Experiment set5S657 for Mycobacterium tuberculosis H37Rv

200 most important genes:

gene	name	fitness	t score	description
Rv2044c		-3.6	-1.3	Conserved hypothetical protein
Rv3249c		-3.0	-1.3	Possible transcriptional regulatory protein (probably TetR-family)
Rv2277c		-2.1	-3.1	Possible glycerolphosphodiesterase
Rv1621c		-2.0	-4.1	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
Rv1284		-1.9	-0.9	Beta-carbonic anhydrase
Rv3193c		-1.8	-2.4	Probable conserved transmembrane protein
Rv0819		-1.8	-2.4	GCN5-related N-acetyltransferase, MshD
Rv1072		-1.8	-1.6	Probable conserved transmembrane protein
Rv0929		-1.7	-3.3	Phosphate-transport integral membrane ABC transporter PstC2
Rv0930		-1.7	-7.3	Probable phosphate-transport integral membrane ABC transporter PstA1
Rv0437c		-1.7	-1.6	Possible phosphatidylserine decarboxylase Psd (PS decarboxylase)
Rv3848		-1.6	-2.2	Probable conserved transmembrane protein
Rv0928		-1.6	-2.9	Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1)
Rv0820		-1.5	-3.7	Probable phosphate-transport ATP-binding protein ABC transporter PhoT
Rv3751		-1.5	-1.9	Probable integrase (fragment)
Rv1821		-1.5	-4.2	Possible preprotein translocase ATPase SecA2
Rv1930c		-1.5	-0.9	Conserved hypothetical protein
Rv1836c		-1.5	-2.2	Conserved protein
Rv3085		-1.4	-1.1	Probable short-chain type dehydrogenase/reductase
Rv0242c		-1.4	-3.1	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)
Rv2733c		-1.4	-2.2	Conserved hypothetical alanine, arginine-rich protein
Rv2731		-1.3	-4.9	Conserved alanine and arginine rich protein
Rv1620c		-1.3	-3.5	Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC
Rv0017c		-1.2	-4.4	Probable cell division protein RodA
Rv2272		-1.2	-0.7	Probable conserved transmembrane protein
Rv2321c		-1.2	-1.4	Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase)
Rv2374c		-1.2	-2.5	Probable heat shock protein transcriptional repressor HrcA
Rv2503c		-1.2	-2.6	Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase)
Rv2376c		-1.2	-0.8	Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2)
Rv1745c		-1.2	-4.5	Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase)
Rv2696c		-1.2	-2.1	Conserved alanine and glycine and valine rich protein
Rv0007		-1.2	-0.8	Possible conserved membrane protein
Rv3819		-1.2	-0.9	Unknown protein
Rv2691		-1.1	-4.6	TRK system potassium uptake protein CeoB
Rv1926c		-1.1	-3.3	Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein)
Rv0361		-1.1	-1.1	Probable conserved membrane protein
Rv3311		-1.1	-3.1	Conserved protein
Rv0674		-1.1	-1.0	Conserved hypothetical protein
Rv3678A		-1.1	-1.4	Conserved hypothetical protein
Rv1420		-1.1	-1.7	Probable excinuclease ABC (subunit C-nuclease) UvrC
Rv2635		-1.0	-0.9	Hypothetical protein
Rv3658c		-1.0	-1.1	Probable conserved transmembrane protein
Rv1730c		-1.0	-3.0	Possible penicillin-binding protein
Rv2694c		-1.0	-3.5	Conserved protein
Rv3650		-1.0	-0.8	PE family protein PE33
Rv0665		-1.0	-2.0	Possible toxin VapC8
Rv1957		-1.0	-1.6	Hypothetical protein
Rv1851		-1.0	-1.6	Urease accessory protein UreF
Rv0653c		-1.0	-3.7	Possible transcriptional regulatory protein (probably TetR-family)
Rv1046c		-1.0	-1.9	Hypothetical protein
Rv2709		-1.0	-3.2	Probable conserved transmembrane protein
Rv2500c		-0.9	-1.1	Possible acyl-CoA dehydrogenase FadE19 (MMGC)
Rv1908c		-0.9	-2.4	Catalase-peroxidase-peroxynitritase T KatG
Rv3200c		-0.9	-2.0	Possible transmembrane cation transporter
Rv3897c		-0.9	-0.8	Conserved hypothetical protein
Rv0989c		-0.9	-5.1	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)
Rv0316		-0.9	-2.4	Possible muconolactone isomerase
Rv1140		-0.9	-1.9	Probable integral membrane protein
Rv2140c		-0.9	-1.1	Conserved protein TB18.6
Rv1013		-0.9	-5.4	Putative polyketide synthase Pks16
Rv2444c		-0.9	-2.3	Possible ribonuclease E Rne
Rv0893c		-0.9	-2.0	Possible S-adenosylmethionine-dependent methyltransferase
Rv0918		-0.9	-1.7	Conserved protein
Rv3700c		-0.9	-1.7	Conserved hypothetical protein
