 -1.0 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv0247c -2.4 -1.2 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0955 -2.4 -1.8 Probable conserved integral membrane protein compare
Rv2026c -2.2 -1.6 Universal stress protein family protein compare
Rv0862c -2.2 -3.4 Conserved protein compare
Rv1010 -2.2 -1.6 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv2989 -2.1 -0.9 Probable transcriptional regulatory protein compare
Rv1003 -2.1 -0.9 Conserved protein compare
Rv0819 -2.1 -4.1 GCN5-related N-acetyltransferase, MshD compare
Rv0007 -2.0 -1.0 Possible conserved membrane protein compare
Rv1836c -1.9 -3.3 Conserved protein compare
Rv1159 -1.9 -2.6 Mannosyltransferase PimE compare
Rv0009 -1.8 -1.0 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv3045 -1.8 -2.2 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv3338 -1.7 -1.6 Conserved hypothetical protein compare
Rv0861c -1.7 -4.6 DNA helicase Ercc3 compare
Rv1411c -1.6 -3.8 Conserved lipoprotein LprG compare
Rv1331 -1.6 -3.8 Conserved hypothetical protein compare
Rv2372c -1.6 -1.8 Conserved hypothetical protein compare
Rv0871 -1.6 -2.5 Probable cold shock-like protein B CspB compare
Rv3143 -1.5 -1.5 Probable response regulator compare
Rv0019c -1.5 -4.8 Conserved protein with FHA domain, FhaB compare
Rv0452 -1.5 -3.9 Possible transcriptional regulatory protein compare
Rv3101c -1.5 -1.3 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv3136 -1.5 -4.7 PPE family protein PPE51 compare
Rv3922c -1.5 -2.3 Possible hemolysin compare
Rv3920c -1.4 -1.3 Conserved protein similar to jag protein compare
Rv1123c -1.4 -2.4 Possible peroxidase BpoB (non-haem peroxidase) compare
Rv1013 -1.4 -6.2 Putative polyketide synthase Pks16 compare
Rv1908c -1.4 -2.1 Catalase-peroxidase-peroxynitritase T KatG compare
Rv0016c -1.4 -3.7 Probable penicillin-binding protein PbpA compare
Rv3033 -1.4 -0.9 Unknown protein compare
Rv1621c -1.4 -1.8 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv3816c -1.4 -1.0 Possible acyltransferase compare
Rv1791 -1.4 -1.3 PE family protein PE19 compare
Rv2140c -1.3 -0.9 Conserved protein TB18.6 compare
Rv0989c -1.3 -6.1 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0018c -1.3 -3.3 Phosphoserine/threonine phosphatase PstP compare
Rv1531 -1.3 -1.5 Conserved protein compare
Rv1974 -1.3 -1.8 Probable conserved membrane protein compare
Rv2680 -1.3 -1.7 Conserved protein compare
Rv0928 -1.3 -2.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2733c -1.2 -2.4 Conserved hypothetical alanine, arginine-rich protein compare
Rv1420 -1.2 -1.3 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2408 -1.2 -1.6 Possible PE family-related protein PE24 compare
Rv1773c -1.2 -2.2 Probable transcriptional regulatory protein compare
Rv2383c -1.2 -3.8 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) compare
Rv3102c -1.2 -2.4 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv0499 -1.2 -2.4 Conserved hypothetical protein compare
Rv3311 -1.2 -2.8 Conserved protein compare
Rv0609 -1.2 -1.3 Possible toxin VapC28. Contains PIN domain. compare
Rv3419c -1.2 -1.4 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv2292c -1.2 -1.1 Hypothetical protein compare
Rv3193c -1.2 -1.5 Probable conserved transmembrane protein compare
Rv2869c -1.2 -1.5 Membrane bound metalloprotease compare
Rv1693 -1.1 -1.2 Conserved hypothetical protein compare
Rv1160 -1.1 -2.0 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) compare
Rv3358 -1.1 -1.8 Toxin RelK compare
Rv2302 -1.1 -0.8 Conserved protein compare
Rv2887 -1.1 -1.2 Probable transcriptional regulatory protein compare
Rv2671 -1.1 -2.6 Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase) compare
Rv1410c -1.1 -5.2 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv2583c -1.1 -3.1 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv2374c -1.1 -2.0 Probable heat shock protein transcriptional repressor HrcA compare
Rv0825c -1.1 -1.7 Conserved protein compare
Rv1100 -1.1 -4.6 Conserved protein compare
Rv1284 -1.1 -0.5 Beta-carbonic anhydrase compare
