Experiment set5S653 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with 2-Mercaptopyridine N-oxide sodium salt 0.0078 mM

200 most important genes:

  gene name fitness t score description  
Rv2989 -4.4 -1.4 Probable transcriptional regulatory protein compare
Rv0929 -3.9 -3.7 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0472c -3.5 -5.4 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv1410c -3.1 -9.7 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0928 -3.1 -5.1 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv2694c -2.9 -4.7 Conserved protein compare
Rv0504c -2.9 -2.6 Conserved protein compare
Rv2335 -2.7 -2.5 Probable serine acetyltransferase CysE (sat) compare
Rv1272c -2.7 -8.3 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv0930 -2.6 -8.9 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0820 -2.5 -4.3 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3655c -2.5 -2.8 Conserved hypothetical protein compare
Rv3208A -2.5 -1.9 Conserved protein TB9.4 compare
Rv0819 -2.4 -3.6 GCN5-related N-acetyltransferase, MshD compare
Rv3920c -2.4 -1.7 Conserved protein similar to jag protein compare
Rv2912c -2.3 -4.1 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3249c -2.3 -1.3 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv3102c -2.3 -3.0 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2774c -2.2 -1.3 Hypothetical protein compare
Rv1420 -2.2 -3.3 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv1821 -2.1 -5.3 Possible preprotein translocase ATPase SecA2 compare
Rv2224c -2.1 -10.9 Probable carboxylesterase CaeA compare
Rv0200 -2.1 -3.1 Possible conserved transmembrane protein compare
Rv1421 -2.1 -3.3 Conserved protein compare
Rv3200c -2.0 -4.9 Possible transmembrane cation transporter compare
Rv3262 -2.0 -1.8 Probable F420 biosynthesis protein FbiB compare
Rv3478 -2.0 -3.7 PE family protein PPE60 compare
Rv1745c -2.0 -5.1 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv1010 -2.0 -1.5 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv0452 -2.0 -4.8 Possible transcriptional regulatory protein compare
Rv1908c -2.0 -2.7 Catalase-peroxidase-peroxynitritase T KatG compare
Rv1273c -2.0 -4.3 Probable drugs-transport transmembrane ATP-binding protein ABC transporter compare
Rv1013 -1.9 -8.7 Putative polyketide synthase Pks16 compare
Rv1290A -1.9 -1.0 Hypothetical protein compare
Rv0655 -1.8 -6.5 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl compare
Rv1620c -1.8 -3.5 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0989c -1.8 -8.2 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv3687c -1.7 -0.9 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) compare
Rv0757 -1.7 -1.9 Possible two component system response transcriptional positive regulator PhoP compare
Rv2691 -1.7 -5.7 TRK system potassium uptake protein CeoB compare
Rv0825c -1.7 -1.9 Conserved protein compare
Rv3591c -1.7 -2.8 Possible hydrolase compare
Rv0323c -1.7 -1.9 Conserved hypothetical protein compare
Rv3101c -1.7 -1.9 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1411c -1.7 -2.8 Conserved lipoprotein LprG compare
Rv0019c -1.6 -4.2 Conserved protein with FHA domain, FhaB compare
Rv0078 -1.6 -1.9 Probable transcriptional regulatory protein compare
Rv3855 -1.6 -5.0 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv3481c -1.6 -1.4 Probable integral membrane protein compare
Rv3717 -1.5 -3.1 Conserved hypothetical protein compare
Rv1364c -1.5 -5.5 Possible sigma factor regulatory protein compare
Rv2173 -1.5 -3.5 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv2975c -1.5 -1.1 Conserved hypothetical protein compare
Rv1791 -1.5 -1.5 PE family protein PE19 compare
Rv1366A -1.5 -0.9 Conserved protein compare
Rv0241c -1.5 -2.5 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0310c -1.5 -1.8 Conserved protein compare
Rv3492c -1.5 -2.2 Conserved hypothetical Mce associated protein compare
Rv1963c -1.5 -1.7 Probable transcriptional repressor (probably TetR-family) Mce3R compare
Rv0642c -1.4 -2.1 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) compare
Rv3311 -1.4 -4.6 Conserved protein compare
Rv3691 -1.4 -1.5 Conserved protein compare
Rv3501c -1.4 -4.8 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv1577c -1.4 -1.2 Probable PhiRv1 phage protein compare
Rv0383c -1.4 -0.9 Possible conserved secreted protein compare
