Experiment set6S680 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv0819		-4.4	-5.2	GCN5-related N-acetyltransferase, MshD
Rv0247c		-3.2	-1.3	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv2140c		-3.1	-2.8	Conserved protein TB18.6
Rv1908c		-2.2	-3.0	Catalase-peroxidase-peroxynitritase T KatG
Rv0949		-2.2	-0.9	Probable ATP-dependent DNA helicase II UvrD1
Rv2272		-2.1	-1.2	Probable conserved transmembrane protein
Rv3277		-2.0	-0.8	Probable conserved transmembrane protein
Rv2372c		-1.9	-2.1	Conserved hypothetical protein
Rv0407		-1.8	-4.6	F420-dependent glucose-6-phosphate dehydrogenase Fgd1
Rv1791		-1.8	-1.8	PE family protein PE19
Rv3920c		-1.8	-1.2	Conserved protein similar to jag protein
Rv0928		-1.8	-2.4	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0955		-1.7	-1.5	Probable conserved integral membrane protein
Rv1621c		-1.7	-3.1	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv3306c		-1.7	-2.0	Probable amidohydrolase AmiB1 (aminohydrolase)
Rv0930		-1.6	-5.9	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0249c		-1.6	-5.2	Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase)
Rv1173		-1.6	-3.3	Probable F420 biosynthesis protein FbiC
Rv0049		-1.6	-3.6	Conserved hypothetical protein
Rv1155		-1.5	-4.8	Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase)
Rv3716c		-1.5	-1.1	Conserved protein
Rv3855		-1.5	-4.9	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv0989c		-1.5	-7.1	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv1102c		-1.5	-1.9	Toxin MazF3
Rv3314c		-1.5	-1.8	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)
Rv1414		-1.5	-1.0	Conserved hypothetical protein
Rv1003		-1.4	-0.7	Conserved protein
Rv3726		-1.4	-1.8	Possible dehydrogenase
Rv2733c		-1.4	-2.4	Conserved hypothetical alanine, arginine-rich protein
Rv2307D		-1.4	-2.2	Hypothetical protein
Rv0820		-1.4	-4.4	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv1745c		-1.4	-5.0	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv1127c		-1.2	-1.3	Probable pyruvate, phosphate dikinase PpdK
Rv0912		-1.2	-2.0	Probable conserved transmembrane protein
Rv0818		-1.2	-3.4	Transcriptional regulatory protein
Rv2694c		-1.2	-3.0	Conserved protein
Rv1117		-1.2	-4.2	Conserved protein
Rv2586c		-1.2	-1.4	Probable protein-export membrane protein SecF
Rv0177		-1.2	-1.5	Probable conserved Mce associated protein
Rv3193c		-1.2	-1.5	Probable conserved transmembrane protein
Rv0047c		-1.2	-4.1	Conserved protein
Rv0353		-1.2	-3.5	Probable heat shock protein transcriptional repressor HspR (MerR family)
Rv2222c		-1.2	-2.2	Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)
Rv0609		-1.2	-1.2	Possible toxin VapC28. Contains PIN domain.
Rv1284		-1.1	-0.6	Beta-carbonic anhydrase
Rv2553c		-1.1	-0.9	Probable conserved membrane protein
Rv3672c		-1.1	-1.1	Conserved hypothetical protein
Rv2680		-1.1	-1.5	Conserved protein
Rv3004		-1.1	-2.3	Low molecular weight protein antigen 6 (CFP-6)
Rv2630		-1.1	-1.1	Hypothetical protein
Rv1502		-1.1	-1.5	Hypothetical protein
Rv0468		-1.1	-1.8	3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv1420		-1.1	-1.8	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv2376c		-1.1	-0.7	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv2985		-1.1	-1.6	Possible hydrolase MutT1
Rv3438		-1.0	-2.1	Conserved protein
Rv2003c		-1.0	-0.9	Conserved hypothetical protein
Rv1620c		-1.0	-2.3	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv2276		-1.0	-1.0	Cytochrome P450 121 Cyp121
Rv1159		-1.0	-2.1	Mannosyltransferase PimE
Rv2647		-1.0	-1.2	Hypothetical protein
Rv3174		-1.0	-1.5	Probable short-chain dehydrogenase/reductase
Rv0018c		-1.0	-2.6	Phosphoserine/threonine phosphatase PstP
Rv3222c		-1.0	-0.9	Conserved hypothetical protein
Rv3647c		-1.0	-0.7	Conserved hypothetical protein
Rv0566c		-1.0	-1.3	Conserved protein
Rv1331		-1.0	-2.4	Conserved hypothetical protein