Rv3856c		-0.9	-1.6	Conserved hypothetical protein
Rv2732c		-0.9	-2.7	Probable conserved transmembrane protein
Rv2009		-0.9	-1.5	Antitoxin VapB15
Rv1165		-0.8	-5.1	Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein)
Rv2231A		-0.8	-2.6	Possible toxin VapC16
Rv2154c		-0.8	-1.9	FtsW-like protein FtsW
Rv3498c		-0.8	-3.9	Mce-family protein Mce4B
Rv2422		-0.8	-1.7	Hypothetical protein
Rv0047c		-0.8	-2.9	Conserved protein
Rv1411c		-0.8	-2.6	Conserved lipoprotein LprG
Rv2173		-0.8	-2.0	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Rv3346c		-0.8	-1.3	Conserved transmembrane protein
Rv3131		-0.8	-1.2	Conserved protein
Rv0237		-0.8	-2.1	Probable conserved lipoprotein LpqI
Rv1502		-0.8	-1.5	Hypothetical protein
Rv3013		-0.8	-1.1	Conserved protein
Rv3237c		-0.8	-2.2	Conserved protein
Rv0379		-0.8	-1.2	Possible protein transport protein SecE2
Rv1262c		-0.8	-1.4	Hypothetical hit-like protein
Rv2707		-0.8	-5.1	Probable conserved transmembrane alanine and leucine rich protein
Rv2517c		-0.8	-2.9	Unknown protein
Rv1410c		-0.8	-4.0	Aminoglycosides/tetracycline-transport integral membrane protein
Rv0168		-0.7	-1.8	Conserved integral membrane protein YrbE1B
Rv3922c		-0.7	-1.5	Possible hemolysin
Rv3140		-0.7	-3.2	Probable acyl-CoA dehydrogenase FadE23
Rv0734		-0.7	-1.5	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)
Rv1513		-0.7	-2.1	Conserved protein
Rv0241c		-0.7	-1.3	Probable 3-hydroxyacyl-thioester dehydratase HtdX
Rv0452		-0.7	-2.1	Possible transcriptional regulatory protein
Rv0019c		-0.7	-2.9	Conserved protein with FHA domain, FhaB
Rv1003		-0.7	-0.5	Conserved protein
Rv3723		-0.7	-2.8	Probable conserved transmembrane protein
Rv3208A		-0.7	-1.1	Conserved protein TB9.4
Rv0494		-0.7	-3.2	Probable transcriptional regulatory protein (probably GntR-family)
Rv1071c		-0.7	-3.5	Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Rv3282		-0.7	-1.1	Conserved hypothetical protein
Rv0499		-0.7	-1.1	Conserved hypothetical protein
Rv0016c		-0.7	-2.5	Probable penicillin-binding protein PbpA
Rv0294		-0.7	-3.2	Probable trans-aconitate methyltransferase Tam
Rv3301c		-0.7	-2.2	Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1
Rv0135c		-0.7	-1.6	Possible transcriptional regulatory protein
Rv3715c		-0.7	-1.3	Probable recombination protein RecR
Rv0243		-0.6	-3.3	Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Rv3284		-0.6	-1.5	Conserved hypothetical protein
Rv1283c		-0.6	-1.6	Probable oligopeptide-transport integral membrane protein ABC transporter OppB
Rv3405c		-0.6	-1.0	Possible transcriptional regulatory protein
Rv3433c		-0.6	-1.5	Conserved protein
Rv3828c		-0.6	-1.4	Possible resolvase
Rv3050c		-0.6	-1.7	Probable transcriptional regulatory protein (probably AsnC-family)
Rv2171		-0.6	-1.8	Probable conserved lipoprotein LppM
Rv0886		-0.6	-3.2	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)
Rv2427A		-0.6	-0.9	'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11
Rv0328		-0.6	-1.2	Possible transcriptional regulatory protein (possibly TetR/AcrR-family)
Rv2144c		-0.6	-2.0	Probable transmembrane protein
Rv1131		-0.6	-1.5	Probable methylcitrate synthase PrpC
Rv3010c		-0.6	-3.0	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)
Rv0531		-0.6	-1.0	Possible conserved membrane protein
Rv3353c		-0.6	-1.4	Conserved hypothetical protein
Rv3174		-0.6	-1.1	Probable short-chain dehydrogenase/reductase
Rv0177		-0.6	-1.0	Probable conserved Mce associated protein
Rv0383c		-0.6	-0.6	Possible conserved secreted protein
Rv2613c		-0.6	-1.6	Conserved protein
Rv3855		-0.6	-2.0	Transcriptional regulatory repressor protein (TetR-family) EthR
Rv2922c		-0.6	-1.6	Probable chromosome partition protein Smc
Rv2276		-0.6	-0.9	Cytochrome P450 121 Cyp121
Rv1884c		-0.6	-1.2	Probable resuscitation-promoting factor RpfC
Rv1121		-0.6	-1.1	Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD)
Rv3512		-0.6	-1.3	PE-PGRS family protein PE_PGRS56
Rv2224c		-0.6	-4.2	Probable carboxylesterase CaeA
Rv3497c		-0.6	-3.3	Mce-family protein Mce4C
