Experiment set6H35 for Pseudomonas stutzeri RCH2

Compare to:

RCH2 defined media with Cisplatin 0.0002 mg/ml

200 most important genes:

  gene name fitness t score description  
Psest_1037 -6.2 -4.3 acetolactate synthase, small subunit compare
Psest_3648 -6.0 -8.2 anthranilate phosphoribosyltransferase compare
Psest_0279 -6.0 -4.1 methionine biosynthesis protein MetW compare
Psest_3650 -5.9 -9.8 anthranilate synthase component I, non-proteobacterial lineages compare
Psest_0153 -5.8 -9.7 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit compare
Psest_3647 -5.8 -8.0 Indole-3-glycerol phosphate synthase compare
Psest_0152 -5.7 -3.9 Imidazoleglycerol-phosphate dehydratase compare
Psest_2545 -5.5 -5.4 recombination protein RecR compare
Psest_2584 -5.5 -7.5 Phosphoribosylanthranilate isomerase compare
Psest_0326 -5.5 -15.0 Taurine catabolism dioxygenase TauD, TfdA family. compare
Psest_0155 -5.4 -3.7 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16) (from data) compare
Psest_1496 -5.4 -3.7 Holliday junction DNA helicase, RuvA subunit compare
Psest_2259 -5.4 -14.8 excinuclease ABC, C subunit conserved
Psest_3226 -5.1 -2.3 Predicted membrane protein compare
Psest_3866 -5.1 -17.1 threonine ammonia-lyase, biosynthetic, long form compare
Psest_0325 -5.0 -15.9 Putative threonine efflux protein compare
Psest_2578 -5.0 -14.5 O-succinylhomoserine sulfhydrylase compare
Psest_0062 -5.0 -7.6 tryptophan synthase, alpha subunit compare
Psest_2591 -5.0 -4.8 3-isopropylmalate dehydratase, large subunit compare
Psest_1473 -5.0 -11.3 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent compare
Psest_2579 -4.9 -8.2 amidophosphoribosyltransferase compare
Psest_3384 -4.8 -10.2 glutamate 5-kinase compare
Psest_0508 -4.8 -10.2 gamma-glutamyl phosphate reductase compare
Psest_3576 -4.7 -24.7 excinuclease ABC, A subunit conserved
Psest_3299 -4.7 -14.5 ATP phosphoribosyltransferase (EC 2.4.2.17) (from data) compare
Psest_3090 -4.7 -7.1 DNA repair protein RecO conserved
Psest_3649 -4.7 -11.6 glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase compare
Psest_1509 -4.7 -13.4 quinolinate synthetase complex, A subunit compare
Psest_0004 -4.6 -16.6 recF protein conserved
Psest_3944 -4.6 -3.1 phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31) (from data) compare
Psest_3864 -4.5 -15.5 Histidinol-phosphatase (EC:3.1.3.15) (from data) compare
Psest_3298 -4.4 -12.1 histidinol dehydrogenase compare
Psest_0280 -4.4 -17.0 homoserine O-acetyltransferase compare
Psest_0687 -4.3 -11.0 ATP phosphoribosyltransferase, regulatory subunit compare
Psest_1295 -4.2 -10.9 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_0063 -4.2 -5.8 tryptophan synthase, beta subunit compare
Psest_4084 -4.2 -18.2 oxaloacetate decarboxylase alpha subunit compare
Psest_2872 -4.1 -2.8 protein RecA compare
Psest_2590 -4.1 -2.6 3-isopropylmalate dehydratase, small subunit compare
Psest_1474 -4.1 -4.8 phosphoribosylaminoimidazole synthetase compare
Psest_0718 -4.0 -6.1 nicotinate-nucleotide pyrophosphorylase compare
Psest_1013 -4.0 -3.9 phosphoribosylamine--glycine ligase compare
Psest_4085 -4.0 -19.0 Biotin carboxylase compare
Psest_3297 -3.9 -13.7 histidinol-phosphate aminotransferase (EC 2.6.1.9) (from data) compare
Psest_0411 -3.9 -12.3 biotin synthetase compare
Psest_2589 -3.8 -13.8 3-isopropylmalate dehydrogenase compare
Psest_0953 -3.8 -15.4 iron-sulfur cluster-binding protein compare
Psest_0952 -3.7 -6.1 Uncharacterized conserved protein compare