Rv1140		-1.0	-1.1	Probable integral membrane protein
Rv2536		-1.0	-4.6	Probable conserved transmembrane protein
Rv2836c		-1.0	-1.7	Possible DNA-damage-inducible protein F DinF
Rv2989		-1.0	-0.5	Probable transcriptional regulatory protein
Rv3922c		-1.0	-2.5	Possible hemolysin
Rv2588c		-1.0	-1.8	Probable conserved membrane protein secretion factor YajC
Rv0472c		-0.9	-2.1	Probable transcriptional regulatory protein (possibly TetR-family)
Rv0081		-0.9	-1.8	Probable transcriptional regulatory protein
Rv2796c		-0.9	-1.6	Probable conserved lipoprotein LppV
Rv1448c		-0.9	-2.8	Probable transaldolase Tal
Rv1245c		-0.9	-2.2	Probable short-chain type dehydrogenase/reductase
Rv3033		-0.9	-0.7	Unknown protein
Rv2206		-0.9	-2.5	Probable conserved transmembrane protein
Rv0504c		-0.9	-1.4	Conserved protein
Rv3261		-0.9	-2.5	Probable F420 biosynthesis protein FbiA
Rv1634		-0.9	-6.2	Possible drug efflux membrane protein
Rv0756c		-0.9	-2.1	Unknown protein
Rv2912c		-0.9	-1.9	Probable transcriptional regulatory protein (probably TetR-family)
Rv0093c		-0.9	-1.4	Probable conserved membrane protein
Rv0248c		-0.9	-4.0	Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Rv2967c		-0.9	-5.7	Probable pyruvate carboxylase Pca (pyruvic carboxylase)
Rv0806c		-0.9	-4.4	Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase)
Rv3610c		-0.9	-2.7	Membrane-bound protease FtsH (cell division protein)
Rv0929		-0.9	-1.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv2696c		-0.9	-1.3	Conserved alanine and glycine and valine rich protein
Rv0157A		-0.9	-1.3	Conserved protein
Rv1035c		-0.9	-0.9	Probable transposase (fragment)
Rv3413c		-0.9	-0.7	Unknown alanine and proline rich protein
Rv2240c		-0.9	-1.2	Unknown protein
Rv2259		-0.9	-2.7	S-nitrosomycothiol reductase MscR
Rv3262		-0.9	-1.3	Probable F420 biosynthesis protein FbiB
Rv1715		-0.9	-0.9	Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Rv2260		-0.8	-1.3	Conserved hypothetical protein
Rv0019c		-0.8	-2.0	Conserved protein with FHA domain, FhaB
Rv2250c		-0.8	-2.0	Possible transcriptional regulatory protein
Rv3311		-0.8	-3.5	Conserved protein
Rv2702		-0.8	-0.6	Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase)
Rv2234		-0.8	-1.6	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Rv0881		-0.8	-1.2	Possible rRNA methyltransferase (rRNA methylase)
Rv1963c		-0.8	-1.2	Probable transcriptional repressor (probably TetR-family) Mce3R
Rv3843c		-0.8	-1.4	Probable conserved transmembrane protein
Rv3249c		-0.8	-1.0	Possible transcriptional regulatory protein (probably TetR-family)
Rv1421		-0.8	-1.3	Conserved protein
Rv3591c		-0.8	-2.4	Possible hydrolase
Rv0306		-0.8	-2.1	Putative oxidoreductase
Rv2709		-0.8	-3.0	Probable conserved transmembrane protein
Rv1672c		-0.8	-1.8	Probable conserved integral membrane transport protein
Rv0168		-0.8	-2.3	Conserved integral membrane protein YrbE1B
Rv1013		-0.8	-4.4	Putative polyketide synthase Pks16
Rv2862A		-0.8	-1.6	Possible antitoxin VapB23
Rv2342		-0.8	-2.9	Conserved hypothetical protein
Rv2344c		-0.8	-2.8	Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase)
Rv2274c		-0.8	-1.6	Possible toxin MazF8
Rv0056		-0.8	-1.5	50S ribosomal protein L9 RplI
Rv1957		-0.8	-0.8	Hypothetical protein
Rv0734		-0.8	-2.2	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv1829		-0.8	-2.4	Conserved protein
Rv3045		-0.8	-1.7	Probable NADP-dependent alcohol dehydrogenase AdhC
Rv0078		-0.7	-1.1	Probable transcriptional regulatory protein
Rv0379		-0.7	-0.7	Possible protein transport protein SecE2
Rv2624c		-0.7	-1.0	Universal stress protein family protein
Rv3494c		-0.7	-4.5	Mce-family protein Mce4F
Rv0176		-0.7	-2.9	Probable conserved Mce associated transmembrane protein
Rv3723		-0.7	-1.8	Probable conserved transmembrane protein
Rv3433c		-0.7	-1.4	Conserved protein
Rv3178		-0.7	-1.2	Conserved hypothetical protein
