Experiment set5S654 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with 2-Mercaptopyridine N-oxide sodium salt 0.0078 mM

200 most important genes:

  gene name fitness t score description  
Rv0504c -5.4 -2.6 Conserved protein compare
Rv0241c -4.4 -4.1 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv1411c -3.3 -5.4 Conserved lipoprotein LprG compare
Rv3306c -3.2 -2.6 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv1272c -2.9 -7.5 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0930 -2.8 -6.3 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv2581c -2.7 -1.9 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv3200c -2.7 -4.0 Possible transmembrane cation transporter compare
Rv3101c -2.5 -2.5 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0049 -2.5 -4.3 Conserved hypothetical protein compare
Rv0245 -2.5 -2.6 Possible oxidoreductase compare
Rv1410c -2.4 -7.7 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv3717 -2.4 -5.5 Conserved hypothetical protein compare
Rv0989c -2.4 -10.2 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv3249c -2.3 -1.2 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3267 -2.3 -2.2 Conserved protein (CPSA-related protein) compare
Rv2694c -2.2 -2.8 Conserved protein compare
Rv1107c -2.2 -1.4 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) compare
Rv3131 -2.2 -1.6 Conserved protein compare
Rv1003 -2.1 -0.8 Conserved protein compare
Rv1986 -2.1 -1.6 Probable conserved integral membrane protein compare
Rv1244 -2.1 -5.7 Probable lipoprotein LpqZ compare
Rv2691 -2.0 -6.8 TRK system potassium uptake protein CeoB compare
Rv0928 -2.0 -4.4 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv1745c -2.0 -4.4 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv0825c -2.0 -2.0 Conserved protein compare
Rv0472c -2.0 -3.2 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv2224c -2.0 -10.2 Probable carboxylesterase CaeA compare
Rv0819 -2.0 -3.4 GCN5-related N-acetyltransferase, MshD compare
Rv0078 -2.0 -1.8 Probable transcriptional regulatory protein compare
Rv1824 -2.0 -1.9 Conserved hypothetical membrane protein compare
Rv3920c -2.0 -1.1 Conserved protein similar to jag protein compare
Rv3655c -1.8 -2.2 Conserved hypothetical protein compare
Rv2869c -1.8 -1.6 Membrane bound metalloprotease compare
Rv0905 -1.8 -2.4 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3102c -1.8 -3.3 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2344c -1.7 -5.2 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv3855 -1.7 -4.7 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv2985 -1.7 -1.3 Possible hydrolase MutT1 compare
Rv1072 -1.7 -1.4 Probable conserved transmembrane protein compare
Rv3171c -1.7 -0.6 Possible non-heme haloperoxidase Hpx compare
Rv0204c -1.7 -4.4 Probable conserved transmembrane protein compare
Rv3481c -1.6 -1.3 Probable integral membrane protein compare
Rv0939 -1.6 -1.1 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv1273c -1.6 -3.5 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv3723 -1.6 -3.8 Probable conserved transmembrane protein compare
Rv0242c -1.6 -2.5 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv0019c -1.6 -4.5 Conserved protein with FHA domain, FhaB compare
Rv0680c -1.5 -1.6 Probable conserved transmembrane protein compare
Rv2321c -1.5 -1.2 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) compare
Rv1836c -1.5 -2.5 Conserved protein compare
Rv1013 -1.5 -7.7 Putative polyketide synthase Pks16 compare
Rv0655 -1.5 -4.5 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv3751 -1.5 -1.7 Probable integrase (fragment) compare
Rv3140 -1.5 -4.0 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2026c -1.4 -1.1 Universal stress protein family protein compare
Rv3856c -1.4 -1.5 Conserved hypothetical protein compare
Rv3005c -1.4 -8.0 Conserved hypothetical protein compare
Rv0018c -1.4 -4.4 Phosphoserine/threonine phosphatase PstP compare
Rv2427A -1.4 -2.6 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv3591c -1.4 -3.1 Possible hydrolase compare
Rv0200 -1.4 -2.1 Possible conserved transmembrane protein compare
Rv2829c -1.4 -1.8 Possible toxin VapC22 compare
Rv0436c -1.4 -1.9 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) compare
Rv3261 -1.4 -2.5 Probable F420 biosynthesis protein FbiA compare