Rv0563 -1.1 -2.6 Probable protease transmembrane protein heat shock protein HtpX compare
Rv0540 -1.1 -2.2 Conserved hypothetical protein compare
Rv0245 -1.1 -1.9 Possible oxidoreductase compare
Rv2190c -1.0 -3.2 Conserved hypothetical protein compare
Rv2183c -1.0 -1.3 Conserved protein compare
Rv0523c -1.0 -1.4 Conserved protein compare
Rv2462c -1.0 -3.0 Probable trigger factor (TF) protein Tig compare
Rv2260 -1.0 -1.5 Conserved hypothetical protein compare
Rv1821 -1.0 -2.6 Possible preprotein translocase ATPase SecA2 compare
Rv3843c -1.0 -1.4 Probable conserved transmembrane protein compare
Rv3642c -1.0 -1.3 Hypothetical protein compare
Rv0020c -1.0 -3.7 Conserved protein with FHA domain, FhaA compare
Rv0632c -1.0 -1.1 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3314c -1.0 -1.4 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv2274c -1.0 -2.0 Possible toxin MazF8 compare
Rv2709 -1.0 -2.8 Probable conserved transmembrane protein compare
Rv2923c -1.0 -1.4 Conserved protein compare
Rv2586c -0.9 -1.2 Probable protein-export membrane protein SecF compare
Rv2945c -0.9 -5.4 Probable conserved lipoprotein LppX compare
Rv0492A -0.9 -1.9 Hypothetical protein compare
Rv3600c -0.9 -2.1 Conserved protein compare
Rv3249c -0.9 -1.1 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2553c -0.9 -0.5 Probable conserved membrane protein compare
Rv0353 -0.9 -2.4 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv3610c -0.9 -1.2 Membrane-bound protease FtsH (cell division protein) compare
Rv2468A -0.9 -3.1 Conserved protein compare
Rv2367c -0.9 -1.8 Conserved hypothetical protein compare
Rv3316 -0.9 -1.9 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) compare
Rv2213 -0.9 -3.4 Probable aminopeptidase PepB compare
Rv2623 -0.9 -2.0 Universal stress protein family protein TB31.7 compare
Rv0675 -0.9 -0.5 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2028c -0.9 -1.1 Universal stress protein family protein compare
Rv1745c -0.9 -2.9 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv1072 -0.9 -0.9 Probable conserved transmembrane protein compare
Rv0248c -0.9 -3.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv3675 -0.9 -2.6 Possible membrane protein compare
Rv2687c -0.8 -1.6 Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter compare
Rv0655 -0.8 -2.9 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1581c -0.8 -1.4 Probable PhiRv1 phage protein compare
Rv2691 -0.8 -4.2 TRK system potassium uptake protein CeoB compare
Rv0249c -0.8 -3.0 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) compare
Rv0508 -0.8 -1.8 Conserved hypothetical protein compare
Rv2657c -0.8 -0.8 Probable PhiRv2 prophage protein compare
Rv2702 -0.8 -0.6 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) compare
Rv1366A -0.8 -1.1 Conserved protein compare
Rv2381c -0.8 -1.0 Polyketide synthetase MbtD (polyketide synthase) compare
Rv0436c -0.8 -1.3 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1062 -0.8 -0.7 Conserved hypothetical protein compare
Rv2936 -0.8 -5.8 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv0177 -0.8 -1.5 Probable conserved Mce associated protein compare
Rv0758 -0.8 -1.6 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0017c -0.8 -3.7 Probable cell division protein RodA compare
Rv3592 -0.8 -2.3 Possible heme degrading protein MhuD compare
Rv2224c -0.8 -5.3 Probable carboxylesterase CaeA compare
Rv3414c -0.7 -2.2 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv3200c -0.7 -1.9 Possible transmembrane cation transporter compare
Rv0472c -0.7 -2.9 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3438 -0.7 -1.2 Conserved protein compare
Rv2772c -0.7 -0.8 Probable conserved transmembrane protein compare
Rv3501c -0.7 -2.4 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv1291c -0.7 -1.0 Conserved hypothetical secreted protein compare
Rv1247c -0.7 -1.6 Antitoxin RelB compare
Rv0545c -0.7 -2.0 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA compare
Rv2821c -0.7 -1.3 Conserved hypothetical protein compare
Rv0622 -0.7 -1.7 Possible membrane protein compare