Rv3188 -1.4 -1.5 Conserved hypothetical protein compare
Rv3803c -1.4 -6.9 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv3493c -1.3 -5.1 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv1531 -1.3 -1.4 Conserved protein compare
Rv2548 -1.3 -1.9 Possible toxin VapC19 compare
Rv1046c -1.3 -2.0 Hypothetical protein compare
Rv3650 -1.3 -0.8 PE family protein PE33 compare
Rv3005c -1.3 -8.0 Conserved hypothetical protein compare
Rv1621c -1.3 -3.3 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv0437c -1.3 -1.2 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv0653c -1.3 -4.2 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0991c -1.3 -1.1 Conserved serine rich protein compare
Rv3162c -1.2 -1.3 Possible integral membrane protein compare
Rv2801c -1.2 -1.0 Toxin MazF9 compare
Rv1798 -1.2 -0.9 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv1072 -1.2 -1.7 Probable conserved transmembrane protein compare
Rv0016c -1.2 -3.3 Probable penicillin-binding protein PbpA compare
Rv0018c -1.2 -3.4 Phosphoserine/threonine phosphatase PstP compare
Rv1824 -1.2 -1.6 Conserved hypothetical membrane protein compare
Rv2696c -1.2 -1.9 Conserved alanine and glycine and valine rich protein compare
Rv0497 -1.2 -1.0 Probable conserved transmembrane protein compare
Rv2567 -1.2 -4.6 Conserved hypothetical alanine and leucine rich protein compare
Rv3723 -1.2 -1.6 Probable conserved transmembrane protein compare
Rv2197c -1.2 -3.8 Probable conserved transmembrane protein compare
Rv2635 -1.2 -0.8 Hypothetical protein compare
Rv0242c -1.2 -2.1 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1244 -1.1 -2.5 Probable lipoprotein LpqZ compare
Rv2869c -1.1 -1.8 Membrane bound metalloprotease compare
Rv1291c -1.1 -1.5 Conserved hypothetical secreted protein compare
Rv3050c -1.1 -3.3 Probable transcriptional regulatory protein (probably AsnC-family) compare
Rv3267 -1.1 -1.8 Conserved protein (CPSA-related protein) compare
Rv3306c -1.1 -1.5 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv1112 -1.1 -0.7 Probable GTP binding protein compare
Rv2272 -1.1 -0.5 Probable conserved transmembrane protein compare
Rv0157 -1.1 -3.2 Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta) compare
Rv3496c -1.1 -6.9 Mce-family protein Mce4D compare
Rv2581c -1.1 -1.2 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) compare
Rv2551c -1.1 -1.4 Conserved hypothetical protein compare
Rv3499c -1.1 -5.3 Mce-family protein Mce4A compare
Rv2344c -1.1 -3.6 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv2348c -1.1 -0.6 Hypothetical protein compare
Rv0367c -1.0 -0.7 Hypothetical protein compare
Rv3693 -1.0 -1.4 Possible conserved membrane protein compare
Rv3565 -1.0 -1.3 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) compare
Rv0868c -1.0 -1.6 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) compare
Rv1836c -1.0 -1.7 Conserved protein compare
Rv3495c -1.0 -7.8 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv1414 -1.0 -0.7 Conserved hypothetical protein compare
Rv3477 -1.0 -0.9 PE family protein PE31 compare
Rv3500c -1.0 -5.1 Conserved integral membrane protein YrbE4B. Possible ABC transporter. compare
Rv3497c -1.0 -4.2 Mce-family protein Mce4C compare
Rv0742 -1.0 -1.9 PE-PGRS family protein PE_PGRS8 compare
Rv2799 -1.0 -5.1 Probable membrane protein compare
Rv1082 -1.0 -3.2 Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) compare
Rv3494c -1.0 -5.8 Mce-family protein Mce4F compare
Rv3498c -1.0 -5.5 Mce-family protein Mce4B compare
Rv0247c -1.0 -0.5 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0734 -1.0 -3.0 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv2277c -1.0 -1.4 Possible glycerolphosphodiesterase compare
Rv0243 -1.0 -5.0 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) compare
Rv0924c -1.0 -3.1 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv0887c -1.0 -1.1 Conserved hypothetical protein compare
Rv0145 -1.0 -4.1 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv3715c -0.9 -1.3 Probable recombination protein RecR compare
Rv2695 -0.9 -4.8 Conserved hypothetical alanine rich protein compare
Rv2553c -0.9 -0.9 Probable conserved membrane protein compare
Rv3658c -0.9 -0.9 Probable conserved transmembrane protein compare
Rv3139 -0.9 -2.7 Probable acyl-CoA dehydrogenase FadE24 compare
Rv0049 -0.9 -2.5 Conserved hypothetical protein compare