Rv2222c -1.4 -2.7 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) compare
Rv2912c -1.4 -2.2 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3139 -1.4 -4.8 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3803c -1.3 -5.7 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv1010 -1.3 -1.2 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1823 -1.3 -4.3 Conserved protein compare
Rv2335 -1.3 -1.2 Probable serine acetyltransferase CysE (sat) compare
Rv3810 -1.3 -1.6 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv2551c -1.3 -1.4 Conserved hypothetical protein compare
Rv3277 -1.3 -0.5 Probable conserved transmembrane protein compare
Rv2173 -1.3 -2.7 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv1420 -1.3 -1.9 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv0452 -1.3 -1.9 Possible transcriptional regulatory protein compare
Rv2696c -1.2 -1.3 Conserved alanine and glycine and valine rich protein compare
Rv1473A -1.2 -1.0 Possible transcriptional regulatory protein compare
Rv2942 -1.2 -8.6 Conserved transmembrane transport protein MmpL7 compare
Rv0157 -1.2 -4.3 Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta) compare
Rv2650c -1.2 -1.0 Possible PhiRv2 prophage protein compare
Rv3478 -1.2 -3.0 PE family protein PPE60 compare
Rv3262 -1.2 -1.6 Probable F420 biosynthesis protein FbiB compare
Rv2171 -1.2 -2.3 Probable conserved lipoprotein LppM compare
Rv1474c -1.2 -3.5 Probable transcriptional regulatory protein compare
Rv3311 -1.2 -4.7 Conserved protein compare
Rv0016c -1.2 -3.8 Probable penicillin-binding protein PbpA compare
Rv0294 -1.1 -1.8 Probable trans-aconitate methyltransferase Tam compare
Rv2850c -1.1 -1.1 Possible magnesium chelatase compare
Rv2774c -1.1 -0.8 Hypothetical protein compare
Rv1364c -1.1 -2.6 Possible sigma factor regulatory protein compare
Rv1173 -1.1 -1.9 Probable F420 biosynthesis protein FbiC compare
Rv1821 -1.1 -3.1 Possible preprotein translocase ATPase SecA2 compare
Rv1421 -1.1 -2.0 Conserved protein compare
Rv2197c -1.1 -3.0 Probable conserved transmembrane protein compare
Rv2695 -1.1 -4.4 Conserved hypothetical alanine rich protein compare
Rv3850 -1.1 -1.1 Conserved protein compare
Rv3305c -1.1 -1.4 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) compare
Rv0615 -1.1 -0.9 Probable integral membrane protein compare
Rv0994 -1.1 -4.8 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv2945c -1.1 -6.1 Probable conserved lipoprotein LppX compare
Rv1220c -1.1 -4.2 Probable methyltransferase compare
Rv3045 -1.1 -2.3 Probable NADP-dependent alcohol dehydrogenase AdhC compare
Rv3498c -1.1 -4.3 Mce-family protein Mce4B compare
Rv2618 -1.1 -4.6 Conserved hypothetical protein compare
Rv2569c -1.1 -4.0 Conserved hypothetical protein compare
Rv2154c -1.1 -1.8 FtsW-like protein FtsW compare
Rv3495c -1.1 -5.9 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv1640c -1.0 -5.8 Lysyl-tRNA synthetase 2 LysX compare
Rv1963c -1.0 -1.3 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv0929 -1.0 -1.7 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv3419c -1.0 -1.1 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv1620c -1.0 -2.4 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv3500c -1.0 -5.2 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv2801c -1.0 -0.8 Toxin MazF9 compare
Rv0499 -1.0 -1.3 Conserved hypothetical protein compare
Rv0757 -1.0 -1.1 Possible two component system response transcriptional positive regulator PhoP compare
Rv2140c -1.0 -1.0 Conserved protein TB18.6 compare
Rv3013 -1.0 -1.0 Conserved protein compare
Rv2991 -1.0 -2.4 Conserved protein compare
Rv3496c -1.0 -6.2 Mce-family protein Mce4D compare
Rv0867c -1.0 -0.6 Possible resuscitation-promoting factor RpfA compare
Rv3237c -1.0 -2.1 Conserved protein compare
Rv1890c -1.0 -1.0 Hypothetical protein compare
Rv0017c -1.0 -3.0 Probable cell division protein RodA compare
Rv3492c -1.0 -1.6 Conserved hypothetical Mce associated protein compare
Rv0818 -1.0 -3.1 Transcriptional regulatory protein compare
Rv0392c -1.0 -0.6 Probable membrane NADH dehydrogenase NdhA compare
Rv1621c -1.0 -1.5 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv3415c -1.0 -3.9 Conserved hypothetical protein compare
