Experiment set6IT050 for Klebsiella michiganensis M5al

Compare to:

L-Proline nitrogen source

200 most important genes:

  gene name fitness t score description  
BWI76_RS18930 -9.5 -5.3 histidinol-phosphate transaminase compare
BWI76_RS20965 -9.0 -5.0 phosphoribosylformylglycinamidine cyclo-ligase compare
BWI76_RS18950 -8.5 -5.3 imidazole glycerol phosphate synthase cyclase subunit compare
BWI76_RS18935 -8.1 -7.9 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase compare
BWI76_RS18920 -7.4 -4.8 ATP phosphoribosyltransferase compare
BWI76_RS27385 -7.2 -5.0 orotate phosphoribosyltransferase compare
BWI76_RS04250 -6.9 -8.2 homoserine kinase compare
BWI76_RS00855 -6.9 -9.4 argininosuccinate lyase compare
BWI76_RS23920 -6.8 -6.0 D-3-phosphoglycerate dehydrogenase compare
BWI76_RS25115 -6.7 -8.0 argininosuccinate synthase compare
BWI76_RS21475 -6.6 -4.8 bifunctional chorismate mutase/prephenate dehydrogenase compare
BWI76_RS18940 -6.6 -6.4 imidazole glycerol phosphate synthase subunit HisH compare
BWI76_RS00990 -6.6 -9.0 ketol-acid reductoisomerase compare
BWI76_RS04675 -6.5 -7.7 3-isopropylmalate dehydrogenase compare
BWI76_RS04645 -6.5 -7.7 3-dehydroquinase compare
BWI76_RS04255 -6.4 -8.7 threonine synthase compare
BWI76_RS04670 -6.0 -9.0 3-isopropylmalate dehydratase large subunit compare
BWI76_RS18925 -6.0 -7.5 histidinol dehydrogenase compare
BWI76_RS04470 -6.0 -11.9 carbamoyl phosphate synthase large subunit compare
BWI76_RS08180 -5.9 -8.4 asparagine synthase B compare
BWI76_RS01615 -5.8 -10.3 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase compare
BWI76_RS21465 -5.8 -5.1 bifunctional chorismate mutase/prephenate dehydratase compare
BWI76_RS09755 -5.7 -9.3 phosphoserine transaminase compare
BWI76_RS07070 -5.6 -6.4 5-(carboxyamino)imidazole ribonucleotide mutase compare
BWI76_RS04160 -5.6 -5.7 phosphoserine phosphatase compare
BWI76_RS11860 -5.6 -8.1 anthranilate synthase component I compare
BWI76_RS00385 -5.5 -9.4 nitrogen assimilation regulatory protein compare
BWI76_RS10990 -5.4 -2.7 dihydroorotase compare
BWI76_RS04245 -5.4 -16.8 bifunctional aspartate kinase/homoserine dehydrogenase I compare
BWI76_RS20350 -5.4 -4.8 amidophosphoribosyltransferase compare
BWI76_RS21265 -5.4 -13.8 phosphoribosylformylglycinamidine synthase compare
BWI76_RS23360 -5.3 -4.9 diaminopimelate decarboxylase compare
BWI76_RS04685 -5.3 -10.5 putative leucine operon leader peptide compare
BWI76_RS02995 -5.3 -7.8 aspartate carbamoyltransferase compare
BWI76_RS04665 -5.2 -19.7 3-isopropylmalate dehydratase small subunit compare
BWI76_RS11850 -5.1 -5.4 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase compare
BWI76_RS20895 -5.0 -5.4 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
BWI76_RS00400 -5.0 -2.8 glutamine synthetase compare
BWI76_RS11845 -5.0 -1.8 tryptophan synthase subunit beta compare
BWI76_RS04465 -5.0 -3.6 carbamoyl-phosphate synthase small subunit compare
BWI76_RS00390 -4.9 -8.8 two-component system sensor histidine kinase NtrB compare
BWI76_RS11840 -4.9 -5.3 tryptophan synthase subunit alpha compare
BWI76_RS01610 -4.8 -7.9 phosphoribosylamine--glycine ligase compare
BWI76_RS03010 -4.8 -7.0 ornithine carbamoyltransferase compare
BWI76_RS04680 -4.7 -10.5 2-isopropylmalate synthase compare
