Experiment set6IT012 for Methanococcus maripaludis S2

Compare to:

formate McAA thiamine dropout

200 most important genes:

  gene name fitness t score description  
MMP_RS01020 -5.8 -1.5 3 4-dihydroxy-2-butanone-4-phosphate synthase compare
MMP_RS06355 -5.1 -5.4 molybdenum cofactor biosynthesis protein MoaE compare
MMP_RS01175 -4.8 -9.1 triphosphoribosyl-dephospho-CoA synthase compare
MMP_RS06975 -4.7 -2.9 sulfide-dependent adenosine diphosphate thiazole synthase compare
MMP_RS06680 -4.3 -19.0 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS06700 -4.3 -19.4 hypothetical protein compare
MMP_RS06685 -4.2 -18.5 formate dehydrogenase H subunit alpha selenocysteine-containing compare
MMP_RS06350 -4.1 -10.8 HesA/MoeB/ThiF family protein compare
MMP_RS05515 -4.0 -11.4 cyclic pyranopterin monophosphate synthase MoaC compare
MMP_RS06345 -3.9 -17.9 formate dehydrogenase accessory sulfurtransferase FdhD compare
MMP_RS01985 -3.7 -11.0 F420-dependent methylenetetrahydromethanopterin dehydrogenase compare
MMP_RS03015 -3.7 -14.3 GTP 3' 8-cyclase MoaA compare
MMP_RS07635 -3.6 -11.8 MogA/MoaB family molybdenum cofactor biosynthesis protein compare
MMP_RS04890 -3.6 -1.3 adenylyltransferase/cytidyltransferase family protein compare
MMP_RS02010 -3.4 -11.2 PHP domain-containing protein compare
MMP_RS07735 -3.4 -1.7 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha compare
MMP_RS07005 -3.3 -1.1 4Fe-4S binding protein compare
MMP_RS06715 -3.3 -21.5 cache domain-containing protein compare
MMP_RS08820 -3.2 -7.5 hypothetical protein compare
MMP_RS08460 -3.1 -3.4 proteasome-activating nucleotidase compare
MMP_RS06720 -3.1 -12.2 response regulator transcription factor compare
MMP_RS00040 -3.1 -4.9 TIGR03576 family pyridoxal phosphate-dependent enzyme compare
MMP_RS01980 -3.0 -20.6 trimeric intracellular cation channel family protein compare
MMP_RS06295 -2.9 -9.5 methanogenesis marker 14 protein compare
MMP_RS01005 -2.7 -2.3 riboflavin synthase compare
MMP_RS03315 -2.7 -1.4 ferrous iron transport protein A compare
MMP_RS04775 -2.7 -4.9 adenosylhomocysteinase compare
MMP_RS08745 -2.7 -8.4 CDP-2 3-bis-(O-geranylgeranyl)-sn-glycerol synthase compare
MMP_RS06730 -2.7 -2.5 phosphopantothenate/pantothenate synthetase compare
MMP_RS03475 -2.7 -1.1 hypothetical protein compare
MMP_RS04900 -2.6 -19.9 hypothetical protein compare
MMP_RS07765 -2.6 -11.3 sodium:alanine symporter family protein compare
MMP_RS08635 -2.5 -3.4 UbiA family prenyltransferase compare
MMP_RS07845 -2.5 -4.6 LL-diaminopimelate aminotransferase compare
MMP_RS04605 -2.5 -6.4 cobalt ECF transporter T component CbiQ compare
MMP_RS06285 -2.5 -3.5 precorrin-6Y C5 15-methyltransferase (decarboxylating) subunit CbiT compare
MMP_RS02195 -2.5 -3.9 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase compare
MMP_RS01500 -2.4 -3.6 CBS domain-containing protein compare
MMP_RS01220 -2.4 -11.6 hypothetical protein compare
MMP_RS03600 -2.4 -3.4 triose-phosphate isomerase compare
MMP_RS07445 -2.4 -6.6 helix-turn-helix domain-containing protein compare
MMP_RS06705 -2.3 -10.3 formate/nitrite transporter family protein compare
MMP_RS01795 -2.3 -3.0 methanogenesis marker 6 protein compare
MMP_RS02340 -2.2 -3.6 DNA-directed RNA polymerase subunit E'' compare