Rv3501c -1.0 -2.7 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv0243 -1.0 -3.4 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv3499c -0.9 -4.5 Mce-family protein Mce4A compare
Rv3287c -0.9 -0.9 Anti-sigma factor RsbW (sigma negative effector) compare
Rv2548 -0.9 -1.5 Possible toxin VapC19 compare
Rv0237 -0.9 -2.5 Probable conserved lipoprotein LpqI compare
Rv1740 -0.9 -1.3 Possible antitoxin VapB34 compare
Rv2936 -0.9 -6.2 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv2779c -0.9 -2.8 Possible transcriptional regulatory protein (probably Lrp/AsnC-family) compare
Rv1116A -0.9 -0.7 Conserved hypothetical protein (fragment) compare
Rv3041c -0.9 -1.2 Probable conserved ATP-binding protein ABC transporter compare
Rv3050c -0.9 -2.7 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv2376c -0.9 -0.4 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) compare
Rv1049 -0.9 -0.9 Probable transcriptional repressor protein compare
Rv0870c -0.9 -1.0 Possible conserved integral membrane protein compare
Rv2938 -0.9 -5.5 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv0892 -0.9 -1.2 Probable monooxygenase compare
Rv3716c -0.9 -0.4 Conserved protein compare
Rv2553c -0.9 -0.7 Probable conserved membrane protein compare
Rv2003c -0.9 -0.7 Conserved hypothetical protein compare
Rv1291c -0.9 -1.2 Conserved hypothetical secreted protein compare
Rv3282 -0.9 -0.9 Conserved hypothetical protein compare
Rv0949 -0.9 -0.5 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2028c -0.9 -0.8 Universal stress protein family protein compare
Rv1561 -0.8 -1.5 Possible toxin VapC11 compare
Rv2369c -0.8 -0.8 Hypothetical protein compare
Rv2372c -0.8 -1.1 Conserved hypothetical protein compare
Rv3494c -0.8 -4.5 Mce-family protein Mce4F compare
Rv3497c -0.8 -3.3 Mce-family protein Mce4C compare
Rv3033 -0.8 -0.5 Unknown protein compare
Rv0381c -0.8 -5.1 Hypothetical protein compare
Rv1683 -0.8 -2.3 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv3165c -0.8 -0.8 Unknown protein compare
Rv3412 -0.8 -2.3 Conserved hypothetical protein compare
Rv0820 -0.8 -1.8 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv0549c -0.8 -0.6 Possible toxin VapC3 compare
Rv3586 -0.8 -1.9 Conserved hypothetical protein compare
Rv2937 -0.8 -5.0 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv2141c -0.8 -3.8 Conserved protein compare
Rv0444c -0.8 -2.9 Anti-sigma factor RskA (regulator of sigma K) compare
Rv3204 -0.8 -0.5 Possible DNA-methyltransferase (modification methylase) compare
Rv1897c -0.8 -1.0 Conserved hypothetical protein compare
Rv3661 -0.8 -3.1 Conserved hypothetical protein compare
Rv3433c -0.8 -1.8 Conserved protein compare
Rv1006 -0.8 -2.9 Unknown protein compare
Rv0145 -0.8 -2.6 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv3208A -0.8 -0.8 Conserved protein TB9.4 compare
Rv2134c -0.8 -2.7 Conserved protein compare
Rv0954 -0.8 -2.2 Probable conserved transmembrane protein compare
Rv2799 -0.7 -4.1 Probable membrane protein compare
Rv3766 -0.7 -1.5 Hypothetical protein compare
Rv1058 -0.7 -1.5 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) compare
Rv3314c -0.7 -0.7 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) compare
Rv0966c -0.7 -1.4 Conserved protein compare
Rv2743c -0.7 -3.4 Possible conserved transmembrane alanine rich protein compare
Rv2216 -0.7 -1.6 Conserved protein compare
Rv1580c -0.7 -1.2 Probable PhiRv1 phage protein compare
Rv3835 -0.7 -1.6 Conserved membrane protein compare
Rv1287 -0.7 -2.7 Conserved hypothetical protein compare
Rv1657 -0.7 -0.9 Probable arginine repressor ArgR (AHRC) compare
Rv0020c -0.7 -2.6 Conserved protein with FHA domain, FhaA compare
Rv3521 -0.7 -2.5 Conserved hypothetical protein compare
Rv1019 -0.7 -3.4 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv0658c -0.7 -1.7 Probable conserved integral membrane protein compare
Rv1886c -0.7 -4.8 Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) compare
Rv0003 -0.7 -1.8 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv0196 -0.7 -2.7 Possible transcriptional regulatory protein compare
Rv2271 -0.7 -1.7 Conserved hypothetical protein compare


Specific Phenotypes

For 6 genes in this experiment

For stress 2-Mercaptopyridine N-oxide sodium salt in Mycobacterium tuberculosis H37Rv

For stress 2-Mercaptopyridine N-oxide sodium salt across organisms