BWI76_RS09760 -4.7 -4.6 3-phosphoshikimate 1-carboxyvinyltransferase compare
BWI76_RS22805 -4.7 -11.3 GTP diphosphokinase compare
BWI76_RS00980 -4.7 -10.3 PLP-dependent threonine dehydratase compare
BWI76_RS00845 -4.7 -7.6 N-acetyl-gamma-glutamyl-phosphate reductase compare
BWI76_RS11965 -4.7 -3.7 orotidine-5'-phosphate decarboxylase compare
BWI76_RS09910 -4.5 -17.0 dihydroorotate dehydrogenase (quinone) compare
BWI76_RS11855 -4.5 -6.3 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase compare
BWI76_RS23230 -4.4 -3.1 exodeoxyribonuclease V subunit beta compare
BWI76_RS26085 -4.4 -3.2 3-dehydroquinate synthase compare
BWI76_RS05200 -4.3 -3.0 bifunctional uridylyltransferase/uridylyl-removing protein compare
BWI76_RS00785 -4.3 -6.6 cystathionine gamma-synthase compare
BWI76_RS25645 -4.3 -9.5 shikimate dehydrogenase compare
BWI76_RS09660 -4.2 -2.9 DNA translocase FtsK compare
BWI76_RS05015 -4.1 -3.1 transcriptional regulator compare
BWI76_RS00850 -3.9 -5.6 acetylglutamate kinase compare
BWI76_RS23365 -3.9 -5.6 LysR family transcriptional regulator compare
BWI76_RS07065 -3.8 -6.3 5-(carboxyamino)imidazole ribonucleotide synthase compare
BWI76_RS01655 -3.8 -5.0 homoserine O-succinyltransferase compare
BWI76_RS01210 -3.7 -3.3 tyrosine recombinase XerC compare
BWI76_RS22760 -3.7 -6.7 sulfite reductase subunit beta compare
BWI76_RS09645 -3.7 -1.7 thioredoxin-disulfide reductase compare
BWI76_RS23240 -3.6 -4.9 exonuclease V subunit gamma compare
BWI76_RS22755 -3.6 -7.3 phosphoadenosine phosphosulfate reductase compare
BWI76_RS00805 -3.5 -3.3 5,10-methylenetetrahydrofolate reductase compare
BWI76_RS20355 -3.5 -2.5 colicin V production protein compare
BWI76_RS18955 -3.5 -4.4 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase compare
BWI76_RS00965 -3.5 -1.6 acetolactate synthase 2 small subunit compare
BWI76_RS00975 -3.4 -6.7 dihydroxy-acid dehydratase compare
BWI76_RS10795 -3.3 -6.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) conserved
BWI76_RS23885 -3.2 -2.1 2-octaprenylphenol hydroxylase compare
BWI76_RS04240 -3.1 -3.1 thr operon leader peptide compare
BWI76_RS01350 -3.1 -1.4 NAD(P)H-flavin reductase compare
BWI76_RS24285 -3.1 -7.1 cystathionine beta-lyase compare
BWI76_RS22765 -3.0 -8.3 sulfite reductase subunit alpha compare
BWI76_RS08520 -3.0 -3.0 colicin transporter TolQ compare
BWI76_RS20435 -2.9 -1.3 chorismate synthase compare
BWI76_RS07780 -2.9 -1.9 hypothetical protein compare
BWI76_RS27390 -2.9 -2.7 ribonuclease PH compare
BWI76_RS09970 -2.8 -4.7 porin OmpA compare
BWI76_RS02330 -2.6 -11.0 aspartate ammonia-lyase compare
BWI76_RS22690 -2.5 -2.1 adenylyl-sulfate kinase compare
BWI76_RS20900 -2.5 -2.0 outer membrane protein assembly factor BamC compare
BWI76_RS01200 -2.5 -2.4 diaminopimelate epimerase compare
BWI76_RS21565 -2.4 -1.6 outer membrane protein assembly factor BamE compare
BWI76_RS17980 -2.2 -4.8 RNA chaperone ProQ compare
BWI76_RS23480 -2.2 -10.2 EAL domain-containing protein compare
BWI76_RS19685 -2.2 -5.1 lysine transporter compare
BWI76_RS08395 -2.2 -2.5 succinate dehydrogenase cytochrome b556 large subunit compare
BWI76_RS25060 -2.1 -3.0 lipoprotein NlpI compare
BWI76_RS25960 -2.1 -5.1 NUDIX hydrolase compare
BWI76_RS20640 -2.1 -4.8 cysteine synthase A compare