MMP_RS07730 -2.2 -3.1 pyruvate synthase subunit beta compare
MMP_RS07605 -2.2 -4.2 diadenylate cyclase compare
MMP_RS07525 -2.2 -10.7 4Fe-4S binding protein compare
MMP_RS06885 -2.2 -3.7 50S ribosome-binding GTPase compare
MMP_RS05550 -2.2 -1.2 cation:proton antiporter compare
MMP_RS08210 -2.2 -3.2 phosphatidylglycerophosphatase A compare
MMP_RS00305 -2.2 -2.8 phosphoribosyl-ATP diphosphatase compare
MMP_RS04615 -2.2 -7.6 PDGLE domain-containing protein compare
MMP_RS04585 -2.2 -10.6 AIR synthase related protein compare
MMP_RS08720 -2.2 -2.7 4Fe-4S binding protein compare
MMP_RS02280 -2.1 -1.5 DUF211 domain-containing protein compare
MMP_RS03640 -2.1 -5.3 archaeal proteasome endopeptidase complex subunit beta compare
MMP_RS08715 -2.1 -2.1 formylmethanofuran dehydrogenase subunit B compare
MMP_RS03025 -2.1 -6.5 molybdenum cofactor guanylyltransferase compare
MMP_RS00300 -2.1 -1.3 6 7-dimethyl-8-ribityllumazine synthase compare
MMP_RS07600 -2.0 -5.1 Ni-sirohydrochlorin a c-diamide synthase compare
MMP_RS01800 -2.0 -6.2 TIGR00303 family protein compare
MMP_RS02355 -2.0 -4.6 30S ribosomal protein S27ae compare
MMP_RS03960 -2.0 -1.6 hypothetical protein compare
MMP_RS01325 -2.0 -3.7 dihydroneopterin aldolase family protein compare
MMP_RS08645 -1.9 -10.0 UPF0179 family protein compare
MMP_RS06400 -1.9 -2.0 4Fe-4S binding protein compare
MMP_RS00895 -1.9 -4.8 hypothetical protein compare
MMP_RS06270 -1.9 -8.6 TIGR00300 family protein compare
MMP_RS01265 -1.9 -2.6 hypothetical protein compare
MMP_RS06105 -1.9 -7.1 hydrogenase maturation peptidase HycI compare
MMP_RS06475 -1.9 -5.1 FAD-dependent oxidoreductase compare
MMP_RS00685 -1.9 -4.4 2-phospho-L-lactate guanylyltransferase compare
MMP_RS03435 -1.8 -2.0 ketol-acid reductoisomerase compare
MMP_RS02165 -1.8 -7.6 tRNA-dihydrouridine synthase compare
MMP_RS05555 -1.8 -1.9 DUF4040 domain-containing protein compare
MMP_RS08790 -1.8 -2.9 translation initiation factor IF-2 subunit alpha compare
MMP_RS00115 -1.7 -11.6 radical SAM protein compare
MMP_RS01545 -1.7 -1.6 CBS domain-containing protein compare
MMP_RS04620 -1.7 -8.6 cobalt transporter CbiM compare
MMP_RS07545 -1.7 -1.9 HTH domain-containing protein compare
MMP_RS03580 -1.7 -5.0 signal recognition particle-docking protein FtsY compare
MMP_RS07630 -1.7 -1.9 ATP-binding cassette domain-containing protein compare
MMP_RS00695 -1.6 -1.1 biotin--[acetyl-CoA-carboxylase] ligase compare
MMP_RS08595 -1.6 -1.7 flagellar protein C compare
MMP_RS04685 -1.6 -3.1 DUF126 domain-containing protein compare
MMP_RS01225 -1.6 -5.8 DUF5379 domain-containing protein compare
MMP_RS02240 -1.6 -4.0 methanogenesis marker 7 protein compare
MMP_RS04500 -1.6 -11.3 adenosylmethionine--8-amino-7-oxononanoate transaminase compare
MMP_RS01380 -1.6 -4.5 PHP domain-containing protein compare
MMP_RS00295 -1.6 -3.4 gamma carbonic anhydrase family protein compare
MMP_RS06370 -1.6 -5.1 biotin synthase BioB compare
MMP_RS04780 -1.6 -3.9 ribonuclease P compare
MMP_RS02345 -1.6 -3.4 GTP-dependent dephospho-CoA kinase family protein compare
MMP_RS07380 -1.6 -2.3 transcription elongation factor Spt5 compare
MMP_RS05510 -1.5 -6.4 Rrf2 family transcriptional regulator compare
MMP_RS06625 -1.5 -2.6 DNA primase compare
MMP_RS06925 -1.5 -3.6 ribonuclease VapC4 compare