Rv0994 -0.9 -4.5 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv0003 -0.9 -2.8 DNA replication and repair protein RecF (single-strand DNA binding protein) compare
Rv3220c -0.9 -2.1 Probable two component sensor kinase compare
Rv3702c -0.9 -2.2 Conserved hypothetical protein compare
Rv2736c -0.9 -1.0 Regulatory protein RecX compare
Rv2427A -0.9 -1.5 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv3334 -0.9 -2.3 Probable transcriptional regulatory protein (probably MerR-family) compare
Rv1982c -0.9 -1.7 Possible toxin VapC36. Contains PIN domain. compare
Rv2144c -0.9 -1.9 Probable transmembrane protein compare
Rv2707 -0.9 -6.1 Probable conserved transmembrane alanine and leucine rich protein compare
Rv3850 -0.8 -1.1 Conserved protein compare
Rv1006 -0.8 -3.0 Unknown protein compare
Rv0009 -0.8 -0.6 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv2154c -0.8 -1.0 FtsW-like protein FtsW compare
Rv3140 -0.8 -2.2 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2668 -0.8 -1.8 Possible exported alanine and valine rich protein compare
Rv2798c -0.8 -1.5 Conserved hypothetical protein compare
Rv2240c -0.8 -1.3 Unknown protein compare
Rv0942 -0.8 -2.6 Hypothetical protein compare
Rv0563 -0.8 -1.5 Probable protease transmembrane protein heat shock protein HtpX compare
Rv3193c -0.8 -0.9 Probable conserved transmembrane protein compare
Rv3178 -0.8 -1.6 Conserved hypothetical protein compare
Rv3222c -0.8 -0.9 Conserved hypothetical protein compare
Rv0954 -0.8 -3.0 Probable conserved transmembrane protein compare
Rv3830c -0.8 -2.9 Transcriptional regulatory protein (probably TetR-family) compare
Rv2790c -0.8 -2.8 Probable lipid-transfer protein Ltp1 compare
Rv3013 -0.8 -0.9 Conserved protein compare
Rv0632c -0.8 -1.2 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2679 -0.8 -2.1 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv1946c -0.8 -0.9 Possible lipoprotein compare
Rv0157A -0.7 -1.0 Conserved protein compare
Rv2496c -0.7 -2.0 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv2922c -0.7 -2.6 Probable chromosome partition protein Smc compare
Rv2206 -0.7 -2.9 Probable conserved transmembrane protein compare
Rv2569c -0.7 -3.0 Conserved hypothetical protein compare
Rv0202c -0.7 -4.5 Probable conserved transmembrane transport protein MmpL11 compare
Rv0385 -0.7 -4.5 Probable monooxygenase compare
Rv2945c -0.7 -5.1 Probable conserved lipoprotein LppX compare
Rv1626 -0.7 -2.2 Probable two-component system transcriptional regulator compare
Rv0622 -0.7 -1.7 Possible membrane protein compare
Rv1962A -0.7 -0.7 Possible antitoxin VapB35 compare
Rv3182 -0.7 -0.3 Conserved hypothetical protein compare
Rv0646c -0.7 -2.2 Probable lipase/esterase LipG compare
Rv1127c -0.7 -0.6 Probable pyruvate, phosphate dikinase PpdK compare
Rv1935c -0.7 -1.9 Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv3164c -0.7 -1.4 Probable methanol dehydrogenase transcriptional regulatory protein MoxR3 compare
Rv1159 -0.7 -1.2 Mannosyltransferase PimE compare
Rv2829c -0.7 -1.2 Possible toxin VapC22 compare
Rv3136 -0.7 -2.5 PPE family protein PPE51 compare
Rv2190c -0.7 -2.2 Conserved hypothetical protein compare
Rv0007 -0.7 -0.4 Possible conserved membrane protein compare
Rv2942 -0.6 -4.7 Conserved transmembrane transport protein MmpL7 compare
Rv2709 -0.6 -3.8 Probable conserved transmembrane protein compare
Rv1640c -0.6 -3.0 Lysyl-tRNA synthetase 2 LysX compare
Rv1344 -0.6 -2.0 Acyl carrier protein (ACP) MbtL compare
Rv1140 -0.6 -1.2 Probable integral membrane protein compare
Rv3417c -0.6 -1.5 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1) compare
Rv3066 -0.6 -3.2 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv0865 -0.6 -1.6 Probable molybdopterin biosynthesis Mog protein compare
Rv0154c -0.6 -2.0 Probable acyl-CoA dehydrogenase FadE2 compare
Rv0130 -0.6 -0.8 Probable 3-hydroxyl-thioester dehydratase compare
Rv3261 -0.6 -1.1 Probable F420 biosynthesis protein FbiA compare
Rv3135 -0.6 -1.9 PPE family protein PPE50 compare
Rv1173 -0.6 -1.1 Probable F420 biosynthesis protein FbiC compare
Rv0885 -0.6 -1.6 Conserved hypothetical protein compare
Rv2248 -0.6 -1.4 Conserved hypothetical protein compare


Specific Phenotypes

For 3 genes in this experiment

For stress 2-Mercaptopyridine N-oxide sodium salt in Mycobacterium tuberculosis H37Rv

For stress 2-Mercaptopyridine N-oxide sodium salt across organisms