BWI76_RS25070 -2.0 -1.6 hypothetical protein compare
BWI76_RS05995 -2.0 -6.7 branched-chain amino acid ABC transporter substrate-binding protein compare
BWI76_RS06475 -2.0 -1.8 protoheme IX farnesyltransferase compare
BWI76_RS05990 -2.0 -4.8 branched-chain amino acid ABC transporter permease compare
BWI76_RS23220 -2.0 -4.2 amino-acid N-acetyltransferase compare
BWI76_RS00345 -2.0 -3.9 protein disulfide oxidoreductase DsbA compare
BWI76_RS21480 -2.0 -6.0 phospho-2-dehydro-3-deoxyheptonate aldolase compare
BWI76_RS25065 -2.0 -2.6 polyribonucleotide nucleotidyltransferase compare
BWI76_RS18630 -2.0 -3.9 nitrogen assimilation transcriptional regulator conserved
BWI76_RS04530 -1.9 -2.8 peptidylprolyl isomerase SurA compare
BWI76_RS06535 -1.8 -3.1 endopeptidase La compare
BWI76_RS02530 -1.8 -2.1 tRNA dimethylallyltransferase compare
BWI76_RS20360 -1.8 -1.3 cell division protein DedD compare
BWI76_RS15835 -1.8 -1.1 hypothetical protein compare
BWI76_RS17345 -1.8 -2.7 nitrate/nitrite two-component system sensor histidine kinase NarX compare
BWI76_RS27430 -1.7 -1.3 (p)ppGpp synthetase compare
BWI76_RS26395 -1.7 -3.6 cell division protein FtsE compare
BWI76_RS20490 -1.7 -3.1 hypothetical protein compare
BWI76_RS25285 -1.7 -1.2 HPr family phosphocarrier protein compare
BWI76_RS05980 -1.7 -6.1 ABC transporter ATP-binding protein compare
BWI76_RS05985 -1.7 -6.4 branched-chain amino acid ABC transporter permease compare
BWI76_RS26055 -1.7 -5.0 siroheme synthase compare
BWI76_RS02580 -1.7 -1.6 23S rRNA (guanosine(2251)-2'-O)-methyltransferase compare
BWI76_RS05120 -1.7 -7.1 bifunctional glycosyl transferase/transpeptidase compare
BWI76_RS17975 -1.7 -3.1 tail-specific protease compare
BWI76_RS05975 -1.7 -5.2 ABC transporter ATP-binding protein compare
BWI76_RS08535 -1.6 -2.5 translocation protein TolB compare
BWI76_RS08525 -1.6 -2.4 colicin transporter compare
BWI76_RS11700 -1.5 -1.4 hypothetical protein compare
BWI76_RS21375 -1.4 -1.6 autonomous glycyl radical cofactor GrcA compare
BWI76_RS02735 -1.4 -3.4 3'(2'),5'-bisphosphate nucleotidase CysQ compare
BWI76_RS25160 -1.4 -2.0 transcription elongation factor GreA compare
BWI76_RS11900 -1.4 -1.4 cob(I)yrinic acid a,c-diamide adenosyltransferase compare
BWI76_RS16965 -1.4 -4.3 murein lipoprotein compare
BWI76_RS27440 -1.4 -2.5 DNA helicase RecG compare
BWI76_RS14615 -1.4 -1.7 hypothetical protein compare
BWI76_RS07725 -1.4 -1.3 iron-enterobactin transporter permease compare
BWI76_RS22695 -1.4 -5.0 sulfate adenylyltransferase compare
BWI76_RS06765 -1.4 -1.8 transcriptional regulator compare
BWI76_RS02410 -1.3 -2.0 EF-P beta-lysylation protein EpmB compare
BWI76_RS16935 -1.3 -1.5 shikimate dehydrogenase compare
BWI76_RS08405 -1.3 -1.6 succinate dehydrogenase flavoprotein subunit compare
BWI76_RS09200 -1.3 -4.7 hypothetical protein compare
BWI76_RS01870 -1.3 -2.6 diacylglycerol kinase compare
BWI76_RS02815 -1.3 -1.7 fructose-bisphosphatase class I compare
BWI76_RS25335 -1.3 -1.7 stringent starvation protein A compare
BWI76_RS19010 -1.3 -2.0 polysaccharide pyruvyl transferase yvff compare
BWI76_RS14325 -1.3 -2.4 maturase compare
BWI76_RS21370 -1.2 -2.0 ATP-dependent RNA helicase SrmB compare
BWI76_RS12885 -1.2 -2.2 hypothetical protein compare
BWI76_RS07185 -1.2 -1.1 hypothetical protein compare