MMP_RS00620 -1.5 -6.2 4Fe-4S binding protein compare
MMP_RS05765 -1.5 -7.3 M42 family metallopeptidase compare
MMP_RS02235 -1.4 -7.6 CBS domain-containing protein compare
MMP_RS08100 -1.4 -7.4 8-amino-7-oxononanoate synthase compare
MMP_RS01700 -1.4 -1.3 dihydroxy-acid dehydratase compare
MMP_RS08095 -1.4 -7.0 dethiobiotin synthase compare
MMP_RS06200 -1.4 -9.2 M24 family metallopeptidase compare
MMP_RS08435 -1.4 -2.5 Era-like GTP-binding protein compare
MMP_RS02800 -1.4 -4.5 nucleotidyltransferase domain-containing protein compare
MMP_RS05430 -1.4 -4.8 TIGR00288 family NYN domain-containing protein compare
MMP_RS06930 -1.4 -8.2 MBL fold metallo-hydrolase compare
MMP_RS05245 -1.4 -9.2 archaeosine biosynthesis radical SAM protein RaSEA compare
MMP_RS00110 -1.3 -3.1 hypothetical protein compare
MMP_RS03400 -1.3 -3.6 archease compare
MMP_RS02175 -1.3 -1.0 DUF1611 domain-containing protein compare
MMP_RS01755 -1.3 -1.2 DUF2097 domain-containing protein compare
MMP_RS02900 -1.3 -0.7 imidazoleglycerol-phosphate dehydratase HisB compare
MMP_RS04870 -1.3 -5.2 TIGR02253 family HAD-type hydrolase compare
MMP_RS08300 -1.3 -1.4 metal-sulfur cluster assembly factor compare
MMP_RS05540 -1.3 -3.9 hypothetical protein compare
MMP_RS07575 -1.3 -2.5 RNA ligase partner protein compare
MMP_RS08105 -1.3 -6.4 6-carboxyhexanoate--CoA ligase compare
MMP_RS07645 -1.2 -4.8 aldehyde dehydrogenase family protein compare
MMP_RS06020 -1.2 -4.3 archaeoflavoprotein AfpA compare
MMP_RS06230 -1.2 -2.5 helix-turn-helix domain-containing protein compare
MMP_RS05920 -1.2 -0.7 50S ribosomal protein L37e compare
MMP_RS07755 -1.2 -1.4 DUF555 domain-containing protein compare
MMP_RS05815 -1.2 -1.4 NOL1/NOP2/sun family putative RNA methylase compare
MMP_RS07425 -1.2 -4.9 GTP-binding protein compare
MMP_RS00060 -1.2 -2.1 3-dehydroquinate synthase II compare
MMP_RS00555 -1.2 -5.1 MFS transporter compare
MMP_RS07365 -1.2 -7.9 2-phosphoglycerate kinase compare
MMP_RS01830 -1.1 -1.8 tRNA-Val compare
MMP_RS06865 -1.1 -1.4 HypC/HybG/HupF family hydrogenase formation chaperone compare
MMP_RS06175 -1.1 -6.0 winged helix-turn-helix transcriptional regulator compare
MMP_RS01385 -1.1 -0.7 imidazole glycerol phosphate synthase subunit HisH compare
MMP_RS08615 -1.1 -2.4 flagellar protein G compare
MMP_RS02190 -1.1 -2.4 sulfopyruvate decarboxylase subunit alpha compare
MMP_RS03035 -1.1 -3.1 4-hydroxy-tetrahydrodipicolinate synthase compare
MMP_RS06895 -1.1 -1.4 selenocysteine-specific translation elongation factor compare
MMP_RS00035 -1.0 -7.0 DUF2098 family protein compare
MMP_RS06215 -1.0 -3.3 30S ribosomal protein S6e compare
MMP_RS03590 -1.0 -3.4 METTL5 family protein compare
MMP_RS03465 -1.0 -1.4 adenine phosphoribosyltransferase compare
MMP_RS06340 -1.0 -4.6 phosphoadenosine phosphosulfate reductase family protein compare
MMP_RS08200 -1.0 -8.0 archaeosine synthase subunit alpha compare
MMP_RS02135 -1.0 -3.3 DUF5612 domain-containing protein compare
MMP_RS03445 -1.0 -1.0 methanogenesis marker 17 protein compare
MMP_RS01610 -1.0 -2.3 hypothetical protein compare
MMP_RS00475 -1.0 -4.9 Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal domain compare
MMP_RS08650 -0.9 -2.7 glutamine--fructose-6-phosphate transaminase (isomerizing) compare