Psest_0954 -3.7 -11.9 Fe-S oxidoreductase compare
Psest_1296 -3.7 -13.0 excinuclease ABC, B subunit conserved
Psest_3159 -3.7 -13.2 phosphoribosylformylglycinamidine synthase, single chain form compare
Psest_1115 -3.6 -6.7 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 compare
Psest_3818 -3.4 -9.8 endoribonuclease L-PSP, putative compare
Psest_1452 -3.4 -9.1 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase compare
Psest_0413 -3.4 -10.6 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) compare
Psest_1772 -3.3 -7.3 Aspartate/tyrosine/aromatic aminotransferase compare
Psest_3129 -3.2 -3.0 tyrosine recombinase XerD compare
Psest_4086 -3.2 -14.5 Transcriptional regulator compare
Psest_3810 -3.2 -3.0 orotate phosphoribosyltransferase compare
Psest_2088 -3.2 -5.1 Uncharacterized protein conserved in bacteria compare
Psest_1947 -3.2 -2.2 dihydroorotate dehydrogenase, subfamily 2 compare
Psest_0489 -3.1 -2.9 phosphoserine phosphatase SerB compare
Psest_3456 -3.1 -2.8 RNA polymerase sigma factor, sigma-70 family compare
Psest_0313 -3.0 -6.9 5,10-methylenetetrahydrofolate reductase, prokaryotic form compare
Psest_3123 -3.0 -6.5 dihydroorotase, homodimeric type compare
Psest_0951 -3.0 -15.1 FAD/FMN-containing dehydrogenases compare
Psest_3766 -2.9 -3.8 Uncharacterized protein conserved in bacteria compare
Psest_0306 -2.9 -17.6 adenosylmethionine-8-amino-7-oxononanoate transaminase compare
Psest_2329 -2.9 -18.5 Transcriptional regulator compare
Psest_3721 -2.9 -9.8 Malic enzyme compare
Psest_3767 -2.9 -3.9 tyrosine recombinase XerC compare
Psest_0412 -2.8 -11.8 8-amino-7-oxononanoate synthase compare
Psest_0415 -2.7 -7.0 dethiobiotin synthase compare
Psest_2104 -2.7 -5.2 IscR-regulated protein YhgI compare
Psest_0955 -2.5 -6.6 D,L-lactate:H+ symporter (from data) compare
Psest_0477 -2.4 -14.3 thiamine biosynthesis protein ThiC compare
Psest_0536 -2.4 -2.8 thiamine-phosphate pyrophosphorylase compare
Psest_0267 -2.4 -13.3 Uncharacterized enzyme of thiazole biosynthesis compare
Psest_3943 -2.3 -4.5 Phosphoribosyl-AMP cyclohydrolase compare
Psest_0962 -2.2 -12.4 DNA repair protein RecN conserved
Psest_0266 -2.1 -7.3 thiamine biosynthesis protein ThiS compare
Psest_0867 -2.1 -1.8 hypothetical protein compare
Psest_3565 -2.1 -2.7 hypothetical protein compare
Psest_4303 -2.1 -1.2 HEAT repeat. compare
Psest_1686 -2.1 -5.8 fatty acid/phospholipid synthesis protein PlsX compare
Psest_4098 -2.0 -3.3 Superfamily I DNA and RNA helicases compare
Psest_3998 -2.0 -6.1 glutamate--cysteine ligase compare
Psest_0170 -2.0 -7.3 5,10-methenyltetrahydrofolate synthetase compare
Psest_0414 -2.0 -5.7 biotin biosynthesis protein BioC compare
Psest_2316 -1.9 -12.9 phosphoenolpyruvate synthase compare
Psest_2646 -1.8 -4.5 SOS regulatory protein LexA compare
Psest_4191 -1.8 -3.8 Transcriptional regulator compare
Psest_0442 -1.8 -7.1 ATPases of the AAA+ class compare
Psest_0207 -1.8 -3.2 hypothetical protein compare
Psest_2988 -1.7 -5.6 aspartate kinase, monofunctional class compare
Psest_2719 -1.7 -4.8 acetylornithine and succinylornithine aminotransferases/succinylornithine transaminase family compare
Psest_1704 -1.7 -3.5 Dehydrogenases (flavoproteins) compare
Psest_1012 -1.7 -6.0 Signal transduction histidine kinase compare
Psest_4298 -1.6 -1.2 Response regulator containing a CheY-like receiver domain and a GGDEF domain compare
Psest_4219 -1.6 -2.5 DNA polymerase I compare
