Experiment set5S660 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Novobiocin sodium salt 0.004 mM

200 most important genes:

  gene name fitness t score description  
Rv1072 -5.4 -2.8 Probable conserved transmembrane protein compare
Rv0929 -5.0 -3.5 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv2869c -3.3 -2.1 Membrane bound metalloprotease compare
Rv3249c -3.1 -1.2 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0819 -3.1 -4.3 GCN5-related N-acetyltransferase, MshD compare
Rv0820 -2.8 -5.6 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3405c -2.7 -2.0 Possible transcriptional regulatory protein compare
Rv3102c -2.7 -3.8 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv3810 -2.5 -2.8 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv0928 -2.5 -5.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv1410c -2.3 -8.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0361 -2.3 -2.0 Probable conserved membrane protein compare
Rv3311 -2.2 -4.5 Conserved protein compare
Rv1908c -2.1 -2.7 Catalase-peroxidase-peroxynitritase T KatG compare
Rv1821 -2.0 -3.8 Possible preprotein translocase ATPase SecA2 compare
Rv1411c -2.0 -3.2 Conserved lipoprotein LprG compare
Rv3306c -2.0 -1.8 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv0930 -2.0 -4.7 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv1824 -2.0 -1.9 Conserved hypothetical membrane protein compare
Rv0642c -2.0 -2.2 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv2224c -1.9 -9.7 Probable carboxylesterase CaeA compare
Rv2047c -1.9 -6.4 Conserved hypothetical protein compare
Rv0497 -1.9 -2.0 Probable conserved transmembrane protein compare
Rv0007 -1.8 -0.9 Possible conserved membrane protein compare
Rv2922c -1.8 -6.3 Probable chromosome partition protein Smc compare
Rv0504c -1.7 -2.2 Conserved protein compare
Rv3717 -1.7 -3.7 Conserved hypothetical protein compare
Rv0959 -1.7 -1.1 Conserved hypothetical protein compare
Rv3101c -1.6 -1.9 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1836c -1.6 -2.2 Conserved protein compare
Rv3267 -1.6 -2.8 Conserved protein (CPSA-related protein) compare
Rv3910 -1.5 -2.6 Probable conserved transmembrane protein compare
Rv0202c -1.5 -6.2 Probable conserved transmembrane transport protein MmpL11 compare
Rv1701 -1.5 -3.5 Probable integrase/recombinase compare
Rv1127c -1.5 -1.2 Probable pyruvate, phosphate dikinase PpdK compare
Rv1620c -1.5 -3.1 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv1291c -1.4 -1.8 Conserved hypothetical secreted protein compare
Rv1766 -1.4 -1.6 Conserved protein compare
Rv0994 -1.4 -6.1 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv0242c -1.4 -3.4 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2630 -1.4 -0.7 Hypothetical protein compare
Rv1013 -1.4 -6.9 Putative polyketide synthase Pks16 compare
Rv1281c -1.4 -5.6 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD compare
Rv3501c -1.4 -3.3 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv2048c -1.4 -3.7 Polyketide synthase Pks12 compare
Rv1823 -1.4 -5.0 Conserved protein compare
Rv3013 -1.3 -1.3 Conserved protein compare
Rv0184 -1.3 -3.3 Conserved hypothetical protein compare
Rv3897c -1.3 -0.8 Conserved hypothetical protein compare
Rv3005c -1.3 -7.0 Conserved hypothetical protein compare
Rv2276 -1.3 -1.3 Cytochrome P450 121 Cyp121 compare
Rv1131 -1.3 -1.7 Probable methylcitrate synthase PrpC compare
Rv2553c -1.3 -1.0 Probable conserved membrane protein compare
Rv0990c -1.3 -0.7 Hypothetical protein compare
Rv0436c -1.2 -2.3 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv1282c -1.2 -2.8 Probable oligopeptide-transport integral membrane protein ABC transporter OppC compare
Rv3716c -1.2 -0.6 Conserved protein compare
Rv0157A -1.2 -1.5 Conserved protein compare
Rv1709 -1.2 -3.9 Possible segregation and condensation protein ScpA compare
Rv3334 -1.2 -1.7 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv0876c -1.1 -2.0 Possible conserved transmembrane protein compare
Rv0450c -1.1 -5.5 Probable conserved transmembrane transport protein MmpL4 compare
Rv2496c -1.1 -1.8 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv1280c -1.1 -5.3 Probable periplasmic oligopeptide-binding lipoprotein OppA compare
Rv0676c -1.1 -8.1 Probable conserved transmembrane transport protein MmpL5 compare