MMP_RS07775 -0.9 -2.9 alanine dehydrogenase compare
MMP_RS07195 -0.9 -4.9 M20 family metallo-hydrolase compare
MMP_RS07685 -0.9 -3.9 TIGR01212 family radical SAM protein compare
MMP_RS05440 -0.9 -5.3 winged helix-turn-helix transcriptional regulator compare
MMP_RS02145 -0.9 -3.6 winged helix-turn-helix transcriptional regulator compare
MMP_RS04710 -0.9 -1.4 hypothetical protein compare
MMP_RS08165 -0.8 -1.2 phosphoglycerate dehydrogenase compare
MMP_RS01085 -0.8 -1.5 hypothetical protein compare
MMP_RS06915 -0.8 -3.4 metallophosphoesterase compare
MMP_RS00915 -0.8 -3.6 DUF116 domain-containing protein compare
MMP_RS06940 -0.8 -1.9 polyprenyl diphosphate synthase compare
MMP_RS03095 -0.8 -3.4 diphthine synthase compare
MMP_RS07180 -0.8 -4.0 DEAD/DEAH box helicase compare
MMP_RS00290 -0.8 -4.5 hypothetical protein compare
MMP_RS05500 -0.8 -5.0 2-isopropylmalate synthase compare
MMP_RS01365 -0.8 -3.1 archaeal proteasome endopeptidase complex subunit alpha compare
MMP_RS07200 -0.8 -3.6 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase compare
MMP_RS01250 -0.8 -2.2 tRNA (guanine(26)-N(2))-dimethyltransferase compare
MMP_RS03340 -0.7 -0.8 ABC transporter ATP-binding protein compare
MMP_RS00720 -0.7 -3.7 metal-dependent hydrolase compare
MMP_RS09035 -0.7 -1.9 hypothetical protein compare
MMP_RS06920 -0.7 -5.1 AAA family ATPase compare
MMP_RS08690 -0.7 -3.3 RNA-guided pseudouridylation complex pseudouridine synthase subunit Cbf5 compare
MMP_RS07710 -0.7 -3.2 cell division protein FtsZ compare
MMP_RS03485 -0.7 -2.2 TIGR00267 family protein compare
MMP_RS05845 -0.7 -1.6 tRNA-intron lyase compare
MMP_RS02405 -0.7 -3.3 hypothetical protein compare
MMP_RS08240 -0.7 -3.1 methanogenesis marker 16 metalloprotein compare
MMP_RS05285 -0.7 -2.8 MMPL family transporter compare
MMP_RS07385 -0.7 -1.2 protein translocase SEC61 complex subunit gamma compare
MMP_RS05875 -0.7 -1.9 hydroxyethylthiazole kinase compare
MMP_RS00515 -0.7 -0.6 DUF655 domain-containing protein compare
MMP_RS07435 -0.7 -1.0 GMP synthase subunit A compare
MMP_RS06590 -0.6 -1.9 GNAT family N-acetyltransferase compare
MMP_RS07790 -0.6 -3.2 segregation/condensation protein A compare
MMP_RS01745 -0.6 -2.6 AMP phosphorylase compare
MMP_RS07860 -0.6 -0.7 hypothetical protein compare
MMP_RS03700 -0.6 -3.3 sodium:proton antiporter compare
MMP_RS03080 -0.6 -1.6 universal stress protein compare
MMP_RS07190 -0.6 -2.4 chromosome segregation protein SMC compare
MMP_RS02170 -0.6 -2.8 CBS domain-containing protein compare
MMP_RS02985 -0.6 -2.1 hypothetical protein compare
MMP_RS00310 -0.6 -4.2 CBS domain-containing protein compare
MMP_RS06120 -0.6 -1.1 UPF0147 family protein compare
MMP_RS06630 -0.6 -0.7 UPF0058 family protein compare
MMP_RS01840 -0.6 -3.1 TIGR00289 family protein compare
MMP_RS01600 -0.6 -1.2 50S ribosomal protein L15e compare
MMP_RS01045 -0.6 -3.3 diphthamide biosynthesis enzyme Dph2 compare
MMP_RS04955 -0.5 -2.1 DNA topoisomerase I compare
MMP_RS06495 -0.5 -1.5 YkgJ family cysteine cluster protein compare
MMP_RS05055 -0.5 -3.7 DUF166 domain-containing protein compare
MMP_RS07535 -0.5 -3.2 4Fe-4S binding protein compare


Specific Phenotypes

None in this experiment

For Methanococcus maripaludis S2 in nutrient t1 experiments