Psest_1640 -1.6 -10.6 (p)ppGpp synthetase, RelA/SpoT family compare
Psest_3449 -1.5 -1.9 DJ-1 family protein compare
Psest_1653 -1.5 -10.9 transcription-repair coupling factor (mfd) conserved
Psest_1031 -1.5 -7.6 Uncharacterized protein conserved in bacteria compare
Psest_2285 -1.5 -4.8 ATP-dependent protease La compare
Psest_2810 -1.5 -4.3 5'/3'-nucleotidase SurE compare
Psest_2308 -1.4 -1.6 Predicted Fe-S protein compare
Psest_0498 -1.4 -2.0 ribosome small subunit-dependent GTPase A compare
Psest_1292 -1.4 -8.7 monothiol glutaredoxin, Grx4 family compare
Psest_4010 -1.4 -2.1 peroxiredoxin, OsmC subfamily compare
Psest_4363 -1.4 -8.1 ATPases involved in chromosome partitioning compare
Psest_0175 -1.4 -5.9 Xaa-Pro aminopeptidase compare
Psest_0722 -1.4 -7.2 Predicted ATPase compare
Psest_0537 -1.3 -1.9 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase compare
Psest_2809 -1.3 -3.0 protein-L-isoaspartate(D-aspartate) O-methyltransferase compare
Psest_1869 -1.3 -6.9 ATP-dependent DNA helicase RecQ conserved
Psest_1511 -1.2 -3.6 Predicted redox protein, regulator of disulfide bond formation compare
Psest_2946 -1.2 -3.7 septum site-determining protein MinD compare
Psest_0327 -1.2 -3.6 Transcriptional regulator compare
Psest_1979 -1.2 -2.6 Nucleotidyltransferase/DNA polymerase involved in DNA repair compare
Psest_1978 -1.1 -7.4 DNA-directed DNA polymerase III (polc) conserved
Psest_3678 -1.1 -4.6 acyl-phosphate glycerol 3-phosphate acyltransferase compare
Psest_1215 -1.1 -1.7 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) compare
Psest_1631 -1.1 -1.4 Uncharacterized conserved small protein compare
Psest_1544 -1.1 -6.0 single-stranded-DNA-specific exonuclease RecJ conserved
Psest_0209 -1.1 -0.6 membrane protein AbrB duplication compare
Psest_3178 -1.1 -2.9 formyltetrahydrofolate deformylase compare
Psest_0485 -1.1 -2.4 clan AA aspartic protease, TIGR02281 family compare
Psest_0193 -1.1 -1.1 conserved hypothetical protein compare
Psest_3012 -1.1 -1.9 cob(II)yrinic acid a,c-diamide reductase compare
Psest_0277 -1.1 -1.9 non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family compare
Psest_3908 -1.1 -1.2 Cytochrome c553 compare
Psest_1532 -1.1 -3.3 DNA recombination-dependent growth factor C compare
Psest_1366 -1.1 -1.3 hypothetical protein compare
Psest_3092 -1.0 -1.9 ribonuclease III, bacterial compare
Psest_2531 -1.0 -8.0 cytochrome c oxidase accessory protein FixG compare
Psest_0725 -1.0 -2.6 Negative regulator of beta-lactamase expression compare
Psest_4287 -1.0 -4.1 Predicted glutamine amidotransferases compare
Psest_4307 -1.0 -2.3 ABC-type Zn2+ transport system, periplasmic component/surface adhesin compare
Psest_0697 -1.0 -3.8 ribosomal protein L9 compare
Psest_3693 -1.0 -1.1 Glycosyltransferases involved in cell wall biogenesis compare
Psest_0296 -1.0 -6.4 glutathione synthetase, prokaryotic compare
Psest_3537 -1.0 -5.3 hypothetical protein compare
Psest_1920 -1.0 -1.4 Uncharacterized protein conserved in bacteria compare
Psest_2613 -1.0 -1.6 hypothetical protein compare
Psest_2864 -1.0 -4.3 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain compare
Psest_2945 -1.0 -1.3 septum site-determining protein MinC compare
Psest_3732 -1.0 -5.8 polyphosphate kinase 1 compare
Psest_1527 -0.9 -6.9 Na+/proline symporter compare
Psest_3177 -0.9 -1.6 hypothetical protein compare
Psest_2236 -0.9 -7.5 Rad3-related DNA helicases conserved
Psest_0292 -0.9 -1.8 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase compare