Rv0037c -1.1 -7.8 Probable conserved integral membrane protein compare
Rv3358 -1.1 -2.7 Toxin RelK compare
Rv0989c -1.1 -5.6 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0954 -1.0 -2.8 Probable conserved transmembrane protein compare
Rv1693 -1.0 -0.9 Conserved hypothetical protein compare
Rv0040c -1.0 -5.7 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv0757 -1.0 -1.4 Possible two component system response transcriptional positive regulator PhoP compare
Rv0204c -1.0 -2.4 Probable conserved transmembrane protein compare
Rv1283c -1.0 -1.8 Probable oligopeptide-transport integral membrane protein ABC transporter OppB compare
Rv1025 -1.0 -0.8 Conserved protein compare
Rv3222c -1.0 -1.0 Conserved hypothetical protein compare
Rv0531 -1.0 -1.2 Possible conserved membrane protein compare
Rv1565c -1.0 -4.3 Conserved hypothetical membrane protein compare
Rv1096 -1.0 -1.0 Possible glycosyl hydrolase compare
Rv0677c -1.0 -2.1 Possible conserved membrane protein MmpS5 compare
Rv3414c -1.0 -2.8 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv1435c -1.0 -3.3 Probable conserved proline, glycine, valine-rich secreted protein compare
Rv1273c -1.0 -2.5 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1421 -1.0 -2.2 Conserved protein compare
Rv2444c -1.0 -2.2 Possible ribonuclease E Rne compare
Rv1608c -1.0 -1.8 Probable peroxidoxin BcpB compare
Rv1006 -1.0 -4.0 Unknown protein compare
Rv1019 -1.0 -5.9 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0472c -0.9 -2.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv2976c -0.9 -0.8 Probable uracil-DNA glycosylase Ung (UDG) compare
Rv2292c -0.9 -0.6 Hypothetical protein compare
Rv2745c -0.9 -1.4 Transcriptional regulatory protein ClgR compare
Rv0397 -0.9 -2.5 Conserved 13E12 repeat family protein compare
Rv0009 -0.9 -0.7 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2799 -0.9 -5.4 Probable membrane protein compare
Rv1049 -0.9 -0.8 Probable transcriptional repressor protein compare
Rv1640c -0.9 -4.4 Lysyl-tRNA synthetase 2 LysX compare
Rv2302 -0.9 -0.7 Conserved protein compare
Rv2374c -0.9 -2.0 Probable heat shock protein transcriptional repressor HrcA compare
Rv3066 -0.9 -3.3 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv3493c -0.9 -3.8 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv2170 -0.9 -0.9 GCN5-related N-acetyltransferase compare
Rv0868c -0.9 -0.8 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv0243 -0.9 -3.9 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv2975c -0.9 -0.7 Conserved hypothetical protein compare
Rv2581c -0.9 -1.1 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv1745c -0.9 -1.6 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv3143 -0.9 -0.8 Probable response regulator compare
Rv3856c -0.9 -1.6 Conserved hypothetical protein compare
Rv0201c -0.9 -1.5 Conserved protein compare
Rv3668c -0.9 -2.5 Possible protease compare
Rv1272c -0.8 -2.7 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0016c -0.8 -2.4 Probable penicillin-binding protein PbpA compare
Rv0199 -0.8 -1.8 Probable conserved membrane protein compare
Rv3346c -0.8 -1.7 Conserved transmembrane protein compare
Rv1244 -0.8 -3.5 Probable lipoprotein LpqZ compare
Rv1004c -0.8 -1.4 Probable membrane protein compare
Rv1730c -0.8 -2.0 Possible penicillin-binding protein compare
Rv2382c -0.8 -0.8 Polyketide synthetase MbtC (polyketide synthase) compare
Rv2985 -0.8 -1.1 Possible hydrolase MutT1 compare
Rv2616 -0.8 -2.9 Conserved protein compare
Rv3162c -0.8 -0.8 Possible integral membrane protein compare
Rv1333 -0.8 -3.8 Probable hydrolase compare
Rv2408 -0.8 -0.8 Possible PE family-related protein PE24 compare
Rv0646c -0.8 -2.6 Probable lipase/esterase LipG compare
Rv0749 -0.8 -2.4 Possible toxin VapC31. Contains PIN domain. compare
Rv3497c -0.8 -4.2 Mce-family protein Mce4C compare
Rv3823c -0.8 -5.4 Conserved integral membrane transport protein MmpL8 compare
Rv1531 -0.8 -1.1 Conserved protein compare
Rv0503c -0.8 -5.5 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) compare
Rv0247c -0.8 -0.4 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv1614 -0.8 -1.6 Possible prolipoprotein diacylglyceryl transferases Lgt compare
Rv3496c -0.8 -4.3 Mce-family protein Mce4D compare
Rv2525c -0.8 -4.4 Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. compare
