Experiment set6IT012 for Klebsiella michiganensis M5al

Compare to:

L-Proline nitrogen source

200 most important genes:

  gene name fitness t score description  
BWI76_RS18930 -9.4 -5.8 histidinol-phosphate transaminase compare
BWI76_RS20350 -7.9 -7.7 amidophosphoribosyltransferase compare
BWI76_RS02995 -7.6 -7.5 aspartate carbamoyltransferase compare
BWI76_RS04470 -7.5 -7.3 carbamoyl phosphate synthase large subunit compare
BWI76_RS01655 -7.3 -8.7 homoserine O-succinyltransferase compare
BWI76_RS11850 -7.3 -10.0 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase compare
BWI76_RS18940 -7.3 -5.0 imidazole glycerol phosphate synthase subunit HisH compare
BWI76_RS18950 -7.0 -6.4 imidazole glycerol phosphate synthase cyclase subunit compare
BWI76_RS20355 -6.9 -4.7 colicin V production protein compare
BWI76_RS04675 -6.9 -6.7 3-isopropylmalate dehydrogenase compare
BWI76_RS00855 -6.8 -8.2 argininosuccinate lyase compare
BWI76_RS04250 -6.8 -6.4 homoserine kinase compare
BWI76_RS23920 -6.6 -6.3 D-3-phosphoglycerate dehydrogenase compare
BWI76_RS00805 -6.2 -4.8 5,10-methylenetetrahydrofolate reductase compare
BWI76_RS24285 -6.1 -8.1 cystathionine beta-lyase compare
BWI76_RS27385 -6.0 -7.2 orotate phosphoribosyltransferase compare
BWI76_RS04245 -6.0 -14.6 bifunctional aspartate kinase/homoserine dehydrogenase I compare
BWI76_RS00990 -6.0 -10.0 ketol-acid reductoisomerase compare
BWI76_RS18925 -6.0 -8.2 histidinol dehydrogenase compare
BWI76_RS21475 -5.9 -5.0 bifunctional chorismate mutase/prephenate dehydrogenase compare
BWI76_RS04685 -5.8 -11.8 putative leucine operon leader peptide compare
BWI76_RS18920 -5.7 -4.7 ATP phosphoribosyltransferase compare
BWI76_RS04645 -5.7 -8.1 3-dehydroquinase compare
BWI76_RS04160 -5.6 -7.1 phosphoserine phosphatase compare
BWI76_RS21465 -5.6 -6.4 bifunctional chorismate mutase/prephenate dehydratase compare
BWI76_RS18935 -5.4 -6.6 bifunctional imidazole glycerol-phosphate dehydratase/histidinol phosphatase compare
BWI76_RS21265 -5.4 -13.0 phosphoribosylformylglycinamidine synthase compare
BWI76_RS04255 -5.3 -11.4 threonine synthase compare
BWI76_RS11840 -5.3 -4.1 tryptophan synthase subunit alpha compare
BWI76_RS04665 -5.3 -19.3 3-isopropylmalate dehydratase small subunit compare
BWI76_RS00785 -5.3 -6.7 cystathionine gamma-synthase compare
BWI76_RS20895 -5.2 -5.8 phosphoribosylaminoimidazolesuccinocarboxamide synthase compare
BWI76_RS00385 -5.2 -10.9 nitrogen assimilation regulatory protein compare
BWI76_RS00980 -5.2 -9.6 PLP-dependent threonine dehydratase compare
BWI76_RS25115 -5.2 -9.4 argininosuccinate synthase compare
BWI76_RS22755 -5.1 -5.8 phosphoadenosine phosphosulfate reductase compare
BWI76_RS09755 -5.1 -7.7 phosphoserine transaminase compare
BWI76_RS01615 -5.1 -10.2 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase compare
BWI76_RS00975 -5.0 -9.1 dihydroxy-acid dehydratase compare
BWI76_RS11845 -4.9 -1.9 tryptophan synthase subunit beta compare
BWI76_RS04670 -4.9 -9.6 3-isopropylmalate dehydratase large subunit compare
BWI76_RS03010 -4.9 -7.4 ornithine carbamoyltransferase compare
BWI76_RS00390 -4.8 -8.6 two-component system sensor histidine kinase NtrB compare
BWI76_RS09910 -4.8 -16.8 dihydroorotate dehydrogenase (quinone) compare
BWI76_RS09760 -4.7 -4.1 3-phosphoshikimate 1-carboxyvinyltransferase compare