Rv0172		-0.7	-4.0	Mce-family protein Mce1D
Rv2976c		-0.7	-0.6	Probable uracil-DNA glycosylase Ung (UDG)
Rv1633		-0.7	-4.3	Probable excinuclease ABC (subunit B-helicase) UvrB
Rv2550c		-0.7	-2.6	Possible antitoxin VapB20
Rv2809		-0.7	-1.8	Hypothetical protein
Rv0161		-0.7	-2.0	Possible oxidoreductase
Rv1170		-0.7	-1.4	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase)
Rv0200		-0.7	-1.2	Possible conserved transmembrane protein
Rv1100		-0.7	-1.9	Conserved protein
Rv1422		-0.7	-0.6	Conserved hypothetical protein
Rv0007		-0.7	-0.5	Possible conserved membrane protein
Rv3643		-0.7	-1.1	Hypothetical protein
Rv3331		-0.7	-1.9	Probable sugar-transport integral membrane protein SugI
Rv1580c		-0.7	-1.4	Probable PhiRv1 phage protein
Rv3553		-0.7	-1.1	Possible oxidoreductase
Rv1495		-0.7	-0.9	Possible toxin MazF4
Rv0924c		-0.7	-2.3	Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP)
Rv2779c		-0.7	-1.5	Possible transcriptional regulatory protein (probably Lrp/AsnC-family)
Rv2544		-0.7	-1.6	Probable conserved lipoprotein LppB
Rv1482c		-0.7	-2.2	Conserved hypothetical protein
Rv3497c		-0.7	-3.8	Mce-family protein Mce4C
Rv3136		-0.7	-2.5	PPE family protein PPE51
Rv1232c		-0.7	-1.3	Conserved protein
Rv0508		-0.7	-2.2	Conserved hypothetical protein
Rv2275		-0.7	-1.4	Conserved hypothetical protein
Rv3055		-0.7	-2.0	Possible transcriptional regulatory protein (probably TetR-family)
Rv0919		-0.6	-1.2	GCN5-related N-acetyltransferase
Rv3600c		-0.6	-2.2	Conserved protein
Rv1679		-0.6	-0.7	Possible acyl-CoA dehydrogenase FadE16
Rv2866		-0.6	-1.7	Toxin RelG
Rv0157		-0.6	-2.1	Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta)
Rv2190c		-0.6	-2.6	Conserved hypothetical protein
Rv1683		-0.6	-2.7	Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase.
Rv2567		-0.6	-3.0	Conserved hypothetical alanine and leucine rich protein
Rv3399		-0.6	-2.4	Possible S-adenosylmethionine-dependent methyltransferase
Rv0563		-0.6	-0.9	Probable protease transmembrane protein heat shock protein HtpX
Rv2500c		-0.6	-0.7	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv3338		-0.6	-0.8	Conserved hypothetical protein
Rv1401		-0.6	-0.7	Possible membrane protein
Rv0173		-0.6	-2.9	Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E)
Rv2173		-0.6	-1.3	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv2792c		-0.6	-1.2	Possible resolvase
Rv3328c		-0.6	-1.7	Probable alternative RNA polymerase sigma factor (fragment) SigJ
Rv3836		-0.6	-2.4	Conserved hypothetical protein
Rv3209		-0.6	-2.2	Conserved hypothetical threonine and proline rich protein
Rv2816c		-0.6	-1.0	Conserved hypothetical protein
Rv0016c		-0.6	-2.0	Probable penicillin-binding protein PbpA
Rv3366		-0.6	-0.7	Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase)
Rv2028c		-0.6	-0.9	Universal stress protein family protein
Rv0171		-0.6	-2.3	Mce-family protein Mce1C
Rv1487		-0.6	-1.7	Conserved membrane protein
Rv2335		-0.6	-0.9	Probable serine acetyltransferase CysE (sat)
Rv2829c		-0.6	-1.4	Possible toxin VapC22
Rv0020c		-0.6	-2.6	Conserved protein with FHA domain, FhaA
Rv0617		-0.6	-1.2	Possible toxin VapC29. Contains PIN domain.
Rv0539		-0.6	-1.1	Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase)
Rv2782c		-0.6	-1.5	Probable zinc protease PepR
Rv3010c		-0.6	-1.7	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Rv1125		-0.6	-2.2	Conserved hypothetical protein
Rv3472		-0.6	-1.7	Conserved protein
Rv1123c		-0.6	-1.2	Possible peroxidase BpoB (non-haem peroxidase)
Rv0033		-0.6	-2.0	Probable acyl carrier protein AcpA (ACP)
Rv2626c		-0.6	-0.9	Hypoxic response protein 1 Hrp1
Rv2237A		-0.6	-0.7	Conserved protein
Rv2132		-0.6	-1.6	Conserved hypothetical protein
Rv1062		-0.6	-0.6	Conserved hypothetical protein
Rv0121c		-0.6	-1.3	Conserved protein

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Menadione across organisms