Rv1851 -0.7 -1.1 Urease accessory protein UreF compare
Rv1006 -0.7 -2.4 Unknown protein compare
Rv0576 -0.7 -1.9 Probable transcriptional regulatory protein (possibly ArsR-family) compare
Rv2919c -0.7 -1.0 Probable nitrogen regulatory protein P-II GlnB compare
Rv1620c -0.7 -1.7 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0204c -0.7 -1.8 Probable conserved transmembrane protein compare
Rv1513 -0.7 -1.3 Conserved protein compare
Rv2937 -0.7 -4.8 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv0251c -0.7 -2.2 Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) compare
Rv1019 -0.7 -3.5 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv1008 -0.7 -2.4 Probable deoxyribonuclease TatD (YJJV protein) compare
Rv3177 -0.7 -1.0 Possible peroxidase (non-haem peroxidase) compare
Rv2938 -0.7 -4.0 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv1963c -0.7 -1.1 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv0924c -0.7 -1.7 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv1009 -0.7 -2.2 Probable resuscitation-promoting factor RpfB compare
Rv2788 -0.7 -1.7 Probable transcriptional repressor SirR compare
Rv2089c -0.7 -0.8 Dipeptidase PepE compare
Rv2376c -0.7 -0.5 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv0322 -0.7 -2.8 Probable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH) compare
Rv1173 -0.7 -1.7 Probable F420 biosynthesis protein FbiC compare
Rv3208A -0.6 -0.8 Conserved protein TB9.4 compare
Rv3198A -0.6 -1.4 Possible glutaredoxin protein compare
Rv0050 -0.6 -1.2 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) compare
Rv0876c -0.6 -1.5 Possible conserved transmembrane protein compare
Rv0240 -0.6 -2.5 Possible toxin VapC24. Contains PIN domain. compare
Rv2737c -0.6 -2.2 RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. compare
Rv2705c -0.6 -1.8 Conserved hypothetical protein compare
Rv3214 -0.6 -0.7 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) compare
Rv3818 -0.6 -2.4 Unknown protein compare
Rv1598c -0.6 -1.1 Conserved protein compare
Rv3132c -0.6 -2.0 Two component sensor histidine kinase DevS compare
Rv1414 -0.6 -0.6 Conserved hypothetical protein compare
Rv0497 -0.6 -0.8 Probable conserved transmembrane protein compare
Rv3170 -0.6 -1.3 Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) compare
Rv1898 -0.6 -1.3 Conserved hypothetical protein compare
Rv1290A -0.6 -0.5 Hypothetical protein compare
Rv3842c -0.6 -2.1 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) compare
Rv3217c -0.6 -0.9 Probable conserved integral membrane protein compare
Rv0474 -0.6 -2.3 Probable transcriptional regulatory protein compare
Rv0665 -0.6 -0.9 Possible toxin VapC8 compare
Rv2942 -0.6 -4.4 Conserved transmembrane transport protein MmpL7 compare
Rv3747 -0.6 -1.3 Conserved protein compare
Rv0229c -0.6 -2.6 Possible conserved membrane protein with PIN domain compare
Rv1644 -0.6 -3.8 Possible 23S rRNA methyltransferase TsnR compare
Rv3760 -0.6 -1.1 Possible conserved membrane protein compare
Rv3069 -0.6 -0.9 Probable conserved transmembrane protein compare
Rv0033 -0.6 -1.7 Probable acyl carrier protein AcpA (ACP) compare
Rv2467 -0.6 -2.9 Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase) compare
Rv2348c -0.6 -0.5 Hypothetical protein compare
Rv2736c -0.6 -0.9 Regulatory protein RecX compare
Rv2368c -0.6 -3.7 Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH) compare
Rv2749 -0.6 -0.9 Conserved protein compare
Rv2670c -0.6 -2.0 Conserved hypothetical protein compare
Rv0275c -0.6 -1.3 Possible transcriptional regulatory protein (possibly TetR-family) compare
Rv0362 -0.6 -3.5 Possible Mg2+ transport transmembrane protein MgtE compare
Rv0157A -0.6 -1.1 Conserved protein compare
Rv0361 -0.6 -0.7 Probable conserved membrane protein compare
Rv0694 -0.6 -2.3 Possible L-lactate dehydrogenase (cytochrome) LldD1 compare
Rv0184 -0.6 -2.6 Conserved hypothetical protein compare
Rv2043c -0.6 -2.0 Pyrazinamidase/nicotinamidase PncA (PZase) compare


Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Malondialdehyde tetrabutylammonium salt across organisms