BWI76_RS07070 -4.6 -7.4 5-(carboxyamino)imidazole ribonucleotide mutase compare
BWI76_RS11965 -4.6 -2.9 orotidine-5'-phosphate decarboxylase compare
BWI76_RS01350 -4.5 -1.7 NAD(P)H-flavin reductase compare
BWI76_RS11855 -4.5 -5.4 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase compare
BWI76_RS07065 -4.5 -6.5 5-(carboxyamino)imidazole ribonucleotide synthase compare
BWI76_RS11860 -4.4 -8.2 anthranilate synthase component I compare
BWI76_RS18955 -4.4 -5.3 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase compare
BWI76_RS23230 -4.4 -3.0 exodeoxyribonuclease V subunit beta compare
BWI76_RS19870 -4.2 -4.1 malate:quinone oxidoreductase compare
BWI76_RS08180 -4.2 -4.9 asparagine synthase B compare
BWI76_RS23360 -4.2 -4.1 diaminopimelate decarboxylase compare
BWI76_RS20965 -4.2 -3.3 phosphoribosylformylglycinamidine cyclo-ligase compare
BWI76_RS04465 -4.1 -3.4 carbamoyl-phosphate synthase small subunit compare
BWI76_RS09660 -4.1 -2.8 DNA translocase FtsK compare
BWI76_RS26085 -4.1 -2.8 3-dehydroquinate synthase compare
BWI76_RS00850 -4.0 -8.1 acetylglutamate kinase compare
BWI76_RS01210 -3.9 -2.4 tyrosine recombinase XerC compare
BWI76_RS04680 -3.9 -8.8 2-isopropylmalate synthase compare
BWI76_RS25645 -3.9 -8.1 shikimate dehydrogenase compare
BWI76_RS08395 -3.8 -2.8 succinate dehydrogenase cytochrome b556 large subunit compare
BWI76_RS22765 -3.8 -12.3 sulfite reductase subunit alpha compare
BWI76_RS22805 -3.8 -8.2 GTP diphosphokinase compare
BWI76_RS10990 -3.8 -4.6 dihydroorotase compare
BWI76_RS01610 -3.7 -5.0 phosphoribosylamine--glycine ligase compare
BWI76_RS00845 -3.7 -7.1 N-acetyl-gamma-glutamyl-phosphate reductase compare
BWI76_RS00345 -3.6 -5.0 protein disulfide oxidoreductase DsbA compare
BWI76_RS09645 -3.5 -1.8 thioredoxin-disulfide reductase compare
BWI76_RS04240 -3.5 -2.9 thr operon leader peptide compare
BWI76_RS23240 -3.5 -5.2 exonuclease V subunit gamma compare
BWI76_RS19010 -3.4 -4.6 polysaccharide pyruvyl transferase yvff compare
BWI76_RS05200 -3.3 -3.8 bifunctional uridylyltransferase/uridylyl-removing protein compare
BWI76_RS23365 -3.3 -7.8 LysR family transcriptional regulator compare
BWI76_RS22760 -3.2 -7.5 sulfite reductase subunit beta compare
BWI76_RS05015 -3.2 -3.2 transcriptional regulator compare
BWI76_RS08520 -3.1 -3.3 colicin transporter TolQ compare
BWI76_RS10795 -3.1 -7.4 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88); Proline dehydrogenase (EC 1.5.5.2) (from data) conserved
BWI76_RS27430 -3.1 -1.5 (p)ppGpp synthetase compare
BWI76_RS00400 -3.1 -2.2 glutamine synthetase compare
BWI76_RS22690 -2.9 -2.4 adenylyl-sulfate kinase compare
BWI76_RS08405 -2.8 -3.1 succinate dehydrogenase flavoprotein subunit compare
BWI76_RS02530 -2.7 -2.2 tRNA dimethylallyltransferase compare
BWI76_RS00965 -2.6 -1.6 acetolactate synthase 2 small subunit compare
BWI76_RS18630 -2.6 -8.3 nitrogen assimilation transcriptional regulator conserved
BWI76_RS23480 -2.6 -12.0 EAL domain-containing protein compare
BWI76_RS21370 -2.6 -2.8 ATP-dependent RNA helicase SrmB compare
BWI76_RS23885 -2.5 -2.1 2-octaprenylphenol hydroxylase compare
BWI76_RS25600 -2.5 -1.6 tRNA-Thr compare
BWI76_RS02330 -2.5 -10.0 aspartate ammonia-lyase compare
BWI76_RS08525 -2.5 -4.6 colicin transporter compare
BWI76_RS23220 -2.3 -7.1 amino-acid N-acetyltransferase compare
