Experiment set5S647 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Ceftriaxone disodium salt hemi(heptahydrate) 0.12 mM

200 most important genes:

  gene name fitness t score description  
Rv3306c -5.1 -2.5 Probable amidohydrolase AmiB1 (aminohydrolase) compare
Rv2989 -4.5 -1.4 Probable transcriptional regulatory protein compare
Rv1102c -2.8 -2.0 Toxin MazF3 compare
Rv1159 -2.7 -3.1 Mannosyltransferase PimE compare
Rv0928 -2.6 -4.0 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv0939 -2.4 -1.4 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase compare
Rv1946c -2.4 -2.9 Possible lipoprotein compare
Rv0929 -2.2 -2.9 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv1930c -2.2 -0.9 Conserved hypothetical protein compare
Rv3102c -2.1 -2.7 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv2553c -2.1 -1.1 Probable conserved membrane protein compare
Rv3819 -2.1 -1.1 Unknown protein compare
Rv1411c -2.1 -4.6 Conserved lipoprotein LprG compare
Rv1410c -2.1 -8.1 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0867c -2.1 -1.1 Possible resuscitation-promoting factor RpfA compare
Rv0504c -2.0 -1.6 Conserved protein compare
Rv1621c -2.0 -4.4 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv2696c -1.9 -2.8 Conserved alanine and glycine and valine rich protein compare
Rv0247c -1.9 -0.8 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) compare
Rv0383c -1.9 -1.1 Possible conserved secreted protein compare
Rv1821 -1.9 -4.8 Possible preprotein translocase ATPase SecA2 compare
Rv1262c -1.8 -1.9 Hypothetical hit-like protein compare
Rv2224c -1.8 -11.3 Probable carboxylesterase CaeA compare
Rv1908c -1.8 -2.8 Catalase-peroxidase-peroxynitritase T KatG compare
Rv2694c -1.8 -1.9 Conserved protein compare
Rv0007 -1.7 -0.9 Possible conserved membrane protein compare
Rv0930 -1.7 -5.2 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0437c -1.7 -1.4 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) compare
Rv2154c -1.6 -2.0 FtsW-like protein FtsW compare
Rv2975c -1.6 -1.2 Conserved hypothetical protein compare
Rv0242c -1.6 -3.1 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv2374c -1.6 -2.2 Probable heat shock protein transcriptional repressor HrcA compare
Rv0955 -1.6 -1.3 Probable conserved integral membrane protein compare
Rv0819 -1.6 -3.2 GCN5-related N-acetyltransferase, MshD compare
Rv3631 -1.5 -0.9 Possible transferase (possibly glycosyltransferase) compare
Rv3267 -1.5 -2.7 Conserved protein (CPSA-related protein) compare
Rv1013 -1.5 -6.7 Putative polyketide synthase Pks16 compare
Rv2706c -1.5 -1.5 Hypothetical protein compare
Rv0531 -1.5 -1.6 Possible conserved membrane protein compare
Rv3811 -1.4 -10.0 Conserved hypothetical protein compare
Rv1836c -1.4 -2.0 Conserved protein compare
Rv3101c -1.4 -1.6 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv0016c -1.3 -4.2 Probable penicillin-binding protein PbpA compare
Rv3833 -1.3 -2.5 Transcriptional regulatory protein (probably AraC-family) compare
Rv2068c -1.3 -8.4 Class a beta-lactamase BlaC compare
Rv3717 -1.3 -3.8 Conserved hypothetical protein compare
Rv0994 -1.3 -6.8 Probable molybdopterin biosynthesis protein MoeA1 compare
Rv1010 -1.3 -0.9 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv1701 -1.2 -2.8 Probable integrase/recombinase compare
Rv1366A -1.2 -1.1 Conserved protein compare
Rv0876c -1.2 -2.3 Possible conserved transmembrane protein compare
Rv2444c -1.2 -2.2 Possible ribonuclease E Rne compare
Rv2190c -1.2 -2.7 Conserved hypothetical protein compare
Rv2707 -1.2 -8.2 Probable conserved transmembrane alanine and leucine rich protein compare
Rv1620c -1.2 -2.9 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv0204c -1.2 -1.8 Probable conserved transmembrane protein compare
Rv2277c -1.2 -1.6 Possible glycerolphosphodiesterase compare
Rv2427A -1.2 -1.8 'Transcriptional regulator OxyR', pseudogene' pseudogene=unknown transl_table=11 compare
Rv3768 -1.2 -2.6 Unknown protein compare
Rv2945c -1.1 -7.8 Probable conserved lipoprotein LppX compare
Rv2348c -1.1 -0.7 Hypothetical protein compare
Rv0989c -1.1 -6.2 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv0742 -1.1 -1.8 PE-PGRS family protein PE_PGRS8 compare
Rv1291c -1.1 -1.6 Conserved hypothetical secreted protein compare
Rv2942 -1.1 -8.0 Conserved transmembrane transport protein MmpL7 compare