Psest_2325 -0.9 -6.3 alpha-L-glutamate ligase-related protein compare
Psest_0060 -0.9 -1.6 Predicted Fe-S protein compare
Psest_3338 -0.9 -1.3 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain compare
Psest_3637 -0.9 -1.9 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases compare
Psest_2532 -0.9 -2.9 Uncharacterized protein conserved in bacteria compare
Psest_0719 -0.9 -5.0 Uncharacterized protein conserved in bacteria compare
Psest_4310 -0.9 -1.2 ABC-type Mn2+/Zn2+ transport systems, permease components compare
Psest_2892 -0.9 -1.8 Transcriptional regulator compare
Psest_2001 -0.9 -1.6 2-phosphoglycolate phosphatase, prokaryotic compare
Psest_0284 -0.9 -6.3 pyridoxal phosphate enzyme, YggS family compare
Psest_0225 -0.8 -1.2 Predicted permease, DMT superfamily compare
Psest_1235 -0.8 -3.9 Leucyl aminopeptidase compare
Psest_3101 -0.8 -6.4 L-aspartate oxidase compare
Psest_2324 -0.8 -7.2 hypothetical protein compare
Psest_4393 -0.8 -4.0 Capsule polysaccharide export protein compare
Psest_2090 -0.8 -2.5 Protein of unknown function (DUF2970). compare
Psest_1163 -0.8 -2.5 diguanylate cyclase (GGDEF) domain compare
Psest_1139 -0.8 -2.7 PAS domain S-box compare
Psest_4126 -0.8 -1.8 Predicted peroxiredoxins compare
Psest_3762 -0.8 -3.9 iron donor protein CyaY compare
Psest_1053 -0.8 -1.4 hypothetical protein compare
Psest_1886 -0.8 -3.2 Uncharacterized protein conserved in bacteria compare
Psest_2447 -0.8 -1.1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) compare
Psest_2323 -0.8 -6.8 Uncharacterized protein conserved in archaea compare
Psest_3860 -0.8 -1.9 Predicted permeases compare
Psest_0673 -0.8 -2.9 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase compare
Psest_0958 -0.8 -4.9 Oligoketide cyclase/lipid transport protein compare
Psest_0357 -0.8 -1.6 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) compare
Psest_2527 -0.8 -5.1 cytochrome c oxidase, cbb3-type, subunit I compare
Psest_3401 -0.8 -4.3 DNA repair protein RadA conserved
Psest_1277 -0.8 -5.9 2-isopropylmalate synthase, yeast type compare
Psest_2421 -0.8 -2.6 formate dehydrogenase family accessory protein FdhD compare
Psest_3853 -0.8 -2.3 ABC-type branched-chain amino acid transport systems, ATPase component compare
Psest_1176 -0.8 -1.9 Urea transporter compare
Psest_0208 -0.8 -4.0 Uncharacterized protein conserved in bacteria compare
Psest_4003 -0.8 -3.2 TIGR00153 family protein compare
Psest_3047 -0.8 -1.0 methionyl-tRNA synthetase/methionyl-tRNA synthetase C-terminal region/beta chain compare
Psest_4134 -0.7 -1.0 Uncharacterized protein conserved in bacteria compare
Psest_2018 -0.7 -2.2 Uncharacterized conserved protein compare
Psest_3843 -0.7 -4.2 4-hydroxybenzoate synthetase (chorismate lyase) compare
Psest_1601 -0.7 -1.2 Signal transduction histidine kinase compare
Psest_1242 -0.7 -2.2 tRNA-guanine transglycosylase, queuosine-34-forming compare
Psest_3931 -0.7 -2.4 Signal transduction histidine kinase, nitrogen specific compare
Psest_3573 -0.7 -2.1 dTDP-4-dehydrorhamnose reductase compare
Psest_2766 -0.7 -1.1 hypothetical protein compare
Psest_1144 -0.7 -1.5 AmpG-related permease compare
Psest_1879 -0.7 -1.8 Trk-type K+ transport systems, membrane components compare
Psest_3697 -0.7 -0.8 Outer membrane lipoprotein carrier protein LolA. compare


Specific Phenotypes

For 10 genes in this experiment

For stress Cisplatin in Pseudomonas stutzeri RCH2

For stress Cisplatin across organisms