BWI76_RS15825 -2.3 -2.5 hypothetical protein compare
BWI76_RS27390 -2.3 -2.2 ribonuclease PH compare
BWI76_RS25065 -2.2 -3.6 polyribonucleotide nucleotidyltransferase compare
BWI76_RS13820 -2.1 -2.1 hypothetical protein compare
BWI76_RS11700 -2.1 -1.8 hypothetical protein compare
BWI76_RS20435 -2.1 -1.5 chorismate synthase compare
BWI76_RS05990 -2.1 -6.3 branched-chain amino acid ABC transporter permease compare
BWI76_RS17975 -2.1 -5.8 tail-specific protease compare
BWI76_RS17980 -2.0 -4.0 RNA chaperone ProQ compare
BWI76_RS17720 -2.0 -1.6 muramoyltetrapeptide carboxypeptidase compare
BWI76_RS25060 -2.0 -4.4 lipoprotein NlpI compare
BWI76_RS09970 -2.0 -5.1 porin OmpA compare
BWI76_RS12090 -2.0 -2.0 HNH endonuclease compare
BWI76_RS19685 -2.0 -6.6 lysine transporter compare
BWI76_RS05120 -1.9 -8.5 bifunctional glycosyl transferase/transpeptidase compare
BWI76_RS25285 -1.9 -1.4 HPr family phosphocarrier protein compare
BWI76_RS27440 -1.9 -3.7 DNA helicase RecG compare
BWI76_RS20640 -1.9 -4.5 cysteine synthase A compare
BWI76_RS25355 -1.9 -8.5 cell division protein ZapE compare
BWI76_RS21480 -1.9 -4.4 phospho-2-dehydro-3-deoxyheptonate aldolase compare
BWI76_RS16965 -1.8 -5.2 murein lipoprotein compare
BWI76_RS00240 -1.8 -2.3 FMN-binding protein MioC compare
BWI76_RS21070 -1.8 -1.9 outer membrane protein assembly factor BamB compare
BWI76_RS08530 -1.7 -2.6 protein TolA compare
BWI76_RS02735 -1.6 -4.0 3'(2'),5'-bisphosphate nucleotidase CysQ compare
BWI76_RS04715 -1.6 -2.0 division/cell wall cluster transcriptional repressor MraZ compare
BWI76_RS00985 -1.6 -4.4 transcriptional regulator IlvY compare
BWI76_RS06015 -1.6 -1.7 hypothetical protein compare
BWI76_RS20050 -1.6 -1.8 hypothetical protein compare
BWI76_RS15835 -1.6 -1.2 hypothetical protein compare
BWI76_RS09195 -1.6 -1.9 N-acetyltransferase compare
BWI76_RS06535 -1.6 -3.9 endopeptidase La compare
BWI76_RS25335 -1.5 -2.5 stringent starvation protein A compare
BWI76_RS23265 -1.5 -3.1 hypothetical protein compare
BWI76_RS16485 -1.5 -1.4 ribonuclease T compare
BWI76_RS20490 -1.5 -2.7 hypothetical protein compare
BWI76_RS01185 -1.5 -2.6 adenylate cyclase compare
BWI76_RS26055 -1.4 -4.3 siroheme synthase compare
BWI76_RS13595 -1.4 -4.4 transcriptional regulator compare
BWI76_RS16895 -1.4 -1.6 3-(3-hydroxy-phenyl)propionate transporter MhpT compare
BWI76_RS05995 -1.4 -5.4 branched-chain amino acid ABC transporter substrate-binding protein compare
BWI76_RS14490 -1.4 -2.6 ABC transporter substrate-binding protein compare
BWI76_RS05980 -1.4 -4.7 ABC transporter ATP-binding protein compare
BWI76_RS05985 -1.3 -4.9 branched-chain amino acid ABC transporter permease compare
BWI76_RS03045 -1.3 -1.1 hypothetical protein compare
BWI76_RS01070 -1.3 -4.2 thiol reductase thioredoxin compare
BWI76_RS05975 -1.3 -2.7 ABC transporter ATP-binding protein compare
BWI76_RS17345 -1.3 -2.3 nitrate/nitrite two-component system sensor histidine kinase NarX compare
BWI76_RS06485 -1.3 -2.1 cytochrome o ubiquinol oxidase subunit III compare
BWI76_RS12145 -1.3 -2.0 hypothetical protein compare
BWI76_RS15810 -1.3 -4.3 hypothetical protein compare
BWI76_RS11235 -1.3 -1.1 hypothetical protein compare
BWI76_RS20970 -1.2 -1.4 phosphoribosylglycinamide formyltransferase compare
BWI76_RS13435 -1.2 -1.5 hypothetical protein compare