Rv0452 -1.1 -3.1 Possible transcriptional regulatory protein compare
Rv0949 -1.1 -0.6 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv0758 -1.1 -2.1 Possible two component system response sensor kinase membrane associated PhoR compare
Rv3013 -1.1 -1.2 Conserved protein compare
Rv0241c -1.1 -2.4 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0098 -1.1 -1.3 Probable fatty acyl CoA thioesterase type III FcoT compare
Rv0964c -1.1 -1.2 Hypothetical protein compare
Rv0200 -1.1 -2.4 Possible conserved transmembrane protein compare
Rv2691 -1.1 -4.8 TRK system potassium uptake protein CeoB compare
Rv3501c -1.1 -3.3 Conserved integral membrane protein YrbE4A. Possible ABC transporter. compare
Rv1244 -1.0 -3.5 Probable lipoprotein LpqZ compare
Rv1006 -1.0 -3.1 Unknown protein compare
Rv0494 -1.0 -2.7 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv3658c -1.0 -1.0 Probable conserved transmembrane protein compare
Rv3249c -1.0 -1.1 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv2046 -1.0 -2.3 Probable lipoprotein LppI compare
Rv2864c -1.0 -6.6 Possible penicillin-binding lipoprotein compare
Rv3498c -1.0 -4.2 Mce-family protein Mce4B compare
Rv2936 -1.0 -7.6 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA compare
Rv1444c -1.0 -1.6 Unknown protein compare
Rv1127c -1.0 -1.2 Probable pyruvate, phosphate dikinase PpdK compare
Rv0177 -1.0 -1.0 Probable conserved Mce associated protein compare
Rv3004 -1.0 -1.4 Low molecular weight protein antigen 6 (CFP-6) compare
Rv2335 -1.0 -1.2 Probable serine acetyltransferase CysE (sat) compare
Rv0954 -1.0 -3.0 Probable conserved transmembrane protein compare
Rv3492c -1.0 -1.8 Conserved hypothetical Mce associated protein compare
Rv0610c -1.0 -1.0 Hypothetical protein compare
Rv0040c -1.0 -5.0 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) compare
Rv0893c -1.0 -2.1 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv0990c -1.0 -0.6 Hypothetical protein compare
Rv3208A -0.9 -1.1 Conserved protein TB9.4 compare
Rv3563 -0.9 -1.1 Probable acyl-CoA dehydrogenase FadE32 compare
Rv1957 -0.9 -1.3 Hypothetical protein compare
Rv1565c -0.9 -4.2 Conserved hypothetical membrane protein compare
Rv1173 -0.9 -1.6 Probable F420 biosynthesis protein FbiC compare
Rv1850 -0.9 -2.0 Urease alpha subunit UreC (urea amidohydrolase) compare
Rv2496c -0.9 -2.4 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB compare
Rv2630 -0.9 -0.5 Hypothetical protein compare
Rv2869c -0.9 -0.9 Membrane bound metalloprotease compare
Rv3139 -0.9 -4.0 Probable acyl-CoA dehydrogenase FadE24 compare
Rv1566c -0.9 -2.3 Possible Inv protein compare
Rv3922c -0.9 -1.4 Possible hemolysin compare
Rv1657 -0.9 -0.9 Probable arginine repressor ArgR (AHRC) compare
Rv2865 -0.9 -1.5 Antitoxin RelF compare
Rv3897c -0.9 -0.9 Conserved hypothetical protein compare
Rv3005c -0.9 -5.0 Conserved hypothetical protein compare
Rv2624c -0.9 -0.8 Universal stress protein family protein compare
Rv2938 -0.9 -6.3 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC compare
Rv3920c -0.9 -0.8 Conserved protein similar to jag protein compare
Rv3405c -0.9 -1.1 Possible transcriptional regulatory protein compare
Rv0444c -0.9 -4.4 Anti-sigma factor RskA (regulator of sigma K) compare
Rv1100 -0.9 -2.4 Conserved protein compare
Rv0586 -0.9 -1.8 Probable transcriptional regulatory protein Mce2R (GntR-family) compare
Rv3497c -0.8 -4.2 Mce-family protein Mce4C compare
Rv3700c -0.8 -1.6 Conserved hypothetical protein compare
Rv3200c -0.8 -2.0 Possible transmembrane cation transporter compare
Rv3414c -0.8 -2.2 Probable alternative RNA polymerase sigma-D factor SigD compare
Rv0520 -0.8 -1.8 Possible methyltransferase/methylase (fragment) compare
Rv3140 -0.8 -3.3 Probable acyl-CoA dehydrogenase FadE23 compare
Rv2937 -0.8 -5.5 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB compare
Rv2525c -0.8 -4.4 Conserved hypothetical protein. Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system. compare
Rv2708c -0.8 -1.3 Conserved hypothetical protein compare
Rv2709 -0.8 -3.0 Probable conserved transmembrane protein compare
Rv1897c -0.8 -1.3 Conserved hypothetical protein compare
Rv0680c -0.8 -1.1 Probable conserved transmembrane protein compare
Rv3494c -0.8 -4.5 Mce-family protein Mce4F compare
Rv0653c -0.8 -2.9 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0573c -0.8 -2.1 Nicotinic acid phosphoribosyltransferase PncB2 compare