BWI76_RS13595 -1.2 -3.2 transcriptional regulator compare
BWI76_RS12090 -1.2 -1.6 HNH endonuclease compare
BWI76_RS14320 -1.2 -1.4 hypothetical protein compare
BWI76_RS26460 -1.2 -3.6 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE compare
BWI76_RS06680 -1.2 -0.9 hypothetical protein compare
BWI76_RS14075 -1.2 -0.9 TetR family transcriptional regulator compare
BWI76_RS15825 -1.2 -1.3 hypothetical protein compare
BWI76_RS15840 -1.2 -2.5 prophage protein compare
BWI76_RS23760 -1.2 -1.5 tRNA-Gly compare
BWI76_RS01070 -1.2 -4.8 thiol reductase thioredoxin compare
BWI76_RS07785 -1.2 -1.3 transcriptional regulator compare
BWI76_RS24260 -1.2 -2.0 hypothetical protein compare
BWI76_RS06910 -1.2 -1.2 transcriptional regulator compare
BWI76_RS03660 -1.1 -3.0 hypothetical protein compare
BWI76_RS09030 -1.1 -4.6 transpeptidase compare
BWI76_RS00985 -1.1 -4.1 transcriptional regulator IlvY compare
BWI76_RS04715 -1.1 -1.3 division/cell wall cluster transcriptional repressor MraZ compare
BWI76_RS22700 -1.1 -3.3 sulfate adenylyltransferase subunit 2 compare
BWI76_RS06530 -1.1 -4.1 ATP-dependent Clp protease ATP-binding subunit ClpX compare
BWI76_RS19325 -1.1 -1.5 mandelate racemase compare
BWI76_RS23265 -1.1 -1.7 hypothetical protein compare
BWI76_RS06015 -1.1 -1.3 hypothetical protein compare
BWI76_RS15830 -1.1 -1.9 hypothetical protein compare
BWI76_RS17045 -1.1 -1.3 hypothetical protein compare
BWI76_RS25870 -1.1 -1.4 elongation factor Tu compare
BWI76_RS08530 -1.1 -2.0 protein TolA compare
BWI76_RS25355 -1.1 -5.0 cell division protein ZapE compare
BWI76_RS24110 -1.1 -1.7 YggU family protein compare
BWI76_RS23270 -1.1 -5.9 phosphoenolpyruvate--protein phosphotransferase PtsP compare
BWI76_RS08580 -1.1 -2.8 quinolinate synthetase compare
BWI76_RS00715 -1.1 -2.4 two-component sensor histidine kinase compare
BWI76_RS01185 -1.1 -2.0 adenylate cyclase compare
BWI76_RS19870 -1.0 -1.1 malate:quinone oxidoreductase compare
BWI76_RS08650 -1.0 -1.5 molybdate ABC transporter permease compare
BWI76_RS18455 -1.0 -1.0 tRNA-Ser compare
BWI76_RS01385 -1.0 -1.7 potassium transporter compare
BWI76_RS18130 -1.0 -2.3 zinc ABC transporter substrate-binding protein compare
BWI76_RS20050 -1.0 -1.3 hypothetical protein compare
BWI76_RS07645 -1.0 -1.4 short-chain dehydrogenase/reductase compare
BWI76_RS21685 -1.0 -1.1 hypothetical protein compare
BWI76_RS14765 -1.0 -2.1 PTS lactose/cellobiose transporter subunit IIB compare
BWI76_RS26570 -1.0 -1.8 anion permease compare
BWI76_RS20880 -1.0 -1.0 esterase compare
BWI76_RS04510 -1.0 -1.2 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) compare
BWI76_RS11125 -1.0 -1.3 metal-dependent hydrolase compare
BWI76_RS11300 -1.0 -0.9 cupin compare
BWI76_RS18715 -1.0 -3.7 hypothetical protein compare
BWI76_RS11430 -1.0 -1.0 lipoprotein compare
BWI76_RS14390 -1.0 -1.2 hypothetical protein compare
BWI76_RS00240 -1.0 -2.2 FMN-binding protein MioC compare
BWI76_RS15810 -1.0 -2.5 hypothetical protein compare
BWI76_RS15435 -1.0 -1.0 hypothetical protein compare
BWI76_RS19405 -1.0 -2.2 LysR family transcriptional regulator compare


Specific Phenotypes

For 7 genes in this experiment

For nitrogen source L-Proline in Klebsiella michiganensis M5al

For nitrogen source L-Proline across organisms