BWI76_RS04845 -1.2 -4.8 nicotinate-nucleotide pyrophosphorylase compare
BWI76_RS06530 -1.2 -3.4 ATP-dependent Clp protease ATP-binding subunit ClpX compare
BWI76_RS09255 -1.2 -2.0 hypothetical protein compare
BWI76_RS16195 -1.2 -1.6 hypothetical protein compare
BWI76_RS02180 -1.2 -1.2 hypothetical protein compare
BWI76_RS21565 -1.2 -1.2 outer membrane protein assembly factor BamE compare
BWI76_RS13330 -1.2 -1.6 tellurite resistance methyltransferase TehB compare
BWI76_RS22695 -1.2 -3.1 sulfate adenylyltransferase compare
BWI76_RS20690 -1.2 -5.4 sulfate ABC transporter ATP-binding protein compare
BWI76_RS20230 -1.2 -1.6 hypothetical protein compare
BWI76_RS24945 -1.1 -1.1 glutamine amidotransferase compare
BWI76_RS16210 -1.1 -1.4 hypothetical protein compare
BWI76_RS25480 -1.1 -2.9 ribonuclease E/G compare
BWI76_RS26890 -1.1 -1.2 hypothetical protein compare
BWI76_RS21580 -1.1 -1.1 SsrA-binding protein compare
BWI76_RS20090 -1.1 -3.1 ribonuclease Z compare
BWI76_RS20700 -1.1 -2.9 sulfate/thiosulfate transporter subunit compare
BWI76_RS08390 -1.1 -1.5 hypothetical protein compare
BWI76_RS10755 -1.1 -1.1 pyrimidine utilization flavin reductase protein F compare
BWI76_RS26455 -1.1 -3.6 4-amino-4-deoxy-L-arabinose-phospho-UDP flippase compare
BWI76_RS02410 -1.1 -1.7 EF-P beta-lysylation protein EpmB compare
BWI76_RS04530 -1.1 -1.7 peptidylprolyl isomerase SurA compare
BWI76_RS11980 -1.1 -1.2 DeoR family transcriptional regulator compare
BWI76_RS04955 -1.1 -1.2 hypoxanthine phosphoribosyltransferase compare
BWI76_RS21115 -1.1 -2.2 3-mercaptopyruvate sulfurtransferase compare
BWI76_RS20695 -1.1 -3.6 sulfate/thiosulfate transporter permease subunit compare
BWI76_RS15990 -1.0 -4.2 serine protease compare
BWI76_RS06765 -1.0 -1.5 transcriptional regulator compare
BWI76_RS24900 -1.0 -1.5 DeoR family transcriptional regulator compare
BWI76_RS24485 -1.0 -1.7 bifunctional dihydroneopterin aldolase/7,8-dihydroneopterin epimerase compare
BWI76_RS24100 -1.0 -1.3 YggS family pyridoxal phosphate enzyme compare
BWI76_RS10835 -1.0 -1.2 hypothetical protein compare
BWI76_RS21075 -1.0 -1.2 membrane protein compare
BWI76_RS14625 -1.0 -1.0 protein TolA compare
BWI76_RS01115 -1.0 -2.5 dTDP-4-amino-4,6-dideoxygalactose transaminase compare
BWI76_RS04570 -1.0 -5.0 RNA polymerase-associated protein RapA compare
BWI76_RS07115 -1.0 -3.5 hypothetical protein compare
BWI76_RS14670 -0.9 -2.0 hypothetical protein compare
BWI76_RS15840 -0.9 -1.9 prophage protein compare
BWI76_RS16935 -0.9 -1.2 shikimate dehydrogenase compare
BWI76_RS06000 -0.9 -6.9 ethanolamine ammonia-lyase small subunit compare
BWI76_RS21095 -0.9 -2.8 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN compare
BWI76_RS15770 -0.9 -4.5 hypothetical protein compare
BWI76_RS22700 -0.9 -3.8 sulfate adenylyltransferase subunit 2 compare
BWI76_RS11105 -0.9 -2.0 aminodeoxychorismate lyase compare
BWI76_RS11170 -0.9 -1.0 hypothetical protein compare
BWI76_RS15410 -0.9 -2.3 N-acetyltransferase compare
BWI76_RS20000 -0.9 -1.5 competence/damage-inducible protein A compare
BWI76_RS12790 -0.9 -0.9 lactate dehydrogenase compare
BWI76_RS11040 -0.9 -2.7 ribonuclease E compare
BWI76_RS11430 -0.9 -0.9 lipoprotein compare


Specific Phenotypes

For 7 genes in this experiment

For nitrogen source L-Proline in Klebsiella michiganensis M5al

For nitrogen source L-Proline across organisms