Rv2774c		-0.6	-0.6	Hypothetical protein
Rv1516c		-0.6	-2.5	Probable sugar transferase
Rv0821c		-0.6	-2.5	Probable phosphate-transport system transcriptional regulatory protein PhoY2
Rv3033		-0.6	-0.4	Unknown protein
Rv3919c		-0.6	-0.9	Probable glucose-inhibited division protein B Gid
Rv0201c		-0.6	-1.1	Conserved protein
Rv0523c		-0.6	-1.3	Conserved protein
Rv0576		-0.6	-1.8	Probable transcriptional regulatory protein (possibly ArsR-family)
Rv0996		-0.6	-2.5	Probable conserved transmembrane protein
Rv3496c		-0.6	-4.0	Mce-family protein Mce4D
Rv3164c		-0.6	-2.2	Probable methanol dehydrogenase transcriptional regulatory protein MoxR3
Rv0188		-0.6	-2.0	Probable conserved transmembrane protein
Rv0818		-0.6	-2.0	Transcriptional regulatory protein
Rv1813c		-0.6	-2.0	Conserved hypothetical protein
Rv0868c		-0.6	-0.9	Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1)
Rv0078		-0.6	-1.2	Probable transcriptional regulatory protein
Rv1490		-0.6	-1.4	Probable membrane protein
Rv3501c		-0.6	-1.7	Conserved integral membrane protein YrbE4A. Possible ABC transporter.
Rv1964		-0.6	-2.0	Conserved hypothetical integral membrane protein YrbE3A
Rv1775		-0.6	-1.7	Conserved hypothetical protein
Rv1925		-0.6	-3.5	Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase)
Rv2250c		-0.6	-2.6	Possible transcriptional regulatory protein
Rv3910		-0.6	-1.1	Probable conserved transmembrane protein
Rv2190c		-0.6	-1.3	Conserved hypothetical protein
Rv1740		-0.6	-1.1	Possible antitoxin VapB34
Rv1111c		-0.6	-1.3	Conserved hypothetical protein
Rv2331A		-0.5	-0.5	Hypothetical protein
Rv0472c		-0.5	-1.6	Probable transcriptional regulatory protein (possibly TetR-family)
Rv3614c		-0.5	-1.7	ESX-1 secretion-associated protein EspD
Rv2737c		-0.5	-2.1	RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Rv0376c		-0.5	-1.5	Conserved hypothetical protein
Rv3139		-0.5	-1.4	Probable acyl-CoA dehydrogenase FadE24
Rv3835		-0.5	-1.7	Conserved membrane protein
Rv3005c		-0.5	-3.6	Conserved hypothetical protein
Rv0760c		-0.5	-1.2	Conserved protein
Rv3170		-0.5	-1.5	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)
Rv3691		-0.5	-0.8	Conserved protein
Rv1897c		-0.5	-0.8	Conserved hypothetical protein
Rv2887		-0.5	-0.5	Probable transcriptional regulatory protein
Rv0751c		-0.5	-1.1	Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh)
Rv3101c		-0.5	-0.9	Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter)
Rv2897c		-0.5	-0.9	Conserved hypothetical protein
Rv2088		-0.5	-0.6	Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J)
Rv1662		-0.5	-1.2	Probable polyketide synthase Pks8
Rv3643		-0.5	-0.6	Hypothetical protein
Rv1010		-0.5	-0.7	Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Rv2862A		-0.5	-1.4	Possible antitoxin VapB23
Rv2318		-0.5	-1.7	Probable periplasmic sugar-binding lipoprotein UspC
Rv0426c		-0.5	-1.1	Possible transmembrane protein
Rv0420c		-0.5	-1.8	Possible transmembrane protein
Rv2342		-0.5	-1.9	Conserved hypothetical protein
Rv1019		-0.5	-3.1	Probable transcriptional regulatory protein (probably TetR-family)
Rv1151c		-0.5	-1.9	Transcriptional regulatory protein
Rv3218		-0.5	-2.8	Conserved protein
Rv2616		-0.5	-2.1	Conserved protein
Rv3416		-0.5	-0.9	Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster.
Rv0056		-0.5	-0.7	50S ribosomal protein L9 RplI
Rv2107		-0.5	-0.6	PE family protein PE22
Rv3571		-0.5	-1.4	Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB
Rv3494c		-0.5	-2.5	Mce-family protein Mce4F
Rv0516c		-0.5	-2.2	Possible anti-anti-sigma factor
Rv3697c		-0.5	-1.6	Possible toxin VapC48. Contains PIN domain.
Rv1421		-0.5	-1.2	Conserved protein
Rv3499c		-0.5	-3.1	Mce-family protein Mce4A
Rv1291c		-0.5	-0.9	Conserved hypothetical secreted protein
Rv3167c		-0.5	-0.8	Probable transcriptional regulatory protein (probably TetR-family)

Specific Phenotypes

None in this experiment

For Mycobacterium tuberculosis H37Rv in stress experiments

For stress Chloramphenicol across organisms