Rv0483 -0.8 -5.1 Probable conserved lipoprotein LprQ compare
Rv1259 -0.8 -0.6 Probable uracil DNA glycosylase, UdgB compare
Rv2216 -0.8 -2.0 Conserved protein compare
Rv0017c -0.8 -2.0 Probable cell division protein RodA compare
Rv0245 -0.8 -1.6 Possible oxidoreductase compare
Rv3493c -0.8 -2.6 Conserved hypothetical Mce associated alanine and valine rich protein compare
Rv3910 -0.8 -1.5 Probable conserved transmembrane protein compare
Rv3220c -0.8 -1.8 Probable two component sensor kinase compare
Rv1178 -0.8 -2.2 Probable aminotransferase compare
Rv3311 -0.8 -2.0 Conserved protein compare
Rv3499c -0.7 -4.7 Mce-family protein Mce4A compare
Rv3855 -0.7 -3.9 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv2049c -0.7 -0.8 Conserved hypothetical protein compare
Rv2197c -0.7 -2.4 Probable conserved transmembrane protein compare
Rv1072 -0.7 -0.7 Probable conserved transmembrane protein compare
Rv2799 -0.7 -4.5 Probable membrane protein compare
Rv1420 -0.7 -1.2 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv0472c -0.7 -2.1 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv0219 -0.7 -1.4 Probable conserved transmembrane protein compare
Rv0905 -0.7 -2.1 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0237 -0.7 -2.4 Probable conserved lipoprotein LpqI compare
Rv2831 -0.7 -2.8 Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv0738 -0.7 -0.6 Conserved protein compare
Rv0760c -0.7 -1.6 Conserved protein compare
Rv2719c -0.7 -2.8 Possible conserved membrane protein compare
Rv1332 -0.7 -0.6 Probable transcriptional regulatory protein compare
Rv0309 -0.7 -1.2 Possible conserved exported protein compare
Rv2206 -0.7 -1.7 Probable conserved transmembrane protein compare
Rv0820 -0.7 -1.5 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv3174 -0.7 -1.1 Probable short-chain dehydrogenase/reductase compare
Rv1009 -0.7 -2.3 Probable resuscitation-promoting factor RpfB compare
Rv1860 -0.7 -2.7 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) compare
Rv2801A -0.7 -2.0 Possible antitoxin MazE9 compare
Rv3358 -0.7 -0.8 Toxin RelK compare
Rv3584 -0.7 -1.4 Possible conserved lipoprotein LpqE compare
Rv3386 -0.7 -0.7 Possible transposase compare
Rv3655c -0.7 -1.2 Conserved hypothetical protein compare
Rv1131 -0.7 -0.9 Probable methylcitrate synthase PrpC compare
Rv3202c -0.7 -3.8 Possible ATP-dependent DNA helicase compare
Rv0918 -0.7 -1.2 Conserved protein compare
Rv0724 -0.7 -3.0 Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase) compare
Rv2529 -0.7 -2.1 Hypothetical protein compare
Rv1887 -0.7 -3.8 Hypothetical protein compare
Rv0121c -0.7 -1.6 Conserved protein compare
Rv2923c -0.7 -1.0 Conserved protein compare
Rv3814c -0.7 -3.5 Possible acyltransferase compare
Rv0018c -0.7 -1.7 Phosphoserine/threonine phosphatase PstP compare
Rv0381c -0.7 -3.2 Hypothetical protein compare
Rv0734 -0.7 -2.0 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) compare
Rv1730c -0.7 -1.9 Possible penicillin-binding protein compare
Rv0924c -0.7 -2.3 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv2661c -0.6 -0.6 Hypothetical protein compare
Rv2790c -0.6 -1.8 Probable lipid-transfer protein Ltp1 compare
Rv3751 -0.6 -1.1 Probable integrase (fragment) compare
Rv3495c -0.6 -3.9 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) compare
Rv2366c -0.6 -1.4 Probable conserved transmembrane protein compare
Rv1745c -0.6 -2.2 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv3413c -0.6 -0.7 Unknown alanine and proline rich protein compare
Rv2240c -0.6 -1.1 Unknown protein compare
Rv1435c -0.6 -1.9 Probable conserved proline, glycine, valine-rich secreted protein compare
Rv0361 -0.6 -0.7 Probable conserved membrane protein compare
Rv2732c -0.6 -1.8 Probable conserved transmembrane protein compare
Rv1626 -0.6 -2.5 Probable two-component system transcriptional regulator compare
Rv2043c -0.6 -1.8 Pyrazinamidase/nicotinamidase PncA (PZase) compare
Rv0973c -0.6 -1.3 Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP) compare
Rv0665 -0.6 -1.3 Possible toxin VapC8 compare
Rv3089 -0.6 -1.5 Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) compare


Specific Phenotypes

For 3 genes in this experiment

For stress Ceftriaxone disodium salt hemi(heptahydrate) in Mycobacterium tuberculosis H37Rv

For stress Ceftriaxone disodium salt hemi(heptahydrate) across organisms