Rv2744c -0.8 -2.1 Conserved 35 kDa alanine rich protein compare
Rv0887c -0.8 -1.0 Conserved hypothetical protein compare
Rv3494c -0.8 -4.9 Mce-family protein Mce4F compare
Rv1091 -0.8 -3.4 PE-PGRS family protein PE_PGRS22 compare
Rv0746 -0.8 -2.8 PE-PGRS family protein PE_PGRS9 compare
Rv2208 -0.8 -1.4 Probable cobalamin 5'-phosphate synthase CobS compare
Rv2937 -0.8 -4.6 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv2694c -0.8 -2.2 Conserved protein compare
Rv1156 -0.8 -4.1 Conserved protein compare
Rv3495c -0.8 -4.3 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv1159 -0.8 -1.4 Mannosyltransferase PimE compare
Rv0634A -0.8 -2.8 Unknown protein compare
Rv2942 -0.8 -5.8 Conserved transmembrane transport protein MmpL7 compare
Rv0483 -0.8 -5.4 Probable conserved lipoprotein LprQ compare
Rv0381c -0.7 -3.5 Hypothetical protein compare
Rv3912 -0.7 -1.9 Hypothetical alanine rich protein compare
Rv2784c -0.7 -3.5 Probable lipoprotein LppU compare
Rv2366c -0.7 -1.6 Probable conserved transmembrane protein compare
Rv1948c -0.7 -1.6 Hypothetical protein compare
Rv0451c -0.7 -0.9 Probable conserved membrane protein MmpS4 compare
Rv2091c -0.7 -2.6 Probable membrane protein compare
Rv2762c -0.7 -0.6 Conserved hypothetical protein compare
Rv2197c -0.7 -3.0 Probable conserved transmembrane protein compare
Rv0098 -0.7 -1.0 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv1366A -0.7 -0.7 Conserved protein compare
Rv3751 -0.7 -1.1 Probable integrase (fragment) compare
Rv0649 -0.7 -2.0 Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT) compare
Rv3277 -0.7 -0.4 Probable conserved transmembrane protein compare
Rv2065 -0.7 -1.6 Precorrin-8X methylmutase CobH (aka precorrin isomerase) compare
Rv1860 -0.7 -1.9 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) compare
Rv3314c -0.7 -0.8 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv1930c -0.7 -0.4 Conserved hypothetical protein compare
Rv2796c -0.7 -1.9 Probable conserved lipoprotein LppV compare
Rv1401 -0.7 -1.0 Possible membrane protein compare
Rv1935c -0.7 -2.2 Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0241c -0.7 -1.9 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv3500c -0.7 -4.9 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv0758 -0.7 -1.6 Possible two component system response sensor kinase membrane associated PhoR compare
Rv0939 -0.7 -0.6 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv2829c -0.7 -1.2 Possible toxin VapC22 compare
Rv0991c -0.7 -0.7 Conserved serine rich protein compare
Rv0378 -0.7 -1.2 Conserved hypothetical glycine rich protein compare
Rv1090 -0.7 -3.5 Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) compare
Rv2064 -0.7 -1.6 Precorrin-3B synthase CobG compare
Rv0949 -0.7 -0.4 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv3344c -0.7 -2.8 PE-PGRS family protein PE_PGRS49 compare
Rv0100 -0.7 -1.5 Conserved hypothetical protein compare
Rv1513 -0.7 -1.6 Conserved protein compare
Rv1897c -0.7 -1.2 Conserved hypothetical protein compare
Rv1433 -0.7 -3.4 Possible conserved exported protein compare
Rv2679 -0.7 -1.8 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0444c -0.7 -2.1 Anti-sigma factor RskA (regulator of sigma K) compare
Rv2317 -0.7 -0.6 Probable sugar-transport integral membrane protein ABC transporter UspB compare
Rv0520 -0.7 -1.7 Possible methyltransferase/methylase (fragment) compare
Rv0622 -0.7 -1.8 Possible membrane protein compare
Rv2529 -0.7 -2.2 Hypothetical protein compare
Rv2203 -0.7 -1.9 Possible conserved membrane protein compare
Rv3488 -0.7 -1.2 Conserved hypothetical protein compare
Rv2476c -0.7 -1.9 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) compare
Rv1003 -0.7 -0.4 Conserved protein compare
Rv3309c -0.7 -1.3 Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) compare
Rv0464c -0.7 -2.9 Conserved protein compare
Rv0745 -0.6 -2.9 Conserved hypothetical protein compare
Rv0270 -0.6 -2.8 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv2945c -0.6 -3.4 Probable conserved lipoprotein LppX compare
Rv1657 -0.6 -0.7 Probable arginine repressor ArgR (AHRC) compare


Specific Phenotypes

For 1 genes in this experiment

For stress Novobiocin sodium salt in Mycobacterium tuberculosis H37Rv

For stress Novobiocin sodium salt across organisms